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Protein

Nuclear receptor-interacting protein 1

Gene

NRIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.7 Publications

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • core promoter sequence-specific DNA binding Source: UniProtKB
  • estrogen receptor binding Source: UniProtKB
  • glucocorticoid receptor binding Source: UniProtKB
  • nuclear hormone receptor binding Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • androgen receptor signaling pathway Source: UniProtKB
  • cellular response to estradiol stimulus Source: BHF-UCL
  • circadian regulation of gene expression Source: UniProtKB
  • circadian rhythm Source: UniProtKB
  • lipid storage Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • ovarian follicle rupture Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1368082. RORA activates gene expression.
R-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-400253. Circadian Clock.
SignaLinkiP48552.
SIGNORiP48552.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-interacting protein 1
Alternative name(s):
Nuclear factor RIP140
Receptor-interacting protein 140
Gene namesi
Name:NRIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:8001. NRIP1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: HPA
  • histone deacetylase complex Source: Ensembl
  • nuclear chromatin Source: BHF-UCL
  • nuclear speck Source: Ensembl
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi440 – 4434PIDL → AAAA: Abolishes interaction with CTBP1. 1 Publication
Mutagenesisi440 – 4423PID → AIA: Abolishes interaction with CTBP1 and attenuates nuclear hormone receptor-dependent transcription repression.
Mutagenesisi442 – 4432DL → AA: Reduces, but does not completely abolish, interaction with CTBP. Reduces transcriptional repression. 2 Publications
Mutagenesisi442 – 4432DL → AS: Disrupts interaction with CTBP1, and CTBP2 to a lesser extent. Disrupts transcriptional repression; when associated with 567-AS-568. 2 Publications
Mutagenesisi446 – 4461K → Q: Disrupts interaction with CTBP1. Decreases lysine acetylation. Disrupts nuclear hormone receptor-dependent transcription repression. 1 Publication
Mutagenesisi446 – 4461K → R: Does not disrupt nuclear hormone receptor-dependent transcription repression. 1 Publication
Mutagenesisi567 – 5682NL → AA: Disrupts transcriptional repression. 2 Publications
Mutagenesisi567 – 5682NL → AS: Disrupts interaction with CTBP1 and CTBP2. Disrupts transcriptional repression; when associated with 442-AS-443. 2 Publications
Mutagenesisi599 – 6035SMDLT → PIAAS: Does not further disrupt transcriptional repression; when associated with 442-AA-443 and 567-AA-568.
Mutagenesisi948 – 9492DL → AA: Abolishes CTBP binding but retains transcriptional repressor activity. 1 Publication

Organism-specific databases

PharmGKBiPA31780.

Polymorphism and mutation databases

BioMutaiNRIP1.
DMDMi9988061.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11581158Nuclear receptor-interacting protein 1PRO_0000057951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041PhosphoserineBy similarity
Modified residuei111 – 1111N6-acetyllysineBy similarity
Modified residuei158 – 1581N6-acetyllysineBy similarity
Modified residuei207 – 2071PhosphothreonineBy similarity
Modified residuei218 – 2181PhosphoserineCombined sources
Modified residuei286 – 2861N6-acetyllysineBy similarity
Modified residuei310 – 3101N6-acetyllysineBy similarity
Modified residuei356 – 3561PhosphoserineBy similarity
Modified residuei378 – 3781PhosphoserineBy similarity
Modified residuei446 – 4461N6-acetyllysine1 Publication
Modified residuei481 – 4811N6-acetyllysineBy similarity
Modified residuei487 – 4871PhosphoserineBy similarity
Modified residuei518 – 5181PhosphoserineBy similarity
Modified residuei528 – 5281N6-acetyllysineBy similarity
Modified residuei542 – 5421PhosphoserineBy similarity
Modified residuei564 – 5641PhosphoserineCombined sources
Modified residuei606 – 6061N6-acetyllysineBy similarity
Modified residuei671 – 6711PhosphoserineCombined sources
Cross-linki756 – 756Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei807 – 8071PhosphoserineCombined sources
Modified residuei931 – 9311N6-acetyllysineBy similarity
Modified residuei1001 – 10011PhosphoserineBy similarity
Cross-linki1105 – 1105Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.By similarity1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP48552.
MaxQBiP48552.
PaxDbiP48552.
PeptideAtlasiP48552.
PRIDEiP48552.

PTM databases

iPTMnetiP48552.
PhosphoSiteiP48552.

Expressioni

Inductioni

Expressed in a circadian manner in the liver (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000180530.
CleanExiHS_NRIP1.
ExpressionAtlasiP48552. baseline and differential.
GenevisibleiP48552. HS.

Organism-specific databases

HPAiHPA046571.
HPA060036.

Interactioni

Subunit structurei

Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1 (By similarity). Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366. Interacts with RORA.By similarity14 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARPC3O151453EBI-746484,EBI-351829
CEP70Q8NHQ13EBI-746484,EBI-739624
DNMT1P263583EBI-746484,EBI-719459
FHL1Q136426EBI-746484,EBI-912547
HDAC3O153792EBI-746484,EBI-607682
LDOC1O957513EBI-746484,EBI-740738
PRMT1Q998734EBI-746484,EBI-78738
RARAP102764EBI-746484,EBI-413374
RARAP10276-23EBI-746484,EBI-10197061
ZNF366Q8N8952EBI-746484,EBI-2813661

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • estrogen receptor binding Source: UniProtKB
  • glucocorticoid receptor binding Source: UniProtKB
  • nuclear hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113843. 57 interactions.
DIPiDIP-5964N.
IntActiP48552. 22 interactions.
MINTiMINT-192711.
STRINGi9606.ENSP00000327213.

Structurei

Secondary structure

1
1158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi379 – 3857Combined sources
Helixi500 – 5056Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GPOX-ray1.95C366-390[»]
2GPPX-ray2.60C/D366-390[»]
4S14X-ray3.54C499-510[»]
4S15X-ray1.90C/D499-510[»]
ProteinModelPortaliP48552.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48552.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 415415Interaction with ZNF366Add
BLAST
Regioni78 – 333256Repression domain 1Add
BLAST
Regioni410 – 700291Repression domain 2Add
BLAST
Regioni431 – 47242Required for targeting to small nuclear fociAdd
BLAST
Regioni735 – 885151Repression domain 3Add
BLAST
Regioni753 – 1158406Interaction with ZNF366Add
BLAST
Regioni1118 – 115841Repression domain 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi21 – 255LXXLL motif 1
Motifi133 – 1375LXXLL motif 2
Motifi185 – 1895LXXLL motif 3
Motifi266 – 2705LXXLL motif 4
Motifi380 – 3845LXXLL motif 5
Motifi440 – 4467CTBP-binding; principal site
Motifi500 – 5045LXXLL motif 6
Motifi565 – 5695CTBP-binding
Motifi599 – 6035CTBP-bindingSequence analysis
Motifi713 – 7175LXXLL motif 7
Motifi819 – 8235LXXLL motif 8
Motifi936 – 9405LXXLL motif 9
Motifi946 – 9505CTBP-binding
Motifi1061 – 107414Ligand-dependent nuclear receptor bindingBy similarityAdd
BLAST

Domaini

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFW7. Eukaryota.
ENOG410XPVS. LUCA.
GeneTreeiENSGT00390000007999.
HOGENOMiHOG000236277.
HOVERGENiHBG052667.
InParanoidiP48552.
KOiK17965.
OMAiVEKDLRC.
OrthoDBiEOG091G07UX.
PhylomeDBiP48552.
TreeFamiTF332210.

Family and domain databases

InterProiIPR026649. NRIP1.
IPR031405. NRIP1_RD1.
IPR031406. NRIP1_RD2.
IPR031407. NRIP1_RD3.
IPR031408. NRIP1_RD4.
[Graphical view]
PANTHERiPTHR15088. PTHR15088. 1 hit.
PfamiPF15687. NRIP1_repr_1. 1 hit.
PF15688. NRIP1_repr_2. 1 hit.
PF15689. NRIP1_repr_3. 1 hit.
PF15690. NRIP1_repr_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHGEELGSD VHQDSIVLTY LEGLLMHQAA GGSGTAVDKK SAGHNEEDQN
60 70 80 90 100
FNISGSAFPT CQSNGPVLNT HTYQGSGMLH LKKARLLQSS EDWNAAKRKR
110 120 130 140 150
LSDSIMNLNV KKEALLAGMV DSVPKGKQDS TLLASLLQSF SSRLQTVALS
160 170 180 190 200
QQIRQSLKEQ GYALSHDSLK VEKDLRCYGV ASSHLKTLLK KSKVKDQKPD
210 220 230 240 250
TNLPDVTKNL IRDRFAESPH HVGQSGTKVM SEPLSCAARL QAVASMVEKR
260 270 280 290 300
ASPATSPKPS VACSQLALLL SSEAHLQQYS REHALKTQNA NQAASERLAA
310 320 330 340 350
MARLQENGQK DVGSYQLPKG MSSHLNGQAR TSSSKLMASK SSATVFQNPM
360 370 380 390 400
GIIPSSPKNA GYKNSLERNN IKQAANNSLL LHLLKSQTIP KPMNGHSHSE
410 420 430 440 450
RGSIFEESST PTTIDEYSDN NPSFTDDSSG DESSYSNCVP IDLSCKHRTE
460 470 480 490 500
KSESDQPVSL DNFTQSLLNT WDPKVPDVDI KEDQDTSKNS KLNSHQKVTL
510 520 530 540 550
LQLLLGHKNE ENVEKNTSPQ GVHNDVSKFN TQNYARTSVI ESPSTNRTTP
560 570 580 590 600
VSTPPLLTSS KAGSPINLSQ HSLVIKWNSP PYVCSTQSEK LTNTASNHSM
610 620 630 640 650
DLTKSKDPPG EKPAQNEGAQ NSATFSASKL LQNLAQCGMQ SSMSVEEQRP
660 670 680 690 700
SKQLLTGNTD KPIGMIDRLN SPLLSNKTNA VEENKAFSSQ PTGPEPGLSG
710 720 730 740 750
SEIENLLERR TVLQLLLGNP NKGKSEKKEK TPLRDESTQE HSERALSEQI
760 770 780 790 800
LMVKIKSEPC DDLQIPNTNV HLSHDAKSAP FLGMAPAVQR SAPALPVSED
810 820 830 840 850
FKSEPVSPQD FSFSKNGLLS RLLRQNQDSY LADDSDRSHR NNEMALLESK
860 870 880 890 900
NLCMVPKKRK LYTEPLENPF KKMKNNIVDA ANNHSAPEVL YGSLLNQEEL
910 920 930 940 950
KFSRNDLEFK YPAGHGSASE SEHRSWARES KSFNVLKQLL LSENCVRDLS
960 970 980 990 1000
PHRSNSVADS KKKGHKNNVT NSKPEFSISS LNGLMYSSTQ PSSCMDNRTF
1010 1020 1030 1040 1050
SYPGVVKTPV SPTFPEHLGC AGSRPESGLL NGCSMPSEKG PIKWVITDAE
1060 1070 1080 1090 1100
KNEYEKDSPR LTKTNPILYY MLQKGGNSVT SRETQDKDIW REASSAESVS
1110 1120 1130 1140 1150
QVTAKEELLP TAETKASFFN LRSPYNSHMG NNASRPHSAN GEVYGLLGSV

LTIKKESE
Length:1,158
Mass (Da):126,942
Last modified:December 1, 2000 - v2
Checksum:i81FC424968E9A5F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241P → R in CAA59108 (PubMed:7641693).Curated
Sequence conflicti721 – 7266NKGKSE → TKGRVK in CAA59108 (PubMed:7641693).Curated
Sequence conflicti954 – 9541S → I in AAH40361 (PubMed:15489334).Curated
Sequence conflicti1080 – 10801T → A in CAA59108 (PubMed:7641693).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371V → I.
Corresponds to variant rs9941840 [ dbSNP | Ensembl ].
VAR_051241
Natural varianti221 – 2211H → R.1 Publication
Corresponds to variant rs139263261 [ dbSNP | Ensembl ].
VAR_023706
Natural varianti315 – 3151Y → F.
Corresponds to variant rs2228507 [ dbSNP | Ensembl ].
VAR_034142
Natural varianti441 – 4411I → V.1 Publication
Corresponds to variant rs150468995 [ dbSNP | Ensembl ].
VAR_023707
Natural varianti448 – 4481R → G Common polymorphism. 2 Publications
Corresponds to variant rs2229742 [ dbSNP | Ensembl ].
VAR_023708
Natural varianti567 – 5671N → S.
Corresponds to variant rs9975169 [ dbSNP | Ensembl ].
VAR_051242
Natural varianti803 – 8031S → L.1 Publication
Corresponds to variant rs61750208 [ dbSNP | Ensembl ].
VAR_023709
Natural varianti1079 – 10791V → F.1 Publication
Corresponds to variant rs140803495 [ dbSNP | Ensembl ].
VAR_023710

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84373 mRNA. Translation: CAA59108.1.
AF248484 Genomic DNA. Translation: AAF62185.1.
AF127577 Genomic DNA. Translation: AAF35255.1.
AL163207 Genomic DNA. Translation: CAB90396.1.
BC040361 mRNA. Translation: AAH40361.1.
CCDSiCCDS13568.1.
PIRiS57348.
RefSeqiNP_003480.2. NM_003489.3.
XP_005261120.1. XM_005261063.3.
XP_005261122.1. XM_005261065.3.
XP_011528049.1. XM_011529747.1.
XP_011528050.1. XM_011529748.2.
XP_011528051.1. XM_011529749.2.
XP_011528053.1. XM_011529751.2.
XP_011528054.1. XM_011529752.1.
UniGeneiHs.155017.

Genome annotation databases

EnsembliENST00000318948; ENSP00000327213; ENSG00000180530.
ENST00000400199; ENSP00000383060; ENSG00000180530.
ENST00000400202; ENSP00000383063; ENSG00000180530.
GeneIDi8204.
KEGGihsa:8204.
UCSCiuc002yjx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84373 mRNA. Translation: CAA59108.1.
AF248484 Genomic DNA. Translation: AAF62185.1.
AF127577 Genomic DNA. Translation: AAF35255.1.
AL163207 Genomic DNA. Translation: CAB90396.1.
BC040361 mRNA. Translation: AAH40361.1.
CCDSiCCDS13568.1.
PIRiS57348.
RefSeqiNP_003480.2. NM_003489.3.
XP_005261120.1. XM_005261063.3.
XP_005261122.1. XM_005261065.3.
XP_011528049.1. XM_011529747.1.
XP_011528050.1. XM_011529748.2.
XP_011528051.1. XM_011529749.2.
XP_011528053.1. XM_011529751.2.
XP_011528054.1. XM_011529752.1.
UniGeneiHs.155017.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GPOX-ray1.95C366-390[»]
2GPPX-ray2.60C/D366-390[»]
4S14X-ray3.54C499-510[»]
4S15X-ray1.90C/D499-510[»]
ProteinModelPortaliP48552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113843. 57 interactions.
DIPiDIP-5964N.
IntActiP48552. 22 interactions.
MINTiMINT-192711.
STRINGi9606.ENSP00000327213.

PTM databases

iPTMnetiP48552.
PhosphoSiteiP48552.

Polymorphism and mutation databases

BioMutaiNRIP1.
DMDMi9988061.

Proteomic databases

EPDiP48552.
MaxQBiP48552.
PaxDbiP48552.
PeptideAtlasiP48552.
PRIDEiP48552.

Protocols and materials databases

DNASUi8204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318948; ENSP00000327213; ENSG00000180530.
ENST00000400199; ENSP00000383060; ENSG00000180530.
ENST00000400202; ENSP00000383063; ENSG00000180530.
GeneIDi8204.
KEGGihsa:8204.
UCSCiuc002yjx.2. human.

Organism-specific databases

CTDi8204.
GeneCardsiNRIP1.
H-InvDBHIX0027827.
HGNCiHGNC:8001. NRIP1.
HPAiHPA046571.
HPA060036.
MIMi602490. gene.
neXtProtiNX_P48552.
PharmGKBiPA31780.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFW7. Eukaryota.
ENOG410XPVS. LUCA.
GeneTreeiENSGT00390000007999.
HOGENOMiHOG000236277.
HOVERGENiHBG052667.
InParanoidiP48552.
KOiK17965.
OMAiVEKDLRC.
OrthoDBiEOG091G07UX.
PhylomeDBiP48552.
TreeFamiTF332210.

Enzyme and pathway databases

ReactomeiR-HSA-1368082. RORA activates gene expression.
R-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-400253. Circadian Clock.
SignaLinkiP48552.
SIGNORiP48552.

Miscellaneous databases

ChiTaRSiNRIP1. human.
EvolutionaryTraceiP48552.
GeneWikiiNRIP1.
GenomeRNAii8204.
PROiP48552.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180530.
CleanExiHS_NRIP1.
ExpressionAtlasiP48552. baseline and differential.
GenevisibleiP48552. HS.

Family and domain databases

InterProiIPR026649. NRIP1.
IPR031405. NRIP1_RD1.
IPR031406. NRIP1_RD2.
IPR031407. NRIP1_RD3.
IPR031408. NRIP1_RD4.
[Graphical view]
PANTHERiPTHR15088. PTHR15088. 1 hit.
PfamiPF15687. NRIP1_repr_1. 1 hit.
PF15688. NRIP1_repr_2. 1 hit.
PF15689. NRIP1_repr_3. 1 hit.
PF15690. NRIP1_repr_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRIP1_HUMAN
AccessioniPrimary (citable) accession number: P48552
Secondary accession number(s): Q8IWE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.