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P48552

- NRIP1_HUMAN

UniProt

P48552 - NRIP1_HUMAN

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Protein
Nuclear receptor-interacting protein 1
Gene
NRIP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors.6 Publications

GO - Molecular functioni

  1. androgen receptor binding Source: UniProtKB
  2. estrogen receptor binding Source: UniProtKB
  3. glucocorticoid receptor binding Source: UniProtKB
  4. nuclear hormone receptor binding Source: UniProtKB
  5. protein binding Source: UniProtKB
  6. transcription coactivator activity Source: UniProtKB
  7. transcription corepressor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. androgen receptor signaling pathway Source: UniProtKB
  2. lipid storage Source: Ensembl
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. ovarian follicle rupture Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  6. positive regulation of transcription, DNA-templated Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP48552.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-interacting protein 1
Alternative name(s):
Nuclear factor RIP140
Receptor-interacting protein 140
Gene namesi
Name:NRIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:8001. NRIP1.

Subcellular locationi

Nucleus
Note: Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.4 Publications

GO - Cellular componenti

  1. cell junction Source: HPA
  2. histone deacetylase complex Source: Ensembl
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi440 – 4434PIDL → AAAA: Abolishes interaction with CTBP1. 1 Publication
Mutagenesisi440 – 4423PID → AIA: Abolishes interaction with CTBP1 and attenuates nuclear hormone receptor-dependent transcription repression.
Mutagenesisi442 – 4432DL → AA: Reduces, but does not completely abolish, interaction with CTBP. Reduces transcriptional repression. 1 Publication
Mutagenesisi442 – 4432DL → AS: Disrupts interaction with CTBP1, and CTBP2 to a lesser extent. Disrupts transcriptional repression; when associated with 567-AS-568. 1 Publication
Mutagenesisi446 – 4461K → Q: Disrupts interaction with CTBP1. Decreases lysine acetylation. Disrupts nuclear hormone receptor-dependent transcription repression. 1 Publication
Mutagenesisi446 – 4461K → R: Does not disrupt nuclear hormone receptor-dependent transcription repression. 1 Publication
Mutagenesisi567 – 5682NL → AA: Disrupts transcriptional repression. 2 Publications
Mutagenesisi567 – 5682NL → AS: Disrupts interaction with CTBP1 and CTBP2. Disrupts transcriptional repression; when associated with 442-AS-443. 2 Publications
Mutagenesisi599 – 6035SMDLT → PIAAS: Does not further disrupt transcriptional repression; when associated with 442-AA-443 and 567-AA-568.
Mutagenesisi948 – 9492DL → AA: Abolishes CTBP binding but retains transcriptional repressor activity. 1 Publication

Organism-specific databases

PharmGKBiPA31780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11581158Nuclear receptor-interacting protein 1
PRO_0000057951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041Phosphoserine By similarity
Modified residuei111 – 1111N6-acetyllysine By similarity
Modified residuei158 – 1581N6-acetyllysine By similarity
Modified residuei207 – 2071Phosphothreonine By similarity
Modified residuei286 – 2861N6-acetyllysine By similarity
Modified residuei310 – 3101N6-acetyllysine By similarity
Modified residuei356 – 3561Phosphoserine By similarity
Modified residuei378 – 3781Phosphoserine By similarity
Modified residuei446 – 4461N6-acetyllysine1 Publication
Modified residuei481 – 4811N6-acetyllysine By similarity
Modified residuei487 – 4871Phosphoserine By similarity
Modified residuei518 – 5181Phosphoserine By similarity
Modified residuei528 – 5281N6-acetyllysine By similarity
Modified residuei542 – 5421Phosphoserine By similarity
Modified residuei606 – 6061N6-acetyllysine By similarity
Modified residuei671 – 6711Phosphoserine By similarity
Modified residuei931 – 9311N6-acetyllysine By similarity
Modified residuei1001 – 10011Phosphoserine By similarity

Post-translational modificationi

Acetylation regulates its nuclear translocation and corepressive activity By similarity. Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP48552.
PRIDEiP48552.

PTM databases

PhosphoSiteiP48552.

Expressioni

Gene expression databases

ArrayExpressiP48552.
BgeeiP48552.
CleanExiHS_NRIP1.
GenevestigatoriP48552.

Organism-specific databases

HPAiHPA046571.

Interactioni

Subunit structurei

Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1 By similarity. Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366.12 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-746484,EBI-739624
DNMT1P263583EBI-746484,EBI-719459
FHL1Q136426EBI-746484,EBI-912547
HDAC3O153792EBI-746484,EBI-607682
LDOC1O957513EBI-746484,EBI-740738
PRMT1Q998734EBI-746484,EBI-78738
ZNF366Q8N8952EBI-746484,EBI-2813661

Protein-protein interaction databases

BioGridi113843. 54 interactions.
DIPiDIP-5964N.
IntActiP48552. 21 interactions.
MINTiMINT-192711.
STRINGi9606.ENSP00000327213.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi379 – 3857

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GPOX-ray1.95C366-390[»]
2GPPX-ray2.60C/D366-390[»]
ProteinModelPortaliP48552.

Miscellaneous databases

EvolutionaryTraceiP48552.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 415415Interaction with ZNF366
Add
BLAST
Regioni78 – 333256Repression domain 1
Add
BLAST
Regioni410 – 700291Repression domain 2
Add
BLAST
Regioni431 – 47242Required for targeting to small nuclear foci
Add
BLAST
Regioni735 – 885151Repression domain 3
Add
BLAST
Regioni753 – 1158406Interaction with ZNF366
Add
BLAST
Regioni1118 – 115841Repression domain 4
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi21 – 255LXXLL motif 1
Motifi133 – 1375LXXLL motif 2
Motifi185 – 1895LXXLL motif 3
Motifi266 – 2705LXXLL motif 4
Motifi380 – 3845LXXLL motif 5
Motifi440 – 4467CTBP-binding; principal site
Motifi500 – 5045LXXLL motif 6
Motifi565 – 5695CTBP-binding
Motifi599 – 6035CTBP-binding Reviewed prediction
Motifi713 – 7175LXXLL motif 7
Motifi819 – 8235LXXLL motif 8
Motifi936 – 9405LXXLL motif 9
Motifi946 – 9505CTBP-binding
Motifi1061 – 107414Ligand-dependent nuclear receptor binding By similarity
Add
BLAST

Domaini

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG47583.
HOGENOMiHOG000236277.
HOVERGENiHBG052667.
InParanoidiP48552.
KOiK17965.
OMAiVEKDLRC.
OrthoDBiEOG7H1JJQ.
PhylomeDBiP48552.
TreeFamiTF332210.

Family and domain databases

InterProiIPR026649. NRIP1.
[Graphical view]
PANTHERiPTHR15088. PTHR15088. 1 hit.

Sequencei

Sequence statusi: Complete.

P48552-1 [UniParc]FASTAAdd to Basket

« Hide

MTHGEELGSD VHQDSIVLTY LEGLLMHQAA GGSGTAVDKK SAGHNEEDQN     50
FNISGSAFPT CQSNGPVLNT HTYQGSGMLH LKKARLLQSS EDWNAAKRKR 100
LSDSIMNLNV KKEALLAGMV DSVPKGKQDS TLLASLLQSF SSRLQTVALS 150
QQIRQSLKEQ GYALSHDSLK VEKDLRCYGV ASSHLKTLLK KSKVKDQKPD 200
TNLPDVTKNL IRDRFAESPH HVGQSGTKVM SEPLSCAARL QAVASMVEKR 250
ASPATSPKPS VACSQLALLL SSEAHLQQYS REHALKTQNA NQAASERLAA 300
MARLQENGQK DVGSYQLPKG MSSHLNGQAR TSSSKLMASK SSATVFQNPM 350
GIIPSSPKNA GYKNSLERNN IKQAANNSLL LHLLKSQTIP KPMNGHSHSE 400
RGSIFEESST PTTIDEYSDN NPSFTDDSSG DESSYSNCVP IDLSCKHRTE 450
KSESDQPVSL DNFTQSLLNT WDPKVPDVDI KEDQDTSKNS KLNSHQKVTL 500
LQLLLGHKNE ENVEKNTSPQ GVHNDVSKFN TQNYARTSVI ESPSTNRTTP 550
VSTPPLLTSS KAGSPINLSQ HSLVIKWNSP PYVCSTQSEK LTNTASNHSM 600
DLTKSKDPPG EKPAQNEGAQ NSATFSASKL LQNLAQCGMQ SSMSVEEQRP 650
SKQLLTGNTD KPIGMIDRLN SPLLSNKTNA VEENKAFSSQ PTGPEPGLSG 700
SEIENLLERR TVLQLLLGNP NKGKSEKKEK TPLRDESTQE HSERALSEQI 750
LMVKIKSEPC DDLQIPNTNV HLSHDAKSAP FLGMAPAVQR SAPALPVSED 800
FKSEPVSPQD FSFSKNGLLS RLLRQNQDSY LADDSDRSHR NNEMALLESK 850
NLCMVPKKRK LYTEPLENPF KKMKNNIVDA ANNHSAPEVL YGSLLNQEEL 900
KFSRNDLEFK YPAGHGSASE SEHRSWARES KSFNVLKQLL LSENCVRDLS 950
PHRSNSVADS KKKGHKNNVT NSKPEFSISS LNGLMYSSTQ PSSCMDNRTF 1000
SYPGVVKTPV SPTFPEHLGC AGSRPESGLL NGCSMPSEKG PIKWVITDAE 1050
KNEYEKDSPR LTKTNPILYY MLQKGGNSVT SRETQDKDIW REASSAESVS 1100
QVTAKEELLP TAETKASFFN LRSPYNSHMG NNASRPHSAN GEVYGLLGSV 1150
LTIKKESE 1158
Length:1,158
Mass (Da):126,942
Last modified:December 1, 2000 - v2
Checksum:i81FC424968E9A5F6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371V → I.
Corresponds to variant rs9941840 [ dbSNP | Ensembl ].
VAR_051241
Natural varianti221 – 2211H → R.1 Publication
Corresponds to variant rs139263261 [ dbSNP | Ensembl ].
VAR_023706
Natural varianti315 – 3151Y → F.
Corresponds to variant rs2228507 [ dbSNP | Ensembl ].
VAR_034142
Natural varianti441 – 4411I → V.1 Publication
Corresponds to variant rs150468995 [ dbSNP | Ensembl ].
VAR_023707
Natural varianti448 – 4481R → G Common polymorphism. 2 Publications
Corresponds to variant rs2229742 [ dbSNP | Ensembl ].
VAR_023708
Natural varianti567 – 5671N → S.
Corresponds to variant rs9975169 [ dbSNP | Ensembl ].
VAR_051242
Natural varianti803 – 8031S → L.1 Publication
Corresponds to variant rs61750208 [ dbSNP | Ensembl ].
VAR_023709
Natural varianti1079 – 10791V → F.1 Publication
VAR_023710

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241P → R in CAA59108. 1 Publication
Sequence conflicti721 – 7266NKGKSE → TKGRVK in CAA59108. 1 Publication
Sequence conflicti954 – 9541S → I in AAH40361. 1 Publication
Sequence conflicti1080 – 10801T → A in CAA59108. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84373 mRNA. Translation: CAA59108.1.
AF248484 Genomic DNA. Translation: AAF62185.1.
AF127577 Genomic DNA. Translation: AAF35255.1.
AL163207 Genomic DNA. Translation: CAB90396.1.
BC040361 mRNA. Translation: AAH40361.1.
CCDSiCCDS13568.1.
PIRiS57348.
RefSeqiNP_003480.2. NM_003489.3.
XP_005261120.1. XM_005261063.1.
XP_005261122.1. XM_005261065.1.
XP_005261123.1. XM_005261066.1.
XP_006724117.1. XM_006724054.1.
UniGeneiHs.155017.

Genome annotation databases

EnsembliENST00000318948; ENSP00000327213; ENSG00000180530.
ENST00000400199; ENSP00000383060; ENSG00000180530.
ENST00000400202; ENSP00000383063; ENSG00000180530.
GeneIDi8204.
KEGGihsa:8204.
UCSCiuc002yjx.2. human.

Polymorphism databases

DMDMi9988061.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84373 mRNA. Translation: CAA59108.1 .
AF248484 Genomic DNA. Translation: AAF62185.1 .
AF127577 Genomic DNA. Translation: AAF35255.1 .
AL163207 Genomic DNA. Translation: CAB90396.1 .
BC040361 mRNA. Translation: AAH40361.1 .
CCDSi CCDS13568.1.
PIRi S57348.
RefSeqi NP_003480.2. NM_003489.3.
XP_005261120.1. XM_005261063.1.
XP_005261122.1. XM_005261065.1.
XP_005261123.1. XM_005261066.1.
XP_006724117.1. XM_006724054.1.
UniGenei Hs.155017.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GPO X-ray 1.95 C 366-390 [» ]
2GPP X-ray 2.60 C/D 366-390 [» ]
ProteinModelPortali P48552.
ModBasei Search...

Protein-protein interaction databases

BioGridi 113843. 54 interactions.
DIPi DIP-5964N.
IntActi P48552. 21 interactions.
MINTi MINT-192711.
STRINGi 9606.ENSP00000327213.

PTM databases

PhosphoSitei P48552.

Polymorphism databases

DMDMi 9988061.

Proteomic databases

PaxDbi P48552.
PRIDEi P48552.

Protocols and materials databases

DNASUi 8204.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318948 ; ENSP00000327213 ; ENSG00000180530 .
ENST00000400199 ; ENSP00000383060 ; ENSG00000180530 .
ENST00000400202 ; ENSP00000383063 ; ENSG00000180530 .
GeneIDi 8204.
KEGGi hsa:8204.
UCSCi uc002yjx.2. human.

Organism-specific databases

CTDi 8204.
GeneCardsi GC21M016333.
H-InvDB HIX0027827.
HGNCi HGNC:8001. NRIP1.
HPAi HPA046571.
MIMi 602490. gene.
neXtProti NX_P48552.
PharmGKBi PA31780.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47583.
HOGENOMi HOG000236277.
HOVERGENi HBG052667.
InParanoidi P48552.
KOi K17965.
OMAi VEKDLRC.
OrthoDBi EOG7H1JJQ.
PhylomeDBi P48552.
TreeFami TF332210.

Enzyme and pathway databases

SignaLinki P48552.

Miscellaneous databases

EvolutionaryTracei P48552.
GeneWikii NRIP1.
GenomeRNAii 8204.
NextBioi 30914.
PROi P48552.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48552.
Bgeei P48552.
CleanExi HS_NRIP1.
Genevestigatori P48552.

Family and domain databases

InterProi IPR026649. NRIP1.
[Graphical view ]
PANTHERi PTHR15088. PTHR15088. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor."
    Cavailles V., Dauvois S., L'Horset F., Lopez G., Hoare S., Kushner P.J., Parker M.G.
    EMBO J. 14:3741-3751(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ESR1, SUBCELLULAR LOCATION, VARIANT GLY-448.
    Tissue: Mammary gland.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. "Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4."
    Yan Z.H., Karam W.G., Staudinger J.L., Medvedev A., Ghanayem B.I., Jetten A.M.
    J. Biol. Chem. 273:10948-10957(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NR2C2.
  5. "Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids."
    Subramaniam N., Treuter E., Okret S.
    J. Biol. Chem. 274:18121-18127(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NR3C1.
  6. "Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP."
    Vo N., Fjeld C., Goodman R.H.
    Mol. Cell. Biol. 21:6181-6188(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTBP1, MUTAGENESIS OF 440-PRO--LEU-443 AND LYS-446, ACETYLATION AT LYS-446.
  7. "Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140."
    Zilliacus J., Holter E., Wakui H., Tazawa H., Treuter E., Gustafsson J.-A.
    Mol. Endocrinol. 15:501-511(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NR3C1 AND YWHAH, IDENTIFICATION IN A COMPLEX WITH NR3C1 AND YWHAH, SUBCELLULAR LOCATION.
  8. "A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action."
    Zennaro M.-C., Souque A., Viengchareun S., Poisson E., Lombes M.
    Mol. Endocrinol. 15:1586-1598(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NR3C2.
  9. "Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140."
    Tazawa H., Osman W., Shoji Y., Treuter E., Gustafsson J.-A., Zilliacus J.
    Mol. Cell. Biol. 23:4187-4198(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NR3C1, SUBCELLULAR LOCATION.
  10. "Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect."
    Teyssier C., Belguise K., Galtier F., Cavailles V., Chalbos D.
    Mol. Endocrinol. 17:287-299(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ESR1; FOS AND JUN.
  11. "Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140."
    Christian M., Tullet J.M.A., Parker M.G.
    J. Biol. Chem. 279:15645-15651(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTBP1 AND CTBP2, MUTAGENESIS OF 442-ASP--LEU-443; 567-ASN--LEU-568 AND 948-ASP--LEU-949, IDENTIFICATION OF REPRESSION DOMAINS.
  12. "Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition."
    Castet A., Boulahtouf A., Versini G., Bonnet S., Augereau P., Vignon F., Khochbin S., Jalaguier S., Cavailles V.
    Nucleic Acids Res. 32:1957-1966(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTBP1; CTBP2; HDAC1; HDAC2; HDAC5 AND HDAC6, MUTAGENESIS OF 442-ASP--LEU-443 AND 567-ASN--LEU-568, SUBCELLULAR LOCATION.
  13. "Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation."
    Huq M.D., Gupta P., Tsai N.P., Wei L.N.
    Mol. Cell. Proteomics 5:2072-2082(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NR2C2.
  14. "ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases."
    Lopez-Garcia J., Periyasamy M., Thomas R.S., Christian M., Leao M., Jat P., Kindle K.B., Heery D.M., Parker M.G., Buluwela L., Kamalati T., Ali S.
    Nucleic Acids Res. 34:6126-6136(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNF366.
  15. "X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation."
    Wang L., Zuercher W.J., Consler T.G., Lambert M.H., Miller A.B., Orband-Miller L.A., McKee D.D., Willson T.M., Nolte R.T.
    J. Biol. Chem. 281:37773-37781(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 366-390 IN COMPLEX WITH ESRRG.
  16. "Preliminary molecular genetic analysis of the receptor interacting protein 140 (RIP140) in women affected by endometriosis."
    Caballero V., Ruiz R., Sainz J.A., Cruz M., Lopez-Nevot M.A., Galan J.J., Real L.M., de Castro F., Lopez-Villaverde V., Ruiz A.
    J. Exp. Clin. Assist. Reprod. 2:11-11(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ARG-221; VAL-441; GLY-448; LEU-803 AND PHE-1079.

Entry informationi

Entry nameiNRIP1_HUMAN
AccessioniPrimary (citable) accession number: P48552
Secondary accession number(s): Q8IWE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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