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Protein

Interferon alpha/beta receptor 2

Gene

IFNAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).7 Publications

GO - Molecular functioni

  • interleukin-20 binding Source: GO_Central
  • protein kinase binding Source: UniProtKB
  • type I interferon binding Source: UniProtKB
  • type I interferon receptor activity Source: UniProtKB

GO - Biological processi

  • cell proliferation Source: Ensembl
  • cell surface receptor signaling pathway Source: ProtInc
  • defense response to virus Source: UniProtKB
  • JAK-STAT cascade Source: ProtInc
  • regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • regulation of type I interferon-mediated signaling pathway Source: Reactome
  • response to interferon-alpha Source: UniProtKB
  • response to interferon-beta Source: UniProtKB
  • response to virus Source: ProtInc
  • type I interferon signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159110-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
SignaLinkiP48551.
SIGNORiP48551.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha/beta receptor 2
Short name:
IFN-R-2
Short name:
IFN-alpha binding protein
Short name:
IFN-alpha/beta receptor 2
Alternative name(s):
Interferon alpha binding protein
Type I interferon receptor 2
Gene namesi
Name:IFNAR2
Synonyms:IFNABR, IFNARB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:5433. IFNAR2.

Subcellular locationi

Isoform 1 :
Isoform 2 :
Isoform 3 :
  • Secreted 2 Publications

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 243ExtracellularSequence analysisAdd BLAST217
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 515CytoplasmicSequence analysisAdd BLAST251

GO - Cellular componenti

  • extracellular region Source: ProtInc
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 45 (IMD45)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination.
See also OMIM:616669

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi269Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318 and F-337. 2 Publications1
Mutagenesisi306Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318 and F-337. 2 Publications1
Mutagenesisi316Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318 and F-337. 2 Publications1
Mutagenesisi318Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337. 2 Publications1
Mutagenesisi337Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-318. 2 Publications1
Mutagenesisi411Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. 2 Publications1
Mutagenesisi512Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-411. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-411. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-411. 2 Publications1

Organism-specific databases

DisGeNETi3455.
MIMi610424. phenotype.
616669. phenotype.
OpenTargetsiENSG00000159110.
PharmGKBiPA29671.

Chemistry databases

ChEMBLiCHEMBL2364170.
DrugBankiDB00011. Interferon alfa-n1.
DB00018. Interferon alfa-n3.
DB00069. Interferon alfacon-1.
DB00060. Interferon beta-1a.
DB00068. Interferon beta-1b.
DB00008. Peginterferon alfa-2a.
DB00022. Peginterferon alfa-2b.

Polymorphism and mutation databases

BioMutaiIFNAR2.
DMDMi1352466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001100627 – 515Interferon alpha/beta receptor 2Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 122Combined sources4 Publications
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi85 ↔ 93Combined sources4 Publications
Glycosylationi87N-linked (GlcNAc...)1 Publication1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)1 Publication1
Disulfide bondi207 ↔ 227Combined sources4 Publications
Modified residuei337Phosphotyrosine2 Publications1
Modified residuei400PhosphoserineCombined sources1
Modified residuei467PhosphoserineBy similarity1
Modified residuei512Phosphotyrosine2 Publications1

Post-translational modificationi

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.3 Publications
Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP48551.
PaxDbiP48551.
PeptideAtlasiP48551.
PRIDEiP48551.

PTM databases

iPTMnetiP48551.
PhosphoSitePlusiP48551.

Miscellaneous databases

PMAP-CutDBQ6FHD7.

Expressioni

Tissue specificityi

Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.3 Publications

Gene expression databases

BgeeiENSG00000159110.
CleanExiHS_IFNAR2.
ExpressionAtlasiP48551. baseline and differential.
GenevisibleiP48551. HS.

Organism-specific databases

HPAiCAB025889.

Interactioni

Subunit structurei

Heterodimer with IFNAR1 (PubMed:8181059, PubMed:7665574, PubMed:10049744, PubMed:24075985, PubMed:21854986). Isoform 1 interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453). Interacts with JAK1 (PubMed:8181059, PubMed:7759950).9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CREBBPQ927934EBI-958408,EBI-81215
IRF9Q009786EBI-958408,EBI-626526
JAK1P234583EBI-958408,EBI-1383438
RACK1P632444EBI-958408,EBI-296739
STAT1P422242EBI-958408,EBI-1057697
STAT2P526304EBI-958408,EBI-1546963
USP18Q9UMW84EBI-958408,EBI-356206

GO - Molecular functioni

  • interleukin-20 binding Source: GO_Central
  • protein kinase binding Source: UniProtKB
  • type I interferon binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109677. 12 interactors.
DIPiDIP-945N.
IntActiP48551. 14 interactors.
MINTiMINT-196715.
STRINGi9606.ENSP00000343957.

Structurei

Secondary structure

1515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 46Combined sources7
Beta strandi49 – 55Combined sources7
Beta strandi59 – 61Combined sources3
Beta strandi65 – 75Combined sources11
Helixi83 – 85Combined sources3
Beta strandi86 – 89Combined sources4
Beta strandi91 – 94Combined sources4
Turni96 – 98Combined sources3
Beta strandi102 – 104Combined sources3
Beta strandi106 – 113Combined sources8
Beta strandi119 – 126Combined sources8
Helixi128 – 131Combined sources4
Beta strandi138 – 143Combined sources6
Beta strandi148 – 153Combined sources6
Helixi159 – 161Combined sources3
Beta strandi167 – 174Combined sources8
Beta strandi177 – 181Combined sources5
Beta strandi186 – 188Combined sources3
Beta strandi191 – 197Combined sources7
Beta strandi205 – 213Combined sources9
Beta strandi226 – 229Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6UNMR-A28-237[»]
1N6VNMR-A28-237[»]
2HYMNMR-A28-237[»]
2KZ1NMR-B28-237[»]
2LAGNMR-B28-237[»]
3S8WX-ray2.60A/B/C131-232[»]
3S9DX-ray2.00B/D37-232[»]
3SE3X-ray4.00C34-232[»]
3SE4X-ray3.50C34-232[»]
ProteinModelPortaliP48551.
SMRiP48551.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48551.

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHB9. Eukaryota.
ENOG410YTXY. LUCA.
GeneTreeiENSGT00510000049322.
HOGENOMiHOG000013219.
HOVERGENiHBG053907.
InParanoidiP48551.
KOiK05131.
OMAiWYTIMSK.
OrthoDBiEOG091G09YY.
PhylomeDBiP48551.
TreeFamiTF335897.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P48551-1) [UniParc]FASTAAdd to basket
Also known as: Long form beta1 Publication, IFNaR2-2, IFNaR2-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS
60 70 80 90 100
ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR
110 120 130 140 150
STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV
160 170 180 190 200
MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL
210 220 230 240 250
IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV
260 270 280 290 300
FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD
310 320 330 340 350
MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA
360 370 380 390 400
SATSTESQLI DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS
410 420 430 440 450
PLQDPFPEED YSSTEGSGGR ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS
460 470 480 490 500
SHLEEMVDPE DPDNVQSNHL LASGEGTQPT FPSPSSEGLW SEDAPSDQSD
510
TSESDVDLGD GYIMR
Length:515
Mass (Da):57,759
Last modified:February 1, 1996 - v1
Checksum:i4D7730D93AA739F4
GO
Isoform 2 (identifier: P48551-2) [UniParc]FASTAAdd to basket
Also known as: Short form beta1 Publication, IFNaR2-1, IFNaR2-1a

The sequence of this isoform differs from the canonical sequence as follows:
     281-331: NFHNFLAWPF...SDSDTEAAPR → RQGLAKGWNA...YKRASLCPSD
     332-515: Missing.

Show »
Length:331
Mass (Da):37,393
Checksum:i6F6A2FD6E7A7449B
GO
Isoform 3 (identifier: P48551-3) [UniParc]FASTAAdd to basket
Also known as: IFNaR2-3, IFNaR2-2a, P401 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     238-239: SA → FS
     240-515: Missing.

Note: Soluble receptor.
Show »
Length:239
Mass (Da):27,384
Checksum:i705E887E728A4FB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151M → V in AAC50202 (PubMed:7665574).Curated1

Polymorphismi

Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0205218F → S Associated with susceptibility to HVB infection; lower cell surface levels; lower induction of MHC class 1 expression by INF-alpha. 2 PublicationsCorresponds to variant rs2229207dbSNPEnsembl.1
Natural variantiVAR_02052210F → V.5 PublicationsCorresponds to variant rs1051393dbSNPEnsembl.1
Natural variantiVAR_020523196I → V.1 PublicationCorresponds to variant rs17860223dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001736238 – 239SA → FS in isoform 3. 2 Publications2
Alternative sequenceiVSP_001737240 – 515Missing in isoform 3. 2 PublicationsAdd BLAST276
Alternative sequenceiVSP_001738281 – 331NFHNF…EAAPR → RQGLAKGWNAVAIHRCSHNA LQSETPELKQSSCLSFPSSW DYKRASLCPSD in isoform 2. 3 PublicationsAdd BLAST51
Alternative sequenceiVSP_001739332 – 515Missing in isoform 2. 3 PublicationsAdd BLAST184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77722 mRNA. Translation: CAA54785.1.
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA. Translation: AAB46417.1.
L42243
, L42238, L42239, L42240, L42323, L42241 Genomic DNA. Translation: AAB46418.1.
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA. Translation: AAB46419.1.
L41942 mRNA. Translation: AAB46413.1.
L41943 mRNA. Translation: AAB46414.1.
L41944 mRNA. Translation: AAB46415.1.
U29584 mRNA. Translation: AAC50202.1.
X89814 mRNA. Translation: CAA61940.1.
X89772 mRNA. Translation: CAA61914.1.
AY740397 Genomic DNA. Translation: AAU21038.1.
AK293059 mRNA. Translation: BAF85748.1.
CR541817 mRNA. Translation: CAG46616.1.
AP000292 Genomic DNA. No translation available.
AP000293 Genomic DNA. No translation available.
AP000294 Genomic DNA. No translation available.
AP000295 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09842.1.
CH471079 Genomic DNA. Translation: EAX09843.1.
CH471079 Genomic DNA. Translation: EAX09844.1.
CH471079 Genomic DNA. Translation: EAX09846.1.
CCDSiCCDS13621.1. [P48551-1]
CCDS13622.1. [P48551-2]
CCDS74782.1. [P48551-3]
PIRiI39073.
S59501.
RefSeqiNP_000865.2. NM_000874.4. [P48551-2]
NP_001276054.1. NM_001289125.1. [P48551-1]
NP_001276055.1. NM_001289126.1. [P48551-3]
NP_001276057.1. NM_001289128.1. [P48551-3]
NP_997467.1. NM_207584.2. [P48551-2]
NP_997468.1. NM_207585.2. [P48551-1]
UniGeneiHs.708195.

Genome annotation databases

EnsembliENST00000342101; ENSP00000343289; ENSG00000159110. [P48551-3]
ENST00000342136; ENSP00000343957; ENSG00000159110. [P48551-1]
ENST00000382264; ENSP00000371699; ENSG00000159110. [P48551-2]
ENST00000404220; ENSP00000384309; ENSG00000159110. [P48551-2]
GeneIDi3455.
KEGGihsa:3455.
UCSCiuc002yrb.5. human. [P48551-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77722 mRNA. Translation: CAA54785.1.
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA. Translation: AAB46417.1.
L42243
, L42238, L42239, L42240, L42323, L42241 Genomic DNA. Translation: AAB46418.1.
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA. Translation: AAB46419.1.
L41942 mRNA. Translation: AAB46413.1.
L41943 mRNA. Translation: AAB46414.1.
L41944 mRNA. Translation: AAB46415.1.
U29584 mRNA. Translation: AAC50202.1.
X89814 mRNA. Translation: CAA61940.1.
X89772 mRNA. Translation: CAA61914.1.
AY740397 Genomic DNA. Translation: AAU21038.1.
AK293059 mRNA. Translation: BAF85748.1.
CR541817 mRNA. Translation: CAG46616.1.
AP000292 Genomic DNA. No translation available.
AP000293 Genomic DNA. No translation available.
AP000294 Genomic DNA. No translation available.
AP000295 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09842.1.
CH471079 Genomic DNA. Translation: EAX09843.1.
CH471079 Genomic DNA. Translation: EAX09844.1.
CH471079 Genomic DNA. Translation: EAX09846.1.
CCDSiCCDS13621.1. [P48551-1]
CCDS13622.1. [P48551-2]
CCDS74782.1. [P48551-3]
PIRiI39073.
S59501.
RefSeqiNP_000865.2. NM_000874.4. [P48551-2]
NP_001276054.1. NM_001289125.1. [P48551-1]
NP_001276055.1. NM_001289126.1. [P48551-3]
NP_001276057.1. NM_001289128.1. [P48551-3]
NP_997467.1. NM_207584.2. [P48551-2]
NP_997468.1. NM_207585.2. [P48551-1]
UniGeneiHs.708195.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6UNMR-A28-237[»]
1N6VNMR-A28-237[»]
2HYMNMR-A28-237[»]
2KZ1NMR-B28-237[»]
2LAGNMR-B28-237[»]
3S8WX-ray2.60A/B/C131-232[»]
3S9DX-ray2.00B/D37-232[»]
3SE3X-ray4.00C34-232[»]
3SE4X-ray3.50C34-232[»]
ProteinModelPortaliP48551.
SMRiP48551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109677. 12 interactors.
DIPiDIP-945N.
IntActiP48551. 14 interactors.
MINTiMINT-196715.
STRINGi9606.ENSP00000343957.

Chemistry databases

ChEMBLiCHEMBL2364170.
DrugBankiDB00011. Interferon alfa-n1.
DB00018. Interferon alfa-n3.
DB00069. Interferon alfacon-1.
DB00060. Interferon beta-1a.
DB00068. Interferon beta-1b.
DB00008. Peginterferon alfa-2a.
DB00022. Peginterferon alfa-2b.

PTM databases

iPTMnetiP48551.
PhosphoSitePlusiP48551.

Polymorphism and mutation databases

BioMutaiIFNAR2.
DMDMi1352466.

Proteomic databases

MaxQBiP48551.
PaxDbiP48551.
PeptideAtlasiP48551.
PRIDEiP48551.

Protocols and materials databases

DNASUi3455.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342101; ENSP00000343289; ENSG00000159110. [P48551-3]
ENST00000342136; ENSP00000343957; ENSG00000159110. [P48551-1]
ENST00000382264; ENSP00000371699; ENSG00000159110. [P48551-2]
ENST00000404220; ENSP00000384309; ENSG00000159110. [P48551-2]
GeneIDi3455.
KEGGihsa:3455.
UCSCiuc002yrb.5. human. [P48551-1]

Organism-specific databases

CTDi3455.
DisGeNETi3455.
GeneCardsiIFNAR2.
HGNCiHGNC:5433. IFNAR2.
HPAiCAB025889.
MIMi602376. gene.
610424. phenotype.
616669. phenotype.
neXtProtiNX_P48551.
OpenTargetsiENSG00000159110.
PharmGKBiPA29671.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHB9. Eukaryota.
ENOG410YTXY. LUCA.
GeneTreeiENSGT00510000049322.
HOGENOMiHOG000013219.
HOVERGENiHBG053907.
InParanoidiP48551.
KOiK05131.
OMAiWYTIMSK.
OrthoDBiEOG091G09YY.
PhylomeDBiP48551.
TreeFamiTF335897.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159110-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
SignaLinkiP48551.
SIGNORiP48551.

Miscellaneous databases

ChiTaRSiIFNAR2. human.
EvolutionaryTraceiP48551.
GeneWikiiIFNAR2.
GenomeRNAii3455.
PMAP-CutDBQ6FHD7.
PROiP48551.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159110.
CleanExiHS_IFNAR2.
ExpressionAtlasiP48551. baseline and differential.
GenevisibleiP48551. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiINAR2_HUMAN
AccessioniPrimary (citable) accession number: P48551
Secondary accession number(s): A8KAJ4
, D3DSE8, D3DSE9, Q15467, Q6FHD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.