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P48547 (KCNC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily C member 1
Alternative name(s):
NGK2
Voltage-gated potassium channel subunit Kv3.1
Voltage-gated potassium channel subunit Kv4
Gene names
Name:KCNC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure

Heteromultimer with KCNG3, KCNG4 and KCNV2.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similarities

Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Potassium voltage-gated channel subfamily C member 1
PRO_0000054051

Regions

Topological domain1 – 190190Cytoplasmic Potential
Transmembrane191 – 20919Helical; Name=Segment S1; Potential
Transmembrane248 – 26720Helical; Name=Segment S2; Potential
Topological domain268 – 2769Cytoplasmic Potential
Transmembrane277 – 29519Helical; Name=Segment S3; Potential
Transmembrane309 – 33123Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain332 – 34413Cytoplasmic Potential
Transmembrane345 – 36622Helical; Name=Segment S5; Potential
Transmembrane415 – 43622Helical; Name=Segment S6; Potential
Topological domain437 – 51175Cytoplasmic Potential
Motif400 – 4056Selectivity filter By similarity

Amino acid modifications

Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P48547 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 10A93478F7120ABB

FASTA51157,942
        10         20         30         40         50         60 
MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP RADEFFFDRH 

        70         80         90        100        110        120 
PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD VEPCCWMTYR QHRDAEEALD 

       130        140        150        160        170        180 
SFGGAPLDNS ADDADADGPG DSGDGEDELE MTKRLALSDS PDGRPGGFWR RWQPRIWALF 

       190        200        210        220        230        240 
EDPYSSRYAR YVAFASLFFI LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE 

       250        260        270        280        290        300 
TEAFLTYIEG VCVVWFTFEF LMRVIFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 

       310        320        330        340        350        360 
KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA 

       370        380        390        400        410        420 
TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT LGYGDMYPQT WSGMLVGALC 

       430        440        450        460        470        480 
ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH 

       490        500        510 
HSTQSDTCPL AQEEILEINR AGRKPLRGMS I 

« Hide

References

[1]"Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15."
Ried T., Rudy B., de Miera E., Lau D., Ward D.C., Sen K.
Genomics 15:405-411(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells."
Grissmer S., Ghanshani S., Dethlefs B., McPherson J.D., Wasmuth J.J., Gutman G.A., Cahalan M.D., Chandy K.G.
J. Biol. Chem. 267:20971-20979(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-475.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S56770 mRNA. Translation: AAB25764.1.
M96747 mRNA. Translation: AAA59458.1.
PIRA46020.
RefSeqNP_004967.1. NM_004976.4.
UniGeneHs.552896.

3D structure databases

ProteinModelPortalP48547.
SMRP48547. Positions 7-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109948. 7 interactions.
STRING9606.ENSP00000265969.

Chemistry

BindingDBP48547.
ChEMBLCHEMBL5529.
GuidetoPHARMACOLOGY548.

PTM databases

PhosphoSiteP48547.

Polymorphism databases

DMDM1352085.

Proteomic databases

PaxDbP48547.
PRIDEP48547.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379472; ENSP00000368785; ENSG00000129159.
GeneID3746.
KEGGhsa:3746.
UCSCuc001mnk.4. human.

Organism-specific databases

CTD3746.
GeneCardsGC11P017756.
HGNCHGNC:6233. KCNC1.
HPAHPA047634.
HPA048249.
MIM176258. gene.
neXtProtNX_P48547.
PharmGKBPA30026.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG280627.
HOGENOMHOG000231012.
HOVERGENHBG105862.
InParanoidP48547.
KOK04887.
PhylomeDBP48547.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressP48547.
BgeeP48547.
CleanExHS_KCNC1.
GenevestigatorP48547.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

ChiTaRSKCNC1. human.
GenomeRNAi3746.
NextBio14659.
PROP48547.
SOURCESearch...

Entry information

Entry nameKCNC1_HUMAN
AccessionPrimary (citable) accession number: P48547
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM