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P48547

- KCNC1_HUMAN

UniProt

P48547 - KCNC1_HUMAN

Protein

Potassium voltage-gated channel subfamily C member 1

Gene

KCNC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. voltage-gated potassium channel activity Source: ProtInc

    GO - Biological processi

    1. potassium ion transport Source: ProtInc
    2. protein homooligomerization Source: InterPro
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily C member 1
    Alternative name(s):
    NGK2
    Voltage-gated potassium channel subunit Kv3.1
    Voltage-gated potassium channel subunit Kv4
    Gene namesi
    Name:KCNC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6233. KCNC1.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30026.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Potassium voltage-gated channel subfamily C member 1PRO_0000054051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP48547.
    PRIDEiP48547.

    PTM databases

    PhosphoSiteiP48547.

    Expressioni

    Gene expression databases

    ArrayExpressiP48547.
    BgeeiP48547.
    CleanExiHS_KCNC1.
    GenevestigatoriP48547.

    Organism-specific databases

    HPAiHPA047634.
    HPA048249.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNG3, KCNG4 and KCNV2.

    Protein-protein interaction databases

    BioGridi109948. 7 interactions.
    STRINGi9606.ENSP00000265969.

    Structurei

    3D structure databases

    ProteinModelPortaliP48547.
    SMRiP48547. Positions 7-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 2769CytoplasmicSequence Analysis
    Topological domaini332 – 34413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini437 – 51175CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei191 – 20919Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26720Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29519Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei309 – 33123Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei345 – 36622Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei415 – 43622Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi400 – 4056Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280627.
    HOGENOMiHOG000231012.
    HOVERGENiHBG105862.
    InParanoidiP48547.
    KOiK04887.
    PhylomeDBiP48547.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005403. K_chnl_volt-dep_Kv3.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01581. KV31CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P48547-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP    50
    RADEFFFDRH PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD 100
    VEPCCWMTYR QHRDAEEALD SFGGAPLDNS ADDADADGPG DSGDGEDELE 150
    MTKRLALSDS PDGRPGGFWR RWQPRIWALF EDPYSSRYAR YVAFASLFFI 200
    LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE TEAFLTYIEG 250
    VCVVWFTFEF LMRVIFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 300
    KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII 350
    FLALGVLIFA TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT 400
    LGYGDMYPQT WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ 450
    KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH HSTQSDTCPL AQEEILEINR 500
    AGRKPLRGMS I 511
    Length:511
    Mass (Da):57,942
    Last modified:February 1, 1996 - v1
    Checksum:i10A93478F7120ABB
    GO
    Isoform 2 (identifier: P48547-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         502-511: GRKPLRGMSI → DSKLNGEVAK...YMPTEAVRVT

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:585
    Mass (Da):65,871
    Checksum:iF8A9D1E6769BCEC5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei502 – 51110GRKPLRGMSI → DSKLNGEVAKAALANEDCPH IDQALTPDEGLPFTRSGTRE RYGPCFLLSTGEYACPPGGG MRKDLCKESPVIAKYMPTEA VRVT in isoform 2. CuratedVSP_055129

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S56770 mRNA. Translation: AAB25764.1.
    AC124056 Genomic DNA. No translation available.
    AC124078 Genomic DNA. No translation available.
    AC124301 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68425.1.
    M96747 mRNA. Translation: AAA59458.1.
    CCDSiCCDS44547.1. [P48547-2]
    CCDS7827.1. [P48547-1]
    PIRiA46020.
    RefSeqiNP_001106212.1. NM_001112741.1.
    NP_004967.1. NM_004976.4.
    UniGeneiHs.552896.

    Genome annotation databases

    EnsembliENST00000265969; ENSP00000265969; ENSG00000129159. [P48547-2]
    ENST00000379472; ENSP00000368785; ENSG00000129159. [P48547-1]
    GeneIDi3746.
    KEGGihsa:3746.
    UCSCiuc001mnk.4. human. [P48547-1]

    Polymorphism databases

    DMDMi1352085.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S56770 mRNA. Translation: AAB25764.1 .
    AC124056 Genomic DNA. No translation available.
    AC124078 Genomic DNA. No translation available.
    AC124301 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68425.1 .
    M96747 mRNA. Translation: AAA59458.1 .
    CCDSi CCDS44547.1. [P48547-2 ]
    CCDS7827.1. [P48547-1 ]
    PIRi A46020.
    RefSeqi NP_001106212.1. NM_001112741.1.
    NP_004967.1. NM_004976.4.
    UniGenei Hs.552896.

    3D structure databases

    ProteinModelPortali P48547.
    SMRi P48547. Positions 7-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109948. 7 interactions.
    STRINGi 9606.ENSP00000265969.

    Chemistry

    BindingDBi P48547.
    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 548.

    PTM databases

    PhosphoSitei P48547.

    Polymorphism databases

    DMDMi 1352085.

    Proteomic databases

    PaxDbi P48547.
    PRIDEi P48547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265969 ; ENSP00000265969 ; ENSG00000129159 . [P48547-2 ]
    ENST00000379472 ; ENSP00000368785 ; ENSG00000129159 . [P48547-1 ]
    GeneIDi 3746.
    KEGGi hsa:3746.
    UCSCi uc001mnk.4. human. [P48547-1 ]

    Organism-specific databases

    CTDi 3746.
    GeneCardsi GC11P017756.
    HGNCi HGNC:6233. KCNC1.
    HPAi HPA047634.
    HPA048249.
    MIMi 176258. gene.
    neXtProti NX_P48547.
    PharmGKBi PA30026.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280627.
    HOGENOMi HOG000231012.
    HOVERGENi HBG105862.
    InParanoidi P48547.
    KOi K04887.
    PhylomeDBi P48547.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    ChiTaRSi KCNC1. human.
    GenomeRNAii 3746.
    NextBioi 14659.
    PROi P48547.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48547.
    Bgeei P48547.
    CleanExi HS_KCNC1.
    Genevestigatori P48547.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005403. K_chnl_volt-dep_Kv3.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01581. KV31CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15."
      Ried T., Rudy B., de Miera E., Lau D., Ward D.C., Sen K.
      Genomics 15:405-411(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells."
      Grissmer S., Ghanshani S., Dethlefs B., McPherson J.D., Wasmuth J.J., Gutman G.A., Cahalan M.D., Chandy K.G.
      J. Biol. Chem. 267:20971-20979(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-475 (ISOFORM 1).

    Entry informationi

    Entry nameiKCNC1_HUMAN
    AccessioniPrimary (citable) accession number: P48547
    Secondary accession number(s): K4DI87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3