P48547 (KCNC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily C member 1

Alternative name(s):
NGK2
Voltage-gated potassium channel subunit Kv3.1
Voltage-gated potassium channel subunit Kv4

Gene names

Name:

KCNC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit structure	Heteromultimer with KCNG3, KCNG4 and KCNV2.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
Sequence similarities	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated potassium channel complex Traceable author statement Ref.2. Source: ProtInc
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Potassium voltage-gated channel subfamily C member 1		PRO_0000054051
Regions
	Topological domain	1 – 190	190	Cytoplasmic Potential
	Transmembrane	191 – 209	19	Helical; Name=Segment S1; Potential
	Transmembrane	248 – 267	20	Helical; Name=Segment S2; Potential
	Topological domain	268 – 276	9	Cytoplasmic Potential
	Transmembrane	277 – 295	19	Helical; Name=Segment S3; Potential
	Transmembrane	309 – 331	23	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	332 – 344	13	Cytoplasmic Potential
	Transmembrane	345 – 366	22	Helical; Name=Segment S5; Potential
	Transmembrane	415 – 436	22	Helical; Name=Segment S6; Potential
	Topological domain	437 – 511	75	Cytoplasmic Potential
	Motif	400 – 405	6	Selectivity filter By similarity
Amino acid modifications
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P48547 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 10A93478F7120ABB	FASTA	511	57,942
	10 20 30 40 50 60 MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP RADEFFFDRH 70 80 90 100 110 120 PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD VEPCCWMTYR QHRDAEEALD 130 140 150 160 170 180 SFGGAPLDNS ADDADADGPG DSGDGEDELE MTKRLALSDS PDGRPGGFWR RWQPRIWALF 190 200 210 220 230 240 EDPYSSRYAR YVAFASLFFI LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE 250 260 270 280 290 300 TEAFLTYIEG VCVVWFTFEF LMRVIFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 310 320 330 340 350 360 KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA 370 380 390 400 410 420 TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT LGYGDMYPQT WSGMLVGALC 430 440 450 460 470 480 ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH 490 500 510 HSTQSDTCPL AQEEILEINR AGRKPLRGMS I

References

[1]	"Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15." Ried T., Rudy B., de Miera E., Lau D., Ward D.C., Sen K. Genomics 15:405-411(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells." Grissmer S., Ghanshani S., Dethlefs B., McPherson J.D., Wasmuth J.J., Gutman G.A., Cahalan M.D., Chandy K.G. J. Biol. Chem. 267:20971-20979(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-475.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S56770 mRNA. Translation: AAB25764.1. M96747 mRNA. Translation: AAA59458.1.
IPI	IPI00010174.
PIR	A46020.
RefSeq	NP_004967.1. NM_004976.4.
UniGene	Hs.552896.
3D structure databases
ProteinModelPortal	P48547.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000265969.
PTM databases
PhosphoSite	P48547.
Polymorphism databases
DMDM	1352085.
Proteomic databases
PaxDb	P48547.
PRIDE	P48547.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379472; ENSP00000368785; ENSG00000129159.
GeneID	3746.
KEGG	hsa:3746.
UCSC	uc001mnk.4. human.
Organism-specific databases
CTD	3746.
GeneCards	GC11P017756.
HGNC	HGNC:6233. KCNC1.
HPA	HPA047634. HPA048249.
MIM	176258. gene.
neXtProt	NX_P48547.
PharmGKB	PA30026.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG280627.
HOGENOM	HOG000231012.
HOVERGEN	HBG105862.
InParanoid	P48547.
KO	K04887.
OrthoDB	EOG4CRKZX.
PhylomeDB	P48547.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	P48547.
CleanEx	HS_KCNC1.
Genevestigator	P48547.
GermOnline	ENSG00000129159. Homo sapiens.
Family and domain databases
Gene3D	1.20.120.350. 1 hit. 3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR027359. K_channel_four-helix_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003974. K_chnl_volt-dep_Kv3. IPR005403. K_chnl_volt-dep_Kv3.1. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01581. KV31CHANNEL. PR01491. KVCHANNEL. PR01498. SHAWCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
BindingDB	P48547.
ChEMBL	CHEMBL5529.
ChiTaRS	KCNC1. human.
GenomeRNAi	3746.
NextBio	14659.
SOURCE	Search...

Entry information

Entry name

KCNC1_HUMAN

Accession

Primary (citable) accession number: P48547

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 29, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.