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P48547

- KCNC1_HUMAN

UniProt

P48547 - KCNC1_HUMAN

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Protein

Potassium voltage-gated channel subfamily C member 1

Gene

KCNC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. voltage-gated potassium channel activity Source: ProtInc

GO - Biological processi

  1. potassium ion transport Source: ProtInc
  2. protein homooligomerization Source: InterPro
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 1
Alternative name(s):
NGK2
Voltage-gated potassium channel subunit Kv3.1
Voltage-gated potassium channel subunit Kv4
Gene namesi
Name:KCNC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6233. KCNC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei191 – 20919Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei248 – 26720Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini268 – 2769CytoplasmicSequence Analysis
Transmembranei277 – 29519Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei309 – 33123Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini332 – 34413CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei345 – 36622Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei415 – 43622Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini437 – 51175CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. plasma membrane Source: Reactome
  2. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Potassium voltage-gated channel subfamily C member 1PRO_0000054051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP48547.
PRIDEiP48547.

PTM databases

PhosphoSiteiP48547.

Expressioni

Gene expression databases

BgeeiP48547.
CleanExiHS_KCNC1.
ExpressionAtlasiP48547. baseline and differential.
GenevestigatoriP48547.

Organism-specific databases

HPAiHPA047634.
HPA048249.

Interactioni

Subunit structurei

Heteromultimer with KCNG3, KCNG4 and KCNV2.

Protein-protein interaction databases

BioGridi109948. 7 interactions.
STRINGi9606.ENSP00000265969.

Structurei

3D structure databases

ProteinModelPortaliP48547.
SMRiP48547. Positions 7-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi400 – 4056Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280627.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiP48547.
KOiK04887.
PhylomeDBiP48547.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P48547-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP
60 70 80 90 100
RADEFFFDRH PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD
110 120 130 140 150
VEPCCWMTYR QHRDAEEALD SFGGAPLDNS ADDADADGPG DSGDGEDELE
160 170 180 190 200
MTKRLALSDS PDGRPGGFWR RWQPRIWALF EDPYSSRYAR YVAFASLFFI
210 220 230 240 250
LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE TEAFLTYIEG
260 270 280 290 300
VCVVWFTFEF LMRVIFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS
310 320 330 340 350
KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII
360 370 380 390 400
FLALGVLIFA TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT
410 420 430 440 450
LGYGDMYPQT WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ
460 470 480 490 500
KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH HSTQSDTCPL AQEEILEINR
510
AGRKPLRGMS I
Length:511
Mass (Da):57,942
Last modified:February 1, 1996 - v1
Checksum:i10A93478F7120ABB
GO
Isoform 2 (identifier: P48547-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     502-511: GRKPLRGMSI → DSKLNGEVAK...YMPTEAVRVT

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:585
Mass (Da):65,871
Checksum:iF8A9D1E6769BCEC5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei502 – 51110GRKPLRGMSI → DSKLNGEVAKAALANEDCPH IDQALTPDEGLPFTRSGTRE RYGPCFLLSTGEYACPPGGG MRKDLCKESPVIAKYMPTEA VRVT in isoform 2. CuratedVSP_055129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56770 mRNA. Translation: AAB25764.1.
AC124056 Genomic DNA. No translation available.
AC124078 Genomic DNA. No translation available.
AC124301 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68425.1.
M96747 mRNA. Translation: AAA59458.1.
CCDSiCCDS44547.1. [P48547-2]
CCDS7827.1. [P48547-1]
PIRiA46020.
RefSeqiNP_001106212.1. NM_001112741.1. [P48547-2]
NP_004967.1. NM_004976.4. [P48547-1]
UniGeneiHs.552896.

Genome annotation databases

EnsembliENST00000265969; ENSP00000265969; ENSG00000129159. [P48547-2]
ENST00000379472; ENSP00000368785; ENSG00000129159. [P48547-1]
GeneIDi3746.
KEGGihsa:3746.
UCSCiuc001mnk.4. human. [P48547-1]
uc009yhc.1. human.

Polymorphism databases

DMDMi1352085.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56770 mRNA. Translation: AAB25764.1 .
AC124056 Genomic DNA. No translation available.
AC124078 Genomic DNA. No translation available.
AC124301 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68425.1 .
M96747 mRNA. Translation: AAA59458.1 .
CCDSi CCDS44547.1. [P48547-2 ]
CCDS7827.1. [P48547-1 ]
PIRi A46020.
RefSeqi NP_001106212.1. NM_001112741.1. [P48547-2 ]
NP_004967.1. NM_004976.4. [P48547-1 ]
UniGenei Hs.552896.

3D structure databases

ProteinModelPortali P48547.
SMRi P48547. Positions 7-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109948. 7 interactions.
STRINGi 9606.ENSP00000265969.

Chemistry

BindingDBi P48547.
ChEMBLi CHEMBL2362996.
DrugBanki DB06637. Dalfampridine.
GuidetoPHARMACOLOGYi 548.

PTM databases

PhosphoSitei P48547.

Polymorphism databases

DMDMi 1352085.

Proteomic databases

PaxDbi P48547.
PRIDEi P48547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265969 ; ENSP00000265969 ; ENSG00000129159 . [P48547-2 ]
ENST00000379472 ; ENSP00000368785 ; ENSG00000129159 . [P48547-1 ]
GeneIDi 3746.
KEGGi hsa:3746.
UCSCi uc001mnk.4. human. [P48547-1 ]
uc009yhc.1. human.

Organism-specific databases

CTDi 3746.
GeneCardsi GC11P017756.
HGNCi HGNC:6233. KCNC1.
HPAi HPA047634.
HPA048249.
MIMi 176258. gene.
neXtProti NX_P48547.
PharmGKBi PA30026.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG280627.
GeneTreei ENSGT00760000118846.
HOGENOMi HOG000231012.
HOVERGENi HBG105862.
InParanoidi P48547.
KOi K04887.
PhylomeDBi P48547.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GenomeRNAii 3746.
NextBioi 14659.
PROi P48547.
SOURCEi Search...

Gene expression databases

Bgeei P48547.
CleanExi HS_KCNC1.
ExpressionAtlasi P48547. baseline and differential.
Genevestigatori P48547.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15."
    Ried T., Rudy B., de Miera E., Lau D., Ward D.C., Sen K.
    Genomics 15:405-411(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells."
    Grissmer S., Ghanshani S., Dethlefs B., McPherson J.D., Wasmuth J.J., Gutman G.A., Cahalan M.D., Chandy K.G.
    J. Biol. Chem. 267:20971-20979(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-475 (ISOFORM 1).

Entry informationi

Entry nameiKCNC1_HUMAN
AccessioniPrimary (citable) accession number: P48547
Secondary accession number(s): K4DI87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3