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Protein

Gastric inhibitory polypeptide receptor

Gene

GIPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

  • activation of adenylate cyclase activity Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • desensitization of G-protein coupled receptor protein signaling pathway Source: Ensembl
  • endocrine pancreas development Source: Ensembl
  • generation of precursor metabolites and energy Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of insulin secretion Source: Ensembl
  • regulation of insulin secretion Source: ParkinsonsUK-UCL
  • response to axon injury Source: Ensembl
  • response to calcium ion Source: Ensembl
  • response to fatty acid Source: Ensembl
  • response to glucose Source: Ensembl
  • response to nutrient Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000010310-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.

Protein family/group databases

TCDBi9.A.14.4.5. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide receptor
Short name:
GIP-R
Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor
Gene namesi
Name:GIPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4271. GIPR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 138ExtracellularSequence analysisAdd BLAST117
Transmembranei139 – 161Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini162 – 169CytoplasmicSequence analysis8
Transmembranei170 – 189Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini190 – 217ExtracellularSequence analysisAdd BLAST28
Transmembranei218 – 242Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini243 – 254CytoplasmicSequence analysisAdd BLAST12
Transmembranei255 – 278Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini279 – 293ExtracellularSequence analysisAdd BLAST15
Transmembranei294 – 319Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini320 – 341CytoplasmicSequence analysisAdd BLAST22
Transmembranei342 – 362Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini363 – 377ExtracellularSequence analysisAdd BLAST15
Transmembranei378 – 398Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini399 – 466CytoplasmicSequence analysisAdd BLAST68

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2696.
OpenTargetsiENSG00000010310.
PharmGKBiPA28682.

Chemistry databases

ChEMBLiCHEMBL4383.
GuidetoPHARMACOLOGYi248.

Polymorphism and mutation databases

BioMutaiGIPR.
DMDMi1346133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001282522 – 466Gastric inhibitory polypeptide receptorAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 701 Publication
Disulfide bondi61 ↔ 1031 Publication
Glycosylationi62N-linked (GlcNAc...)1 Publication1
Glycosylationi77N-linked (GlcNAc...)1 Publication1
Disulfide bondi84 ↔ 1181 Publication

Post-translational modificationi

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48546.
PeptideAtlasiP48546.
PRIDEiP48546.

PTM databases

iPTMnetiP48546.
PhosphoSitePlusiP48546.

Expressioni

Gene expression databases

BgeeiENSG00000010310.
CleanExiHS_GIPR.
ExpressionAtlasiP48546. baseline and differential.
GenevisibleiP48546. HS.

Organism-specific databases

HPAiCAB022710.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GLP1R.2 Publications

Protein-protein interaction databases

BioGridi108963. 1 interactor.
DIPiDIP-46468N.
STRINGi9606.ENSP00000467494.

Chemistry databases

BindingDBiP48546.

Structurei

Secondary structure

1466
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 52Combined sources21
Beta strandi67 – 71Combined sources5
Beta strandi78 – 83Combined sources6
Beta strandi86 – 88Combined sources3
Helixi91 – 94Combined sources4
Beta strandi98 – 103Combined sources6
Beta strandi105 – 107Combined sources3
Beta strandi109 – 114Combined sources6
Helixi116 – 118Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QKHX-ray1.90A24-138[»]
4HJ0X-ray3.00A/B24-138[»]
ProteinModelPortaliP48546.
SMRiP48546.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48546.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP48546.
KOiK04580.
OMAiGELYQRW.
OrthoDBiEOG091G0NF8.
PhylomeDBiP48546.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P48546-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL
60 70 80 90 100
AAAEPPSGLA CNGSFDMYVC WDYAAPNATA RASCPWYLPW HHHVAAGFVL
110 120 130 140 150
RQCGSDGQWG LWRDHTQCEN PEKNEAFLDQ RLILERLQVM YTVGYSLSLA
160 170 180 190 200
TLLLALLILS LFRRLHCTRN YIHINLFTSF MLRAAAILSR DRLLPRPGPY
210 220 230 240 250
LGDQALALWN QALAACRTAQ IVTQYCVGAN YTWLLVEGVY LHSLLVLVGG
260 270 280 290 300
SEEGHFRYYL LLGWGAPALF VIPWVIVRYL YENTQCWERN EVKAIWWIIR
310 320 330 340 350
TPILMTILIN FLIFIRILGI LLSKLRTRQM RCRDYRLRLA RSTLTLVPLL
360 370 380 390 400
GVHEVVFAPV TEEQARGALR FAKLGFEIFL SSFQGFLVSV LYCFINKEVQ
410 420 430 440 450
SEIRRGWHHC RLRRSLGEEQ RQLPERAFRA LPSGSGPGEV PTSRGLSSGT
460
LPGPGNEASR ELESYC
Length:466
Mass (Da):53,157
Last modified:February 1, 1996 - v1
Checksum:iCA5CF86BA0E32383
GO
Isoform 2 (identifier: P48546-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-419: QSEIRRGWHHCRLRRSLGEE → GRDPAAAPALWRQRGVRRRL
     420-466: Missing.

Show »
Length:419
Mass (Da):48,071
Checksum:i688BE1EFDD62D9FF
GO
Isoform 3 (identifier: P48546-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-93: Missing.

Show »
Length:430
Mass (Da):49,062
Checksum:i3CCE33270176FC7C
GO

Sequence cautioni

The sequence CAA57426 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12R → G in AAB35419 (PubMed:7589426).Curated1
Sequence conflicti104G → R in AAB35419 (PubMed:7589426).Curated1
Sequence conflicti117Missing in CAA57426 (PubMed:7556958).Curated1
Sequence conflicti337L → V in AAB35419 (PubMed:7589426).Curated1
Sequence conflicti367 – 371GALRF → APCV in CAA57426 (PubMed:7556958).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029333136R → W.Corresponds to variant rs13306402dbSNPEnsembl.1
Natural variantiVAR_011808207A → V.Corresponds to variant rs1800436dbSNPEnsembl.1
Natural variantiVAR_011809262L → V.Corresponds to variant rs5392dbSNPEnsembl.1
Natural variantiVAR_011810354E → Q.Corresponds to variant rs1800437dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05386658 – 93Missing in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_053867400 – 419QSEIR…SLGEE → GRDPAAAPALWRQRGVRRRL in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_053868420 – 466Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39231 mRNA. Translation: AAA84418.1.
S79852 mRNA. Translation: AAB35419.2.
X81832 mRNA. Translation: CAA57426.1. Frameshift.
D49559 Genomic DNA. Translation: BAA08503.1.
AC006132 Genomic DNA. Translation: AAC97984.1.
AC007191 Genomic DNA. Translation: AAD22674.1.
BC093723 mRNA. Translation: AAH93723.1.
BC101673 mRNA. Translation: AAI01674.1.
BC143300 mRNA. Translation: AAI43301.1.
CCDSiCCDS12671.1. [P48546-1]
CCDS82367.1. [P48546-3]
PIRiG02234.
I37411.
S66676.
RefSeqiNP_000155.1. NM_000164.3. [P48546-1]
NP_001295347.1. NM_001308418.1. [P48546-3]
UniGeneiHs.251412.
Hs.658534.

Genome annotation databases

EnsembliENST00000263281; ENSP00000263281; ENSG00000010310. [P48546-2]
ENST00000304207; ENSP00000305321; ENSG00000010310. [P48546-3]
ENST00000590918; ENSP00000467494; ENSG00000010310. [P48546-1]
GeneIDi2696.
KEGGihsa:2696.
UCSCiuc002pct.2. human. [P48546-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39231 mRNA. Translation: AAA84418.1.
S79852 mRNA. Translation: AAB35419.2.
X81832 mRNA. Translation: CAA57426.1. Frameshift.
D49559 Genomic DNA. Translation: BAA08503.1.
AC006132 Genomic DNA. Translation: AAC97984.1.
AC007191 Genomic DNA. Translation: AAD22674.1.
BC093723 mRNA. Translation: AAH93723.1.
BC101673 mRNA. Translation: AAI01674.1.
BC143300 mRNA. Translation: AAI43301.1.
CCDSiCCDS12671.1. [P48546-1]
CCDS82367.1. [P48546-3]
PIRiG02234.
I37411.
S66676.
RefSeqiNP_000155.1. NM_000164.3. [P48546-1]
NP_001295347.1. NM_001308418.1. [P48546-3]
UniGeneiHs.251412.
Hs.658534.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QKHX-ray1.90A24-138[»]
4HJ0X-ray3.00A/B24-138[»]
ProteinModelPortaliP48546.
SMRiP48546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108963. 1 interactor.
DIPiDIP-46468N.
STRINGi9606.ENSP00000467494.

Chemistry databases

BindingDBiP48546.
ChEMBLiCHEMBL4383.
GuidetoPHARMACOLOGYi248.

Protein family/group databases

TCDBi9.A.14.4.5. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP48546.
PhosphoSitePlusiP48546.

Polymorphism and mutation databases

BioMutaiGIPR.
DMDMi1346133.

Proteomic databases

PaxDbiP48546.
PeptideAtlasiP48546.
PRIDEiP48546.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263281; ENSP00000263281; ENSG00000010310. [P48546-2]
ENST00000304207; ENSP00000305321; ENSG00000010310. [P48546-3]
ENST00000590918; ENSP00000467494; ENSG00000010310. [P48546-1]
GeneIDi2696.
KEGGihsa:2696.
UCSCiuc002pct.2. human. [P48546-1]

Organism-specific databases

CTDi2696.
DisGeNETi2696.
GeneCardsiGIPR.
HGNCiHGNC:4271. GIPR.
HPAiCAB022710.
MIMi137241. gene.
neXtProtiNX_P48546.
OpenTargetsiENSG00000010310.
PharmGKBiPA28682.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP48546.
KOiK04580.
OMAiGELYQRW.
OrthoDBiEOG091G0NF8.
PhylomeDBiP48546.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000010310-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.

Miscellaneous databases

EvolutionaryTraceiP48546.
GeneWikiiGastric_inhibitory_polypeptide_receptor.
GenomeRNAii2696.
PROiP48546.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000010310.
CleanExiHS_GIPR.
ExpressionAtlasiP48546. baseline and differential.
GenevisibleiP48546. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIPR_HUMAN
AccessioniPrimary (citable) accession number: P48546
Secondary accession number(s): B7WP14
, B7ZKQ0, Q14401, Q16400, Q52M04, Q9UPI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.