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P48545

- KCNJ5_MOUSE

UniProt

P48545 - KCNJ5_MOUSE

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Protein

G protein-activated inward rectifier potassium channel 4

Gene

Kcnj5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei179 – 1791Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

  1. G-protein activated inward rectifier potassium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-activated inward rectifier potassium channel 4
Short name:
GIRK-4
Alternative name(s):
Cardiac inward rectifier
Short name:
CIR
Heart KATP channel
Inward rectifier K(+) channel Kir3.4
KATP-1
Potassium channel, inwardly rectifying subfamily J member 5
Gene namesi
Name:Kcnj5
Synonyms:Girk4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:104755. Kcnj5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419G protein-activated inward rectifier potassium channel 4PRO_0000154935Add
BLAST

Proteomic databases

PRIDEiP48545.

PTM databases

PhosphoSiteiP48545.

Expressioni

Tissue specificityi

Predominantly atrial and pancreatic expression.

Gene expression databases

BgeeiP48545.
ExpressionAtlasiP48545. baseline and differential.
GenevestigatoriP48545.

Interactioni

Subunit structurei

May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliP48545.
SMRiP48545. Positions 51-370.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686CytoplasmicBy similarityAdd
BLAST
Topological domaini112 – 13524ExtracellularBy similarityAdd
BLAST
Topological domaini155 – 1639ExtracellularBy similarity
Topological domaini186 – 419234CytoplasmicBy similarityAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei136 – 14712Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei148 – 1547Pore-formingBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei87 – 11125Helical; Name=M1By similarityAdd
BLAST
Transmembranei164 – 18522Helical; Name=M2By similarityAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi149 – 1546Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72812.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiP48545.
KOiK04999.
OMAiQARSSYM.
OrthoDBiEOG7XPZ5K.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003277. K_chnl_inward-rec_Kir3.4.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01330. KIR34CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P48545-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGDSRNAMN QDMEIGVTSQ DHKKIPKQAR DYIPIATDRT RLLTEGKKPR
60 70 80 90 100
QRYMEKTGKC NVHHGNVQET YRYLSDLFTT LVDLKWRFNL LVFTMVYTIT
110 120 130 140 150
WLFFGFIWWL IAYVRGDLDH VGDQEWIPCV ENLSGFVSAF LFSIETETTI
160 170 180 190 200
GYGFRVITEK CPEGIILLLV QAILGSIVNA FMVGCMFVKI SQPKKRAETL
210 220 230 240 250
MFSNNAVISM RDEKLCLMFR VGDLRNSHIV EASIRAKLIK SRQTKEGEFI
260 270 280 290 300
PLNQTDINVG FDTGDDRLFL VSPLIISHEI NEKSPFWEMS RAQLEQEEFE
310 320 330 340 350
VVVILEGMVE ATGMTCQARS SYMDTEVLWG HRFTPVLTLE KGFYEVDYNT
360 370 380 390 400
FHDTYETNTP SCCAKELAEM KRSGRLLQYL PSPPLLGGCA EAGNEAEAEK
410
DEEGEPNGLS VSQATRGSM
Length:419
Mass (Da):47,669
Last modified:July 27, 2011 - v3
Checksum:i8383373921C7356A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021L → V in AAB01687. (PubMed:7499385)Curated
Sequence conflicti109 – 1091W → G in AAB01687. (PubMed:7499385)Curated
Sequence conflicti172 – 1721A → P in AAC53116. 1 PublicationCurated
Sequence conflicti193 – 1931P → S in AAB01687. (PubMed:7499385)Curated
Sequence conflicti214 – 2141K → N in AAC53116. 1 PublicationCurated
Sequence conflicti232 – 2321A → V in AAB01687. (PubMed:7499385)Curated
Sequence conflicti269 – 2691F → L in AAB01687. (PubMed:7499385)Curated
Sequence conflicti287 – 2871W → V in AAB01687. (PubMed:7499385)Curated
Sequence conflicti296 – 2961Q → P in AAC53116. 1 PublicationCurated
Sequence conflicti351 – 3511F → S in AAC53116. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33631 mRNA. Translation: AAB01687.1.
AF403131 Genomic DNA. Translation: AAC53116.1.
AK164058 mRNA. Translation: BAE37606.1.
CH466522 Genomic DNA. Translation: EDL25354.1.
CCDSiCCDS22952.1.
RefSeqiNP_034735.3. NM_010605.4.
XP_006510102.1. XM_006510039.1.
XP_006510103.1. XM_006510040.1.
XP_006510104.1. XM_006510041.1.
UniGeneiMm.69472.

Genome annotation databases

EnsembliENSMUST00000034533; ENSMUSP00000034533; ENSMUSG00000032034.
GeneIDi16521.
KEGGimmu:16521.
UCSCiuc009orw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33631 mRNA. Translation: AAB01687.1 .
AF403131 Genomic DNA. Translation: AAC53116.1 .
AK164058 mRNA. Translation: BAE37606.1 .
CH466522 Genomic DNA. Translation: EDL25354.1 .
CCDSi CCDS22952.1.
RefSeqi NP_034735.3. NM_010605.4.
XP_006510102.1. XM_006510039.1.
XP_006510103.1. XM_006510040.1.
XP_006510104.1. XM_006510041.1.
UniGenei Mm.69472.

3D structure databases

ProteinModelPortali P48545.
SMRi P48545. Positions 51-370.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 437.

PTM databases

PhosphoSitei P48545.

Proteomic databases

PRIDEi P48545.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034533 ; ENSMUSP00000034533 ; ENSMUSG00000032034 .
GeneIDi 16521.
KEGGi mmu:16521.
UCSCi uc009orw.1. mouse.

Organism-specific databases

CTDi 3762.
MGIi MGI:104755. Kcnj5.

Phylogenomic databases

eggNOGi NOG72812.
GeneTreei ENSGT00760000118842.
HOGENOMi HOG000237325.
HOVERGENi HBG006178.
InParanoidi P48545.
KOi K04999.
OMAi QARSSYM.
OrthoDBi EOG7XPZ5K.
TreeFami TF313676.

Enzyme and pathway databases

Reactomei REACT_208837. Activation of G protein gated Potassium channels.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

NextBioi 289897.
PROi P48545.
SOURCEi Search...

Gene expression databases

Bgeei P48545.
ExpressionAtlasi P48545. baseline and differential.
Genevestigatori P48545.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003277. K_chnl_inward-rec_Kir3.4.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01330. KIR34CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels."
    Lesage F., Guillemare E., Fink M., Duprat F., Heurteaux C., Fosset M., Romey G., Barhanin J., Lazdunski M.
    J. Biol. Chem. 270:28660-28667(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. Wickman K.D., James M.R., Seldin M.F., Gendler S.J., Clapham D.E.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKCNJ5_MOUSE
AccessioniPrimary (citable) accession number: P48545
Secondary accession number(s): P97508, Q3TPX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3