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P48544

- KCNJ5_HUMAN

UniProt

P48544 - KCNJ5_HUMAN

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Protein

G protein-activated inward rectifier potassium channel 4

Gene
KCNJ5, GIRK4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei179 – 1791Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

GO - Molecular functioni

  1. G-protein activated inward rectifier potassium channel activity Source: UniProtKB
  2. protein binding Source: BHF-UCL

GO - Biological processi

  1. potassium ion transmembrane transport Source: GOC
  2. potassium ion transport Source: ProtInc
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Protein family/group databases

TCDBi1.A.2.1.3. inward rectifier k(+) channel (irk-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-activated inward rectifier potassium channel 4
Short name:
GIRK-4
Alternative name(s):
Cardiac inward rectifier
Short name:
CIR
Heart KATP channel
Inward rectifier K(+) channel Kir3.4
Short name:
IRK-4
KATP-1
Potassium channel, inwardly rectifying subfamily J member 5
Gene namesi
Name:KCNJ5
Synonyms:GIRK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6266. KCNJ5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686Cytoplasmic By similarityAdd
BLAST
Transmembranei87 – 11125Helical; Name=M1; By similarityAdd
BLAST
Topological domaini112 – 13524Extracellular By similarityAdd
BLAST
Intramembranei136 – 14712Helical; Pore-forming; Name=H5; By similarityAdd
BLAST
Intramembranei148 – 1547Pore-forming; By similarity
Topological domaini155 – 1639Extracellular By similarity
Transmembranei164 – 18522Helical; Name=M2; By similarityAdd
BLAST
Topological domaini186 – 419234Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. plasma membrane Source: Reactome
  2. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Long QT syndrome 13 (LQT13) [MIM:613485]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti387 – 3871G → R in LQT13. 1 Publication
Corresponds to variant rs199830292 [ dbSNP | Ensembl ].
VAR_063766
Familial hyperaldosteronism 3 (FH3) [MIM:613677]: A form of hyperaldosteronism characterized by hypertension secondary to massive adrenal mineralocorticoid production. Like patients with familial hyperaldosteronism type 1 (glucocorticoid-remediable aldosteronism), patients with FH3 present with childhood hypertension, elevated aldosteronism levels, and high levels of the hybrid steroids 18-oxocortisol and 18-hydroxycortisol. However, hypertension and aldosteronism are not reversed by administration of exogenous glucocorticoids and patients require adrenalectomy to control hypertension.
Note: The disease is caused by mutations affecting the gene represented in this entry.3 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511G → E in FH3; results in a profound alteration of channel function with loss of channel selectivity and membrane depolarization. 2 Publications
VAR_067090
Natural varianti151 – 1511G → R in FH3 and APA; detected as germline mutation in a kindred with severe primary aldosteronism and adrenocortical hyperplasia; recurrent mutation in APA; somatic mutation; results in loss of channel selectivity and membrane depolarization. 5 Publications
VAR_065930
Natural varianti158 – 1581T → A in FH3; also found in aldosterone-producing adrenal adenoma. 2 Publications
VAR_065931
Somatic mutations in KCNJ5 have been found in aldosterone-producing adrenal adenomas (APA) and can be responsible for aldosteronism associated with cell autonomous proliferation. APAs are typically solitary, well circumscribed tumors diagnosed between ages 30 and 70. They come to medical attention due to new or worsening hypertension, often with hypokalemia. The precise role of KCNJ5 mutations in APA is under debate. They produce increased sodium conductance and cell depolarization, which in adrenal glomerulosa cells produces calcium entry, the signal for aldosterone production and cell proliferation. However, they may not be causative of APA development but may be a consequence of tumorigenesis, playing only a contributory role toward aldosterone overproduction and tumor growth (1 Publication). Somatic mutations in KCNJ5 have not been found in non-aldosterone secreting adrenal adenomas suggesting that they are specifically associated with APA (1 Publication and 1 Publication).4 Publications

Keywords - Diseasei

Disease mutation, Long QT syndrome

Organism-specific databases

MIMi613485. phenotype.
613677. phenotype.
Orphaneti85142. Aldosterone-producing adenoma.
251274. Familial hyperaldosteronism type 3.
101016. Romano-Ward syndrome.
PharmGKBiPA216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419G protein-activated inward rectifier potassium channel 4PRO_0000154934Add
BLAST

Proteomic databases

PaxDbiP48544.
PRIDEiP48544.

PTM databases

PhosphoSiteiP48544.

Expressioni

Tissue specificityi

Islets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa.1 Publication

Gene expression databases

ArrayExpressiP48544.
BgeeiP48544.
CleanExiHS_KCNJ5.
GenevestigatoriP48544.

Organism-specific databases

HPAiCAB022569.
HPA014722.
HPA017353.

Interactioni

Subunit structurei

May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger By similarity.

Protein-protein interaction databases

BioGridi109964. 4 interactions.
MINTiMINT-90031.
STRINGi9606.ENSP00000339960.

Structurei

3D structure databases

ProteinModelPortaliP48544.
SMRiP48544. Positions 51-370.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi149 – 1546Selectivity filter By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72812.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiP48544.
KOiK04999.
OMAiQARSSYM.
OrthoDBiEOG7XPZ5K.
PhylomeDBiP48544.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003277. K_chnl_inward-rec_Kir3.4.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01330. KIR34CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P48544-1 [UniParc]FASTAAdd to Basket

« Hide

MAGDSRNAMN QDMEIGVTPW DPKKIPKQAR DYVPIATDRT RLLAEGKKPR    50
QRYMEKSGKC NVHHGNVQET YRYLSDLFTT LVDLKWRFNL LVFTMVYTVT 100
WLFFGFIWWL IAYIRGDLDH VGDQEWIPCV ENLSGFVSAF LFSIETETTI 150
GYGFRVITEK CPEGIILLLV QAILGSIVNA FMVGCMFVKI SQPKKRAETL 200
MFSNNAVISM RDEKLCLMFR VGDLRNSHIV EASIRAKLIK SRQTKEGEFI 250
PLNQTDINVG FDTGDDRLFL VSPLIISHEI NQKSPFWEMS QAQLHQEEFE 300
VVVILEGMVE ATGMTCQARS SYMDTEVLWG HRFTPVLTLE KGFYEVDYNT 350
FHDTYETNTP SCCAKELAEM KREGRLLQYL PSPPLLGGCA EAGLDAEAEQ 400
NEEDEPKGLG GSREARGSV 419
Length:419
Mass (Da):47,668
Last modified:May 18, 2010 - v2
Checksum:i7C14A6B0B7EA0FD4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391R → H.1 Publication
VAR_065929
Natural varianti145 – 1451E → Q Found in aldosterone-producing adrenal adenoma samples; somatic mutation. 1 Publication
VAR_069182
Natural varianti151 – 1511G → E in FH3; results in a profound alteration of channel function with loss of channel selectivity and membrane depolarization. 2 Publications
VAR_067090
Natural varianti151 – 1511G → R in FH3 and APA; detected as germline mutation in a kindred with severe primary aldosteronism and adrenocortical hyperplasia; recurrent mutation in APA; somatic mutation; results in loss of channel selectivity and membrane depolarization. 5 Publications
VAR_065930
Natural varianti158 – 1581T → A in FH3; also found in aldosterone-producing adrenal adenoma. 2 Publications
VAR_065931
Natural varianti168 – 1681L → R in APA; somatic mutation; recurrent mutation; results in loss of channel selectivity and membrane depolarization. 4 Publications
VAR_065932
Natural varianti210 – 2101M → I.1 Publication
Corresponds to variant rs138295501 [ dbSNP | Ensembl ].
VAR_065933
Natural varianti282 – 2821Q → E.6 Publications
Corresponds to variant rs7102584 [ dbSNP | Ensembl ].
VAR_063107
Natural varianti387 – 3871G → R in LQT13. 1 Publication
Corresponds to variant rs199830292 [ dbSNP | Ensembl ].
VAR_063766

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351I → T in AAB07045. 1 Publication
Sequence conflicti388 – 3881G → R in CAA58565. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39195 mRNA. Translation: AAB53093.1.
X83582 mRNA. Translation: CAA58565.1.
L47208 mRNA. Translation: AAB07269.1.
U52154 mRNA. Translation: AAB07045.1.
D50134 mRNA. Translation: BAA08814.1.
AP000920 Genomic DNA. No translation available.
AK312837 mRNA. Translation: BAG35691.1.
BC069571 mRNA. Translation: AAH69571.1.
BC074838 mRNA. Translation: AAH74838.2.
BC069386 mRNA. Translation: AAH69386.1.
BC069482 mRNA. Translation: AAH69482.1.
BC069499 mRNA. Translation: AAH69499.1.
BC074839 mRNA. Translation: AAH74839.2.
CCDSiCCDS8479.1.
PIRiG02232.
RefSeqiNP_000881.3. NM_000890.3.
XP_005271600.1. XM_005271543.1.
UniGeneiHs.444595.
Hs.632109.

Genome annotation databases

EnsembliENST00000338350; ENSP00000339960; ENSG00000120457.
ENST00000529694; ENSP00000433295; ENSG00000120457.
ENST00000533599; ENSP00000434266; ENSG00000120457.
GeneIDi3762.
KEGGihsa:3762.
UCSCiuc001qet.3. human.

Polymorphism databases

DMDMi296434543.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39195 mRNA. Translation: AAB53093.1 .
X83582 mRNA. Translation: CAA58565.1 .
L47208 mRNA. Translation: AAB07269.1 .
U52154 mRNA. Translation: AAB07045.1 .
D50134 mRNA. Translation: BAA08814.1 .
AP000920 Genomic DNA. No translation available.
AK312837 mRNA. Translation: BAG35691.1 .
BC069571 mRNA. Translation: AAH69571.1 .
BC074838 mRNA. Translation: AAH74838.2 .
BC069386 mRNA. Translation: AAH69386.1 .
BC069482 mRNA. Translation: AAH69482.1 .
BC069499 mRNA. Translation: AAH69499.1 .
BC074839 mRNA. Translation: AAH74839.2 .
CCDSi CCDS8479.1.
PIRi G02232.
RefSeqi NP_000881.3. NM_000890.3.
XP_005271600.1. XM_005271543.1.
UniGenei Hs.444595.
Hs.632109.

3D structure databases

ProteinModelPortali P48544.
SMRi P48544. Positions 51-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109964. 4 interactions.
MINTi MINT-90031.
STRINGi 9606.ENSP00000339960.

Chemistry

ChEMBLi CHEMBL3038488.
DrugBanki DB01016. Glibenclamide.
GuidetoPHARMACOLOGYi 437.

Protein family/group databases

TCDBi 1.A.2.1.3. inward rectifier k(+) channel (irk-c) family.

PTM databases

PhosphoSitei P48544.

Polymorphism databases

DMDMi 296434543.

Proteomic databases

PaxDbi P48544.
PRIDEi P48544.

Protocols and materials databases

DNASUi 3762.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338350 ; ENSP00000339960 ; ENSG00000120457 .
ENST00000529694 ; ENSP00000433295 ; ENSG00000120457 .
ENST00000533599 ; ENSP00000434266 ; ENSG00000120457 .
GeneIDi 3762.
KEGGi hsa:3762.
UCSCi uc001qet.3. human.

Organism-specific databases

CTDi 3762.
GeneCardsi GC11P128760.
GeneReviewsi KCNJ5.
HGNCi HGNC:6266. KCNJ5.
HPAi CAB022569.
HPA014722.
HPA017353.
MIMi 600734. gene.
613485. phenotype.
613677. phenotype.
neXtProti NX_P48544.
Orphaneti 85142. Aldosterone-producing adenoma.
251274. Familial hyperaldosteronism type 3.
101016. Romano-Ward syndrome.
PharmGKBi PA216.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72812.
HOGENOMi HOG000237325.
HOVERGENi HBG006178.
InParanoidi P48544.
KOi K04999.
OMAi QARSSYM.
OrthoDBi EOG7XPZ5K.
PhylomeDBi P48544.
TreeFami TF313676.

Enzyme and pathway databases

Reactomei REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Miscellaneous databases

GeneWikii KCNJ5.
GenomeRNAii 3762.
NextBioi 14751.
PROi P48544.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48544.
Bgeei P48544.
CleanExi HS_KCNJ5.
Genevestigatori P48544.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003277. K_chnl_inward-rec_Kir3.4.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01330. KIR34CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Chan K.W., Langan M.N., Sui J., Kozak A., Pabon A., Ladias J.A.A., Logothetis D.E.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-282.
    Tissue: Pancreas.
  2. "Cloning and functional expression of a rat heart KATP channel."
    Ashford M.L.J., Bond C.T., Blair T.A., Adelman J.P.
    Nature 370:456-459(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-282.
  3. Cited for: RETRACTION.
  4. "A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels."
    Spauschus A., Lentes K.U., Wischmeyer E., Dissmann E., Karschin C., Karschin A.
    J. Neurosci. 16:930-938(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-282.
  5. "Co-expression of human Kir3 subunits can yield channels with different functional properties."
    Schoots O., Wilson J.M., Ethier N., Bigras E., Hebert T.E., Van Tol H.H.M.
    Cell. Signal. 11:871-883(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-282.
    Tissue: Pituitary.
  6. "Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel."
    Iizuka M., Kubo Y., Tsunenari I., Pan C.X., Akiba I., Kono T.
    Recept. Channels 3:299-315(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-282.
    Tissue: Heart.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-282.
    Tissue: Lung.
  10. Cited for: TISSUE SPECIFICITY, VARIANT FH3 ALA-158, VARIANTS APA ARG-151 AND ARG-168, CHARACTERIZATION OF VARIANTS APA ARG-151 AND ARG-168, VARIANTS HIS-39 AND ILE-210.
  11. Cited for: VARIANT LQT13 ARG-387.
  12. Cited for: VARIANTS APA ARG-151 AND ARG-168, VARIANTS FH3 GLU-151 AND ALA-158, CHARACTERIZATION OF VARIANT FH3 GLU-151.
  13. Cited for: VARIANTS APA ARG-151 AND ARG-168.
  14. Cited for: VARIANTS APA ARG-151 AND ARG-168, VARIANT GLN-145.
  15. "Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5."
    Scholl U.I., Nelson-Williams C., Yue P., Grekin R., Wyatt R.J., Dillon M.J., Couch R., Hammer L.K., Harley F.L., Farhi A., Wang W.H., Lifton R.P.
    Proc. Natl. Acad. Sci. U.S.A. 109:2533-2538(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS FH3 ARG-151 AND GLU-151.

Entry informationi

Entry nameiKCNJ5_HUMAN
AccessioniPrimary (citable) accession number: P48544
Secondary accession number(s): B2R744
, Q6DK13, Q6DK14, Q92807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi