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Protein

Purkinje cell protein 4

Gene

PCP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable regulator of calmodulin signaling.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Purkinje cell protein 4
Alternative name(s):
Brain-specific antigen PCP-4
Brain-specific polypeptide PEP-19
Gene namesi
Name:PCP4
Synonyms:PEP19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:8742. PCP4.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytosol Source: UniProtKB
  • neurofilament Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33087.

Polymorphism and mutation databases

BioMutaiPCP4.
DMDMi3915800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6262Purkinje cell protein 4PRO_0000058306Add
BLAST

Proteomic databases

PaxDbiP48539.
PeptideAtlasiP48539.
PRIDEiP48539.

PTM databases

iPTMnetiP48539.
PhosphoSiteiP48539.

Expressioni

Gene expression databases

BgeeiP48539.
CleanExiHS_PCP4.
ExpressionAtlasiP48539. baseline and differential.
GenevisibleiP48539. HS.

Organism-specific databases

HPAiHPA005792.

Interactioni

Subunit structurei

Binds to both calcium-free and calcium activated calmodulin, affinity for calcium-bound form is 50-fold greater.

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-4287270,EBI-750109

Protein-protein interaction databases

BioGridi111150. 4 interactions.
IntActiP48539. 4 interactions.
STRINGi9606.ENSP00000329403.

Structurei

3D structure databases

DisProtiDP00592.
ProteinModelPortaliP48539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 6224IQAdd
BLAST

Domaini

Mostly intrisically disordered, with residual structure localized to the IQ motif.1 Publication

Sequence similaritiesi

Belongs to the PCP4 family.Curated
Contains 1 IQ domain.Curated

Phylogenomic databases

eggNOGiENOG410J2B1. Eukaryota.
ENOG410Z4EX. LUCA.
GeneTreeiENSGT00530000064267.
HOGENOMiHOG000054222.
InParanoidiP48539.
OMAiFQIDMDA.
OrthoDBiEOG7Z0K0G.
PhylomeDBiP48539.
TreeFamiTF336068.

Family and domain databases

InterProiIPR033236. PCP4.
[Graphical view]
PANTHERiPTHR15359:SF7. PTHR15359:SF7. 1 hit.

Sequencei

Sequence statusi: Complete.

P48539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERQGAGAT NGKDKTSGEN DGQKKVQEEF DIDMDAPETE RAAVAIQSQF
60
RKFQKKKAGS QS
Length:62
Mass (Da):6,791
Last modified:January 23, 2007 - v3
Checksum:i99ED306DE41BF29D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91A → P in CAA63724 (PubMed:8931698).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93349 mRNA. Translation: CAA63724.1.
U53709, U53707, U53708 Genomic DNA. Translation: AAC00024.1.
U52969 mRNA. Translation: AAB09033.1.
AM183336 mRNA. Translation: CAJ70630.1.
AF064857 Genomic DNA. Translation: AAC23994.1.
AF416716 mRNA. Translation: AAL16810.1.
AK289964 mRNA. Translation: BAF82653.1.
CR450319 mRNA. Translation: CAG29315.1.
AL163281 Genomic DNA. Translation: CAB90443.1.
CH471079 Genomic DNA. Translation: EAX09623.1.
BC013791 mRNA. Translation: AAH13791.1.
CCDSiCCDS33563.1.
RefSeqiNP_006189.2. NM_006198.2.
UniGeneiHs.80296.

Genome annotation databases

EnsembliENST00000328619; ENSP00000329403; ENSG00000183036.
GeneIDi5121.
KEGGihsa:5121.
UCSCiuc002yyp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93349 mRNA. Translation: CAA63724.1.
U53709, U53707, U53708 Genomic DNA. Translation: AAC00024.1.
U52969 mRNA. Translation: AAB09033.1.
AM183336 mRNA. Translation: CAJ70630.1.
AF064857 Genomic DNA. Translation: AAC23994.1.
AF416716 mRNA. Translation: AAL16810.1.
AK289964 mRNA. Translation: BAF82653.1.
CR450319 mRNA. Translation: CAG29315.1.
AL163281 Genomic DNA. Translation: CAB90443.1.
CH471079 Genomic DNA. Translation: EAX09623.1.
BC013791 mRNA. Translation: AAH13791.1.
CCDSiCCDS33563.1.
RefSeqiNP_006189.2. NM_006198.2.
UniGeneiHs.80296.

3D structure databases

DisProtiDP00592.
ProteinModelPortaliP48539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111150. 4 interactions.
IntActiP48539. 4 interactions.
STRINGi9606.ENSP00000329403.

PTM databases

iPTMnetiP48539.
PhosphoSiteiP48539.

Polymorphism and mutation databases

BioMutaiPCP4.
DMDMi3915800.

Proteomic databases

PaxDbiP48539.
PeptideAtlasiP48539.
PRIDEiP48539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328619; ENSP00000329403; ENSG00000183036.
GeneIDi5121.
KEGGihsa:5121.
UCSCiuc002yyp.4. human.

Organism-specific databases

CTDi5121.
GeneCardsiPCP4.
HGNCiHGNC:8742. PCP4.
HPAiHPA005792.
MIMi601629. gene.
neXtProtiNX_P48539.
PharmGKBiPA33087.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2B1. Eukaryota.
ENOG410Z4EX. LUCA.
GeneTreeiENSGT00530000064267.
HOGENOMiHOG000054222.
InParanoidiP48539.
OMAiFQIDMDA.
OrthoDBiEOG7Z0K0G.
PhylomeDBiP48539.
TreeFamiTF336068.

Miscellaneous databases

GeneWikiiPCP4.
GenomeRNAii5121.
PROiP48539.
SOURCEiSearch...

Gene expression databases

BgeeiP48539.
CleanExiHS_PCP4.
ExpressionAtlasiP48539. baseline and differential.
GenevisibleiP48539. HS.

Family and domain databases

InterProiIPR033236. PCP4.
[Graphical view]
PANTHERiPTHR15359:SF7. PTHR15359:SF7. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3."
    Chen H.M., Bouras C., Antonarakis S.E.
    Hum. Genet. 98:672-677(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "Molecular genetic characterization and comparative mapping of the human PCP4 gene."
    Cabin D.E., Gardiner K., Reeves R.H.
    Somat. Cell Mol. Genet. 22:167-175(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-o activation in mouse models of Down syndrome."
    Mouton-Liger F., Thomas S., Rattenbach R., Magnol L., Larigaldie V., Ledru A., Herault Y., Verney C., Creau N.
    J. Comp. Neurol. 519:2779-2802(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal kidney.
  4. Taudien S., Nordsiek G., Korenberg J., Drescher B., Weber J., Schattevoy R., Rosenthal A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Kang L., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal cortex.
  11. "PEP-19, an intrinsically disordered regulator of calmodulin signaling."
    Kleerekoper Q.K., Putkey J.A.
    J. Biol. Chem. 284:7455-7464(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CALMODULIN.

Entry informationi

Entry nameiPCP4_HUMAN
AccessioniPrimary (citable) accession number: P48539
Secondary accession number(s): A6NDJ9, Q6ICS4, Q93059
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.