P48539 (PCP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Purkinje cell protein 4

Alternative name(s):
Brain-specific antigen PCP-4
Brain-specific polypeptide PEP-19

Gene names

Name:	PCP4
Synonyms:	PEP19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	62 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable regulator of calmodulin signaling. Ref.11
Subunit structure	Binds to both calcium-free and calcium activated calmodulin, affinity for calcium-bound form is 50-fold greater. Ref.11
Domain	Mostly intrisically disordered, with residual structure localized to the IQ motif (Ref.11).
Sequence similarities	Belongs to the PCP4 family. Contains 1 IQ domain.

Ontologies

Keywords
Ligand	Calmodulin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	central nervous system development Traceable author statement Ref.2. Source: ProtInc
Cellular_component	cytosol Inferred from direct assay PubMed 16780588. Source: UniProtKB nucleus Inferred from direct assay PubMed 16780588. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 62	62	Purkinje cell protein 4		PRO_0000058306
Regions
	Domain	39 – 62	24	IQ
Experimental info
	Sequence conflict	9	1	A → P in CAA63724. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P48539 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 99ED306DE41BF29D	FASTA	62	6,791
	10 20 30 40 50 60 MSERQGAGAT NGKDKTSGEN DGQKKVQEEF DIDMDAPETE RAAVAIQSQF RKFQKKKAGS QS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3." Chen H.M., Bouras C., Antonarakis S.E. Hum. Genet. 98:672-677(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.
[2]	"Molecular genetic characterization and comparative mapping of the human PCP4 gene." Cabin D.E., Gardiner K., Reeves R.H. Somat. Cell Mol. Genet. 22:167-175(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]	"PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-o activation in mouse models of Down syndrome." Mouton-Liger F., Thomas S., Rattenbach R., Magnol L., Larigaldie V., Ledru A., Herault Y., Verney C., Creau N. J. Comp. Neurol. 519:2779-2802(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal kidney.
[4]	Taudien S., Nordsiek G., Korenberg J., Drescher B., Weber J., Schattevoy R., Rosenthal A. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	Kang L., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal cortex.
[11]	"PEP-19, an intrinsically disordered regulator of calmodulin signaling." Kleerekoper Q.K., Putkey J.A. J. Biol. Chem. 284:7455-7464(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CALMODULIN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X93349 mRNA. Translation: CAA63724.1. U53709, U53707, U53708 Genomic DNA. Translation: AAC00024.1. U52969 mRNA. Translation: AAB09033.1. AM183336 mRNA. Translation: CAJ70630.1. AF064857 Genomic DNA. Translation: AAC23994.1. AF416716 mRNA. Translation: AAL16810.1. AK289964 mRNA. Translation: BAF82653.1. CR450319 mRNA. Translation: CAG29315.1. AL163281 Genomic DNA. Translation: CAB90443.1. CH471079 Genomic DNA. Translation: EAX09623.1. BC013791 mRNA. Translation: AAH13791.1.
IPI	IPI00010148.
RefSeq	NP_006189.2. NM_006198.2.
UniGene	Hs.80296.
3D structure databases
ProteinModelPortal	P48539.
ModBase	Search...
Protein-protein interaction databases
IntAct	P48539. 1 interaction.
STRING	9606.ENSP00000329403.
PTM databases
PhosphoSite	P48539.
Polymorphism databases
DMDM	3915800.
Proteomic databases
PaxDb	P48539.
PRIDE	P48539.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328619; ENSP00000329403; ENSG00000183036.
GeneID	5121.
KEGG	hsa:5121.
UCSC	uc002yyp.3. human.
Organism-specific databases
CTD	5121.
GeneCards	GC21P041239.
HGNC	HGNC:8742. PCP4.
HPA	HPA005792.
MIM	601629. gene.
neXtProt	NX_P48539.
PharmGKB	PA33087.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84413.
HOGENOM	HOG000054222.
InParanoid	P48539.
OMA	MTACEAD.
OrthoDB	EOG4D530D.
PhylomeDB	P48539.
Gene expression databases
ArrayExpress	P48539.
Bgee	P48539.
CleanEx	HS_PCP4.
Genevestigator	P48539.
GermOnline	ENSG00000183036. Homo sapiens.
Family and domain databases
PROSITE	PS50096. IQ. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5121.
NextBio	19746.
SOURCE	Search...

Entry information

Entry name

PCP4_HUMAN

Accession

Primary (citable) accession number: P48539
Secondary accession number(s): A6NDJ9, Q6ICS4, Q93059

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.