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Protein

Calmodulin regulator protein PCP4

Gene

PCP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed:19106096, PubMed:23204517, PubMed:27876793). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways (PubMed:21491429).4 Publications

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB

GO - Biological processi

  • calmodulin dependent kinase signaling pathway Source: UniProtKB
  • positive regulation of neuron differentiation Source: UniProtKB

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin regulator protein PCP4Curated
Alternative name(s):
Brain-specific polypeptide PEP-191 Publication
Purkinje cell protein 4Imported
Gene namesi
Name:PCP41 PublicationImported
Synonyms:PEP191 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000183036.10.
HGNCiHGNC:8742. PCP4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi29E → A: No effect on the calmodulin modulator function. 1 Publication1
Mutagenesisi31D → A: Decreased calmodulin modulator function. 1 Publication1
Mutagenesisi33D → A: Decreased calmodulin modulator function. 1 Publication1
Mutagenesisi35D → A: No effect on the calmodulin modulator function. 1 Publication1
Mutagenesisi37P → G: Loss of the calmodulin modulator function. 1 Publication1
Mutagenesisi40E → A: Decreased calmodulin modulator function. 1 Publication1

Organism-specific databases

DisGeNETi5121.
OpenTargetsiENSG00000183036.
PharmGKBiPA33087.

Polymorphism and mutation databases

BioMutaiPCP4.
DMDMi3915800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583061 – 62Calmodulin regulator protein PCP4Add BLAST62

Proteomic databases

PaxDbiP48539.
PeptideAtlasiP48539.
PRIDEiP48539.

PTM databases

iPTMnetiP48539.
PhosphoSitePlusiP48539.

Expressioni

Gene expression databases

BgeeiENSG00000183036.
CleanExiHS_PCP4.
ExpressionAtlasiP48539. baseline and differential.
GenevisibleiP48539. HS.

Organism-specific databases

HPAiHPA005792.

Interactioni

Subunit structurei

Binds to both calcium-free and calcium-bound calmodulin. The affinity for the calcium-bound form is 50-fold greater.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-4287270,EBI-750109

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111150. 9 interactors.
IntActiP48539. 5 interactors.
STRINGi9606.ENSP00000329403.

Structurei

Secondary structure

162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 36Combined sources3
Helixi37 – 58Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N77NMR-B3-62[»]
DisProtiDP00592.
ProteinModelPortaliP48539.
SMRiP48539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 62IQPROSITE-ProRule annotationAdd BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 40Acidic; binds calcium and is required for modulating the calcium-binding kinetics of calmodulin1 PublicationAdd BLAST13

Domaini

Mostly intrinsically disordered, with residual structure localized to the IQ domain which mediates the interaction with calmodulin.1 Publication

Sequence similaritiesi

Belongs to the PCP4 family.Curated

Phylogenomic databases

eggNOGiENOG410J2B1. Eukaryota.
ENOG410Z4EX. LUCA.
GeneTreeiENSGT00530000064267.
HOGENOMiHOG000054222.
InParanoidiP48539.
OMAiDMEAPET.
OrthoDBiEOG091G17RW.
PhylomeDBiP48539.
TreeFamiTF336068.

Family and domain databases

InterProiView protein in InterPro
IPR033236. PCP4.
PANTHERiPTHR15359:SF7. PTHR15359:SF7. 1 hit.

Sequencei

Sequence statusi: Complete.

P48539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERQGAGAT NGKDKTSGEN DGQKKVQEEF DIDMDAPETE RAAVAIQSQF
60
RKFQKKKAGS QS
Length:62
Mass (Da):6,791
Last modified:January 23, 2007 - v3
Checksum:i99ED306DE41BF29D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → P in CAA63724 (PubMed:8931698).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93349 mRNA. Translation: CAA63724.1.
U53709, U53707, U53708 Genomic DNA. Translation: AAC00024.1.
U52969 mRNA. Translation: AAB09033.1.
AM183336 mRNA. Translation: CAJ70630.1.
AF064857 Genomic DNA. Translation: AAC23994.1.
AF416716 mRNA. Translation: AAL16810.1.
AK289964 mRNA. Translation: BAF82653.1.
CR450319 mRNA. Translation: CAG29315.1.
AL163281 Genomic DNA. Translation: CAB90443.1.
CH471079 Genomic DNA. Translation: EAX09623.1.
BC013791 mRNA. Translation: AAH13791.1.
CCDSiCCDS33563.1.
RefSeqiNP_006189.2. NM_006198.2.
UniGeneiHs.80296.

Genome annotation databases

EnsembliENST00000328619; ENSP00000329403; ENSG00000183036.
GeneIDi5121.
KEGGihsa:5121.
UCSCiuc002yyp.4. human.

Similar proteinsi

Entry informationi

Entry nameiPCP4_HUMAN
AccessioniPrimary (citable) accession number: P48539
Secondary accession number(s): A6NDJ9, Q6ICS4, Q93059
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families