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Protein

Serine/threonine-protein phosphatase PP-X isozyme 1

Gene

PPX1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Manganese 1By similarity1
Metal bindingi53Manganese 1By similarity1
Metal bindingi79Manganese 1By similarity1
Metal bindingi79Manganese 2By similarity1
Metal bindingi111Manganese 2By similarity1
Active sitei112Proton donorBy similarity1
Metal bindingi161Manganese 2By similarity1
Metal bindingi236Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: TAIR

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-X isozyme 1 (EC:3.1.3.16)
Gene namesi
Name:PPX1
Synonyms:EP124, EP129
Ordered Locus Names:At4g26720
ORF Names:F10M23.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G26720
TAIRilocus:2116402 AT4G26720

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588861 – 305Serine/threonine-protein phosphatase PP-X isozyme 1Add BLAST305

Proteomic databases

PaxDbiP48529
PRIDEiP48529

Expressioni

Tissue specificityi

Ubiquitous, mostly expressed in root mersitems, flowers, and vascular tissues.1 Publication

Gene expression databases

ExpressionAtlasiP48529 baseline and differential
GenevisibleiP48529 AT

Interactioni

Subunit structurei

Interacts with TAP46.2 Publications

Protein-protein interaction databases

BioGridi14066, 1 interactor
STRINGi3702.AT4G26720.1

Structurei

3D structure databases

ProteinModelPortaliP48529
SMRiP48529
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0372 Eukaryota
COG0639 LUCA
HOGENOMiHOG000172696
InParanoidiP48529
KOiK15423
OMAiNRIFCTH
OrthoDBiEOG09360F9Z
PhylomeDBiP48529

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P48529-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLDRQIGQ LKRCEPLSES EVKALCLKAM EILVEESNVQ RVDAPVTLCG
60 70 80 90 100
DIHGQFYDMM ELFKVGGDCP KTNYLFMGDF VDRGYYSVET FLLLLALKVR
110 120 130 140 150
YPDRITLIRG NHESRQITQV YGFYDECLRK YGSSNVWRYC TDIFDYMSLS
160 170 180 190 200
AVVENKIFCV HGGLSPAIMT LDQIRTIDRK QEVPHDGAMC DLLWSDPEDI
210 220 230 240 250
VDGWGLSPRG AGFLFGGSVV TSFNHSNNID YIARAHQLVM EGYKWMFDSQ
260 270 280 290 300
IVTVWSAPNY CYRCGNVASI LELDENLNKE FRVFDAAQQD SRGPPAKKPA

PDYFL
Length:305
Mass (Da):34,738
Last modified:February 1, 1996 - v1
Checksum:i3FBBEADB2DA5B650
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22587 mRNA Translation: CAA80302.1
AF030289 Genomic DNA Translation: AAB86418.1
AL035440 Genomic DNA Translation: CAB36518.1
AL161565 Genomic DNA Translation: CAB79527.1
CP002687 Genomic DNA Translation: AEE85245.1
PIRiS42558
RefSeqiNP_194402.1, NM_118806.6
UniGeneiAt.106

Genome annotation databases

EnsemblPlantsiAT4G26720.1; AT4G26720.1; AT4G26720
GeneIDi828779
GrameneiAT4G26720.1; AT4G26720.1; AT4G26720
KEGGiath:AT4G26720

Similar proteinsi

Entry informationi

Entry nameiPPX1_ARATH
AccessioniPrimary (citable) accession number: P48529
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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