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P48528

- PPX2_ARATH

UniProt

P48528 - PPX2_ARATH

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Protein
Serine/threonine-protein phosphatase PP-X isozyme 2
Gene
PPX2, At5g55260, MCO15.21
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511Manganese 1 By similarity
Metal bindingi53 – 531Manganese 1 By similarity
Metal bindingi79 – 791Manganese 1 By similarity
Metal bindingi79 – 791Manganese 2 By similarity
Metal bindingi111 – 1111Manganese 2 By similarity
Active sitei112 – 1121Proton donor By similarity
Metal bindingi161 – 1611Manganese 2 By similarity
Metal bindingi236 – 2361Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: TAIR
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G55260-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-X isozyme 2 (EC:3.1.3.16)
Gene namesi
Name:PPX2
Ordered Locus Names:At5g55260
ORF Names:MCO15.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G55260.

Subcellular locationi

Plastid stroma 1 Publication

GO - Cellular componenti

  1. plastid stroma Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Serine/threonine-protein phosphatase PP-X isozyme 2
PRO_0000058887Add
BLAST

Proteomic databases

PaxDbiP48528.
PRIDEiP48528.

Expressioni

Tissue specificityi

Ubiquitous, mostly expressed in root mersitems, flowers, and vascular tissues.1 Publication

Gene expression databases

GenevestigatoriP48528.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G55260.1-P.

Structurei

3D structure databases

ProteinModelPortaliP48528.
SMRiP48528. Positions 3-289.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
InParanoidiP48528.
KOiK15423.
OMAiVFNHRND.
PhylomeDBiP48528.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48528-1 [UniParc]FASTAAdd to Basket

« Hide

MSDLDKQIEQ LKRCEALKES EVKALCLKAM EILVEESNVQ RVDAPVTICG    50
DIHGQFYDMK ELFKVGGDCP KTNYLFLGDF VDRGFYSVET FLLLLALKVR 100
YPDRITLIRG NHESRQITQV YGFYDECLRK YGSVNVWRYC TDIFDYLSLS 150
ALVENKIFCV HGGLSPAIMT LDQIRAIDRK QEVPHDGAMC DLLWSDPEDI 200
VDGWGLSPRG AGFLFGGSVV TSFNHSNNID YICRAHQLVM EGYKWMFNSQ 250
IVTVWSAPNY CYRCGNVAAI LELDENLNKE FRVFDAAPQE SRGALAKKPA 300
PDYFL 305
Length:305
Mass (Da):34,726
Last modified:December 1, 2000 - v2
Checksum:i77DF2B662F3B1FB1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731N → H in CAA80312. 1 Publication
Sequence conflicti226 – 2261S → L in CAA80312. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22596 mRNA. Translation: CAA80312.1.
AF030290 Genomic DNA. Translation: AAB86419.1.
AB010071 Genomic DNA. Translation: BAB08595.1.
CP002688 Genomic DNA. Translation: AED96607.1.
BT024716 mRNA. Translation: ABD59054.1.
PIRiS42559.
RefSeqiNP_200337.1. NM_124908.3.
UniGeneiAt.105.

Genome annotation databases

EnsemblPlantsiAT5G55260.1; AT5G55260.1; AT5G55260.
GeneIDi835619.
KEGGiath:AT5G55260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22596 mRNA. Translation: CAA80312.1 .
AF030290 Genomic DNA. Translation: AAB86419.1 .
AB010071 Genomic DNA. Translation: BAB08595.1 .
CP002688 Genomic DNA. Translation: AED96607.1 .
BT024716 mRNA. Translation: ABD59054.1 .
PIRi S42559.
RefSeqi NP_200337.1. NM_124908.3.
UniGenei At.105.

3D structure databases

ProteinModelPortali P48528.
SMRi P48528. Positions 3-289.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT5G55260.1-P.

Proteomic databases

PaxDbi P48528.
PRIDEi P48528.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G55260.1 ; AT5G55260.1 ; AT5G55260 .
GeneIDi 835619.
KEGGi ath:AT5G55260.

Organism-specific databases

TAIRi AT5G55260.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172696.
InParanoidi P48528.
KOi K15423.
OMAi VFNHRND.
PhylomeDBi P48528.

Enzyme and pathway databases

BioCyci ARA:AT5G55260-MONOMER.

Miscellaneous databases

PROi P48528.

Gene expression databases

Genevestigatori P48528.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and molecular cloning of two homologues of protein phosphatase X from Arabidopsis thaliana."
    Perez-Callejon E., Casamayor A., Pujol G., Clua E., Ferrer A., Arino J.
    Plant Mol. Biol. 23:1177-1185(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leaf.
  2. "The Arabidopsis thaliana PPX/PP4 phosphatases: molecular cloning and structural organization of the genes and immunolocalization of the proteins to plastids."
    Pujol G., Baskin T.I., Casamayor A., Cortadellas N., Ferrer A., Arino J.
    Plant Mol. Biol. 44:499-511(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  3. "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones."
    Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:41-54(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Arabidopsis ORF clones."
    Shinn P., Chen H., Kim C.J., Ecker J.R.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Arabidopsis PPP family of serine/threonine phosphatases."
    Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
    Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPPX2_ARATH
AccessioniPrimary (citable) accession number: P48528
Secondary accession number(s): O22626, Q29Q40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: June 11, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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