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Protein

Serine/threonine-protein phosphatase PP-X isozyme 2

Gene

PPX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Manganese 1By similarity1
Metal bindingi53Manganese 1By similarity1
Metal bindingi79Manganese 1By similarity1
Metal bindingi79Manganese 2By similarity1
Metal bindingi111Manganese 2By similarity1
Active sitei112Proton donorBy similarity1
Metal bindingi161Manganese 2By similarity1
Metal bindingi236Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: TAIR

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-X isozyme 2 (EC:3.1.3.16)
Gene namesi
Name:PPX2
Ordered Locus Names:At5g55260
ORF Names:MCO15.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G55260.
TAIRilocus:2161700. AT5G55260.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588871 – 305Serine/threonine-protein phosphatase PP-X isozyme 2Add BLAST305

Proteomic databases

PaxDbiP48528.

Expressioni

Tissue specificityi

Ubiquitous, mostly expressed in root mersitems, flowers, and vascular tissues.1 Publication

Gene expression databases

ExpressionAtlasiP48528. baseline and differential.
GenevisibleiP48528. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G55260.1.

Structurei

3D structure databases

ProteinModelPortaliP48528.
SMRiP48528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0372. Eukaryota.
COG0639. LUCA.
HOGENOMiHOG000172696.
InParanoidiP48528.
KOiK15423.
OMAiPDRMTLI.
OrthoDBiEOG09360F9Z.
PhylomeDBiP48528.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P48528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLDKQIEQ LKRCEALKES EVKALCLKAM EILVEESNVQ RVDAPVTICG
60 70 80 90 100
DIHGQFYDMK ELFKVGGDCP KTNYLFLGDF VDRGFYSVET FLLLLALKVR
110 120 130 140 150
YPDRITLIRG NHESRQITQV YGFYDECLRK YGSVNVWRYC TDIFDYLSLS
160 170 180 190 200
ALVENKIFCV HGGLSPAIMT LDQIRAIDRK QEVPHDGAMC DLLWSDPEDI
210 220 230 240 250
VDGWGLSPRG AGFLFGGSVV TSFNHSNNID YICRAHQLVM EGYKWMFNSQ
260 270 280 290 300
IVTVWSAPNY CYRCGNVAAI LELDENLNKE FRVFDAAPQE SRGALAKKPA

PDYFL
Length:305
Mass (Da):34,726
Last modified:December 1, 2000 - v2
Checksum:i77DF2B662F3B1FB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73N → H in CAA80312 (PubMed:8292782).Curated1
Sequence conflicti226S → L in CAA80312 (PubMed:8292782).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22596 mRNA. Translation: CAA80312.1.
AF030290 Genomic DNA. Translation: AAB86419.1.
AB010071 Genomic DNA. Translation: BAB08595.1.
CP002688 Genomic DNA. Translation: AED96607.1.
BT024716 mRNA. Translation: ABD59054.1.
PIRiS42559.
RefSeqiNP_200337.1. NM_124908.4.
UniGeneiAt.105.

Genome annotation databases

EnsemblPlantsiAT5G55260.1; AT5G55260.1; AT5G55260.
GeneIDi835619.
GrameneiAT5G55260.1; AT5G55260.1; AT5G55260.
KEGGiath:AT5G55260.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPPX2_ARATH
AccessioniPrimary (citable) accession number: P48528
Secondary accession number(s): O22626, Q29Q40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: June 7, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families