CD151 antigen - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P48509 (CD151_HUMAN)

Last modified November 25, 2008. Version 76. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    CD151 antigen
Alternative name(s):
    Platelet-endothelial tetraspan antigen 3
      Short name=PETA-3
    GP27
    Membrane glycoprotein SFA-1
    Tetraspanin-24
      Short name=Tspan-24
    CD_antigen=CD151

Gene names

Name:	CD151
Synonyms:	TSPAN24

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.
Subunit structure	Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.
Induction	By HTLV-1.
Polymorphism	CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.
Involvement in disease	Defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]. NPEBD is characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

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Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Disease	Deafness Epidermolysis bullosa
Domain	Transmembrane
Molecular function	Blood group antigen
PTM	Glycoprotein Lipoprotein Palmitate
Gene Ontology (GO)
Biological process	cell adhesion Non-traceable author statement. Source: ProtInc sensory perception of sound Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: InterPro
Cellular component	integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc membrane fraction Ref.2 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 253

253

CD151 antigen

PRO_0000219230

Regions

Topological domain

1 – 18

Cytoplasmic Potential

Transmembrane

19 – 39

Potential

Topological domain

40 – 57

Extracellular Potential

Transmembrane

58 – 78

Potential

Topological domain

79 – 91

Cytoplasmic Potential

Transmembrane

92 – 112

Potential

Topological domain

113 – 221

109

Extracellular Potential

Transmembrane

222 – 242

Potential

Topological domain

243 – 253

Cytoplasmic Potential

Amino acid modifications

Lipidation

S-palmitoyl cysteine

Lipidation

S-palmitoyl cysteine

Lipidation

242

S-palmitoyl cysteine

Lipidation

243

S-palmitoyl cysteine

Glycosylation

159

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

120

T → M

VAR_025098

Natural variant

132

K → R

VAR_012490

Natural variant

137

P → S

VAR_012491

Natural variant

178

R → H

VAR_021153

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Sequences

Sequence

Length

Mass (Da)

Tools

P48509-1 [UniParc].

Last modified January 24, 2006. Version 3.
Checksum: 0C8FE4CF2C3C286D
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FASTA

253

28,295

        10         20         30         40         50         60 
MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASGTYLAT 

        70         80         90        100        110        120 
AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYAYYQQLNT 

       130        140        150        160        170        180 
ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV 

       190        200        210        220        230        240 
PDSCCKTVVA LCGQRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF 

       250 
TCCLYRSLKL EHY

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3." Fitter S., Tetaz T.J., Berndt M.C., Ashman L.K. Blood 86:1348-1355(1995) [PubMed: 7632941] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Platelet.
[2]	"SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily." Hasegawa H., Utsunomiya Y., Kishimoto K., Yanagisawa K., Fujita S. J. Virol. 70:3258-3263(1996) [PubMed: 8627808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-132 AND SER-137.
[3]	"Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene." Whittock N.V., McLean W.H.I. Biochem. Biophys. Res. Commun. 281:425-430(2001) [PubMed: 11181065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-132 AND SER-137.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)." Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O., Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-120.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Kidney.
[9]	"Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology." Yang X., Claas C., Kraeft S.K., Chen L.B., Wang Z., Kreidberg J.A., Hemler M.E. Mol. Biol. Cell 13:767-781(2002) [PubMed: 11907260] [Abstract] Cited for: PALMITOYLATION AT CYS-11; CYS-15; CYS-242 AND CYS-243.
[10]	"CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin." Karamatic Crew V., Burton N., Kagan A., Green C.A., Levene C., Flinter F., Brady R.L., Daniels G., Anstee D.J. Blood 104:2217-2223(2004) [PubMed: 15265795] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN RAPH BLOOD GROUP SYSTEM, INVOLVEMENT IN NPEBD, VARIANT HIS-178.
+	Additional computationally mapped references.

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Web resources

BGMUT

Blood group antigen gene mutation database"

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Cross-references

Sequence databases
	U14650 mRNA. Translation: AAA87064.1. D29963 mRNA. Translation: BAA06229.1. AF315942 Genomic DNA. Translation: AAK14179.1. BT007397 mRNA. Translation: AAP36061.1. BT020132 mRNA. Translation: AAV38934.1. CR456826 mRNA. Translation: CAG33107.1. CR542098 mRNA. Translation: CAG46895.1. DQ074789 Genomic DNA. Translation: AAY68211.1. BC001374 mRNA. Translation: AAH01374.1. BC013302 mRNA. Translation: AAH13302.1.
RefSeq	NP_001034579.1. NP_004348.2. NP_620598.1. NP_620599.1.
UniGene	Hs.654379
3D structure databases
ModBase	Search...
Polymorphism databases
SeattleSNPs	Search...
Proteomic databases
PeptideAtlas	P48509.
Genome annotation databases
Ensembl	ENSG00000177697. Homo sapiens. [Contig view]
GeneID	977.
KEGG	hsa:977.
Organism-specific databases
H-InvDB	HIX0021759.
HGNC	HGNC:1630. CD151.
HPA	CAB002428. HPA011906.
MIM	179620. phenotype. 602243. gene. 609057. phenotype.
PharmGKB	PA26189.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P48509.
HOVERGEN	P48509.
Gene expression databases
CleanEx	HS_CD151.
GermOnline	ENSG00000177697. Homo sapiens.
Family and domain databases
InterPro	IPR000830. RDS_ROM. IPR000301. Transmem_4. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PRINTS	PR00218. PERIPHERNRDS. PR00259. TMFOUR.
PROSITE	PS00421. TM4_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4102.
SOURCE	Search...

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Entry information

Entry name

CD151_HUMAN

Accession

Primary (citable) accession number: P48509
Secondary accession number(s): Q14826, Q86U54, Q96TE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 24, 2006
Last modified:	November 25, 2008
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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