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Protein

CD151 antigen

Gene

CD151

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.1 Publication

GO - Molecular functioni

  • integrin binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen

Enzyme and pathway databases

ReactomeiREACT_150180. Assembly of collagen fibrils and other multimeric structures.
REACT_20537. Type I hemidesmosome assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
CD151 antigen
Alternative name(s):
GP27
Membrane glycoprotein SFA-1
Platelet-endothelial tetraspan antigen 3
Short name:
PETA-3
Tetraspanin-24
Short name:
Tspan-24
CD_antigen: CD151
Gene namesi
Name:CD151
Synonyms:TSPAN24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1630. CD151.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Topological domaini40 – 5718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST
Topological domaini79 – 9113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Topological domaini113 – 221109ExtracellularSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Topological domaini243 – 25311CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • basement membrane Source: CACAO
  • cytosol Source: Reactome
  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.

See also OMIM:609057

Keywords - Diseasei

Deafness, Epidermolysis bullosa

Organism-specific databases

MIMi179620. phenotype.
609057. phenotype.
Orphaneti300333. Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome.
PharmGKBiPA26189.

Polymorphism and mutation databases

BioMutaiCD151.
DMDMi85687560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253CD151 antigenPRO_0000219230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi11 – 111S-palmitoyl cysteine1 Publication
Lipidationi15 – 151S-palmitoyl cysteine1 Publication
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Lipidationi242 – 2421S-palmitoyl cysteine1 Publication
Lipidationi243 – 2431S-palmitoyl cysteine1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP48509.
PaxDbiP48509.
PeptideAtlasiP48509.
PRIDEiP48509.

PTM databases

PhosphoSiteiP48509.

Expressioni

Tissue specificityi

Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.1 Publication

Inductioni

By HTLV-1.

Gene expression databases

BgeeiP48509.
CleanExiHS_CD151.
ExpressionAtlasiP48509. baseline and differential.
GenevisibleiP48509. HS.

Organism-specific databases

HPAiCAB002428.
HPA011906.

Interactioni

Subunit structurei

Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.

Binary interactionsi

WithEntry#Exp.IntActNotes
GRAMD1CQ8IYS03EBI-10210332,EBI-7054335

Protein-protein interaction databases

BioGridi107415. 6 interactions.
IntActiP48509. 1 interaction.
STRINGi9606.ENSP00000324101.

Structurei

3D structure databases

ProteinModelPortaliP48509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281510.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiP48509.
KOiK06537.
OMAiCATFKEQ.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP48509.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS
60 70 80 90 100
LLASGTYLAT AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII
110 120 130 140 150
FLLEIIAGIL AYAYYQQLNT ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ
160 170 180 190 200
QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV PDSCCKTVVA LCGQRDHASN
210 220 230 240 250
IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF TCCLYRSLKL

EHY
Length:253
Mass (Da):28,295
Last modified:January 24, 2006 - v3
Checksum:i0C8FE4CF2C3C286D
GO

Polymorphismi

CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201T → M.1 Publication
Corresponds to variant rs34215390 [ dbSNP | Ensembl ].
VAR_025098
Natural varianti132 – 1321K → R.2 Publications
Corresponds to variant rs55840993 [ dbSNP | Ensembl ].
VAR_012490
Natural varianti137 – 1371P → S.2 Publications
Corresponds to variant rs55841393 [ dbSNP | Ensembl ].
VAR_012491
Natural varianti178 – 1781R → H.1 Publication
VAR_021153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14650 mRNA. Translation: AAA87064.1.
D29963 mRNA. Translation: BAA06229.1.
AF315942 Genomic DNA. Translation: AAK14179.1.
BT007397 mRNA. Translation: AAP36061.1.
BT020132 mRNA. Translation: AAV38934.1.
CR456826 mRNA. Translation: CAG33107.1.
CR542098 mRNA. Translation: CAG46895.1.
AK293073 mRNA. Translation: BAF85762.1.
DQ074789 Genomic DNA. Translation: AAY68211.1.
AP006621 Genomic DNA. No translation available.
AP006623 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02400.1.
BC001374 mRNA. Translation: AAH01374.1.
BC013302 mRNA. Translation: AAH13302.1.
CCDSiCCDS7719.1.
RefSeqiNP_001034579.1. NM_001039490.1.
NP_004348.2. NM_004357.4.
NP_620598.1. NM_139029.1.
NP_620599.1. NM_139030.3.
UniGeneiHs.654379.

Genome annotation databases

EnsembliENST00000322008; ENSP00000324101; ENSG00000177697.
ENST00000397420; ENSP00000380565; ENSG00000177697.
ENST00000397421; ENSP00000380566; ENSG00000177697.
ENST00000530726; ENSP00000432385; ENSG00000177697.
GeneIDi977.
KEGGihsa:977.
UCSCiuc001lry.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14650 mRNA. Translation: AAA87064.1.
D29963 mRNA. Translation: BAA06229.1.
AF315942 Genomic DNA. Translation: AAK14179.1.
BT007397 mRNA. Translation: AAP36061.1.
BT020132 mRNA. Translation: AAV38934.1.
CR456826 mRNA. Translation: CAG33107.1.
CR542098 mRNA. Translation: CAG46895.1.
AK293073 mRNA. Translation: BAF85762.1.
DQ074789 Genomic DNA. Translation: AAY68211.1.
AP006621 Genomic DNA. No translation available.
AP006623 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02400.1.
BC001374 mRNA. Translation: AAH01374.1.
BC013302 mRNA. Translation: AAH13302.1.
CCDSiCCDS7719.1.
RefSeqiNP_001034579.1. NM_001039490.1.
NP_004348.2. NM_004357.4.
NP_620598.1. NM_139029.1.
NP_620599.1. NM_139030.3.
UniGeneiHs.654379.

3D structure databases

ProteinModelPortaliP48509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107415. 6 interactions.
IntActiP48509. 1 interaction.
STRINGi9606.ENSP00000324101.

PTM databases

PhosphoSiteiP48509.

Polymorphism and mutation databases

BioMutaiCD151.
DMDMi85687560.

Proteomic databases

MaxQBiP48509.
PaxDbiP48509.
PeptideAtlasiP48509.
PRIDEiP48509.

Protocols and materials databases

DNASUi977.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322008; ENSP00000324101; ENSG00000177697.
ENST00000397420; ENSP00000380565; ENSG00000177697.
ENST00000397421; ENSP00000380566; ENSG00000177697.
ENST00000530726; ENSP00000432385; ENSG00000177697.
GeneIDi977.
KEGGihsa:977.
UCSCiuc001lry.3. human.

Organism-specific databases

CTDi977.
GeneCardsiGC11P000835.
HGNCiHGNC:1630. CD151.
HPAiCAB002428.
HPA011906.
MIMi179620. phenotype.
602243. gene.
609057. phenotype.
neXtProtiNX_P48509.
Orphaneti300333. Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome.
PharmGKBiPA26189.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG281510.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiP48509.
KOiK06537.
OMAiCATFKEQ.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP48509.
TreeFamiTF352892.

Enzyme and pathway databases

ReactomeiREACT_150180. Assembly of collagen fibrils and other multimeric structures.
REACT_20537. Type I hemidesmosome assembly.

Miscellaneous databases

GeneWikiiCD151.
GenomeRNAii977.
NextBioi4102.
PROiP48509.
SOURCEiSearch...

Gene expression databases

BgeeiP48509.
CleanExiHS_CD151.
ExpressionAtlasiP48509. baseline and differential.
GenevisibleiP48509. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3."
    Fitter S., Tetaz T.J., Berndt M.C., Ashman L.K.
    Blood 86:1348-1355(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Platelet.
  2. "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily."
    Hasegawa H., Utsunomiya Y., Kishimoto K., Yanagisawa K., Fujita S.
    J. Virol. 70:3258-3263(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-132 AND SER-137.
  3. "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene."
    Whittock N.V., McLean W.H.I.
    Biochem. Biophys. Res. Commun. 281:425-430(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-132 AND SER-137.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  8. SeattleSNPs variation discovery resource
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-120.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Kidney.
  12. "Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology."
    Yang X., Claas C., Kraeft S.K., Chen L.B., Wang Z., Kreidberg J.A., Hemler M.E.
    Mol. Biol. Cell 13:767-781(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-11; CYS-15; CYS-242 AND CYS-243.
  13. "CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin."
    Karamatic Crew V., Burton N., Kagan A., Green C.A., Levene C., Flinter F., Brady R.L., Daniels G., Anstee D.J.
    Blood 104:2217-2223(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN RAPH BLOOD GROUP SYSTEM, INVOLVEMENT IN NPEBD, VARIANT HIS-178.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCD151_HUMAN
AccessioniPrimary (citable) accession number: P48509
Secondary accession number(s): A8KAK8
, E9PI15, Q14826, Q86U54, Q96TE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 24, 2006
Last modified: July 22, 2015
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.