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P48509 (CD151_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD151 antigen
Alternative name(s):
GP27
Membrane glycoprotein SFA-1
Platelet-endothelial tetraspan antigen 3
Short name=PETA-3
Tetraspanin-24
Short name=Tspan-24
CD_antigen=CD151
Gene names
Name:CD151
Synonyms:TSPAN24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Ref.13

Subunit structure

Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes. Ref.13

Induction

By HTLV-1.

Polymorphism

CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.

Involvement in disease

Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253CD151 antigen
PRO_0000219230

Regions

Topological domain1 – 1818Cytoplasmic Potential
Transmembrane19 – 3921Helical; Potential
Topological domain40 – 5718Extracellular Potential
Transmembrane58 – 7821Helical; Potential
Topological domain79 – 9113Cytoplasmic Potential
Transmembrane92 – 11221Helical; Potential
Topological domain113 – 221109Extracellular Potential
Transmembrane222 – 24221Helical; Potential
Topological domain243 – 25311Cytoplasmic Potential

Amino acid modifications

Lipidation111S-palmitoyl cysteine Ref.12
Lipidation151S-palmitoyl cysteine Ref.12
Lipidation2421S-palmitoyl cysteine Ref.12
Lipidation2431S-palmitoyl cysteine Ref.12
Glycosylation1591N-linked (GlcNAc...) Potential

Natural variations

Natural variant1201T → M. Ref.8
Corresponds to variant rs34215390 [ dbSNP | Ensembl ].
VAR_025098
Natural variant1321K → R. Ref.2 Ref.3
Corresponds to variant rs55840993 [ dbSNP | Ensembl ].
VAR_012490
Natural variant1371P → S. Ref.2 Ref.3
Corresponds to variant rs55841393 [ dbSNP | Ensembl ].
VAR_012491
Natural variant1781R → H. Ref.13
VAR_021153

Sequences

Sequence LengthMass (Da)Tools
P48509 [UniParc].

Last modified January 24, 2006. Version 3.
Checksum: 0C8FE4CF2C3C286D

FASTA25328,295
        10         20         30         40         50         60 
MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASGTYLAT 

        70         80         90        100        110        120 
AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYAYYQQLNT 

       130        140        150        160        170        180 
ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV 

       190        200        210        220        230        240 
PDSCCKTVVA LCGQRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF 

       250 
TCCLYRSLKL EHY 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3."
Fitter S., Tetaz T.J., Berndt M.C., Ashman L.K.
Blood 86:1348-1355(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Platelet.
[2]"SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily."
Hasegawa H., Utsunomiya Y., Kishimoto K., Yanagisawa K., Fujita S.
J. Virol. 70:3258-3263(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-132 AND SER-137.
[3]"Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene."
Whittock N.V., McLean W.H.I.
Biochem. Biophys. Res. Commun. 281:425-430(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-132 AND SER-137.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[8]SeattleSNPs variation discovery resource
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-120.
[9]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Kidney.
[12]"Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology."
Yang X., Claas C., Kraeft S.K., Chen L.B., Wang Z., Kreidberg J.A., Hemler M.E.
Mol. Biol. Cell 13:767-781(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PALMITOYLATION AT CYS-11; CYS-15; CYS-242 AND CYS-243.
[13]"CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin."
Karamatic Crew V., Burton N., Kagan A., Green C.A., Levene C., Flinter F., Brady R.L., Daniels G., Anstee D.J.
Blood 104:2217-2223(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN RAPH BLOOD GROUP SYSTEM, INVOLVEMENT IN NPEBD, VARIANT HIS-178.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14650 mRNA. Translation: AAA87064.1.
D29963 mRNA. Translation: BAA06229.1.
AF315942 Genomic DNA. Translation: AAK14179.1.
BT007397 mRNA. Translation: AAP36061.1.
BT020132 mRNA. Translation: AAV38934.1.
CR456826 mRNA. Translation: CAG33107.1.
CR542098 mRNA. Translation: CAG46895.1.
AK293073 mRNA. Translation: BAF85762.1.
DQ074789 Genomic DNA. Translation: AAY68211.1.
AP006621 Genomic DNA. No translation available.
AP006623 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02400.1.
BC001374 mRNA. Translation: AAH01374.1.
BC013302 mRNA. Translation: AAH13302.1.
CCDSCCDS7719.1.
RefSeqNP_001034579.1. NM_001039490.1.
NP_004348.2. NM_004357.4.
NP_620598.1. NM_139029.1.
NP_620599.1. NM_139030.3.
UniGeneHs.654379.

3D structure databases

ProteinModelPortalP48509.
SMRP48509. Positions 112-219.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107415. 6 interactions.
STRING9606.ENSP00000324101.

PTM databases

PhosphoSiteP48509.

Polymorphism databases

DMDM85687560.

Proteomic databases

MaxQBP48509.
PaxDbP48509.
PeptideAtlasP48509.
PRIDEP48509.

Protocols and materials databases

DNASU977.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322008; ENSP00000324101; ENSG00000177697.
ENST00000397420; ENSP00000380565; ENSG00000177697.
ENST00000397421; ENSP00000380566; ENSG00000177697.
ENST00000530726; ENSP00000432385; ENSG00000177697.
GeneID977.
KEGGhsa:977.
UCSCuc001lry.3. human.

Organism-specific databases

CTD977.
GeneCardsGC11P000835.
HGNCHGNC:1630. CD151.
HPACAB002428.
HPA011906.
MIM179620. phenotype.
602243. gene.
609057. phenotype.
neXtProtNX_P48509.
Orphanet300333. Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome.
PharmGKBPA26189.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281510.
HOGENOMHOG000230651.
HOVERGENHBG107306.
InParanoidP48509.
KOK06537.
OMARVYFILL.
OrthoDBEOG7PGDRZ.
PhylomeDBP48509.
TreeFamTF352892.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.
REACT_118779. Extracellular matrix organization.

Gene expression databases

ArrayExpressP48509.
BgeeP48509.
CleanExHS_CD151.
GenevestigatorP48509.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCD151. human.
GeneWikiCD151.
GenomeRNAi977.
NextBio4102.
PROP48509.
SOURCESearch...

Entry information

Entry nameCD151_HUMAN
AccessionPrimary (citable) accession number: P48509
Secondary accession number(s): A8KAK8 expand/collapse secondary AC list , E9PI15, Q14826, Q86U54, Q96TE3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Blood group antigen proteins

Nomenclature of blood group antigens and list of entries