Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot P48509 (CD151_HUMAN)

Last modified November 25, 2008. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CD151 antigen
Alternative name(s):
    Platelet-endothelial tetraspan antigen 3
      Short name=PETA-3
    GP27
    Membrane glycoprotein SFA-1
    Tetraspanin-24
      Short name=Tspan-24
    CD_antigen=CD151
Gene names
Name: CD151
Synonyms: TSPAN24
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.

Subunit structure

Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.

Induction

By HTLV-1.

Polymorphism

CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.

Involvement in disease

Defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]. NPEBD is characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords

   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DiseaseDeafness
Epidermolysis bullosa
   DomainTransmembrane
   Molecular functionBlood group antigen
   PTMGlycoprotein
Lipoprotein
Palmitate

Gene Ontology (GO)

   Biological processcell adhesion

Non-traceable author statement. Source: ProtInc

sensory perception of sound

Inferred from electronic annotation. Source: UniProtKB-KW

visual perception

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to plasma membrane Ref.2

Traceable author statement. Source: ProtInc

membrane fraction Ref.2

Traceable author statement. Source: ProtInc

   Molecular functionprotein binding

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253CD151 antigen
PRO_0000219230

Regions

Topological domain1 – 1818Cytoplasmic Potential
Transmembrane19 – 3921 Potential
Topological domain40 – 5718Extracellular Potential
Transmembrane58 – 7821 Potential
Topological domain79 – 9113Cytoplasmic Potential
Transmembrane92 – 11221 Potential
Topological domain113 – 221109Extracellular Potential
Transmembrane222 – 24221 Potential
Topological domain243 – 25311Cytoplasmic Potential

Amino acid modifications

Lipidation111S-palmitoyl cysteine
Lipidation151S-palmitoyl cysteine
Lipidation2421S-palmitoyl cysteine
Lipidation2431S-palmitoyl cysteine
Glycosylation1591N-linked (GlcNAc...) Potential

Natural variations

Natural variant1201T → M
VAR_025098
Natural variant1321K → R
VAR_012490
Natural variant1371P → S
VAR_012491
Natural variant1781R → H
VAR_021153

Sequences

Sequence LengthMass (Da)Tools
P48509-1 [UniParc].

Last modified January 24, 2006. Version 3.
Checksum: 0C8FE4CF2C3C286D

FASTA25328,295
        10         20         30         40         50         60 
MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASGTYLAT 

        70         80         90        100        110        120 
AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYAYYQQLNT 

       130        140        150        160        170        180 
ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV 

       190        200        210        220        230        240 
PDSCCKTVVA LCGQRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF 

       250 
TCCLYRSLKL EHY 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3."
Fitter S., Tetaz T.J., Berndt M.C., Ashman L.K.
Blood 86:1348-1355(1995) [PubMed: 7632941] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Platelet.
[2]"SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily."
Hasegawa H., Utsunomiya Y., Kishimoto K., Yanagisawa K., Fujita S.
J. Virol. 70:3258-3263(1996) [PubMed: 8627808] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-132 AND SER-137.
[3]"Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene."
Whittock N.V., McLean W.H.I.
Biochem. Biophys. Res. Commun. 281:425-430(2001) [PubMed: 11181065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-132 AND SER-137.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."
Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O., Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A.
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-120.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Kidney.
[9]"Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology."
Yang X., Claas C., Kraeft S.K., Chen L.B., Wang Z., Kreidberg J.A., Hemler M.E.
Mol. Biol. Cell 13:767-781(2002) [PubMed: 11907260] [Abstract]
Cited for: PALMITOYLATION AT CYS-11; CYS-15; CYS-242 AND CYS-243.
[10]"CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin."
Karamatic Crew V., Burton N., Kagan A., Green C.A., Levene C., Flinter F., Brady R.L., Daniels G., Anstee D.J.
Blood 104:2217-2223(2004) [PubMed: 15265795] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN RAPH BLOOD GROUP SYSTEM, INVOLVEMENT IN NPEBD, VARIANT HIS-178.
+Additional computationally mapped references.

Web resources

BGMUT

Blood group antigen gene mutation database"

Cross-references

Sequence databases

U14650 mRNA. Translation: AAA87064.1.
D29963 mRNA. Translation: BAA06229.1.
AF315942 Genomic DNA. Translation: AAK14179.1.
BT007397 mRNA. Translation: AAP36061.1.
BT020132 mRNA. Translation: AAV38934.1.
CR456826 mRNA. Translation: CAG33107.1.
CR542098 mRNA. Translation: CAG46895.1.
DQ074789 Genomic DNA. Translation: AAY68211.1.
BC001374 mRNA. Translation: AAH01374.1.
BC013302 mRNA. Translation: AAH13302.1.
RefSeqNP_001034579.1.
NP_004348.2.
NP_620598.1.
NP_620599.1.
UniGeneHs.654379

3D structure databases

ModBaseSearch...

Polymorphism databases

SeattleSNPsSearch...

Proteomic databases

PeptideAtlasP48509.

Genome annotation databases

EnsemblENSG00000177697. Homo sapiens. [Contig view]
GeneID977.
KEGGhsa:977.

Organism-specific databases

H-InvDBHIX0021759.
HGNCHGNC:1630. CD151.
HPACAB002428.
HPA011906.
MIM179620. phenotype.
602243. gene.
609057. phenotype.
PharmGKBPA26189.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP48509.
HOVERGENP48509.

Gene expression databases

CleanExHS_CD151.
GermOnlineENSG00000177697. Homo sapiens.

Family and domain databases

InterProIPR000830. RDS_ROM.
IPR000301. Transmem_4.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSPR00218. PERIPHERNRDS.
PR00259. TMFOUR.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio4102.
SOURCESearch...

Entry information

Entry nameCD151_HUMAN
AccessionPrimary (citable) accession number: P48509
Secondary accession number(s): Q14826, Q86U54, Q96TE3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 24, 2006
Last modified: November 25, 2008
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Blood group antigen proteins

Nomenclature of blood group antigens and list of entries

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents