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P48509

- CD151_HUMAN

UniProt

P48509 - CD151_HUMAN

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Protein

CD151 antigen

Gene
CD151, TSPAN24
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. cell junction assembly Source: Reactome
  3. cell migration Source: Ensembl
  4. extracellular matrix organization Source: Reactome
  5. hemidesmosome assembly Source: Reactome
  6. T cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen

Enzyme and pathway databases

ReactomeiREACT_150180. Assembly of collagen fibrils and other multimeric structures.
REACT_20537. Type I hemidesmosome assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
CD151 antigen
Alternative name(s):
GP27
Membrane glycoprotein SFA-1
Platelet-endothelial tetraspan antigen 3
Short name:
PETA-3
Tetraspanin-24
Short name:
Tspan-24
CD_antigen: CD151
Gene namesi
Name:CD151
Synonyms:TSPAN24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1630. CD151.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei19 – 3921Helical; Reviewed predictionAdd
BLAST
Topological domaini40 – 5718Extracellular Reviewed predictionAdd
BLAST
Transmembranei58 – 7821Helical; Reviewed predictionAdd
BLAST
Topological domaini79 – 9113Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei92 – 11221Helical; Reviewed predictionAdd
BLAST
Topological domaini113 – 221109Extracellular Reviewed predictionAdd
BLAST
Transmembranei222 – 24221Helical; Reviewed predictionAdd
BLAST
Topological domaini243 – 25311Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Deafness, Epidermolysis bullosa

Organism-specific databases

MIMi179620. phenotype.
609057. phenotype.
Orphaneti300333. Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome.
PharmGKBiPA26189.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253CD151 antigenPRO_0000219230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi11 – 111S-palmitoyl cysteine1 Publication
Lipidationi15 – 151S-palmitoyl cysteine1 Publication
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction
Lipidationi242 – 2421S-palmitoyl cysteine1 Publication
Lipidationi243 – 2431S-palmitoyl cysteine1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP48509.
PaxDbiP48509.
PeptideAtlasiP48509.
PRIDEiP48509.

PTM databases

PhosphoSiteiP48509.

Expressioni

Tissue specificityi

Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.1 Publication

Inductioni

By HTLV-1.

Gene expression databases

ArrayExpressiP48509.
BgeeiP48509.
CleanExiHS_CD151.
GenevestigatoriP48509.

Organism-specific databases

HPAiCAB002428.
HPA011906.

Interactioni

Subunit structurei

Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.

Protein-protein interaction databases

BioGridi107415. 6 interactions.
STRINGi9606.ENSP00000324101.

Structurei

3D structure databases

ProteinModelPortaliP48509.
SMRiP48509. Positions 112-219.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281510.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiP48509.
KOiK06537.
OMAiRVYFILL.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP48509.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48509-1 [UniParc]FASTAAdd to Basket

« Hide

MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS    50
LLASGTYLAT AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII 100
FLLEIIAGIL AYAYYQQLNT ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ 150
QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV PDSCCKTVVA LCGQRDHASN 200
IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF TCCLYRSLKL 250
EHY 253
Length:253
Mass (Da):28,295
Last modified:January 24, 2006 - v3
Checksum:i0C8FE4CF2C3C286D
GO

Polymorphismi

CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201T → M.1 Publication
Corresponds to variant rs34215390 [ dbSNP | Ensembl ].
VAR_025098
Natural varianti132 – 1321K → R.2 Publications
Corresponds to variant rs55840993 [ dbSNP | Ensembl ].
VAR_012490
Natural varianti137 – 1371P → S.2 Publications
Corresponds to variant rs55841393 [ dbSNP | Ensembl ].
VAR_012491
Natural varianti178 – 1781R → H.1 Publication
VAR_021153

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14650 mRNA. Translation: AAA87064.1.
D29963 mRNA. Translation: BAA06229.1.
AF315942 Genomic DNA. Translation: AAK14179.1.
BT007397 mRNA. Translation: AAP36061.1.
BT020132 mRNA. Translation: AAV38934.1.
CR456826 mRNA. Translation: CAG33107.1.
CR542098 mRNA. Translation: CAG46895.1.
AK293073 mRNA. Translation: BAF85762.1.
DQ074789 Genomic DNA. Translation: AAY68211.1.
AP006621 Genomic DNA. No translation available.
AP006623 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02400.1.
BC001374 mRNA. Translation: AAH01374.1.
BC013302 mRNA. Translation: AAH13302.1.
CCDSiCCDS7719.1.
RefSeqiNP_001034579.1. NM_001039490.1.
NP_004348.2. NM_004357.4.
NP_620598.1. NM_139029.1.
NP_620599.1. NM_139030.3.
UniGeneiHs.654379.

Genome annotation databases

EnsembliENST00000322008; ENSP00000324101; ENSG00000177697.
ENST00000397420; ENSP00000380565; ENSG00000177697.
ENST00000397421; ENSP00000380566; ENSG00000177697.
ENST00000530726; ENSP00000432385; ENSG00000177697.
GeneIDi977.
KEGGihsa:977.
UCSCiuc001lry.3. human.

Polymorphism databases

DMDMi85687560.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14650 mRNA. Translation: AAA87064.1 .
D29963 mRNA. Translation: BAA06229.1 .
AF315942 Genomic DNA. Translation: AAK14179.1 .
BT007397 mRNA. Translation: AAP36061.1 .
BT020132 mRNA. Translation: AAV38934.1 .
CR456826 mRNA. Translation: CAG33107.1 .
CR542098 mRNA. Translation: CAG46895.1 .
AK293073 mRNA. Translation: BAF85762.1 .
DQ074789 Genomic DNA. Translation: AAY68211.1 .
AP006621 Genomic DNA. No translation available.
AP006623 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02400.1 .
BC001374 mRNA. Translation: AAH01374.1 .
BC013302 mRNA. Translation: AAH13302.1 .
CCDSi CCDS7719.1.
RefSeqi NP_001034579.1. NM_001039490.1.
NP_004348.2. NM_004357.4.
NP_620598.1. NM_139029.1.
NP_620599.1. NM_139030.3.
UniGenei Hs.654379.

3D structure databases

ProteinModelPortali P48509.
SMRi P48509. Positions 112-219.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107415. 6 interactions.
STRINGi 9606.ENSP00000324101.

PTM databases

PhosphoSitei P48509.

Polymorphism databases

DMDMi 85687560.

Proteomic databases

MaxQBi P48509.
PaxDbi P48509.
PeptideAtlasi P48509.
PRIDEi P48509.

Protocols and materials databases

DNASUi 977.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322008 ; ENSP00000324101 ; ENSG00000177697 .
ENST00000397420 ; ENSP00000380565 ; ENSG00000177697 .
ENST00000397421 ; ENSP00000380566 ; ENSG00000177697 .
ENST00000530726 ; ENSP00000432385 ; ENSG00000177697 .
GeneIDi 977.
KEGGi hsa:977.
UCSCi uc001lry.3. human.

Organism-specific databases

CTDi 977.
GeneCardsi GC11P000835.
HGNCi HGNC:1630. CD151.
HPAi CAB002428.
HPA011906.
MIMi 179620. phenotype.
602243. gene.
609057. phenotype.
neXtProti NX_P48509.
Orphaneti 300333. Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome.
PharmGKBi PA26189.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281510.
HOGENOMi HOG000230651.
HOVERGENi HBG107306.
InParanoidi P48509.
KOi K06537.
OMAi RVYFILL.
OrthoDBi EOG7PGDRZ.
PhylomeDBi P48509.
TreeFami TF352892.

Enzyme and pathway databases

Reactomei REACT_150180. Assembly of collagen fibrils and other multimeric structures.
REACT_20537. Type I hemidesmosome assembly.

Miscellaneous databases

ChiTaRSi CD151. human.
GeneWikii CD151.
GenomeRNAii 977.
NextBioi 4102.
PROi P48509.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48509.
Bgeei P48509.
CleanExi HS_CD151.
Genevestigatori P48509.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3."
    Fitter S., Tetaz T.J., Berndt M.C., Ashman L.K.
    Blood 86:1348-1355(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Platelet.
  2. "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily."
    Hasegawa H., Utsunomiya Y., Kishimoto K., Yanagisawa K., Fujita S.
    J. Virol. 70:3258-3263(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-132 AND SER-137.
  3. "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene."
    Whittock N.V., McLean W.H.I.
    Biochem. Biophys. Res. Commun. 281:425-430(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-132 AND SER-137.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  8. SeattleSNPs variation discovery resource
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-120.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Kidney.
  12. "Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology."
    Yang X., Claas C., Kraeft S.K., Chen L.B., Wang Z., Kreidberg J.A., Hemler M.E.
    Mol. Biol. Cell 13:767-781(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-11; CYS-15; CYS-242 AND CYS-243.
  13. "CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin."
    Karamatic Crew V., Burton N., Kagan A., Green C.A., Levene C., Flinter F., Brady R.L., Daniels G., Anstee D.J.
    Blood 104:2217-2223(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN RAPH BLOOD GROUP SYSTEM, INVOLVEMENT IN NPEBD, VARIANT HIS-178.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCD151_HUMAN
AccessioniPrimary (citable) accession number: P48509
Secondary accession number(s): A8KAK8
, E9PI15, Q14826, Q86U54, Q96TE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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