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Protein

Triosephosphate isomerase

Gene
N/A
Organism
Leishmania mexicana
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase, Triosephosphate isomerase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121Substrate
Binding sitei14 – 141Substrate
Active sitei96 – 961Electrophile
Active sitei168 – 1681Proton acceptor

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis, Pentose shunt

Enzyme and pathway databases

BRENDAi5.3.1.1. 2951.
UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
OrganismiLeishmania mexicana
Taxonomic identifieri5665 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Glycosome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Triosephosphate isomerasePRO_0000090137Add
BLAST

Interactioni

Subunit structurei

Homodimer.2 Publications

Structurei

Secondary structure

1
251
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 125Combined sources
Helixi19 – 3113Combined sources
Beta strandi39 – 435Combined sources
Helixi46 – 483Combined sources
Helixi49 – 557Combined sources
Beta strandi61 – 666Combined sources
Beta strandi69 – 713Combined sources
Helixi81 – 866Combined sources
Beta strandi91 – 955Combined sources
Helixi97 – 1026Combined sources
Helixi107 – 11913Combined sources
Beta strandi123 – 1286Combined sources
Helixi132 – 1365Combined sources
Helixi140 – 15213Combined sources
Helixi158 – 1625Combined sources
Beta strandi163 – 1675Combined sources
Helixi170 – 1723Combined sources
Beta strandi173 – 1764Combined sources
Helixi181 – 19818Combined sources
Helixi201 – 2066Combined sources
Beta strandi208 – 2147Combined sources
Turni217 – 2193Combined sources
Helixi220 – 2245Combined sources
Beta strandi231 – 2355Combined sources
Helixi236 – 2394Combined sources
Helixi243 – 2486Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AMKX-ray1.83A1-251[»]
1IF2X-ray2.00A1-251[»]
1N55X-ray0.83A1-251[»]
1QDSX-ray2.00A1-251[»]
2VXNX-ray0.82A1-251[»]
2Y61X-ray0.99A1-251[»]
2Y62X-ray1.08A1-251[»]
2Y63X-ray1.97A1-251[»]
ProteinModelPortaliP48499.
SMRiP48499. Positions 2-251.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48499.

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKPQPIAA ANWKCNGTTA SIEKLVQVFN EHTISHDVQC VVAPTFVHIP
60 70 80 90 100
LVQAKLRNPK YVISAENAIA KSGAFTGEVS MPILKDIGVH WVILGHSERR
110 120 130 140 150
TYYGETDEIV AQKVSEACKQ GFMVIACIGE TLQQREANQT AKVVLSQTSA
160 170 180 190 200
IAAKLTKDAW NQVVLAYEPV WAIGTGKVAT PEQAQEVHLL LRKWVSENIG
210 220 230 240 250
TDVAAKLRIL YGGSVNAANA ATLYAKPDIN GFLVGGASLK PEFRDIIDAT

R
Length:251
Mass (Da):27,178
Last modified:February 1, 1996 - v1
Checksum:i987DFEED46F1E3EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74797 Genomic DNA. Translation: CAA52804.1.
PIRiS42356.

Genome annotation databases

GeneDBiLmxM.24.0850.1:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74797 Genomic DNA. Translation: CAA52804.1.
PIRiS42356.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AMKX-ray1.83A1-251[»]
1IF2X-ray2.00A1-251[»]
1N55X-ray0.83A1-251[»]
1QDSX-ray2.00A1-251[»]
2VXNX-ray0.82A1-251[»]
2Y61X-ray0.99A1-251[»]
2Y62X-ray1.08A1-251[»]
2Y63X-ray1.97A1-251[»]
ProteinModelPortaliP48499.
SMRiP48499. Positions 2-251.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiLmxM.24.0850.1:pep.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.
BRENDAi5.3.1.1. 2951.

Miscellaneous databases

EvolutionaryTraceiP48499.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPIS_LEIME
AccessioniPrimary (citable) accession number: P48499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.