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P48488

- PP1_MEDSV

UniProt

P48488 - PP1_MEDSV

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Protein

Serine/threonine-protein phosphatase PP1

Gene

PP1

Organism
Medicago sativa subsp. varia (Alfalfa) (Medicago varia)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Manganese 1By similarity
Metal bindingi63 – 631Manganese 1By similarity
Metal bindingi89 – 891Manganese 1By similarity
Metal bindingi89 – 891Manganese 2By similarity
Metal bindingi121 – 1211Manganese 2By similarity
Active sitei122 – 1221Proton donorBy similarity
Metal bindingi170 – 1701Manganese 2By similarity
Metal bindingi245 – 2451Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 (EC:3.1.3.16)
Gene namesi
Name:PP1
OrganismiMedicago sativa subsp. varia (Alfalfa) (Medicago varia)
Taxonomic identifieri36902 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Serine/threonine-protein phosphatase PP1PRO_0000058807Add
BLAST

Proteomic databases

PRIDEiP48488.

Structurei

3D structure databases

ProteinModelPortaliP48488.
SMRiP48488. Positions 6-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48488-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDTVLDDII KKLVSAKNGR TTKQVHLTEA DIRQLCTSAK EIFLSQPNLL
60 70 80 90 100
ELEAPIKICG DVHGQFSDLL RLFEYGGYPP EANYLFLGDY VDRGKQSIET
110 120 130 140 150
ICLLLAYKIK YKENFFLLRG NHECASINRI YGFYDECKRR YNVRLWKTFT
160 170 180 190 200
DCFNCLPVAA LVDEKILCMH GGLSPELKNL DQIRNIARPI DVPDHGLLCD
210 220 230 240 250
LLWADPDKDL EGWGENDRGV SFTFGADKVV EFLEHHDLDL ICRAHQVVED
260 270 280 290 300
GYEFFAKRKL VTVFSAPNYC GEFDNAGAMM SVDDSLTCSF QILKSSDKKG
310 320
KVGFGNNSSR PGTPPHKGGK N
Length:321
Mass (Da):36,248
Last modified:February 1, 1996 - v1
Checksum:iB2528E7BFCA0CA38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80788 mRNA. Translation: CAA56766.1.
PIRiS46282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80788 mRNA. Translation: CAA56766.1 .
PIRi S46282.

3D structure databases

ProteinModelPortali P48488.
SMRi P48488. Positions 6-305.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P48488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of phosphoprotein phosphatase 1 from alfalfa."
    Pay A., Pirck M., Boerge L., Hirt H., Heberle-Bors E.
    Mol. Gen. Genet. 244:176-182(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPP1_MEDSV
AccessioniPrimary (citable) accession number: P48488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3