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P48488

- PP1_MEDSV

UniProt

P48488 - PP1_MEDSV

Protein

Serine/threonine-protein phosphatase PP1

Gene

PP1

Organism
Medicago sativa subsp. varia (Alfalfa) (Medicago varia)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611Manganese 1By similarity
    Metal bindingi63 – 631Manganese 1By similarity
    Metal bindingi89 – 891Manganese 1By similarity
    Metal bindingi89 – 891Manganese 2By similarity
    Metal bindingi121 – 1211Manganese 2By similarity
    Active sitei122 – 1221Proton donorBy similarity
    Metal bindingi170 – 1701Manganese 2By similarity
    Metal bindingi245 – 2451Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1 (EC:3.1.3.16)
    Gene namesi
    Name:PP1
    OrganismiMedicago sativa subsp. varia (Alfalfa) (Medicago varia)
    Taxonomic identifieri36902 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Serine/threonine-protein phosphatase PP1PRO_0000058807Add
    BLAST

    Proteomic databases

    PRIDEiP48488.

    Structurei

    3D structure databases

    ProteinModelPortaliP48488.
    SMRiP48488. Positions 6-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48488-1 [UniParc]FASTAAdd to Basket

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    MDDTVLDDII KKLVSAKNGR TTKQVHLTEA DIRQLCTSAK EIFLSQPNLL    50
    ELEAPIKICG DVHGQFSDLL RLFEYGGYPP EANYLFLGDY VDRGKQSIET 100
    ICLLLAYKIK YKENFFLLRG NHECASINRI YGFYDECKRR YNVRLWKTFT 150
    DCFNCLPVAA LVDEKILCMH GGLSPELKNL DQIRNIARPI DVPDHGLLCD 200
    LLWADPDKDL EGWGENDRGV SFTFGADKVV EFLEHHDLDL ICRAHQVVED 250
    GYEFFAKRKL VTVFSAPNYC GEFDNAGAMM SVDDSLTCSF QILKSSDKKG 300
    KVGFGNNSSR PGTPPHKGGK N 321
    Length:321
    Mass (Da):36,248
    Last modified:February 1, 1996 - v1
    Checksum:iB2528E7BFCA0CA38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80788 mRNA. Translation: CAA56766.1.
    PIRiS46282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80788 mRNA. Translation: CAA56766.1 .
    PIRi S46282.

    3D structure databases

    ProteinModelPortali P48488.
    SMRi P48488. Positions 6-305.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P48488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of phosphoprotein phosphatase 1 from alfalfa."
      Pay A., Pirck M., Boerge L., Hirt H., Heberle-Bors E.
      Mol. Gen. Genet. 244:176-182(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPP1_MEDSV
    AccessioniPrimary (citable) accession number: P48488
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3