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P48484 (PP14_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP1 isozyme 4

EC=3.1.3.16
Gene names
Name:TOPP4
Ordered Locus Names:At2g39840
ORF Names:T5I7.14
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 321320Serine/threonine-protein phosphatase PP1 isozyme 4
PRO_0000058800

Sites

Active site1351Proton donor By similarity
Metal binding741Iron By similarity
Metal binding761Iron By similarity
Metal binding1021Iron By similarity
Metal binding1021Manganese By similarity
Metal binding1341Manganese By similarity
Metal binding1831Manganese By similarity
Metal binding2581Manganese By similarity

Amino acid modifications

Modified residue21N-acetylalanine Ref.7

Sequences

Sequence LengthMass (Da)Tools
P48484 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 9E96830AB996FFB3

FASTA32136,372
        10         20         30         40         50         60 
MATTTTTQGQ QTAIDSAVLD DIIRRLTEVR LARPGKQVQL SEAEIKQLCT TARDIFLQQP 

        70         80         90        100        110        120 
NLLELEAPIK ICGDIHGQYS DLLRLFEYGG FPPSANYLFL GDYVDRGKQS LETICLLLAY 

       130        140        150        160        170        180 
KIKYPGNFFL LRGNHECASI NRIYGFYDEC KRRFNVRVWK VFTDCFNCLP VAALIDDKIL 

       190        200        210        220        230        240 
CMHGGLSPDL DHLDEIRNLP RPTMIPDTGL LCDLLWSDPG KDVKGWGMND RGVSYTFGPD 

       250        260        270        280        290        300 
KVSEFLTKHD LDLVCRAHQV VEDGYEFFAD RQLVTVFSAP NYCGEFDNAG AMMSVDENLM 

       310        320 
CSFQILKPAE KKTKFMMSTK I 

« Hide

References

« Hide 'large scale' references
[1]"Expression of multiple type 1 phosphoprotein phosphatases in Arabidopsis thaliana."
Smith R.D., Walker J.C.
Plant Mol. Biol. 21:307-316(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Arabidopsis ORF clones."
Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. expand/collapse author list , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[6]"Arabidopsis PPP family of serine/threonine phosphatases."
Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[7]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M93411 mRNA. Translation: AAA32839.1.
AC003000 Genomic DNA. Translation: AAB87136.1.
CP002685 Genomic DNA. Translation: AEC09737.1.
BT026118 mRNA. Translation: ABG48474.1.
AK229028 mRNA. Translation: BAF00914.1.
PIRS31088.
RefSeqNP_181514.1. NM_129543.2.
UniGeneAt.310.

3D structure databases

ProteinModelPortalP48484.
SMRP48484. Positions 19-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid3909. 2 interactions.
STRING3702.AT2G39840.1-P.

Proteomic databases

PaxDbP48484.
PRIDEP48484.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G39840.1; AT2G39840.1; AT2G39840.
GeneID818571.
KEGGath:AT2G39840.

Organism-specific databases

TAIRAT2G39840.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172697.
InParanoidP48484.
KOK06269.
OMAGKDVQGW.
PhylomeDBP48484.
ProtClustDBCLSN2683376.

Enzyme and pathway databases

BioCycARA:AT2G39840-MONOMER.

Gene expression databases

ArrayExpressP48484.
GenevestigatorP48484.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP14_ARATH
AccessionPrimary (citable) accession number: P48484
Secondary accession number(s): Q147H5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names