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P48481

- PP12_ACEPE

UniProt

P48481 - PP12_ACEPE

Protein

Serine/threonine-protein phosphatase PP1 isozyme 2

Gene
N/A
Organism
Acetabularia peniculus (Green alga) (Polyphysa peniculus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611Manganese 1By similarity
    Metal bindingi63 – 631Manganese 1By similarity
    Metal bindingi89 – 891Manganese 1By similarity
    Metal bindingi89 – 891Manganese 2By similarity
    Metal bindingi121 – 1211Manganese 2By similarity
    Active sitei122 – 1221Proton donorBy similarity
    Metal bindingi170 – 1701Manganese 2By similarity
    Metal bindingi245 – 2451Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1 isozyme 2 (EC:3.1.3.16)
    OrganismiAcetabularia peniculus (Green alga) (Polyphysa peniculus)
    Taxonomic identifieri35862 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeChlorophytaUlvophyceaeDasycladalesPolyphysaceaeAcetabularia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Serine/threonine-protein phosphatase PP1 isozyme 2PRO_0000058796Add
    BLAST

    Proteomic databases

    PRIDEiP48481.

    Structurei

    3D structure databases

    ProteinModelPortaliP48481.
    SMRiP48481. Positions 3-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48481-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEESAVDDVI ERLLEVRNNR PGKQVNLAEG EIRQLCLTAK DVFMSQPNLL    50
    ELEAPIKICG DIHGQYTDLL RLFEYGGFPP EANYLFLGDY VDRGKQSLET 100
    ICLLLAFKVK YPKNFFLLRG NHECASINRI YGFYDVCKRR YNIRLWKTFT 150
    DCFNCLPACA LVDEKIICMH GGLSPELKSL DAIRHIPRPT DVPDTGLLCD 200
    LLWSDPDKDV AGWGENDRGV SYTFGPDTVT GFLQKHDLDL ICRAHQVVED 250
    GYEFFAKRQL VTLFSAPNYC GEFDNAGALM SVDDTLMCSF QILKPSEKKG 300
    KLLYGSGALA GPGRGTPRR 319
    Length:319
    Mass (Da):35,924
    Last modified:February 1, 1996 - v1
    Checksum:i2725A2668FB4BA14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28632 Genomic DNA. Translation: CAA82264.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28632 Genomic DNA. Translation: CAA82264.1 .

    3D structure databases

    ProteinModelPortali P48481.
    SMRi P48481. Positions 3-305.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P48481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein phosphatase 2A, a potential regulator of actin dynamics and actin-based organelle motility in the green alga Acetabularia."
      Menzel D., Vugrek O., Frank S., Elsner-Menzel C.
      Eur. J. Cell Biol. 67:179-187(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPP12_ACEPE
    AccessioniPrimary (citable) accession number: P48481
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3