P48480 (PP11_ACECL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Serine/threonine-protein phosphatase PP1 isozyme 1 EC=3.1.3.16
Organism	Acetabularia cliftonii (Green alga)
Taxonomic identifier	35862 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Chlorophyta › Ulvophyceae › Dasycladales › Polyphysaceae › Acetabularia

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-1 subfamily.

Ontologies

Keywords
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Serine/threonine-protein phosphatase PP1 isozyme 1		PRO_0000058795
Sites
	Active site	122	1	Proton donor By similarity
	Metal binding	61	1	Iron By similarity
	Metal binding	63	1	Iron By similarity
	Metal binding	89	1	Iron By similarity
	Metal binding	89	1	Manganese By similarity
	Metal binding	121	1	Manganese By similarity
	Metal binding	170	1	Manganese By similarity
	Metal binding	245	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48480 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 80696B708B768E22	FASTA	319	36,313
	10 20 30 40 50 60 MDESTVDDVI ERLLEVRNNR PGKQVQLTES EIRLLCLTSK EILSEQPNLL ELEAPIKICG 70 80 90 100 110 120 DIHGQYTDLL RLFEYGGFPP EANYLFLGDY VDRGKQSLET ICLLLAFKIK YPENFFILRG 130 140 150 160 170 180 NHECASINRI YGFYDECKRR YNIRLWKTFT DCFNCLPVAA IVDEKILCMH GGLSPELKTL 190 200 210 220 230 240 EQIRRIPRPT DVPDTGLLCD LLWADPDKDV QGWGENDRGV SYTFGPDTVT EFLQRHDLDL 250 260 270 280 290 300 VCRAHQVVED GYEFFAKRQL VTLFSAPNYC GEFDNAGALM SVDDTLMCSF QILKPSEKKG 310 KFMQGGNSLA GAGRGTPRR

References

[1]	"Protein phosphatase 2A, a potential regulator of actin dynamics and actin-based organelle motility in the green alga Acetabularia." Menzel D., Vugrek O., Frank S., Elsner-Menzel C. Eur. J. Cell Biol. 67:179-187(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z28627 Genomic DNA. Translation: CAA82263.1.
3D structure databases
ProteinModelPortal	P48480.
SMR	P48480. Positions 3-306.
ModBase	Search...
Proteomic databases
PRIDE	P48480.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PP11_ACECL

Accession

Primary (citable) accession number: P48480

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program