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P48467 (KINH_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin heavy chain
Gene names
Name:kin
ORF Names:NCU09730
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora ›

Protein attributes

Sequence length928 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.

Subcellular location

Cytoplasm › cytoskeleton Probable.

Domain

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similarities

Belongs to the kinesin-like protein family. Kinesin subfamily.

Contains 1 kinesin-motor domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 928928Kinesin heavy chain
PRO_0000125362

Regions

Domain1 – 337337Kinesin-motor
Nucleotide binding88 – 958ATP
Nucleotide binding238 – 2458ATP Potential
Coiled coil343 – 866524 Potential

Secondary structure

1 .................................................................. 928
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P48467 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 2E2475195F674C02

FASTA928102,411
        10         20         30         40         50         60 
MSSSANSIKV VARFRPQNRV EIESGGQPIV TFQGPDTCTV DSKEAQGSFT FDRVFDMSCK 

        70         80         90        100        110        120 
QSDIFDFSIK PTVDDILNGY NGTVFAYGQT GAGKSYTMMG TSIDDPDGRG VIPRIVEQIF 

       130        140        150        160        170        180 
TSILSSAANI EYTVRVSYME IYMERIRDLL APQNDNLPVH EEKNRGVYVK GLLEIYVSSV 

       190        200        210        220        230        240 
QEVYEVMRRG GNARAVAATN MNQESSRSHS IFVITITQKN VETGSAKSGQ LFLVDLAGSE 

       250        260        270        280        290        300 
KVGKTGASGQ TLEEAKKINK SLSALGMVIN ALTDGKSSHV PYRDSKLTRI LQESLGGNSR 

       310        320        330        340        350        360 
TTLIINCSPS SYNDAETLST LRFGMRAKSI KNKAKVNAEL SPAELKQMLA KAKTQITSFE 

       370        380        390        400        410        420 
NYIVNLESEV QVWRGGETVP KEKWVPPLEL AITPSKSAST TARPSTPSRL LPESRAETPA 

       430        440        450        460        470        480 
ISDRAGTPSL PLDKDEREEF LRRENELQDQ IAEKESIAAA AERQLRETKE ELIALKDHDS 

       490        500        510        520        530        540 
KLGKENERLI SESNEFKMQL ERLAFENKEA QITIDGLKDA NSELTAELDE VKQQMLDMKM 

       550        560        570        580        590        600 
SAKETSAVLD EKEKKKAEKM AKMMAGFDLS GDVFSDNERA VADAIAQLDA LFEISSAGDA 

       610        620        630        640        650        660 
IPPEDIKALR EKLVETQGFV RQAELSSFSA ASSDAEARKR AELEARLEAL QQEHEELLSR 

       670        680        690        700        710        720 
NLTEADKEEV KALLAKSLSD KSAVQVELVE QLKADIALKN SETEHLKALV DDLQRRVKAG 

       730        740        750        760        770        780 
GAGVAMANGK TVQQQLAEFD VMKKSLMRDL QNRCERVVEL EISLDETREQ YNNVLRSSNN 

       790        800        810        820        830        840 
RAQQKKMAFL ERNLEQLTQV QRQLVEQNSA LKKEVAIAER KLMARNERIQ SLESLLQESQ 

       850        860        870        880        890        900 
EKMAQANHKF EVQLAAVKDR LEAAKAGSTR GLGTDAGLGG FSIGSRIAKP LRGGGDAVAG 

       910        920 
ATATNPTIAT LQQNPPENKR SSWFFQKS

« Hide

References

« Hide 'large scale' references
[1]"The Neurospora organelle motor: a distant relative of conventional kinesin with unconventional properties."
Steinberg G., Schliwa M.
Mol. Biol. Cell 6:1605-1618(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: 74A.
[2]Kirchner J.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[4]"Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules."
Song Y.-H., Marx A., Muller J., Woehlke G., Schliwa M., Krebs A., Hoenger A., Mandelkow E.
EMBO J. 20:6213-6225(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-355 IN COMPLEX WITH ADP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L47106 mRNA. Translation: AAB52961.1.
AABX02000083 Genomic DNA. Translation: EAA35196.2.
PIRT10164.
RefSeqXP_964432.2. XM_959339.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GOJX-ray2.30A1-355[»]
ProteinModelPortalP48467.
SMRP48467. Positions 2-355.
ModBaseSearch...

Protein-protein interaction databases

STRING5141.NCU09730.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000009500; EFNCRP00000009482; EFNCRG00000009481.
GeneID3880594.
KEGGncr:NCU09730.

Phylogenomic databases

eggNOGCOG5059.
HOGENOMHOG000216718.
OMACCSPASY.
OrthoDBEOG4NPBBS.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP48467.

Entry information

Entry nameKINH_NEUCR
AccessionPrimary (citable) accession number: P48467
Secondary accession number(s): Q7RVK5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1999
Last modified: May 29, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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