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P48467

- KINH_NEUCR

UniProt

P48467 - KINH_NEUCR

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Protein

Kinesin heavy chain

Gene
kin, NCU09730
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi88 – 958ATP
Nucleotide bindingi238 – 2458ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: InterPro

GO - Biological processi

  1. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin heavy chain
Gene namesi
Name:kin
ORF Names:NCU09730
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 4, Linkage Group IV

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. kinesin complex Source: InterPro
  3. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 928928Kinesin heavy chainPRO_0000125362Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU09730.1.

Structurei

Secondary structure

1
928
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146
Helixi19 – 224
Turni23 – 253
Beta strandi30 – 323
Beta strandi37 – 404
Beta strandi47 – 504
Beta strandi52 – 554
Helixi61 – 688
Helixi70 – 767
Turni77 – 793
Beta strandi82 – 876
Helixi94 – 985
Turni106 – 1083
Helixi111 – 12414
Beta strandi130 – 14213
Beta strandi145 – 1484
Beta strandi159 – 1624
Turni163 – 1653
Beta strandi166 – 1694
Helixi180 – 20021
Helixi205 – 2073
Beta strandi209 – 22012
Turni221 – 2233
Beta strandi226 – 23510
Beta strandi245 – 2473
Turni252 – 2554
Helixi256 – 2583
Helixi261 – 27414
Helixi282 – 2843
Helixi286 – 2905
Helixi292 – 2943
Beta strandi300 – 3078
Helixi311 – 3133
Helixi314 – 32815
Beta strandi338 – 3414
Beta strandi343 – 3453

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GOJX-ray2.30A1-355[»]
ProteinModelPortaliP48467.
SMRiP48467. Positions 2-355.

Miscellaneous databases

EvolutionaryTraceiP48467.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 330324Kinesin motorAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili343 – 866524 Reviewed predictionAdd
BLAST

Domaini

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
HOGENOMiHOG000216718.
OMAiGTMRENE.
OrthoDBiEOG7RRFGF.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48467-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSANSIKV VARFRPQNRV EIESGGQPIV TFQGPDTCTV DSKEAQGSFT    50
FDRVFDMSCK QSDIFDFSIK PTVDDILNGY NGTVFAYGQT GAGKSYTMMG 100
TSIDDPDGRG VIPRIVEQIF TSILSSAANI EYTVRVSYME IYMERIRDLL 150
APQNDNLPVH EEKNRGVYVK GLLEIYVSSV QEVYEVMRRG GNARAVAATN 200
MNQESSRSHS IFVITITQKN VETGSAKSGQ LFLVDLAGSE KVGKTGASGQ 250
TLEEAKKINK SLSALGMVIN ALTDGKSSHV PYRDSKLTRI LQESLGGNSR 300
TTLIINCSPS SYNDAETLST LRFGMRAKSI KNKAKVNAEL SPAELKQMLA 350
KAKTQITSFE NYIVNLESEV QVWRGGETVP KEKWVPPLEL AITPSKSAST 400
TARPSTPSRL LPESRAETPA ISDRAGTPSL PLDKDEREEF LRRENELQDQ 450
IAEKESIAAA AERQLRETKE ELIALKDHDS KLGKENERLI SESNEFKMQL 500
ERLAFENKEA QITIDGLKDA NSELTAELDE VKQQMLDMKM SAKETSAVLD 550
EKEKKKAEKM AKMMAGFDLS GDVFSDNERA VADAIAQLDA LFEISSAGDA 600
IPPEDIKALR EKLVETQGFV RQAELSSFSA ASSDAEARKR AELEARLEAL 650
QQEHEELLSR NLTEADKEEV KALLAKSLSD KSAVQVELVE QLKADIALKN 700
SETEHLKALV DDLQRRVKAG GAGVAMANGK TVQQQLAEFD VMKKSLMRDL 750
QNRCERVVEL EISLDETREQ YNNVLRSSNN RAQQKKMAFL ERNLEQLTQV 800
QRQLVEQNSA LKKEVAIAER KLMARNERIQ SLESLLQESQ EKMAQANHKF 850
EVQLAAVKDR LEAAKAGSTR GLGTDAGLGG FSIGSRIAKP LRGGGDAVAG 900
ATATNPTIAT LQQNPPENKR SSWFFQKS 928
Length:928
Mass (Da):102,411
Last modified:July 15, 1999 - v2
Checksum:i2E2475195F674C02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L47106 mRNA. Translation: AAB52961.1.
CM002239 Genomic DNA. Translation: EAA35196.2.
PIRiT10164.
RefSeqiXP_964432.2. XM_959339.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000009500; EFNCRP00000009482; EFNCRG00000009481.
GeneIDi3880594.
KEGGincr:NCU09730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L47106 mRNA. Translation: AAB52961.1 .
CM002239 Genomic DNA. Translation: EAA35196.2 .
PIRi T10164.
RefSeqi XP_964432.2. XM_959339.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GOJ X-ray 2.30 A 1-355 [» ]
ProteinModelPortali P48467.
SMRi P48467. Positions 2-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU09730.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000009500 ; EFNCRP00000009482 ; EFNCRG00000009481 .
GeneIDi 3880594.
KEGGi ncr:NCU09730.

Phylogenomic databases

eggNOGi COG5059.
HOGENOMi HOG000216718.
OMAi GTMRENE.
OrthoDBi EOG7RRFGF.

Miscellaneous databases

EvolutionaryTracei P48467.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Neurospora organelle motor: a distant relative of conventional kinesin with unconventional properties."
    Steinberg G., Schliwa M.
    Mol. Biol. Cell 6:1605-1618(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: 74A.
  2. Kirchner J.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  4. "Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules."
    Song Y.-H., Marx A., Muller J., Woehlke G., Schliwa M., Krebs A., Hoenger A., Mandelkow E.
    EMBO J. 20:6213-6225(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-355 IN COMPLEX WITH ADP.

Entry informationi

Entry nameiKINH_NEUCR
AccessioniPrimary (citable) accession number: P48467
Secondary accession number(s): Q7RVK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1999
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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