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Protein

Kinesin heavy chain

Gene

kin

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi88 – 95ATP8
Nucleotide bindingi238 – 245ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
  • microtubule lateral binding Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin heavy chain
Gene namesi
Name:kin
ORF Names:NCU09730
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 4, Linkage Group IV

Organism-specific databases

EuPathDBiFungiDB:NCU09730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253621 – 928Kinesin heavy chainAdd BLAST928

Proteomic databases

PRIDEiP48467

Interactioni

GO - Molecular functioni

  • microtubule lateral binding Source: CAFA

Structurei

Secondary structure

1928
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 14Combined sources6
Helixi19 – 22Combined sources4
Turni23 – 25Combined sources3
Beta strandi30 – 32Combined sources3
Beta strandi37 – 40Combined sources4
Beta strandi47 – 50Combined sources4
Beta strandi52 – 55Combined sources4
Helixi61 – 68Combined sources8
Helixi70 – 76Combined sources7
Turni77 – 79Combined sources3
Beta strandi82 – 87Combined sources6
Helixi94 – 98Combined sources5
Turni106 – 108Combined sources3
Helixi111 – 124Combined sources14
Beta strandi130 – 142Combined sources13
Beta strandi145 – 148Combined sources4
Beta strandi159 – 162Combined sources4
Turni163 – 165Combined sources3
Beta strandi166 – 169Combined sources4
Helixi180 – 200Combined sources21
Helixi205 – 207Combined sources3
Beta strandi209 – 220Combined sources12
Turni221 – 223Combined sources3
Beta strandi226 – 235Combined sources10
Beta strandi245 – 247Combined sources3
Turni252 – 255Combined sources4
Helixi256 – 258Combined sources3
Helixi261 – 274Combined sources14
Helixi282 – 284Combined sources3
Helixi286 – 290Combined sources5
Helixi292 – 294Combined sources3
Beta strandi300 – 307Combined sources8
Helixi311 – 313Combined sources3
Helixi314 – 328Combined sources15
Beta strandi338 – 341Combined sources4
Beta strandi343 – 345Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GOJX-ray2.30A1-355[»]
ProteinModelPortaliP48467
SMRiP48467
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48467

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 330Kinesin motorPROSITE-ProRule annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili343 – 866Sequence analysisAdd BLAST524

Domaini

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000216718
InParanoidiP48467
KOiK10396
OMAiNDCAKKI
OrthoDBiEOG092C2D4G

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSANSIKV VARFRPQNRV EIESGGQPIV TFQGPDTCTV DSKEAQGSFT
60 70 80 90 100
FDRVFDMSCK QSDIFDFSIK PTVDDILNGY NGTVFAYGQT GAGKSYTMMG
110 120 130 140 150
TSIDDPDGRG VIPRIVEQIF TSILSSAANI EYTVRVSYME IYMERIRDLL
160 170 180 190 200
APQNDNLPVH EEKNRGVYVK GLLEIYVSSV QEVYEVMRRG GNARAVAATN
210 220 230 240 250
MNQESSRSHS IFVITITQKN VETGSAKSGQ LFLVDLAGSE KVGKTGASGQ
260 270 280 290 300
TLEEAKKINK SLSALGMVIN ALTDGKSSHV PYRDSKLTRI LQESLGGNSR
310 320 330 340 350
TTLIINCSPS SYNDAETLST LRFGMRAKSI KNKAKVNAEL SPAELKQMLA
360 370 380 390 400
KAKTQITSFE NYIVNLESEV QVWRGGETVP KEKWVPPLEL AITPSKSAST
410 420 430 440 450
TARPSTPSRL LPESRAETPA ISDRAGTPSL PLDKDEREEF LRRENELQDQ
460 470 480 490 500
IAEKESIAAA AERQLRETKE ELIALKDHDS KLGKENERLI SESNEFKMQL
510 520 530 540 550
ERLAFENKEA QITIDGLKDA NSELTAELDE VKQQMLDMKM SAKETSAVLD
560 570 580 590 600
EKEKKKAEKM AKMMAGFDLS GDVFSDNERA VADAIAQLDA LFEISSAGDA
610 620 630 640 650
IPPEDIKALR EKLVETQGFV RQAELSSFSA ASSDAEARKR AELEARLEAL
660 670 680 690 700
QQEHEELLSR NLTEADKEEV KALLAKSLSD KSAVQVELVE QLKADIALKN
710 720 730 740 750
SETEHLKALV DDLQRRVKAG GAGVAMANGK TVQQQLAEFD VMKKSLMRDL
760 770 780 790 800
QNRCERVVEL EISLDETREQ YNNVLRSSNN RAQQKKMAFL ERNLEQLTQV
810 820 830 840 850
QRQLVEQNSA LKKEVAIAER KLMARNERIQ SLESLLQESQ EKMAQANHKF
860 870 880 890 900
EVQLAAVKDR LEAAKAGSTR GLGTDAGLGG FSIGSRIAKP LRGGGDAVAG
910 920
ATATNPTIAT LQQNPPENKR SSWFFQKS
Length:928
Mass (Da):102,411
Last modified:July 15, 1999 - v2
Checksum:i2E2475195F674C02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47106 mRNA Translation: AAB52961.1
CM002239 Genomic DNA Translation: EAA35196.2
PIRiT10164
RefSeqiXP_964432.2, XM_959339.3

Genome annotation databases

EnsemblFungiiEAA35196; EAA35196; NCU09730
GeneIDi3880594
KEGGincr:NCU09730

Similar proteinsi

Entry informationi

Entry nameiKINH_NEUCR
AccessioniPrimary (citable) accession number: P48467
Secondary accession number(s): Q7RVK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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