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P48461

- PP11_DROME

UniProt

P48461 - PP11_DROME

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Protein

Serine/threonine-protein phosphatase alpha-1 isoform

Gene

Pp1alpha-96A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Manganese 1By similarity
Metal bindingi64 – 641Manganese 1By similarity
Metal bindingi90 – 901Manganese 1By similarity
Metal bindingi90 – 901Manganese 2By similarity
Metal bindingi122 – 1221Manganese 2By similarity
Active sitei123 – 1231Proton donorBy similarity
Metal bindingi171 – 1711Manganese 2By similarity
Metal bindingi246 – 2461Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: FlyBase
  2. positive regulation of innate immune response Source: FlyBase
  3. protein dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

SignaLinkiP48461.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase alpha-1 isoform (EC:3.1.3.16)
Gene namesi
Name:Pp1alpha-96A
Synonyms:Pp1-96A
ORF Names:CG6593
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003134. Pp1alpha-96A.

Subcellular locationi

GO - Cellular componenti

  1. protein phosphatase type 1 complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Serine/threonine-protein phosphatase alpha-1 isoformPRO_0000058791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei315 – 3151Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48461.
PRIDEiP48461.

Expressioni

Gene expression databases

BgeeiP48461.

Interactioni

Subunit structurei

Interacts with Nop17l.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NiPp1Q9V7W93EBI-91997,EBI-108894
Nop17lQ0E9G34EBI-91997,EBI-150380

Protein-protein interaction databases

BioGridi67848. 14 interactions.
DIPiDIP-19812N.
IntActiP48461. 24 interactions.
MINTiMINT-190817.

Structurei

3D structure databases

ProteinModelPortaliP48461.
SMRiP48461. Positions 5-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
InParanoidiP48461.
KOiK06269.
OMAiPRGANSK.
OrthoDBiEOG7TJ3K3.
PhylomeDBiP48461.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48461-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDIMNIDSI ISRLLEVRGA RPGKNVQLSE SEIRSLCLKS REIFLSQPIL
60 70 80 90 100
LELEAPLKIC GDIHGQYYDL LRLFEYGGFP PESNYLFLGD YVDRGKQSLE
110 120 130 140 150
TICLLLAYKI KYAENFFLLR GNHECASINR IYGFYDECKR RYTIKLWKTF
160 170 180 190 200
TDCFNCLPVA AIVDEKIFCC HGGLSPDLSS MEQIRRIMRP TDVPDQGLLC
210 220 230 240 250
DLLWSDPDKD TMGWGENDRG VSFTFGAEVV GKFLQKHEFD LICRAHQVVE
260 270 280 290 300
DGYEFFAKRQ LVTLFSAPNY CGEFDNAGAM MSVDDTLMCS FQILKPADKR
310 320
RFVYPNFGSS GRPLTPPRGA NNKNKKK
Length:327
Mass (Da):37,370
Last modified:February 1, 1996 - v1
Checksum:i372390FBBB3CA8F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56438 mRNA. Translation: CAA39820.1.
AE014297 Genomic DNA. Translation: AAF56306.1.
BT016110 mRNA. Translation: AAV36995.1.
PIRiS13827.
RefSeqiNP_001262919.1. NM_001275990.1.
NP_524484.1. NM_079760.3.
UniGeneiDm.2362.

Genome annotation databases

EnsemblMetazoaiFBtr0084642; FBpp0084026; FBgn0003134.
GeneIDi42922.
KEGGidme:Dmel_CG6593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56438 mRNA. Translation: CAA39820.1 .
AE014297 Genomic DNA. Translation: AAF56306.1 .
BT016110 mRNA. Translation: AAV36995.1 .
PIRi S13827.
RefSeqi NP_001262919.1. NM_001275990.1.
NP_524484.1. NM_079760.3.
UniGenei Dm.2362.

3D structure databases

ProteinModelPortali P48461.
SMRi P48461. Positions 5-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 67848. 14 interactions.
DIPi DIP-19812N.
IntActi P48461. 24 interactions.
MINTi MINT-190817.

Proteomic databases

PaxDbi P48461.
PRIDEi P48461.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084642 ; FBpp0084026 ; FBgn0003134 .
GeneIDi 42922.
KEGGi dme:Dmel_CG6593.

Organism-specific databases

CTDi 42922.
FlyBasei FBgn0003134. Pp1alpha-96A.

Phylogenomic databases

eggNOGi COG0639.
GeneTreei ENSGT00530000062911.
InParanoidi P48461.
KOi K06269.
OMAi PRGANSK.
OrthoDBi EOG7TJ3K3.
PhylomeDBi P48461.

Enzyme and pathway databases

SignaLinki P48461.

Miscellaneous databases

ChiTaRSi Pp1alpha-96A. drosophila.
GenomeRNAii 42922.
NextBioi 831285.

Gene expression databases

Bgeei P48461.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila contains three genes that encode distinct isoforms of protein phosphatase 1."
    Dombradi V., Axton J.M., Brewis N.D., da Cruz e Silva E.F., Alphey L., Cohen P.T.W.
    Eur. J. Biochem. 194:739-745(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila."
    Bennett D., Lyulcheva E., Alphey L.
    J. Mol. Biol. 364:196-212(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NOP17L.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-315, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiPP11_DROME
AccessioniPrimary (citable) accession number: P48461
Secondary accession number(s): Q5U0Y2, Q9VC69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3