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P48460

- YY06_CAEEL

UniProt

P48460 - YY06_CAEEL

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Protein

Putative serine/threonine-protein phosphatase C27B7.6

Gene

C27B7.6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Manganese 1By similarity
Metal bindingi67 – 671Manganese 1By similarity
Metal bindingi93 – 931Manganese 1By similarity
Metal bindingi93 – 931Manganese 2By similarity
Metal bindingi125 – 1251Manganese 2By similarity
Active sitei126 – 1261Proton donorBy similarity
Metal bindingi174 – 1741Manganese 2By similarity
Metal bindingi252 – 2521Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase C27B7.6 (EC:3.1.3.16)
Gene namesi
ORF Names:C27B7.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiC27B7.6; CE43510; WBGene00007763.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Putative serine/threonine-protein phosphatase C27B7.6PRO_0000058916Add
BLAST

Proteomic databases

PaxDbiP48460.

Interactioni

Protein-protein interaction databases

STRINGi6239.C27B7.6.

Structurei

3D structure databases

ProteinModelPortaliP48460.
SMRiP48460. Positions 44-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi425 – 44824Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
InParanoidiP48460.
OMAiTEHANTE.
OrthoDBiEOG7QRQZZ.
PhylomeDBiP48460.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48460-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLETEHANTE VHELCRQMIA RIEKYGTLEG FSDSDILEVL KTIKEILEPL
60 70 80 90 100
PCLIEIIAPV VVFGDIHGQL GDLLQFTNEV GRPPDFQYLF LGDYVDRGPN
110 120 130 140 150
SLEVTVWLFC MKILFSKKVH LLRGNHEVRR VNTMYGFKEE MMRKRNSHLW
160 170 180 190 200
KVFNDVFAEL SICASINRKI LCMHGGISPK IESWDSLTGM TKPRVHGDCE
210 220 230 240 250
HGLIVDLIWS DPNRKDDTIQ FNKMRGISTL FGKSVVDNLC TTLAIDLIIR
260 270 280 290 300
AHEMKEKGHT FEFDNRLLTV FSAPYYSGHN SNLGSVATIS KSLKLRIVTL
310 320 330 340 350
KPNKGYDRSK LDKRTLHDFE KNFQPLDENP RKNISCQFNV PPNGQKMSPF
360 370 380 390 400
LGEYSMFAHE TQFCKKDNET PVKKPYSSNQ DEDHSVLDMI RKTQKGYGVE
410 420 430 440 450
VSLKDKVMSL ESIRKKLGMT TSTTPPPPRT PSPDAPLAQS PPIPRSPPSS

TENA
Length:454
Mass (Da):51,597
Last modified:October 5, 2010 - v4
Checksum:i425C550C7B010E0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54236 Genomic DNA. Translation: CAA90981.4.
PIRiT19505.
RefSeqiNP_501547.3. NM_069146.4.
UniGeneiCel.13464.

Genome annotation databases

EnsemblMetazoaiC27B7.6; C27B7.6; WBGene00007763.
GeneIDi182956.
KEGGicel:CELE_C27B7.6.
UCSCiC27B7.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54236 Genomic DNA. Translation: CAA90981.4 .
PIRi T19505.
RefSeqi NP_501547.3. NM_069146.4.
UniGenei Cel.13464.

3D structure databases

ProteinModelPortali P48460.
SMRi P48460. Positions 44-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.C27B7.6.

Proteomic databases

PaxDbi P48460.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C27B7.6 ; C27B7.6 ; WBGene00007763 .
GeneIDi 182956.
KEGGi cel:CELE_C27B7.6.
UCSCi C27B7.6. c. elegans.

Organism-specific databases

CTDi 182956.
WormBasei C27B7.6 ; CE43510 ; WBGene00007763 .

Phylogenomic databases

eggNOGi COG0639.
GeneTreei ENSGT00530000062911.
InParanoidi P48460.
OMAi TEHANTE.
OrthoDBi EOG7QRQZZ.
PhylomeDBi P48460.

Miscellaneous databases

NextBioi 919424.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYY06_CAEEL
AccessioniPrimary (citable) accession number: P48460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 105 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3