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P48460

- YY06_CAEEL

UniProt

P48460 - YY06_CAEEL

Protein

Putative serine/threonine-protein phosphatase C27B7.6

Gene

C27B7.6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 4 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi65 – 651Manganese 1By similarity
    Metal bindingi67 – 671Manganese 1By similarity
    Metal bindingi93 – 931Manganese 1By similarity
    Metal bindingi93 – 931Manganese 2By similarity
    Metal bindingi125 – 1251Manganese 2By similarity
    Active sitei126 – 1261Proton donorBy similarity
    Metal bindingi174 – 1741Manganese 2By similarity
    Metal bindingi252 – 2521Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative serine/threonine-protein phosphatase C27B7.6 (EC:3.1.3.16)
    Gene namesi
    ORF Names:C27B7.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiC27B7.6; CE43510; WBGene00007763.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454Putative serine/threonine-protein phosphatase C27B7.6PRO_0000058916Add
    BLAST

    Proteomic databases

    PaxDbiP48460.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.C27B7.6.

    Structurei

    3D structure databases

    ProteinModelPortaliP48460.
    SMRiP48460. Positions 20-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi425 – 44824Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    GeneTreeiENSGT00530000062911.
    InParanoidiP48460.
    OMAiTEHANTE.
    OrthoDBiEOG7QRQZZ.
    PhylomeDBiP48460.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48460-1 [UniParc]FASTAAdd to Basket

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    MLETEHANTE VHELCRQMIA RIEKYGTLEG FSDSDILEVL KTIKEILEPL    50
    PCLIEIIAPV VVFGDIHGQL GDLLQFTNEV GRPPDFQYLF LGDYVDRGPN 100
    SLEVTVWLFC MKILFSKKVH LLRGNHEVRR VNTMYGFKEE MMRKRNSHLW 150
    KVFNDVFAEL SICASINRKI LCMHGGISPK IESWDSLTGM TKPRVHGDCE 200
    HGLIVDLIWS DPNRKDDTIQ FNKMRGISTL FGKSVVDNLC TTLAIDLIIR 250
    AHEMKEKGHT FEFDNRLLTV FSAPYYSGHN SNLGSVATIS KSLKLRIVTL 300
    KPNKGYDRSK LDKRTLHDFE KNFQPLDENP RKNISCQFNV PPNGQKMSPF 350
    LGEYSMFAHE TQFCKKDNET PVKKPYSSNQ DEDHSVLDMI RKTQKGYGVE 400
    VSLKDKVMSL ESIRKKLGMT TSTTPPPPRT PSPDAPLAQS PPIPRSPPSS 450
    TENA 454
    Length:454
    Mass (Da):51,597
    Last modified:October 5, 2010 - v4
    Checksum:i425C550C7B010E0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54236 Genomic DNA. Translation: CAA90981.4.
    PIRiT19505.
    RefSeqiNP_501547.3. NM_069146.4.
    UniGeneiCel.13464.

    Genome annotation databases

    EnsemblMetazoaiC27B7.6; C27B7.6; WBGene00007763.
    GeneIDi182956.
    KEGGicel:CELE_C27B7.6.
    UCSCiC27B7.6. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54236 Genomic DNA. Translation: CAA90981.4 .
    PIRi T19505.
    RefSeqi NP_501547.3. NM_069146.4.
    UniGenei Cel.13464.

    3D structure databases

    ProteinModelPortali P48460.
    SMRi P48460. Positions 20-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.C27B7.6.

    Proteomic databases

    PaxDbi P48460.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C27B7.6 ; C27B7.6 ; WBGene00007763 .
    GeneIDi 182956.
    KEGGi cel:CELE_C27B7.6.
    UCSCi C27B7.6. c. elegans.

    Organism-specific databases

    CTDi 182956.
    WormBasei C27B7.6 ; CE43510 ; WBGene00007763 .

    Phylogenomic databases

    eggNOGi COG0639.
    GeneTreei ENSGT00530000062911.
    InParanoidi P48460.
    OMAi TEHANTE.
    OrthoDBi EOG7QRQZZ.
    PhylomeDBi P48460.

    Miscellaneous databases

    NextBioi 919424.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiYY06_CAEEL
    AccessioniPrimary (citable) accession number: P48460
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 104 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3