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Protein

Putative serine/threonine-protein phosphatase C27B7.6

Gene

C27B7.6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Manganese 1By similarity
Metal bindingi67 – 671Manganese 1By similarity
Metal bindingi93 – 931Manganese 1By similarity
Metal bindingi93 – 931Manganese 2By similarity
Metal bindingi125 – 1251Manganese 2By similarity
Active sitei126 – 1261Proton donorBy similarity
Metal bindingi174 – 1741Manganese 2By similarity
Metal bindingi252 – 2521Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase C27B7.6 (EC:3.1.3.16)
Gene namesi
ORF Names:C27B7.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC27B7.6; CE43510; WBGene00007763.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Putative serine/threonine-protein phosphatase C27B7.6PRO_0000058916Add
BLAST

Proteomic databases

PaxDbiP48460.

Interactioni

Protein-protein interaction databases

STRINGi6239.C27B7.6.

Structurei

3D structure databases

ProteinModelPortaliP48460.
SMRiP48460. Positions 44-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi425 – 44824Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
InParanoidiP48460.
OMAiTEHANTE.
OrthoDBiEOG7QRQZZ.
PhylomeDBiP48460.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLETEHANTE VHELCRQMIA RIEKYGTLEG FSDSDILEVL KTIKEILEPL
60 70 80 90 100
PCLIEIIAPV VVFGDIHGQL GDLLQFTNEV GRPPDFQYLF LGDYVDRGPN
110 120 130 140 150
SLEVTVWLFC MKILFSKKVH LLRGNHEVRR VNTMYGFKEE MMRKRNSHLW
160 170 180 190 200
KVFNDVFAEL SICASINRKI LCMHGGISPK IESWDSLTGM TKPRVHGDCE
210 220 230 240 250
HGLIVDLIWS DPNRKDDTIQ FNKMRGISTL FGKSVVDNLC TTLAIDLIIR
260 270 280 290 300
AHEMKEKGHT FEFDNRLLTV FSAPYYSGHN SNLGSVATIS KSLKLRIVTL
310 320 330 340 350
KPNKGYDRSK LDKRTLHDFE KNFQPLDENP RKNISCQFNV PPNGQKMSPF
360 370 380 390 400
LGEYSMFAHE TQFCKKDNET PVKKPYSSNQ DEDHSVLDMI RKTQKGYGVE
410 420 430 440 450
VSLKDKVMSL ESIRKKLGMT TSTTPPPPRT PSPDAPLAQS PPIPRSPPSS

TENA
Length:454
Mass (Da):51,597
Last modified:October 5, 2010 - v4
Checksum:i425C550C7B010E0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54236 Genomic DNA. Translation: CAA90981.4.
PIRiT19505.
RefSeqiNP_501547.3. NM_069146.4.
UniGeneiCel.13464.

Genome annotation databases

EnsemblMetazoaiC27B7.6; C27B7.6; WBGene00007763.
GeneIDi182956.
KEGGicel:CELE_C27B7.6.
UCSCiC27B7.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54236 Genomic DNA. Translation: CAA90981.4.
PIRiT19505.
RefSeqiNP_501547.3. NM_069146.4.
UniGeneiCel.13464.

3D structure databases

ProteinModelPortaliP48460.
SMRiP48460. Positions 44-302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C27B7.6.

Proteomic databases

PaxDbiP48460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC27B7.6; C27B7.6; WBGene00007763.
GeneIDi182956.
KEGGicel:CELE_C27B7.6.
UCSCiC27B7.6. c. elegans.

Organism-specific databases

CTDi182956.
WormBaseiC27B7.6; CE43510; WBGene00007763.

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
InParanoidiP48460.
OMAiTEHANTE.
OrthoDBiEOG7QRQZZ.
PhylomeDBiP48460.

Miscellaneous databases

NextBioi919424.
PROiP48460.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYY06_CAEEL
AccessioniPrimary (citable) accession number: P48460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 5, 2010
Last modified: May 27, 2015
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.