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Protein

Putative serine/threonine-protein phosphatase C23G10.1

Gene

C23G10.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Manganese 1By similarity
Metal bindingi96 – 961Manganese 1By similarity
Metal bindingi124 – 1241Manganese 1By similarity
Metal bindingi124 – 1241Manganese 2By similarity
Metal bindingi156 – 1561Manganese 2By similarity
Active sitei157 – 1571Proton donorBy similarity
Metal bindingi208 – 2081Manganese 2By similarity
Metal bindingi282 – 2821Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase C23G10.1 (EC:3.1.3.16)
Gene namesi
ORF Names:C23G10.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC23G10.1a; CE27721; WBGene00016010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Putative serine/threonine-protein phosphatase C23G10.1PRO_0000058914Add
BLAST

Proteomic databases

PaxDbiP48459.
PRIDEiP48459.

Expressioni

Gene expression databases

ExpressionAtlasiP48459. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.C23G10.1b.

Structurei

3D structure databases

ProteinModelPortaliP48459.
SMRiP48459. Positions 41-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
HOGENOMiHOG000172697.
InParanoidiP48459.
KOiK01090.
OrthoDBiEOG78D7Q1.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPRVPEV AEMSAVSDND VIKEKGARDK MFQKQSDESN KMFAEHFIKT
60 70 80 90 100
LLACKGMTKI RTMDIFRLIH ICKKIFTVQK SMVEIDGPVR ICGDLHGQYP
110 120 130 140 150
DLIRLFAQVL GGFPPDSNYL FLGDYVDRGS FNLEVILLCL AYKARYPNNF
160 170 180 190 200
MMLRGNHEVI HINEKYGFKD EVFNRKGEYH DELYPEFNEM MDMMPLVALV
210 220 230 240 250
GGRILCMHGG LSQHIKSLDD LRNLRRPFHS EDECLENDIM WSDPAKVSGW
260 270 280 290 300
TANPRGASVQ FGENEVKEMC KLLDIDLIVR GHQVVQDGYE FFAGKKLVTV
310 320 330 340 350
FSAPHYMQSF TNSAAVCKVS AGLEVSFEVL KPEDIRVEEI KCSAESSCAS

DMQQ
Length:354
Mass (Da):40,306
Last modified:September 26, 2001 - v2
Checksum:i7965CD59B8424EB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080630 Genomic DNA. Translation: CCD65292.1.
RefSeqiNP_498352.1. NM_065951.3.
UniGeneiCel.10819.

Genome annotation databases

EnsemblMetazoaiC23G10.1a; C23G10.1a; WBGene00016010.
GeneIDi175880.
KEGGicel:CELE_C23G10.1.
UCSCiC23G10.1b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080630 Genomic DNA. Translation: CCD65292.1.
RefSeqiNP_498352.1. NM_065951.3.
UniGeneiCel.10819.

3D structure databases

ProteinModelPortaliP48459.
SMRiP48459. Positions 41-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C23G10.1b.

Proteomic databases

PaxDbiP48459.
PRIDEiP48459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC23G10.1a; C23G10.1a; WBGene00016010.
GeneIDi175880.
KEGGicel:CELE_C23G10.1.
UCSCiC23G10.1b. c. elegans.

Organism-specific databases

CTDi175880.
WormBaseiC23G10.1a; CE27721; WBGene00016010.

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
HOGENOMiHOG000172697.
InParanoidiP48459.
KOiK01090.
OrthoDBiEOG78D7Q1.

Miscellaneous databases

NextBioi890126.
PROiP48459.

Gene expression databases

ExpressionAtlasiP48459. baseline and differential.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYSD1_CAEEL
AccessioniPrimary (citable) accession number: P48459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 26, 2001
Last modified: April 29, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.