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P48458

- YT91_CAEEL

UniProt

P48458 - YT91_CAEEL

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Protein

Putative serine/threonine-protein phosphatase C06A1.3

Gene

C06A1.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931Manganese 1By similarity
Metal bindingi95 – 951Manganese 1By similarity
Metal bindingi121 – 1211Manganese 1By similarity
Metal bindingi121 – 1211Manganese 2By similarity
Metal bindingi153 – 1531Manganese 2By similarity
Active sitei154 – 1541Proton donorBy similarity
Metal bindingi202 – 2021Manganese 2By similarity
Metal bindingi277 – 2771Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase C06A1.3 (EC:3.1.3.16)
Gene namesi
ORF Names:C06A1.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiC06A1.3; CE02116; WBGene00007354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Putative serine/threonine-protein phosphatase C06A1.3PRO_0000058915Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiP48458. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi39942. 1 interaction.
STRINGi6239.C06A1.3.

Structurei

3D structure databases

ProteinModelPortaliP48458.
SMRiP48458. Positions 62-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
HOGENOMiHOG000172697.
InParanoidiP48458.
KOiK01090.
OMAiIFMEESN.
PhylomeDBiP48458.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48458-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTDGNNNKK GSKEGPKSSE ISKFDLAKEN PKLAEWMDDC IKRMNSLYKD
60 70 80 90 100
TNINICNVMT GHEIISIIRM VEAIFMEESN LCEAEAPIKV IGDIHAQYQD
110 120 130 140 150
MNRLFDLIGR VPEEKLMFLG DYVDRGPQGI EVLILLFCLK IRYRDRIYLL
160 170 180 190 200
RGNHETPSVN KIYGFYVECQ YKYGIGLWWD FQSCFNRMPM SGLISKRVLC
210 220 230 240 250
MHGGLSPELI NLDTIRNIPR PCEPLDRGLL IDLLWSDPTN KGEGWFHSIR
260 270 280 290 300
GISYMFGKGV VEQACKSLEI DLIIRAHQVV QDGYEMMTGR RLITVFSVPN
310 320 330 340 350
YCAQFTNAAA VVCLNANLQI SFQQMIPPPL PEGTKAKAAP AIAIDPNIDA
360
ARADKDAIKP FVKE
Length:364
Mass (Da):41,208
Last modified:February 1, 1996 - v1
Checksum:i1384EAB0C9729913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49886 Genomic DNA. Translation: CAA90052.1.
PIRiT18972.
RefSeqiNP_496276.1. NM_063875.3.
UniGeneiCel.15976.

Genome annotation databases

EnsemblMetazoaiC06A1.3; C06A1.3; WBGene00007354.
GeneIDi174626.
KEGGicel:CELE_C06A1.3.
UCSCiC06A1.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49886 Genomic DNA. Translation: CAA90052.1 .
PIRi T18972.
RefSeqi NP_496276.1. NM_063875.3.
UniGenei Cel.15976.

3D structure databases

ProteinModelPortali P48458.
SMRi P48458. Positions 62-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39942. 1 interaction.
STRINGi 6239.C06A1.3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C06A1.3 ; C06A1.3 ; WBGene00007354 .
GeneIDi 174626.
KEGGi cel:CELE_C06A1.3.
UCSCi C06A1.3. c. elegans.

Organism-specific databases

CTDi 174626.
WormBasei C06A1.3 ; CE02116 ; WBGene00007354 .

Phylogenomic databases

eggNOGi COG0639.
GeneTreei ENSGT00530000062911.
HOGENOMi HOG000172697.
InParanoidi P48458.
KOi K01090.
OMAi IFMEESN.
PhylomeDBi P48458.

Miscellaneous databases

NextBioi 884822.

Gene expression databases

ExpressionAtlasi P48458. baseline and differential.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYT91_CAEEL
AccessioniPrimary (citable) accession number: P48458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3