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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit

Gene

cnaA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe3+By similarityNote: Binds 1 Fe3+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112IronBy similarity1
Metal bindingi114IronBy similarity1
Metal bindingi140IronBy similarity1
Metal bindingi140ZincBy similarity1
Metal bindingi172ZincBy similarity1
Active sitei173Proton donorBy similarity1
Metal bindingi221ZincBy similarity1
Metal bindingi303ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Hydrolase, Protein phosphatase
LigandIron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit (EC:3.1.3.16)
Alternative name(s):
Calmodulin-dependent calcineurin A subunit
Gene namesi
Name:cnaA
ORF Names:AN8820
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome III
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588341 – 549Serine/threonine-protein phosphatase 2B catalytic subunitAdd BLAST549

Proteomic databases

PRIDEiP48457

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006237

Structurei

3D structure databases

ProteinModelPortaliP48457
SMRiP48457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172699
InParanoidiP48457
KOiK04348
OMAiLWSLKIW
OrthoDBiEOG092C1CSB

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P48457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRNLARAVA DKQPVPEIDF TLHVMEDGTQ VSTLERVVKE VQAPALNKPS
60 70 80 90 100
DDQFWDPEEP TKPNLQFLKQ HFYREGRLTE DQALWIIQAG TQILKSEPNL
110 120 130 140 150
LEMDAPITVC GDVHGQYYDL MKLFEVGGDP AETRYLFLGD YVDRGYFSIE
160 170 180 190 200
CVLYLWALKI WYPNTLWLLR GNHECRHLTD YFTFKLECKH KYSERIYEAC
210 220 230 240 250
IESFCALPLA AVMNKQFLCI HGGLSPELHT LEDIKSIDRF REPPTHGLMC
260 270 280 290 300
DILWADPLED FGQEKTGDYF IHNSVRGCSY FFSYPAACAF LEKNNLLSVI
310 320 330 340 350
RAHEAQDAGY RMYRKTRTTG FPSVMTIFSA PNYLDVYNNK AAVLKYENNV
360 370 380 390 400
MNIRQFNCTP HPYWLPNFMD VFTWSLPFVG EKITDMLIAI LNTCSKEELE
410 420 430 440 450
DETPSTISPA EPSPPMPMDT VDTESTEFKR RAIKNKILAI GRLSRVFQVL
460 470 480 490 500
REESERVTEL KTAAGGRLPA GTLMLGAEGI KQAITNFEDA RKVDLQNERL
510 520 530 540
PPSHDEVVRR SEEERRIALD RAQHEADNDT GLATVARRIS MKIPSTTRR
Length:549
Mass (Da):63,007
Last modified:November 16, 2011 - v3
Checksum:iECD795FCBBDF4991
GO

Sequence cautioni

The sequence AAA57873 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAA60108 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti386 – 387ML → IV in AAA57873 (PubMed:8013455).Curated2
Sequence conflicti541M → MVRRIR in AAA57873 (PubMed:8013455).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13919 Genomic DNA Translation: AAA57873.1 Different initiation.
AACD01000162 Genomic DNA Translation: EAA60108.1 Different initiation.
BN001303 Genomic DNA Translation: CBF77949.1
PIRiS46322
RefSeqiXP_682089.1, XM_676997.1

Genome annotation databases

EnsemblFungiiCADANIAT00006237; CADANIAP00006237; CADANIAG00006237
EAA60108; EAA60108; AN8820.2
GeneIDi2868443
KEGGiani:AN8820.2

Similar proteinsi

Entry informationi

Entry nameiPP2B_EMENI
AccessioniPrimary (citable) accession number: P48457
Secondary accession number(s): C8V9L3, Q5ASB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health