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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit 1

Gene

CanA1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe3+By similarityNote: Binds 1 Fe3+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130IronBy similarity1
Metal bindingi132IronBy similarity1
Metal bindingi158IronBy similarity1
Metal bindingi158ZincBy similarity1
Metal bindingi190ZincBy similarity1
Active sitei191Proton donorBy similarity1
Metal bindingi239ZincBy similarity1
Metal bindingi321ZincBy similarity1

GO - Molecular functioni

  • calcium-dependent protein serine/threonine phosphatase activity Source: FlyBase
  • calmodulin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • medium-term memory Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • protein dephosphorylation Source: FlyBase
  • regulation of innate immune response Source: FlyBase
  • response to nitric oxide Source: FlyBase
  • sleep Source: FlyBase
  • vesicle-mediated transport Source: FlyBase

Keywordsi

Molecular functionCalmodulin-binding, Hydrolase, Protein phosphatase
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-2025928 Calcineurin activates NFAT
R-DME-2871809 FCERI mediated Ca+2 mobilization
R-DME-4086398 Ca2+ pathway
R-DME-5607763 CLEC7A (Dectin-1) induces NFAT activation
SignaLinkiP48456

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit 1 (EC:3.1.3.16)
Alternative name(s):
Calmodulin-dependent calcineurin A1 subunit
Gene namesi
Name:CanA1
Synonyms:CNA1, PpD14
ORF Names:CG1455
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0010015 CanA1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588301 – 622Serine/threonine-protein phosphatase 2B catalytic subunit 1Add BLAST622

Proteomic databases

PaxDbiP48456
PRIDEiP48456

Expressioni

Gene expression databases

BgeeiFBgn0010015
ExpressionAtlasiP48456 baseline and differential
GenevisibleiP48456 DM

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi68520, 14 interactors
IntActiP48456, 5 interactors
STRINGi7227.FBpp0085094

Structurei

3D structure databases

ProteinModelPortaliP48456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

eggNOGiKOG0375 Eukaryota
COG0639 LUCA
GeneTreeiENSGT00530000063087
InParanoidiP48456
KOiK04348
OrthoDBiEOG091G094R
PhylomeDBiP48456

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P48456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATSTRSSV TRKSSLSKSS SSDKSAKSSS NSSKSPTAAS GNKQKMQYTK
60 70 80 90 100
TRERMVDDVP LPPTHKLTMS EVYDDPKTGK PNFDALRQHF LLEGRIEEAV
110 120 130 140 150
ALRIITEGAA LLREEKNMID VEAPITVCGD IHGQFFDLVK LFEVGGPPAT
160 170 180 190 200
TRYLFLGDYV DRGYFSIECV LYLWSLKITY PTTLSLLRGN HECRHLTEYF
210 220 230 240 250
TFKQECIIKY SESIYDACME AFDCLPLAAL LNQQFLCIHG GLSPEIFTLD
260 270 280 290 300
DIKTLNRFRE PPAYGPMCDL LWSDPLEDFG NEKTNEFFSH NSVRGCSYFF
310 320 330 340 350
SYSACCEFLQ KNNLLSIVRA HEAQDAGYRM YRKNQVTGFP SLITIFSAPN
360 370 380 390 400
YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK
410 420 430 440 450
VTEMLVNILN ICSDDELVAG PDDELEEELR KKIVLVPANA SNNNNNNNTP
460 470 480 490 500
SKPASMSALR KEIIRNKIRA IGKMSRVFSI LREESESVLQ LKGLTPTGAL
510 520 530 540 550
PVGALSGGRD SLKEALQGLT ASSHIHSFAE AKGLDAVNER MPPRRPLLMS
560 570 580 590 600
ASSSSITTVT RSSSSSSNNN NNNSNTSSTT TTKDISNTSS NDTATVTKTS
610 620
RTTVKSATTS NVRAGFTAKK FP
Length:622
Mass (Da):69,133
Last modified:August 30, 2005 - v2
Checksum:iFAD967D2123EFAE9
GO

Sequence cautioni

The sequence AAA28410 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti459L → V in AAA28410 (PubMed:1331060).Curated1
Sequence conflicti622P → S in AAA28410 (PubMed:1331060).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF57105.3
AY128480 mRNA Translation: AAM75073.1
M97012 mRNA Translation: AAA28410.1 Different initiation.
S39996 Genomic DNA Translation: AAB22466.1
PIRiB44307
RefSeqiNP_001247378.2, NM_001260449.2
NP_524600.3, NM_079861.4
UniGeneiDm.1902

Genome annotation databases

EnsemblMetazoaiFBtr0085732; FBpp0085094; FBgn0010015
FBtr0334546; FBpp0306613; FBgn0010015
GeneIDi43670
KEGGidme:Dmel_CG1455

Similar proteinsi

Entry informationi

Entry nameiPP2B1_DROME
AccessioniPrimary (citable) accession number: P48456
Secondary accession number(s): Q8MQN3, Q9TY69, Q9VA20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 30, 2005
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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