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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Gene

Ppp3cc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe3+By similarityNote: Binds 1 Fe3+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861IronBy similarity
Metal bindingi88 – 881IronBy similarity
Metal bindingi114 – 1141IronBy similarity
Metal bindingi114 – 1141ZincBy similarity
Metal bindingi146 – 1461ZincBy similarity
Active sitei147 – 1471Proton donorBy similarity
Metal bindingi195 – 1951ZincBy similarity
Metal bindingi277 – 2771ZincBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Calmodulin-binding, Iron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_318722. Activation of BAD and translocation to mitochondria.
REACT_325290. DARPP-32 events.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC:3.1.3.16)
Alternative name(s):
CAM-PRP catalytic subunit
Calcineurin, testis-specific catalytic subunit
Calmodulin-dependent calcineurin A subunit gamma isoform
Gene namesi
Name:Ppp3cc
Synonyms:Calnc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:107162. Ppp3cc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformPRO_0000058829Add
BLAST

Proteomic databases

MaxQBiP48455.
PaxDbiP48455.
PRIDEiP48455.

PTM databases

PhosphoSiteiP48455.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiP48455.
ExpressionAtlasiP48455. baseline and differential.
GenevisibleiP48455. MM.

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

Protein-protein interaction databases

BioGridi202346. 3 interactions.
IntActiP48455. 1 interaction.
STRINGi10090.ENSMUSP00000077532.

Structurei

3D structure databases

ProteinModelPortaliP48455.
SMRiP48455. Positions 11-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOVERGENiHBG002819.
InParanoidiP48455.
KOiK04348.
OMAiXTVEAVE.
OrthoDBiEOG7BZVSC.
PhylomeDBiP48455.
TreeFamiTF105557.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRRPQFST TERVIKAVPF PPTRRLTLKE VFENGKPKMD LLKNHLVKEG
60 70 80 90 100
RVEEEVALKI INDGAAILKQ EKTMIEVEAP ITVCGDVHGQ FFDLMKLFEV
110 120 130 140 150
GGSPSNTRYL FLGDYVDRGY FSIECVLYLW SLKINHPKTL FLLRGNHECR
160 170 180 190 200
HLTEYFTFKQ ECRIKYSEMV YDACMHTFDC LPLAALLNQQ FLCVHGGMSP
210 220 230 240 250
EITCLEDIRK LDRFSEPPAF GPVCDLLWSD PLEDYGSEKT LEHYTHNTVR
260 270 280 290 300
GCSYFFSYPA VCEFLQNNSL LSIIRAHEAQ DAGYRMYRKN QATGFPSLIT
310 320 330 340 350
IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL
360 370 380 390 400
PFVGEKVTEM LVNILNICSD EEMNVTDEEG ATTGRKEVIK NKIRAIGKMA
410 420 430 440 450
RVFTVLREES ENVLTLKGLT PTGTLPLGVL SGGKQTIETA KQEAAEEREA
460 470 480 490 500
IRGFTIAHRI RSFEEARGLD RINERMPPRK EASYHHDAGR MHSHSHPPHP
510
QASRRTDHGK KAL
Length:513
Mass (Da):58,699
Last modified:February 1, 1996 - v1
Checksum:i521CB2B1DD9E03A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81475 mRNA. Translation: AAA39968.1.
CCDSiCCDS36968.1.
PIRiA38193.
RefSeqiNP_032941.1. NM_008915.3.
UniGeneiMm.439683.

Genome annotation databases

EnsembliENSMUST00000078434; ENSMUSP00000077532; ENSMUSG00000022092.
GeneIDi19057.
KEGGimmu:19057.
UCSCiuc007unp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81475 mRNA. Translation: AAA39968.1.
CCDSiCCDS36968.1.
PIRiA38193.
RefSeqiNP_032941.1. NM_008915.3.
UniGeneiMm.439683.

3D structure databases

ProteinModelPortaliP48455.
SMRiP48455. Positions 11-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202346. 3 interactions.
IntActiP48455. 1 interaction.
STRINGi10090.ENSMUSP00000077532.

PTM databases

PhosphoSiteiP48455.

Proteomic databases

MaxQBiP48455.
PaxDbiP48455.
PRIDEiP48455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078434; ENSMUSP00000077532; ENSMUSG00000022092.
GeneIDi19057.
KEGGimmu:19057.
UCSCiuc007unp.1. mouse.

Organism-specific databases

CTDi5533.
MGIiMGI:107162. Ppp3cc.

Phylogenomic databases

eggNOGiCOG0639.
HOVERGENiHBG002819.
InParanoidiP48455.
KOiK04348.
OMAiXTVEAVE.
OrthoDBiEOG7BZVSC.
PhylomeDBiP48455.
TreeFamiTF105557.

Enzyme and pathway databases

ReactomeiREACT_318722. Activation of BAD and translocation to mitochondria.
REACT_325290. DARPP-32 events.

Miscellaneous databases

ChiTaRSiPpp3cc. mouse.
NextBioi295550.
PROiP48455.
SOURCEiSearch...

Gene expression databases

BgeeiP48455.
ExpressionAtlasiP48455. baseline and differential.
GenevisibleiP48455. MM.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a calmodulin-dependent phosphatase from murine testis: identification of a developmentally expressed nonneural isoenzyme."
    Muramatsu T., Giri P.R., Higuchi S., Kincaid R.L.
    Proc. Natl. Acad. Sci. U.S.A. 89:529-533(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiPP2BC_MOUSE
AccessioniPrimary (citable) accession number: P48455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.