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P48455 (PP2BC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

EC=3.1.3.16
Alternative name(s):
CAM-PRP catalytic subunit
Calcineurin, testis-specific catalytic subunit
Calmodulin-dependent calcineurin A subunit gamma isoform
Gene names
Name:Ppp3cc
Synonyms:Calnc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 Fe3+ ion per subunit By similarity.

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

Tissue specificity

Testis.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2B subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
PRO_0000058829

Sites

Active site1471Proton donor By similarity
Metal binding861Iron By similarity
Metal binding881Iron By similarity
Metal binding1141Iron By similarity
Metal binding1141Zinc By similarity
Metal binding1461Zinc By similarity
Metal binding1951Zinc By similarity
Metal binding2771Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P48455 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 521CB2B1DD9E03A0

FASTA51358,699
        10         20         30         40         50         60 
MSVRRPQFST TERVIKAVPF PPTRRLTLKE VFENGKPKMD LLKNHLVKEG RVEEEVALKI 

        70         80         90        100        110        120 
INDGAAILKQ EKTMIEVEAP ITVCGDVHGQ FFDLMKLFEV GGSPSNTRYL FLGDYVDRGY 

       130        140        150        160        170        180 
FSIECVLYLW SLKINHPKTL FLLRGNHECR HLTEYFTFKQ ECRIKYSEMV YDACMHTFDC 

       190        200        210        220        230        240 
LPLAALLNQQ FLCVHGGMSP EITCLEDIRK LDRFSEPPAF GPVCDLLWSD PLEDYGSEKT 

       250        260        270        280        290        300 
LEHYTHNTVR GCSYFFSYPA VCEFLQNNSL LSIIRAHEAQ DAGYRMYRKN QATGFPSLIT 

       310        320        330        340        350        360 
IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL PFVGEKVTEM 

       370        380        390        400        410        420 
LVNILNICSD EEMNVTDEEG ATTGRKEVIK NKIRAIGKMA RVFTVLREES ENVLTLKGLT 

       430        440        450        460        470        480 
PTGTLPLGVL SGGKQTIETA KQEAAEEREA IRGFTIAHRI RSFEEARGLD RINERMPPRK 

       490        500        510 
EASYHHDAGR MHSHSHPPHP QASRRTDHGK KAL 

« Hide

References

[1]"Molecular cloning of a calmodulin-dependent phosphatase from murine testis: identification of a developmentally expressed nonneural isoenzyme."
Muramatsu T., Giri P.R., Higuchi S., Kincaid R.L.
Proc. Natl. Acad. Sci. U.S.A. 89:529-533(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81475 mRNA. Translation: AAA39968.1.
PIRA38193.
RefSeqNP_032941.1. NM_008915.2.
UniGeneMm.439683.

3D structure databases

ProteinModelPortalP48455.
SMRP48455. Positions 11-368.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202346. 3 interactions.
IntActP48455. 1 interaction.

PTM databases

PhosphoSiteP48455.

Proteomic databases

PaxDbP48455.
PRIDEP48455.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000078434; ENSMUSP00000077532; ENSMUSG00000022092.
GeneID19057.
KEGGmmu:19057.
UCSCuc007unp.1. mouse.

Organism-specific databases

CTD5533.
MGIMGI:107162. Ppp3cc.

Phylogenomic databases

eggNOGCOG0639.
HOVERGENHBG002819.
InParanoidP48455.
KOK04348.
OMAKINYPKT.
OrthoDBEOG7BZVSC.
PhylomeDBP48455.
TreeFamTF105557.

Gene expression databases

ArrayExpressP48455.
BgeeP48455.
GenevestigatorP48455.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPPP3CC. mouse.
NextBio295550.
PROP48455.
SOURCESearch...

Entry information

Entry namePP2BC_MOUSE
AccessionPrimary (citable) accession number: P48455
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot