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P48455

- PP2BC_MOUSE

UniProt

P48455 - PP2BC_MOUSE

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Protein
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Gene
Ppp3cc, Calnc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 1 Fe3+ ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron By similarity
Metal bindingi88 – 881Iron By similarity
Metal bindingi114 – 1141Iron By similarity
Metal bindingi114 – 1141Zinc By similarity
Metal bindingi146 – 1461Zinc By similarity
Active sitei147 – 1471Proton donor By similarity
Metal bindingi195 – 1951Zinc By similarity
Metal bindingi277 – 2771Zinc By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Calmodulin-binding, Iron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_203795. DARPP-32 events.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC:3.1.3.16)
Alternative name(s):
CAM-PRP catalytic subunit
Calcineurin, testis-specific catalytic subunit
Calmodulin-dependent calcineurin A subunit gamma isoform
Gene namesi
Name:Ppp3cc
Synonyms:Calnc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:107162. Ppp3cc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
PRO_0000058829Add
BLAST

Proteomic databases

PaxDbiP48455.
PRIDEiP48455.

PTM databases

PhosphoSiteiP48455.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

ArrayExpressiP48455.
BgeeiP48455.
GenevestigatoriP48455.

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

Protein-protein interaction databases

BioGridi202346. 3 interactions.
IntActiP48455. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP48455.
SMRiP48455. Positions 11-368.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOVERGENiHBG002819.
InParanoidiP48455.
KOiK04348.
OMAiKINYPKT.
OrthoDBiEOG7BZVSC.
PhylomeDBiP48455.
TreeFamiTF105557.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48455-1 [UniParc]FASTAAdd to Basket

« Hide

MSVRRPQFST TERVIKAVPF PPTRRLTLKE VFENGKPKMD LLKNHLVKEG    50
RVEEEVALKI INDGAAILKQ EKTMIEVEAP ITVCGDVHGQ FFDLMKLFEV 100
GGSPSNTRYL FLGDYVDRGY FSIECVLYLW SLKINHPKTL FLLRGNHECR 150
HLTEYFTFKQ ECRIKYSEMV YDACMHTFDC LPLAALLNQQ FLCVHGGMSP 200
EITCLEDIRK LDRFSEPPAF GPVCDLLWSD PLEDYGSEKT LEHYTHNTVR 250
GCSYFFSYPA VCEFLQNNSL LSIIRAHEAQ DAGYRMYRKN QATGFPSLIT 300
IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL 350
PFVGEKVTEM LVNILNICSD EEMNVTDEEG ATTGRKEVIK NKIRAIGKMA 400
RVFTVLREES ENVLTLKGLT PTGTLPLGVL SGGKQTIETA KQEAAEEREA 450
IRGFTIAHRI RSFEEARGLD RINERMPPRK EASYHHDAGR MHSHSHPPHP 500
QASRRTDHGK KAL 513
Length:513
Mass (Da):58,699
Last modified:February 1, 1996 - v1
Checksum:i521CB2B1DD9E03A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81475 mRNA. Translation: AAA39968.1.
CCDSiCCDS36968.1.
PIRiA38193.
RefSeqiNP_032941.1. NM_008915.2.
UniGeneiMm.439683.

Genome annotation databases

EnsembliENSMUST00000078434; ENSMUSP00000077532; ENSMUSG00000022092.
GeneIDi19057.
KEGGimmu:19057.
UCSCiuc007unp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81475 mRNA. Translation: AAA39968.1 .
CCDSi CCDS36968.1.
PIRi A38193.
RefSeqi NP_032941.1. NM_008915.2.
UniGenei Mm.439683.

3D structure databases

ProteinModelPortali P48455.
SMRi P48455. Positions 11-368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202346. 3 interactions.
IntActi P48455. 1 interaction.

PTM databases

PhosphoSitei P48455.

Proteomic databases

PaxDbi P48455.
PRIDEi P48455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078434 ; ENSMUSP00000077532 ; ENSMUSG00000022092 .
GeneIDi 19057.
KEGGi mmu:19057.
UCSCi uc007unp.1. mouse.

Organism-specific databases

CTDi 5533.
MGIi MGI:107162. Ppp3cc.

Phylogenomic databases

eggNOGi COG0639.
HOVERGENi HBG002819.
InParanoidi P48455.
KOi K04348.
OMAi KINYPKT.
OrthoDBi EOG7BZVSC.
PhylomeDBi P48455.
TreeFami TF105557.

Enzyme and pathway databases

Reactomei REACT_203795. DARPP-32 events.

Miscellaneous databases

ChiTaRSi PPP3CC. mouse.
NextBioi 295550.
PROi P48455.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48455.
Bgeei P48455.
Genevestigatori P48455.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a calmodulin-dependent phosphatase from murine testis: identification of a developmentally expressed nonneural isoenzyme."
    Muramatsu T., Giri P.R., Higuchi S., Kincaid R.L.
    Proc. Natl. Acad. Sci. U.S.A. 89:529-533(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiPP2BC_MOUSE
AccessioniPrimary (citable) accession number: P48455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi