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P48455

- PP2BC_MOUSE

UniProt

P48455 - PP2BC_MOUSE

Protein

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Gene

Ppp3cc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 Fe3+ ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861IronBy similarity
    Metal bindingi88 – 881IronBy similarity
    Metal bindingi114 – 1141IronBy similarity
    Metal bindingi114 – 1141ZincBy similarity
    Metal bindingi146 – 1461ZincBy similarity
    Active sitei147 – 1471Proton donorBy similarity
    Metal bindingi195 – 1951ZincBy similarity
    Metal bindingi277 – 2771ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Calmodulin-binding, Iron, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_203795. DARPP-32 events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC:3.1.3.16)
    Alternative name(s):
    CAM-PRP catalytic subunit
    Calcineurin, testis-specific catalytic subunit
    Calmodulin-dependent calcineurin A subunit gamma isoform
    Gene namesi
    Name:Ppp3cc
    Synonyms:Calnc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:107162. Ppp3cc.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformPRO_0000058829Add
    BLAST

    Proteomic databases

    PaxDbiP48455.
    PRIDEiP48455.

    PTM databases

    PhosphoSiteiP48455.

    Expressioni

    Tissue specificityi

    Testis.

    Gene expression databases

    ArrayExpressiP48455.
    BgeeiP48455.
    GenevestigatoriP48455.

    Interactioni

    Subunit structurei

    Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

    Protein-protein interaction databases

    BioGridi202346. 3 interactions.
    IntActiP48455. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP48455.
    SMRiP48455. Positions 11-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOVERGENiHBG002819.
    InParanoidiP48455.
    KOiK04348.
    OMAiKINYPKT.
    OrthoDBiEOG7BZVSC.
    PhylomeDBiP48455.
    TreeFamiTF105557.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48455-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVRRPQFST TERVIKAVPF PPTRRLTLKE VFENGKPKMD LLKNHLVKEG    50
    RVEEEVALKI INDGAAILKQ EKTMIEVEAP ITVCGDVHGQ FFDLMKLFEV 100
    GGSPSNTRYL FLGDYVDRGY FSIECVLYLW SLKINHPKTL FLLRGNHECR 150
    HLTEYFTFKQ ECRIKYSEMV YDACMHTFDC LPLAALLNQQ FLCVHGGMSP 200
    EITCLEDIRK LDRFSEPPAF GPVCDLLWSD PLEDYGSEKT LEHYTHNTVR 250
    GCSYFFSYPA VCEFLQNNSL LSIIRAHEAQ DAGYRMYRKN QATGFPSLIT 300
    IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL 350
    PFVGEKVTEM LVNILNICSD EEMNVTDEEG ATTGRKEVIK NKIRAIGKMA 400
    RVFTVLREES ENVLTLKGLT PTGTLPLGVL SGGKQTIETA KQEAAEEREA 450
    IRGFTIAHRI RSFEEARGLD RINERMPPRK EASYHHDAGR MHSHSHPPHP 500
    QASRRTDHGK KAL 513
    Length:513
    Mass (Da):58,699
    Last modified:February 1, 1996 - v1
    Checksum:i521CB2B1DD9E03A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81475 mRNA. Translation: AAA39968.1.
    CCDSiCCDS36968.1.
    PIRiA38193.
    RefSeqiNP_032941.1. NM_008915.2.
    UniGeneiMm.439683.

    Genome annotation databases

    EnsembliENSMUST00000078434; ENSMUSP00000077532; ENSMUSG00000022092.
    GeneIDi19057.
    KEGGimmu:19057.
    UCSCiuc007unp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81475 mRNA. Translation: AAA39968.1 .
    CCDSi CCDS36968.1.
    PIRi A38193.
    RefSeqi NP_032941.1. NM_008915.2.
    UniGenei Mm.439683.

    3D structure databases

    ProteinModelPortali P48455.
    SMRi P48455. Positions 11-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202346. 3 interactions.
    IntActi P48455. 1 interaction.

    PTM databases

    PhosphoSitei P48455.

    Proteomic databases

    PaxDbi P48455.
    PRIDEi P48455.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078434 ; ENSMUSP00000077532 ; ENSMUSG00000022092 .
    GeneIDi 19057.
    KEGGi mmu:19057.
    UCSCi uc007unp.1. mouse.

    Organism-specific databases

    CTDi 5533.
    MGIi MGI:107162. Ppp3cc.

    Phylogenomic databases

    eggNOGi COG0639.
    HOVERGENi HBG002819.
    InParanoidi P48455.
    KOi K04348.
    OMAi KINYPKT.
    OrthoDBi EOG7BZVSC.
    PhylomeDBi P48455.
    TreeFami TF105557.

    Enzyme and pathway databases

    Reactomei REACT_203795. DARPP-32 events.

    Miscellaneous databases

    ChiTaRSi PPP3CC. mouse.
    NextBioi 295550.
    PROi P48455.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48455.
    Bgeei P48455.
    Genevestigatori P48455.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a calmodulin-dependent phosphatase from murine testis: identification of a developmentally expressed nonneural isoenzyme."
      Muramatsu T., Giri P.R., Higuchi S., Kincaid R.L.
      Proc. Natl. Acad. Sci. U.S.A. 89:529-533(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiPP2BC_MOUSE
    AccessioniPrimary (citable) accession number: P48455
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3