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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Gene

Ppp3cc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe3+By similarityNote: Binds 1 Fe3+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86IronBy similarity1
Metal bindingi88IronBy similarity1
Metal bindingi114IronBy similarity1
Metal bindingi114ZincBy similarity1
Metal bindingi146ZincBy similarity1
Active sitei147Proton donorBy similarity1
Metal bindingi195ZincBy similarity1
Metal bindingi277ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Hydrolase, Protein phosphatase
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-111447. Activation of BAD and translocation to mitochondria.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC:3.1.3.16)
Alternative name(s):
CAM-PRP catalytic subunit
Calcineurin, testis-specific catalytic subunit
Calmodulin-dependent calcineurin A subunit gamma isoform
Gene namesi
Name:Ppp3cc
Synonyms:Calnc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:107162. Ppp3cc.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588291 – 513Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformAdd BLAST513

Proteomic databases

EPDiP48455.
PaxDbiP48455.
PeptideAtlasiP48455.
PRIDEiP48455.

PTM databases

iPTMnetiP48455.
PhosphoSitePlusiP48455.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSMUSG00000022092.
ExpressionAtlasiP48455. baseline and differential.
GenevisibleiP48455. MM.

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202346. 3 interactors.
IntActiP48455. 1 interactor.
STRINGi10090.ENSMUSP00000077532.

Structurei

3D structure databases

ProteinModelPortaliP48455.
SMRiP48455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

eggNOGiKOG0375. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00530000063087.
HOVERGENiHBG002819.
InParanoidiP48455.
KOiK04348.
OMAiFSLQHKI.
OrthoDBiEOG091G094R.
PhylomeDBiP48455.
TreeFamiTF105557.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P48455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRRPQFST TERVIKAVPF PPTRRLTLKE VFENGKPKMD LLKNHLVKEG
60 70 80 90 100
RVEEEVALKI INDGAAILKQ EKTMIEVEAP ITVCGDVHGQ FFDLMKLFEV
110 120 130 140 150
GGSPSNTRYL FLGDYVDRGY FSIECVLYLW SLKINHPKTL FLLRGNHECR
160 170 180 190 200
HLTEYFTFKQ ECRIKYSEMV YDACMHTFDC LPLAALLNQQ FLCVHGGMSP
210 220 230 240 250
EITCLEDIRK LDRFSEPPAF GPVCDLLWSD PLEDYGSEKT LEHYTHNTVR
260 270 280 290 300
GCSYFFSYPA VCEFLQNNSL LSIIRAHEAQ DAGYRMYRKN QATGFPSLIT
310 320 330 340 350
IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL
360 370 380 390 400
PFVGEKVTEM LVNILNICSD EEMNVTDEEG ATTGRKEVIK NKIRAIGKMA
410 420 430 440 450
RVFTVLREES ENVLTLKGLT PTGTLPLGVL SGGKQTIETA KQEAAEEREA
460 470 480 490 500
IRGFTIAHRI RSFEEARGLD RINERMPPRK EASYHHDAGR MHSHSHPPHP
510
QASRRTDHGK KAL
Length:513
Mass (Da):58,699
Last modified:February 1, 1996 - v1
Checksum:i521CB2B1DD9E03A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81475 mRNA. Translation: AAA39968.1.
CCDSiCCDS36968.1.
PIRiA38193.
RefSeqiNP_032941.1. NM_008915.3.
UniGeneiMm.439683.

Genome annotation databases

EnsembliENSMUST00000078434; ENSMUSP00000077532; ENSMUSG00000022092.
GeneIDi19057.
KEGGimmu:19057.
UCSCiuc007unp.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPP2BC_MOUSE
AccessioniPrimary (citable) accession number: P48455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 7, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families