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P48454

- PP2BC_HUMAN

UniProt

P48454 - PP2BC_HUMAN

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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Gene
PPP3CC, CALNA3, CNA3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 1 Fe3+ ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron By similarity
Metal bindingi88 – 881Iron By similarity
Metal bindingi114 – 1141Iron By similarity
Metal bindingi114 – 1141Zinc By similarity
Metal bindingi146 – 1461Zinc By similarity
Active sitei147 – 1471Proton donor By similarity
Metal bindingi195 – 1951Zinc By similarity
Metal bindingi277 – 2771Zinc By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: Reactome
  2. intrinsic apoptotic signaling pathway Source: Reactome
  3. positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Calmodulin-binding, Iron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15334. DARPP-32 events.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC:3.1.3.16)
Alternative name(s):
CAM-PRP catalytic subunit
Calcineurin, testis-specific catalytic subunit
Calmodulin-dependent calcineurin A subunit gamma isoform
Gene namesi
Name:PPP3CC
Synonyms:CALNA3, CNA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:9316. PPP3CC.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformPRO_0000058828Add
BLAST

Proteomic databases

MaxQBiP48454.
PaxDbiP48454.
PRIDEiP48454.

PTM databases

PhosphoSiteiP48454.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

ArrayExpressiP48454.
BgeeiP48454.
CleanExiHS_PPP3CC.
GenevestigatoriP48454.

Organism-specific databases

HPAiCAB024950.
HPA023396.

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

Protein-protein interaction databases

BioGridi111525. 10 interactions.
IntActiP48454. 7 interactions.
STRINGi9606.ENSP00000240139.

Structurei

3D structure databases

ProteinModelPortaliP48454.
SMRiP48454. Positions 8-368.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172699.
HOVERGENiHBG002819.
KOiK04348.
OMAiKINYPKT.
PhylomeDBiP48454.
TreeFamiTF105557.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P48454-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGRRFHLST TDRVIKAVPF PPTQRLTFKE VFENGKPKVD VLKNHLVKEG    50
RLEEEVALKI INDGAAILRQ EKTMIEVDAP ITVCGDIHGQ FFDLMKLFEV 100
GGSPSNTRYL FLGDYVDRGY FSIECVLYLW SLKINHPKTL FLLRGNHECR 150
HLTDYFTFKQ ECRIKYSEQV YDACMETFDC LPLAALLNQQ FLCVHGGMSP 200
EITSLDDIRK LDRFTEPPAF GPVCDLLWSD PSEDYGNEKT LEHYTHNTVR 250
GCSYFYSYPA VCEFLQNNNL LSIIRAHEAQ DAGYRMYRKS QATGFPSLIT 300
IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL 350
PFVGEKVTEM LVNVLNICSD DELISDDEAE GSTTVRKEII RNKIRAIGKM 400
ARVFSILRQE SESVLTLKGL TPTGTLPLGV LSGGKQTIET ATVEAVEARE 450
AIRGFSLQHK IRSFEEARGL DRINERMPPR KDSIHAGGPM KSVTSAHSHA 500
AHRSDQGKKA HS 512
Length:512
Mass (Da):58,129
Last modified:September 1, 2009 - v3
Checksum:i1C3AA7996660D575
GO
Isoform 2 (identifier: P48454-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     442-451: Missing.

Show »
Length:502
Mass (Da):57,073
Checksum:i8ED89CC321A6DF0B
GO
Isoform 3 (identifier: P48454-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-380: E → EDHYIPSYQK

Show »
Length:521
Mass (Da):59,262
Checksum:iBC240A119202E701
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti501 – 5011A → V.
Corresponds to variant rs28764007 [ dbSNP | Ensembl ].
VAR_061758

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei380 – 3801E → EDHYIPSYQK in isoform 3. VSP_045211
Alternative sequencei442 – 45110Missing in isoform 2. VSP_037946

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti485 – 4862HA → YP in AAB23769. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S46622 mRNA. Translation: AAB23769.1.
AY007249 mRNA. Translation: AAG02563.1.
AK299415 mRNA. Translation: BAG61397.1.
AC037459 Genomic DNA. No translation available.
AC087854 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63677.1.
CH471080 Genomic DNA. Translation: EAW63679.1.
BC004864 mRNA. Translation: AAH04864.1.
CCDSiCCDS34859.1. [P48454-1]
CCDS59093.1. [P48454-3]
CCDS59094.1. [P48454-2]
PIRiJC1283.
RefSeqiNP_001230903.1. NM_001243974.1. [P48454-3]
NP_001230904.1. NM_001243975.1. [P48454-2]
NP_005596.2. NM_005605.4. [P48454-1]
UniGeneiHs.731683.

Genome annotation databases

EnsembliENST00000240139; ENSP00000240139; ENSG00000120910. [P48454-1]
ENST00000289963; ENSP00000289963; ENSG00000120910. [P48454-2]
ENST00000397775; ENSP00000380878; ENSG00000120910. [P48454-3]
GeneIDi5533.
KEGGihsa:5533.
UCSCiuc003xbs.3. human. [P48454-1]
uc003xbt.3. human. [P48454-2]
uc011kzi.2. human.

Polymorphism databases

DMDMi257051041.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S46622 mRNA. Translation: AAB23769.1 .
AY007249 mRNA. Translation: AAG02563.1 .
AK299415 mRNA. Translation: BAG61397.1 .
AC037459 Genomic DNA. No translation available.
AC087854 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63677.1 .
CH471080 Genomic DNA. Translation: EAW63679.1 .
BC004864 mRNA. Translation: AAH04864.1 .
CCDSi CCDS34859.1. [P48454-1 ]
CCDS59093.1. [P48454-3 ]
CCDS59094.1. [P48454-2 ]
PIRi JC1283.
RefSeqi NP_001230903.1. NM_001243974.1. [P48454-3 ]
NP_001230904.1. NM_001243975.1. [P48454-2 ]
NP_005596.2. NM_005605.4. [P48454-1 ]
UniGenei Hs.731683.

3D structure databases

ProteinModelPortali P48454.
SMRi P48454. Positions 8-368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111525. 10 interactions.
IntActi P48454. 7 interactions.
STRINGi 9606.ENSP00000240139.

Chemistry

BindingDBi P48454.

PTM databases

PhosphoSitei P48454.

Polymorphism databases

DMDMi 257051041.

Proteomic databases

MaxQBi P48454.
PaxDbi P48454.
PRIDEi P48454.

Protocols and materials databases

DNASUi 5533.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240139 ; ENSP00000240139 ; ENSG00000120910 . [P48454-1 ]
ENST00000289963 ; ENSP00000289963 ; ENSG00000120910 . [P48454-2 ]
ENST00000397775 ; ENSP00000380878 ; ENSG00000120910 . [P48454-3 ]
GeneIDi 5533.
KEGGi hsa:5533.
UCSCi uc003xbs.3. human. [P48454-1 ]
uc003xbt.3. human. [P48454-2 ]
uc011kzi.2. human.

Organism-specific databases

CTDi 5533.
GeneCardsi GC08P022298.
H-InvDB HIX0201288.
HGNCi HGNC:9316. PPP3CC.
HPAi CAB024950.
HPA023396.
MIMi 114107. gene.
neXtProti NX_P48454.
PharmGKBi PA33680.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172699.
HOVERGENi HBG002819.
KOi K04348.
OMAi KINYPKT.
PhylomeDBi P48454.
TreeFami TF105557.

Enzyme and pathway databases

Reactomei REACT_15334. DARPP-32 events.

Miscellaneous databases

ChiTaRSi PPP3CC. human.
GeneWikii PPP3CC.
GenomeRNAii 5533.
NextBioi 21434.
PROi P48454.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48454.
Bgeei P48454.
CleanExi HS_PPP3CC.
Genevestigatori P48454.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)."
    Muramatsu T., Kincaid R.L.
    Biochem. Biophys. Res. Commun. 188:265-271(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "Isoform specific expression of calcineurin in endothelial cells."
    Bako E., Aydonian A., Verin A.D., Garcia J.G.N.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Endothelial cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Tongue.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymphoma.

Entry informationi

Entry nameiPP2BC_HUMAN
AccessioniPrimary (citable) accession number: P48454
Secondary accession number(s): B4DRT5, Q9BSS6, Q9H4M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 1, 2009
Last modified: September 3, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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