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P48454

- PP2BC_HUMAN

UniProt

P48454 - PP2BC_HUMAN

Protein

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Gene

PPP3CC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 Fe3+ ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861IronBy similarity
    Metal bindingi88 – 881IronBy similarity
    Metal bindingi114 – 1141IronBy similarity
    Metal bindingi114 – 1141ZincBy similarity
    Metal bindingi146 – 1461ZincBy similarity
    Active sitei147 – 1471Proton donorBy similarity
    Metal bindingi195 – 1951ZincBy similarity
    Metal bindingi277 – 2771ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic process Source: Reactome
    2. intrinsic apoptotic signaling pathway Source: Reactome
    3. positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Calmodulin-binding, Iron, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_15334. DARPP-32 events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC:3.1.3.16)
    Alternative name(s):
    CAM-PRP catalytic subunit
    Calcineurin, testis-specific catalytic subunit
    Calmodulin-dependent calcineurin A subunit gamma isoform
    Gene namesi
    Name:PPP3CC
    Synonyms:CALNA3, CNA3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:9316. PPP3CC.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33680.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformPRO_0000058828Add
    BLAST

    Proteomic databases

    MaxQBiP48454.
    PaxDbiP48454.
    PRIDEiP48454.

    PTM databases

    PhosphoSiteiP48454.

    Expressioni

    Tissue specificityi

    Testis.

    Gene expression databases

    ArrayExpressiP48454.
    BgeeiP48454.
    CleanExiHS_PPP3CC.
    GenevestigatoriP48454.

    Organism-specific databases

    HPAiCAB024950.
    HPA023396.

    Interactioni

    Subunit structurei

    Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

    Protein-protein interaction databases

    BioGridi111525. 10 interactions.
    IntActiP48454. 7 interactions.
    STRINGi9606.ENSP00000240139.

    Structurei

    3D structure databases

    ProteinModelPortaliP48454.
    SMRiP48454. Positions 8-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172699.
    HOVERGENiHBG002819.
    KOiK04348.
    OMAiKINYPKT.
    PhylomeDBiP48454.
    TreeFamiTF105557.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P48454-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGRRFHLST TDRVIKAVPF PPTQRLTFKE VFENGKPKVD VLKNHLVKEG    50
    RLEEEVALKI INDGAAILRQ EKTMIEVDAP ITVCGDIHGQ FFDLMKLFEV 100
    GGSPSNTRYL FLGDYVDRGY FSIECVLYLW SLKINHPKTL FLLRGNHECR 150
    HLTDYFTFKQ ECRIKYSEQV YDACMETFDC LPLAALLNQQ FLCVHGGMSP 200
    EITSLDDIRK LDRFTEPPAF GPVCDLLWSD PSEDYGNEKT LEHYTHNTVR 250
    GCSYFYSYPA VCEFLQNNNL LSIIRAHEAQ DAGYRMYRKS QATGFPSLIT 300
    IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL 350
    PFVGEKVTEM LVNVLNICSD DELISDDEAE GSTTVRKEII RNKIRAIGKM 400
    ARVFSILRQE SESVLTLKGL TPTGTLPLGV LSGGKQTIET ATVEAVEARE 450
    AIRGFSLQHK IRSFEEARGL DRINERMPPR KDSIHAGGPM KSVTSAHSHA 500
    AHRSDQGKKA HS 512
    Length:512
    Mass (Da):58,129
    Last modified:September 1, 2009 - v3
    Checksum:i1C3AA7996660D575
    GO
    Isoform 2 (identifier: P48454-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         442-451: Missing.

    Show »
    Length:502
    Mass (Da):57,073
    Checksum:i8ED89CC321A6DF0B
    GO
    Isoform 3 (identifier: P48454-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         380-380: E → EDHYIPSYQK

    Show »
    Length:521
    Mass (Da):59,262
    Checksum:iBC240A119202E701
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti485 – 4862HA → YP in AAB23769. (PubMed:1339277)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti501 – 5011A → V.
    Corresponds to variant rs28764007 [ dbSNP | Ensembl ].
    VAR_061758

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei380 – 3801E → EDHYIPSYQK in isoform 3. 1 PublicationVSP_045211
    Alternative sequencei442 – 45110Missing in isoform 2. 2 PublicationsVSP_037946

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S46622 mRNA. Translation: AAB23769.1.
    AY007249 mRNA. Translation: AAG02563.1.
    AK299415 mRNA. Translation: BAG61397.1.
    AC037459 Genomic DNA. No translation available.
    AC087854 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63677.1.
    CH471080 Genomic DNA. Translation: EAW63679.1.
    BC004864 mRNA. Translation: AAH04864.1.
    CCDSiCCDS34859.1. [P48454-1]
    CCDS59093.1. [P48454-3]
    CCDS59094.1. [P48454-2]
    PIRiJC1283.
    RefSeqiNP_001230903.1. NM_001243974.1. [P48454-3]
    NP_001230904.1. NM_001243975.1. [P48454-2]
    NP_005596.2. NM_005605.4. [P48454-1]
    UniGeneiHs.731683.

    Genome annotation databases

    EnsembliENST00000240139; ENSP00000240139; ENSG00000120910. [P48454-1]
    ENST00000289963; ENSP00000289963; ENSG00000120910. [P48454-2]
    ENST00000397775; ENSP00000380878; ENSG00000120910. [P48454-3]
    GeneIDi5533.
    KEGGihsa:5533.
    UCSCiuc003xbs.3. human. [P48454-1]
    uc003xbt.3. human. [P48454-2]
    uc011kzi.2. human.

    Polymorphism databases

    DMDMi257051041.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S46622 mRNA. Translation: AAB23769.1 .
    AY007249 mRNA. Translation: AAG02563.1 .
    AK299415 mRNA. Translation: BAG61397.1 .
    AC037459 Genomic DNA. No translation available.
    AC087854 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63677.1 .
    CH471080 Genomic DNA. Translation: EAW63679.1 .
    BC004864 mRNA. Translation: AAH04864.1 .
    CCDSi CCDS34859.1. [P48454-1 ]
    CCDS59093.1. [P48454-3 ]
    CCDS59094.1. [P48454-2 ]
    PIRi JC1283.
    RefSeqi NP_001230903.1. NM_001243974.1. [P48454-3 ]
    NP_001230904.1. NM_001243975.1. [P48454-2 ]
    NP_005596.2. NM_005605.4. [P48454-1 ]
    UniGenei Hs.731683.

    3D structure databases

    ProteinModelPortali P48454.
    SMRi P48454. Positions 8-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111525. 10 interactions.
    IntActi P48454. 7 interactions.
    STRINGi 9606.ENSP00000240139.

    Chemistry

    BindingDBi P48454.

    PTM databases

    PhosphoSitei P48454.

    Polymorphism databases

    DMDMi 257051041.

    Proteomic databases

    MaxQBi P48454.
    PaxDbi P48454.
    PRIDEi P48454.

    Protocols and materials databases

    DNASUi 5533.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240139 ; ENSP00000240139 ; ENSG00000120910 . [P48454-1 ]
    ENST00000289963 ; ENSP00000289963 ; ENSG00000120910 . [P48454-2 ]
    ENST00000397775 ; ENSP00000380878 ; ENSG00000120910 . [P48454-3 ]
    GeneIDi 5533.
    KEGGi hsa:5533.
    UCSCi uc003xbs.3. human. [P48454-1 ]
    uc003xbt.3. human. [P48454-2 ]
    uc011kzi.2. human.

    Organism-specific databases

    CTDi 5533.
    GeneCardsi GC08P022298.
    H-InvDB HIX0201288.
    HGNCi HGNC:9316. PPP3CC.
    HPAi CAB024950.
    HPA023396.
    MIMi 114107. gene.
    neXtProti NX_P48454.
    PharmGKBi PA33680.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172699.
    HOVERGENi HBG002819.
    KOi K04348.
    OMAi KINYPKT.
    PhylomeDBi P48454.
    TreeFami TF105557.

    Enzyme and pathway databases

    Reactomei REACT_15334. DARPP-32 events.

    Miscellaneous databases

    ChiTaRSi PPP3CC. human.
    GeneWikii PPP3CC.
    GenomeRNAii 5533.
    NextBioi 21434.
    PROi P48454.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48454.
    Bgeei P48454.
    CleanExi HS_PPP3CC.
    Genevestigatori P48454.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)."
      Muramatsu T., Kincaid R.L.
      Biochem. Biophys. Res. Commun. 188:265-271(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "Isoform specific expression of calcineurin in endothelial cells."
      Bako E., Aydonian A., Verin A.D., Garcia J.G.N.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Endothelial cell.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Tongue.
    4. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymphoma.

    Entry informationi

    Entry nameiPP2BC_HUMAN
    AccessioniPrimary (citable) accession number: P48454
    Secondary accession number(s): B4DRT5, Q9BSS6, Q9H4M5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3