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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Gene

PPP3CC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe3+By similarityNote: Binds 1 Fe3+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86IronBy similarity1
Metal bindingi88IronBy similarity1
Metal bindingi114IronBy similarity1
Metal bindingi114ZincBy similarity1
Metal bindingi146ZincBy similarity1
Active sitei147Proton donorBy similarity1
Metal bindingi195ZincBy similarity1
Metal bindingi277ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Hydrolase, Protein phosphatase
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-180024 DARPP-32 events
SIGNORiP48454

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC:3.1.3.16)
Alternative name(s):
CAM-PRP catalytic subunit
Calcineurin, testis-specific catalytic subunit
Calmodulin-dependent calcineurin A subunit gamma isoform
Gene namesi
Name:PPP3CC
Synonyms:CALNA3, CNA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000120910.14
HGNCiHGNC:9316 PPP3CC
MIMi114107 gene
neXtProtiNX_P48454

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5533
OpenTargetsiENSG00000120910
PharmGKBiPA33680

Polymorphism and mutation databases

BioMutaiPPP3CC
DMDMi257051041

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588281 – 512Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei483PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP48454
MaxQBiP48454
PaxDbiP48454
PeptideAtlasiP48454
PRIDEiP48454

PTM databases

DEPODiP48454
iPTMnetiP48454
PhosphoSitePlusiP48454

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSG00000120910
CleanExiHS_PPP3CC
ExpressionAtlasiP48454 baseline and differential
GenevisibleiP48454 HS

Organism-specific databases

HPAiCAB024950
HPA023396

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

Binary interactionsi

WithEntry#Exp.IntActNotes
AMPHP494183EBI-2827192,EBI-7121510

GO - Molecular functioni

Protein-protein interaction databases

BioGridi11152543 interactors.
IntActiP48454 8 interactors.
STRINGi9606.ENSP00000240139

Structurei

3D structure databases

ProteinModelPortaliP48454
SMRiP48454
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

eggNOGiKOG0375 Eukaryota
COG0639 LUCA
GeneTreeiENSGT00530000063087
HOGENOMiHOG000172699
HOVERGENiHBG002819
InParanoidiP48454
KOiK04348
OMAiFSLQHKI
OrthoDBiEOG091G094R
PhylomeDBiP48454
TreeFamiTF105557

Family and domain databases

Gene3Di3.60.21.101 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P48454-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRRFHLST TDRVIKAVPF PPTQRLTFKE VFENGKPKVD VLKNHLVKEG
60 70 80 90 100
RLEEEVALKI INDGAAILRQ EKTMIEVDAP ITVCGDIHGQ FFDLMKLFEV
110 120 130 140 150
GGSPSNTRYL FLGDYVDRGY FSIECVLYLW SLKINHPKTL FLLRGNHECR
160 170 180 190 200
HLTDYFTFKQ ECRIKYSEQV YDACMETFDC LPLAALLNQQ FLCVHGGMSP
210 220 230 240 250
EITSLDDIRK LDRFTEPPAF GPVCDLLWSD PSEDYGNEKT LEHYTHNTVR
260 270 280 290 300
GCSYFYSYPA VCEFLQNNNL LSIIRAHEAQ DAGYRMYRKS QATGFPSLIT
310 320 330 340 350
IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL
360 370 380 390 400
PFVGEKVTEM LVNVLNICSD DELISDDEAE GSTTVRKEII RNKIRAIGKM
410 420 430 440 450
ARVFSILRQE SESVLTLKGL TPTGTLPLGV LSGGKQTIET ATVEAVEARE
460 470 480 490 500
AIRGFSLQHK IRSFEEARGL DRINERMPPR KDSIHAGGPM KSVTSAHSHA
510
AHRSDQGKKA HS
Length:512
Mass (Da):58,129
Last modified:September 1, 2009 - v3
Checksum:i1C3AA7996660D575
GO
Isoform 2 (identifier: P48454-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     442-451: Missing.

Show »
Length:502
Mass (Da):57,073
Checksum:i8ED89CC321A6DF0B
GO
Isoform 3 (identifier: P48454-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-380: E → EDHYIPSYQK

Show »
Length:521
Mass (Da):59,262
Checksum:iBC240A119202E701
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti485 – 486HA → YP in AAB23769 (PubMed:1339277).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061758501A → V. Corresponds to variant dbSNP:rs28764007Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045211380E → EDHYIPSYQK in isoform 3. 1 Publication1
Alternative sequenceiVSP_037946442 – 451Missing in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46622 mRNA Translation: AAB23769.1
AY007249 mRNA Translation: AAG02563.1
AK299415 mRNA Translation: BAG61397.1
AC037459 Genomic DNA No translation available.
AC087854 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63677.1
CH471080 Genomic DNA Translation: EAW63679.1
BC004864 mRNA Translation: AAH04864.1
CCDSiCCDS34859.1 [P48454-1]
CCDS59093.1 [P48454-3]
CCDS59094.1 [P48454-2]
PIRiJC1283
RefSeqiNP_001230903.1, NM_001243974.1 [P48454-3]
NP_001230904.1, NM_001243975.1 [P48454-2]
NP_005596.2, NM_005605.4 [P48454-1]
UniGeneiHs.731683

Genome annotation databases

EnsembliENST00000240139; ENSP00000240139; ENSG00000120910 [P48454-1]
ENST00000289963; ENSP00000289963; ENSG00000120910 [P48454-2]
ENST00000397775; ENSP00000380878; ENSG00000120910 [P48454-3]
GeneIDi5533
KEGGihsa:5533
UCSCiuc003xbs.4 human [P48454-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPP2BC_HUMAN
AccessioniPrimary (citable) accession number: P48454
Secondary accession number(s): B4DRT5, Q9BSS6, Q9H4M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 1, 2009
Last modified: April 25, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome