Reviewed,
UniProtKB/Swiss-Prot P48448 (AL3B2_HUMAN)
Last modified
November 25, 2008.
Version 81.
History...
Clusters with 100%,
90%,
50% identity |
Documents (7) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Aldehyde dehydrogenase family 3 member B2 EC=1.2.1.5 Alternative name(s): Aldehyde dehydrogenase 8 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 385 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H. |
| Pathway | Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. |
| Tissue specificity | Salivary gland. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | cellular alcohol metabolic process Ref.2 Traceable author statement. Source: ProtInc cellular aldehyde metabolic processInferred from electronic annotation. Source: InterPro lipid metabolic process Ref.2Traceable author statement. Source: ProtInc oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-chloroallyl aldehyde dehydrogenase activity Ref.2 Traceable author statement. Source: ProtInc aldehyde dehydrogenase [NAD(P)+] activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 385 | 385 | Aldehyde dehydrogenase family 3 member B2 | PRO_0000056484 | |||||
Regions | |||||||||
| Nucleotide binding | 107 – 112 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 129 | 1 | By similarity | ||||||
| Active site | 163 | 1 | By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 50 | 1 | A → T: dbSNP rs3741178. | VAR_022058 | |||||
Experimental info | |||||||||
| Sequence conflict | 2 | 1 | K → E in BAC03897. Ref.3 | ||||||
| Sequence conflict | 47 – 49 | 3 | ALA → TLP Ref.1 Ref.2 | ||||||
| Sequence conflict | 52 | 1 | N → S in AAH07685. Ref.4 | ||||||
| Sequence conflict | 132 | 1 | G → V in BAC03897. Ref.3 | ||||||
| Sequence conflict | 276 | 1 | R → W in AAH07685. Ref.4 | ||||||
| Sequence conflict | 290 | 1 | S → R Ref.1 Ref.2 | ||||||
| Sequence conflict | 361 | 1 | R → H in AAH07685. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes." Hsu L.C., Chang W.-C., Lin S.W., Yoshida A. Adv. Exp. Med. Biol. 372:159-168(1995) [PubMed: 7484374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Salivary gland. |
| [2] | "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family." Hsu L.C., Chang W.-C. Gene 174:319-322(1996) [PubMed: 8890755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Salivary gland. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
Cross-references
Sequence databases | |
|---|---|
| U37519 mRNA. Translation: AAA85441.1. AK092464 mRNA. Translation: BAC03897.1. BC007685 mRNA. Translation: AAH07685.1. | |
| PIR | JC5019. |
| RefSeq | NP_000686.2. NP_001026786.1. |
| UniGene | Hs.87539 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AD3 based on UniProtKB P11883. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P48448. |
Genome annotation databases | |
| Ensembl | ENSG00000132746. Homo sapiens. [Contig view] |
| GeneID | 222. |
| KEGG | hsa:222. |
Organism-specific databases | |
| HGNC | HGNC:411. ALDH3B2. |
| MIM | 601917. gene. |
| PharmGKB | PA24700. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P48448. |
| HOVERGEN | P48448. |
Gene expression databases | |
| ArrayExpress | P48448. |
| CleanEx | HS_ALDH3B2. |
| GermOnline | ENSG00000132746. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016163. Ald_DHase_C. IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR012394. Ald_DHase_NAD(P). IPR015590. Aldehyde_DHase. [Graphical view] |
| Gene3D | G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF15. ALDH. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00157. NADH. |
| NextBio | 900. |
| SOURCE | Search... |
Entry information
| Entry name | AL3B2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P48448 Secondary accession number(s): Q8NAL5, Q96IB2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


