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P48448

- AL3B2_HUMAN

UniProt

P48448 - AL3B2_HUMAN

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Protein
Aldehyde dehydrogenase family 3 member B2
Gene
ALDH3B2, ALDH8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291 By similarity
Active sitei163 – 1631 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1126NAD By similarity

GO - Molecular functioni

  1. 3-chloroallyl aldehyde dehydrogenase activity Source: ProtInc
  2. aldehyde dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

GO - Biological processi

  1. alcohol metabolic process Source: ProtInc
  2. ethanol catabolic process Source: UniProtKB-UniPathway
  3. lipid metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B2 (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 8
Gene namesi
Name:ALDH3B2
Synonyms:ALDH8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:411. ALDH3B2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Aldehyde dehydrogenase family 3 member B2
PRO_0000056484Add
BLAST

Proteomic databases

PaxDbiP48448.
PRIDEiP48448.

PTM databases

PhosphoSiteiP48448.

Expressioni

Tissue specificityi

Salivary gland.

Gene expression databases

ArrayExpressiP48448.
BgeeiP48448.
CleanExiHS_ALDH3B2.
GenevestigatoriP48448.

Organism-specific databases

HPAiHPA045132.

Interactioni

Protein-protein interaction databases

BioGridi106724. 1 interaction.
STRINGi9606.ENSP00000255084.

Structurei

3D structure databases

ProteinModelPortaliP48448.
SMRiP48448. Positions 3-364.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiP48448.
KOiK00129.
OMAiATCNDAF.
OrthoDBiEOG73RBB3.
PhylomeDBiP48448.
TreeFamiTF314264.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48448-1 [UniParc]FASTAAdd to Basket

« Hide

MKDEPRSTNL FMKLDSVFIW KEPFGLVLII APWNYPLNLT LVLLVGALAA    50
GSCVVLKPSE ISQGTEKVLA EVLPQYLDQS CFAVVLGGPQ ETGQLLEHKL 100
DYIFFTGSPR VGKIVMTAAT KHLTPVTLEL GGKNPCYVDD NCDPQTVANR 150
VAWFCYFNAG QTCVAPDYVL CSPEMQERLL PALQSTITRF YGDDPQSSPN 200
LGHIINQKQF QRLRALLGCS RVAIGGQSNE SDRYIAPTVL VDVQETEPVM 250
QEEIFGPILP IVNVQSVDEA IKFINRQEKP LALYAFSNSS QVVNQMLERT 300
SSGSFGGNEG FTYISLLSVP FGGVGHSGMG RYHGKFTFDT FSHHRTCLLA 350
PSGLEKLKEI HYPPYTDWNQ QLLRWGMGSQ SCTLL 385
Length:385
Mass (Da):42,635
Last modified:February 9, 2010 - v3
Checksum:i418879E834C3F9C6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501A → T.
Corresponds to variant rs3741178 [ dbSNP | Ensembl ].
VAR_022058
Natural varianti52 – 521S → N.3 Publications
Corresponds to variant rs1551888 [ dbSNP | Ensembl ].
VAR_058696
Natural varianti203 – 2031H → R.5 Publications
Corresponds to variant rs6591270 [ dbSNP | Ensembl ].
VAR_058697
Natural varianti220 – 2201S → G.5 Publications
Corresponds to variant rs2447571 [ dbSNP | Ensembl ].
VAR_058698
Natural varianti276 – 2761R → W.2 Publications
Corresponds to variant rs17856219 [ dbSNP | Ensembl ].
VAR_058699
Natural varianti302 – 3021S → R.
Corresponds to variant rs4646826 [ dbSNP | Ensembl ].
VAR_055699
Natural varianti361 – 3611H → R.3 Publications
Corresponds to variant rs1551886 [ dbSNP | Ensembl ].
VAR_058700

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21K → E in BAC03897. 1 Publication
Sequence conflicti47 – 493ALA → TLP in AAA85441. 1 Publication
Sequence conflicti47 – 493ALA → TLP no nucleotide entry 1 Publication
Sequence conflicti132 – 1321G → V in BAC03897. 1 Publication
Sequence conflicti290 – 2901S → R in AAA85441. 1 Publication
Sequence conflicti290 – 2901S → R no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37519 mRNA. Translation: AAA85441.1.
BT006810 mRNA. Translation: AAP35456.1.
AK092464 mRNA. Translation: BAC03897.1.
AP003385 mRNA. No translation available.
BC007685 mRNA. Translation: AAH07685.1.
CCDSiCCDS31622.1.
PIRiJC5019.
RefSeqiNP_000686.2. NM_000695.3.
NP_001026786.1. NM_001031615.1.
UniGeneiHs.87539.

Genome annotation databases

EnsembliENST00000349015; ENSP00000255084; ENSG00000132746.
ENST00000530069; ENSP00000431595; ENSG00000132746.
GeneIDi222.
KEGGihsa:222.
UCSCiuc001omr.3. human.

Polymorphism databases

DMDMi288558849.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37519 mRNA. Translation: AAA85441.1 .
BT006810 mRNA. Translation: AAP35456.1 .
AK092464 mRNA. Translation: BAC03897.1 .
AP003385 mRNA. No translation available.
BC007685 mRNA. Translation: AAH07685.1 .
CCDSi CCDS31622.1.
PIRi JC5019.
RefSeqi NP_000686.2. NM_000695.3.
NP_001026786.1. NM_001031615.1.
UniGenei Hs.87539.

3D structure databases

ProteinModelPortali P48448.
SMRi P48448. Positions 3-364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106724. 1 interaction.
STRINGi 9606.ENSP00000255084.

Chemistry

DrugBanki DB00157. NADH.

PTM databases

PhosphoSitei P48448.

Polymorphism databases

DMDMi 288558849.

Proteomic databases

PaxDbi P48448.
PRIDEi P48448.

Protocols and materials databases

DNASUi 222.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000349015 ; ENSP00000255084 ; ENSG00000132746 .
ENST00000530069 ; ENSP00000431595 ; ENSG00000132746 .
GeneIDi 222.
KEGGi hsa:222.
UCSCi uc001omr.3. human.

Organism-specific databases

CTDi 222.
GeneCardsi GC11M067429.
HGNCi HGNC:411. ALDH3B2.
HPAi HPA045132.
MIMi 601917. gene.
neXtProti NX_P48448.
PharmGKBi PA24700.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271515.
HOVERGENi HBG050483.
InParanoidi P48448.
KOi K00129.
OMAi ATCNDAF.
OrthoDBi EOG73RBB3.
PhylomeDBi P48448.
TreeFami TF314264.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Miscellaneous databases

GeneWikii ALDH3B2.
GenomeRNAii 222.
NextBioi 900.
PROi P48448.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48448.
Bgeei P48448.
CleanExi HS_ALDH3B2.
Genevestigatori P48448.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes."
    Hsu L.C., Chang W.-C., Lin S.W., Yoshida A.
    Adv. Exp. Med. Biol. 372:159-168(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-52; ARG-203; GLY-220 AND ARG-361.
    Tissue: Salivary gland.
  2. "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family."
    Hsu L.C., Chang W.-C.
    Gene 174:319-322(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-52; ARG-203; GLY-220 AND ARG-361.
    Tissue: Salivary gland.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-203; GLY-220 AND TRP-276.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-52; ARG-203; GLY-220 AND ARG-361.
    Tissue: Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-203; GLY-220 AND TRP-276.
    Tissue: Placenta.

Entry informationi

Entry nameiAL3B2_HUMAN
AccessioniPrimary (citable) accession number: P48448
Secondary accession number(s): Q53Y98, Q8NAL5, Q96IB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 9, 2010
Last modified: July 9, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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