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P48448

- AL3B2_HUMAN

UniProt

P48448 - AL3B2_HUMAN

Protein

Aldehyde dehydrogenase family 3 member B2

Gene

ALDH3B2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291By similarity
    Active sitei163 – 1631By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi107 – 1126NADBy similarity

    GO - Molecular functioni

    1. 3-chloroallyl aldehyde dehydrogenase activity Source: ProtInc
    2. aldehyde dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

    GO - Biological processi

    1. alcohol metabolic process Source: ProtInc
    2. ethanol catabolic process Source: UniProtKB-UniPathway
    3. lipid metabolic process Source: ProtInc

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 3 member B2 (EC:1.2.1.5)
    Alternative name(s):
    Aldehyde dehydrogenase 8
    Gene namesi
    Name:ALDH3B2
    Synonyms:ALDH8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:411. ALDH3B2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24700.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385Aldehyde dehydrogenase family 3 member B2PRO_0000056484Add
    BLAST

    Proteomic databases

    PaxDbiP48448.
    PRIDEiP48448.

    PTM databases

    PhosphoSiteiP48448.

    Expressioni

    Tissue specificityi

    Salivary gland.

    Gene expression databases

    ArrayExpressiP48448.
    BgeeiP48448.
    CleanExiHS_ALDH3B2.
    GenevestigatoriP48448.

    Organism-specific databases

    HPAiHPA045132.

    Interactioni

    Protein-protein interaction databases

    BioGridi106724. 1 interaction.
    STRINGi9606.ENSP00000255084.

    Structurei

    3D structure databases

    ProteinModelPortaliP48448.
    SMRiP48448. Positions 3-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271515.
    HOVERGENiHBG050483.
    InParanoidiP48448.
    KOiK00129.
    OMAiATCNDAF.
    OrthoDBiEOG73RBB3.
    PhylomeDBiP48448.
    TreeFamiTF314264.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48448-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDEPRSTNL FMKLDSVFIW KEPFGLVLII APWNYPLNLT LVLLVGALAA    50
    GSCVVLKPSE ISQGTEKVLA EVLPQYLDQS CFAVVLGGPQ ETGQLLEHKL 100
    DYIFFTGSPR VGKIVMTAAT KHLTPVTLEL GGKNPCYVDD NCDPQTVANR 150
    VAWFCYFNAG QTCVAPDYVL CSPEMQERLL PALQSTITRF YGDDPQSSPN 200
    LGHIINQKQF QRLRALLGCS RVAIGGQSNE SDRYIAPTVL VDVQETEPVM 250
    QEEIFGPILP IVNVQSVDEA IKFINRQEKP LALYAFSNSS QVVNQMLERT 300
    SSGSFGGNEG FTYISLLSVP FGGVGHSGMG RYHGKFTFDT FSHHRTCLLA 350
    PSGLEKLKEI HYPPYTDWNQ QLLRWGMGSQ SCTLL 385
    Length:385
    Mass (Da):42,635
    Last modified:February 9, 2010 - v3
    Checksum:i418879E834C3F9C6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21K → E in BAC03897. (PubMed:14702039)Curated
    Sequence conflicti47 – 493ALA → TLP in AAA85441. (PubMed:7484374)Curated
    Sequence conflicti47 – 493ALA → TLP no nucleotide entry (PubMed:8890755)Curated
    Sequence conflicti132 – 1321G → V in BAC03897. (PubMed:14702039)Curated
    Sequence conflicti290 – 2901S → R in AAA85441. (PubMed:7484374)Curated
    Sequence conflicti290 – 2901S → R no nucleotide entry (PubMed:8890755)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501A → T.
    Corresponds to variant rs3741178 [ dbSNP | Ensembl ].
    VAR_022058
    Natural varianti52 – 521S → N.3 Publications
    Corresponds to variant rs1551888 [ dbSNP | Ensembl ].
    VAR_058696
    Natural varianti203 – 2031H → R.5 Publications
    Corresponds to variant rs6591270 [ dbSNP | Ensembl ].
    VAR_058697
    Natural varianti220 – 2201S → G.5 Publications
    Corresponds to variant rs2447571 [ dbSNP | Ensembl ].
    VAR_058698
    Natural varianti276 – 2761R → W.2 Publications
    Corresponds to variant rs17856219 [ dbSNP | Ensembl ].
    VAR_058699
    Natural varianti302 – 3021S → R.
    Corresponds to variant rs4646826 [ dbSNP | Ensembl ].
    VAR_055699
    Natural varianti361 – 3611H → R.3 Publications
    Corresponds to variant rs1551886 [ dbSNP | Ensembl ].
    VAR_058700

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37519 mRNA. Translation: AAA85441.1.
    BT006810 mRNA. Translation: AAP35456.1.
    AK092464 mRNA. Translation: BAC03897.1.
    AP003385 mRNA. No translation available.
    BC007685 mRNA. Translation: AAH07685.1.
    CCDSiCCDS31622.1.
    PIRiJC5019.
    RefSeqiNP_000686.2. NM_000695.3.
    NP_001026786.1. NM_001031615.1.
    UniGeneiHs.87539.

    Genome annotation databases

    EnsembliENST00000349015; ENSP00000255084; ENSG00000132746.
    ENST00000530069; ENSP00000431595; ENSG00000132746.
    GeneIDi222.
    KEGGihsa:222.
    UCSCiuc001omr.3. human.

    Polymorphism databases

    DMDMi288558849.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37519 mRNA. Translation: AAA85441.1 .
    BT006810 mRNA. Translation: AAP35456.1 .
    AK092464 mRNA. Translation: BAC03897.1 .
    AP003385 mRNA. No translation available.
    BC007685 mRNA. Translation: AAH07685.1 .
    CCDSi CCDS31622.1.
    PIRi JC5019.
    RefSeqi NP_000686.2. NM_000695.3.
    NP_001026786.1. NM_001031615.1.
    UniGenei Hs.87539.

    3D structure databases

    ProteinModelPortali P48448.
    SMRi P48448. Positions 3-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106724. 1 interaction.
    STRINGi 9606.ENSP00000255084.

    Chemistry

    DrugBanki DB00157. NADH.

    PTM databases

    PhosphoSitei P48448.

    Polymorphism databases

    DMDMi 288558849.

    Proteomic databases

    PaxDbi P48448.
    PRIDEi P48448.

    Protocols and materials databases

    DNASUi 222.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349015 ; ENSP00000255084 ; ENSG00000132746 .
    ENST00000530069 ; ENSP00000431595 ; ENSG00000132746 .
    GeneIDi 222.
    KEGGi hsa:222.
    UCSCi uc001omr.3. human.

    Organism-specific databases

    CTDi 222.
    GeneCardsi GC11M067429.
    HGNCi HGNC:411. ALDH3B2.
    HPAi HPA045132.
    MIMi 601917. gene.
    neXtProti NX_P48448.
    PharmGKBi PA24700.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271515.
    HOVERGENi HBG050483.
    InParanoidi P48448.
    KOi K00129.
    OMAi ATCNDAF.
    OrthoDBi EOG73RBB3.
    PhylomeDBi P48448.
    TreeFami TF314264.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Miscellaneous databases

    GeneWikii ALDH3B2.
    GenomeRNAii 222.
    NextBioi 900.
    PROi P48448.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48448.
    Bgeei P48448.
    CleanExi HS_ALDH3B2.
    Genevestigatori P48448.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes."
      Hsu L.C., Chang W.-C., Lin S.W., Yoshida A.
      Adv. Exp. Med. Biol. 372:159-168(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-52; ARG-203; GLY-220 AND ARG-361.
      Tissue: Salivary gland.
    2. "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family."
      Hsu L.C., Chang W.-C.
      Gene 174:319-322(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-52; ARG-203; GLY-220 AND ARG-361.
      Tissue: Salivary gland.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-203; GLY-220 AND TRP-276.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-52; ARG-203; GLY-220 AND ARG-361.
      Tissue: Placenta.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-203; GLY-220 AND TRP-276.
      Tissue: Placenta.

    Entry informationi

    Entry nameiAL3B2_HUMAN
    AccessioniPrimary (citable) accession number: P48448
    Secondary accession number(s): Q53Y98, Q8NAL5, Q96IB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3