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Reviewed, UniProtKB/Swiss-Prot P48448 (AL3B2_HUMAN)

Last modified November 25, 2008. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Aldehyde dehydrogenase family 3 member B2
    EC=1.2.1.5
Alternative name(s):
    Aldehyde dehydrogenase 8
Gene names
Name: ALDH3B2
Synonyms: ALDH8
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Tissue specificity

Salivary gland.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385Aldehyde dehydrogenase family 3 member B2
PRO_0000056484

Regions

Nucleotide binding107 – 1126NAD By similarity

Sites

Active site1291 By similarity
Active site1631 By similarity

Natural variations

Natural variant501A → T: dbSNP rs3741178.
VAR_022058

Experimental info

Sequence conflict21K → E in BAC03897. Ref.3
Sequence conflict47 – 493ALA → TLP Ref.1 Ref.2
Sequence conflict521N → S in AAH07685. Ref.4
Sequence conflict1321G → V in BAC03897. Ref.3
Sequence conflict2761R → W in AAH07685. Ref.4
Sequence conflict2901S → R Ref.1 Ref.2
Sequence conflict3611R → H in AAH07685. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P48448-1 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: ED91203A6194B240

FASTA38542,670
        10         20         30         40         50         60 
MKDEPRSTNL FMKLDSVFIW KEPFGLVLII APWNYPLNLT LVLLVGALAA GNCVVLKPSE 

        70         80         90        100        110        120 
ISQGTEKVLA EVLPQYLDQS CFAVVLGGPQ ETGQLLEHKL DYIFFTGSPR VGKIVMTAAT 

       130        140        150        160        170        180 
KHLTPVTLEL GGKNPCYVDD NCDPQTVANR VAWFCYFNAG QTCVAPDYVL CSPEMQERLL 

       190        200        210        220        230        240 
PALQSTITRF YGDDPQSSPN LGRIINQKQF QRLRALLGCG RVAIGGQSNE SDRYIAPTVL 

       250        260        270        280        290        300 
VDVQETEPVM QEEIFGPILP IVNVQSVDEA IKFINRQEKP LALYAFSNSS QVVNQMLERT 

       310        320        330        340        350        360 
SSGSFGGNEG FTYISLLSVP FGGVGHSGMG RYHGKFTFDT FSHHRTCLLA PSGLEKLKEI 

       370        380 
RYPPYTDWNQ QLLRWGMGSQ SCTLL

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References

« Hide 'large scale' references
[1]"Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes."
Hsu L.C., Chang W.-C., Lin S.W., Yoshida A.
Adv. Exp. Med. Biol. 372:159-168(1995) [PubMed: 7484374] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Salivary gland.
[2]"Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family."
Hsu L.C., Chang W.-C.
Gene 174:319-322(1996) [PubMed: 8890755] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Salivary gland.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

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Cross-references

Sequence databases

U37519 mRNA. Translation: AAA85441.1.
AK092464 mRNA. Translation: BAC03897.1.
BC007685 mRNA. Translation: AAH07685.1.
PIRJC5019.
RefSeqNP_000686.2.
NP_001026786.1.
UniGeneHs.87539

3D structure databases

HSSPHSSP built from PDB template 1AD3 based on UniProtKB P11883.
ModBaseSearch...

PTM databases

PhosphoSiteP48448.

Genome annotation databases

EnsemblENSG00000132746. Homo sapiens. [Contig view]
GeneID222.
KEGGhsa:222.

Organism-specific databases

HGNCHGNC:411. ALDH3B2.
MIM601917. gene.
PharmGKBPA24700.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP48448.
HOVERGENP48448.

Gene expression databases

ArrayExpressP48448.
CleanExHS_ALDH3B2.
GermOnlineENSG00000132746. Homo sapiens.

Family and domain databases

InterProIPR016163. Ald_DHase_C.
IPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR012394. Ald_DHase_NAD(P).
IPR015590. Aldehyde_DHase.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PTHR11699:SF15. ALDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00157. NADH.
NextBio900.
SOURCESearch...

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Entry information

Entry nameAL3B2_HUMAN
AccessionPrimary (citable) accession number: P48448
Secondary accession number(s): Q8NAL5, Q96IB2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 7, 2005
Last modified: November 25, 2008
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents