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Protein

Aldehyde dehydrogenase family 3 member B2

Gene

ALDH3B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291By similarity
Active sitei163 – 1631By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1126NADBy similarity

GO - Molecular functioni

  1. 3-chloroallyl aldehyde dehydrogenase activity Source: ProtInc
  2. aldehyde dehydrogenase (NAD) activity Source: GO_Central
  3. aldehyde dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

GO - Biological processi

  1. alcohol metabolic process Source: ProtInc
  2. ethanol catabolic process Source: UniProtKB-UniPathway
  3. lipid metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B2 (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 8
Gene namesi
Name:ALDH3B2
Synonyms:ALDH8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:411. ALDH3B2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Aldehyde dehydrogenase family 3 member B2PRO_0000056484Add
BLAST

Proteomic databases

PaxDbiP48448.
PRIDEiP48448.

PTM databases

PhosphoSiteiP48448.

Expressioni

Tissue specificityi

Salivary gland.

Gene expression databases

BgeeiP48448.
CleanExiHS_ALDH3B2.
ExpressionAtlasiP48448. baseline and differential.
GenevestigatoriP48448.

Organism-specific databases

HPAiHPA045132.

Interactioni

Protein-protein interaction databases

BioGridi106724. 7 interactions.
STRINGi9606.ENSP00000255084.

Structurei

3D structure databases

ProteinModelPortaliP48448.
SMRiP48448. Positions 3-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiP48448.
KOiK00129.
OMAiDEPRSTN.
OrthoDBiEOG73RBB3.
PhylomeDBiP48448.
TreeFamiTF314264.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDEPRSTNL FMKLDSVFIW KEPFGLVLII APWNYPLNLT LVLLVGALAA
60 70 80 90 100
GSCVVLKPSE ISQGTEKVLA EVLPQYLDQS CFAVVLGGPQ ETGQLLEHKL
110 120 130 140 150
DYIFFTGSPR VGKIVMTAAT KHLTPVTLEL GGKNPCYVDD NCDPQTVANR
160 170 180 190 200
VAWFCYFNAG QTCVAPDYVL CSPEMQERLL PALQSTITRF YGDDPQSSPN
210 220 230 240 250
LGHIINQKQF QRLRALLGCS RVAIGGQSNE SDRYIAPTVL VDVQETEPVM
260 270 280 290 300
QEEIFGPILP IVNVQSVDEA IKFINRQEKP LALYAFSNSS QVVNQMLERT
310 320 330 340 350
SSGSFGGNEG FTYISLLSVP FGGVGHSGMG RYHGKFTFDT FSHHRTCLLA
360 370 380
PSGLEKLKEI HYPPYTDWNQ QLLRWGMGSQ SCTLL
Length:385
Mass (Da):42,635
Last modified:February 9, 2010 - v3
Checksum:i418879E834C3F9C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21K → E in BAC03897 (PubMed:14702039).Curated
Sequence conflicti47 – 493ALA → TLP in AAA85441 (PubMed:7484374).Curated
Sequence conflicti47 – 493ALA → TLP no nucleotide entry (PubMed:8890755).Curated
Sequence conflicti132 – 1321G → V in BAC03897 (PubMed:14702039).Curated
Sequence conflicti290 – 2901S → R in AAA85441 (PubMed:7484374).Curated
Sequence conflicti290 – 2901S → R no nucleotide entry (PubMed:8890755).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501A → T.
Corresponds to variant rs3741178 [ dbSNP | Ensembl ].
VAR_022058
Natural varianti52 – 521S → N.3 Publications
Corresponds to variant rs1551888 [ dbSNP | Ensembl ].
VAR_058696
Natural varianti203 – 2031H → R.5 Publications
Corresponds to variant rs6591270 [ dbSNP | Ensembl ].
VAR_058697
Natural varianti220 – 2201S → G.5 Publications
Corresponds to variant rs2447571 [ dbSNP | Ensembl ].
VAR_058698
Natural varianti276 – 2761R → W.2 Publications
Corresponds to variant rs17856219 [ dbSNP | Ensembl ].
VAR_058699
Natural varianti302 – 3021S → R.
Corresponds to variant rs4646826 [ dbSNP | Ensembl ].
VAR_055699
Natural varianti361 – 3611H → R.3 Publications
Corresponds to variant rs1551886 [ dbSNP | Ensembl ].
VAR_058700

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37519 mRNA. Translation: AAA85441.1.
BT006810 mRNA. Translation: AAP35456.1.
AK092464 mRNA. Translation: BAC03897.1.
AP003385 mRNA. No translation available.
BC007685 mRNA. Translation: AAH07685.1.
CCDSiCCDS31622.1.
PIRiJC5019.
RefSeqiNP_000686.2. NM_000695.3.
NP_001026786.1. NM_001031615.1.
UniGeneiHs.87539.

Genome annotation databases

EnsembliENST00000349015; ENSP00000255084; ENSG00000132746.
ENST00000530069; ENSP00000431595; ENSG00000132746.
GeneIDi222.
KEGGihsa:222.
UCSCiuc001omr.3. human.

Polymorphism databases

DMDMi288558849.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37519 mRNA. Translation: AAA85441.1.
BT006810 mRNA. Translation: AAP35456.1.
AK092464 mRNA. Translation: BAC03897.1.
AP003385 mRNA. No translation available.
BC007685 mRNA. Translation: AAH07685.1.
CCDSiCCDS31622.1.
PIRiJC5019.
RefSeqiNP_000686.2. NM_000695.3.
NP_001026786.1. NM_001031615.1.
UniGeneiHs.87539.

3D structure databases

ProteinModelPortaliP48448.
SMRiP48448. Positions 3-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106724. 7 interactions.
STRINGi9606.ENSP00000255084.

PTM databases

PhosphoSiteiP48448.

Polymorphism databases

DMDMi288558849.

Proteomic databases

PaxDbiP48448.
PRIDEiP48448.

Protocols and materials databases

DNASUi222.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349015; ENSP00000255084; ENSG00000132746.
ENST00000530069; ENSP00000431595; ENSG00000132746.
GeneIDi222.
KEGGihsa:222.
UCSCiuc001omr.3. human.

Organism-specific databases

CTDi222.
GeneCardsiGC11M067429.
HGNCiHGNC:411. ALDH3B2.
HPAiHPA045132.
MIMi601917. gene.
neXtProtiNX_P48448.
PharmGKBiPA24700.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiP48448.
KOiK00129.
OMAiDEPRSTN.
OrthoDBiEOG73RBB3.
PhylomeDBiP48448.
TreeFamiTF314264.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Miscellaneous databases

ChiTaRSiALDH3B2. human.
GeneWikiiALDH3B2.
GenomeRNAii222.
NextBioi900.
PROiP48448.
SOURCEiSearch...

Gene expression databases

BgeeiP48448.
CleanExiHS_ALDH3B2.
ExpressionAtlasiP48448. baseline and differential.
GenevestigatoriP48448.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes."
    Hsu L.C., Chang W.-C., Lin S.W., Yoshida A.
    Adv. Exp. Med. Biol. 372:159-168(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-52; ARG-203; GLY-220 AND ARG-361.
    Tissue: Salivary gland.
  2. "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family."
    Hsu L.C., Chang W.-C.
    Gene 174:319-322(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-52; ARG-203; GLY-220 AND ARG-361.
    Tissue: Salivary gland.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-203; GLY-220 AND TRP-276.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-52; ARG-203; GLY-220 AND ARG-361.
    Tissue: Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-203; GLY-220 AND TRP-276.
    Tissue: Placenta.

Entry informationi

Entry nameiAL3B2_HUMAN
AccessioniPrimary (citable) accession number: P48448
Secondary accession number(s): Q53Y98, Q8NAL5, Q96IB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 9, 2010
Last modified: February 4, 2015
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.