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Protein

Aldehyde dehydrogenase family 3 member B2

Gene

ALDH3B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Oxidizes medium and long chain aldehydes into non-toxic fatty acids.By similarity

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, mitochondrial (ALDH2), Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), Aldehyde dehydrogenase family 3 member B1 (ALDH3B1), Aldehyde dehydrogenase family 3 member B2 (ALDH3B2)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129By similarity1
Active sitei163By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi107 – 112NADBy similarity6

GO - Molecular functioni

GO - Biological processi

  • alcohol metabolic process Source: ProtInc
  • ethanol catabolic process Source: UniProtKB-UniPathway
  • lipid metabolic process Source: ProtInc
  • sphingolipid biosynthetic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciZFISH:HS05686-MONOMER.
ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B2 (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 8
Gene namesi
Name:ALDH3B2
Synonyms:ALDH8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:411. ALDH3B2.

Subcellular locationi

  • Lipid droplet By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet

Pathology & Biotechi

Organism-specific databases

DisGeNETi222.
OpenTargetsiENSG00000132746.
PharmGKBiPA24700.

Chemistry databases

ChEMBLiCHEMBL3542434.

Polymorphism and mutation databases

BioMutaiALDH3B2.
DMDMi288558849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564841 – 385Aldehyde dehydrogenase family 3 member B2Add BLAST385
PropeptideiPRO_0000436532383 – 385Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei382Cysteine methyl esterBy similarity1
Lipidationi382S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Geranylgeranylation is important for localization to lipid droplets and enzyme activity.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP48448.
PaxDbiP48448.
PeptideAtlasiP48448.
PRIDEiP48448.

PTM databases

iPTMnetiP48448.
PhosphoSitePlusiP48448.

Expressioni

Tissue specificityi

Salivary gland.

Gene expression databases

BgeeiENSG00000132746.
CleanExiHS_ALDH3B2.
ExpressionAtlasiP48448. baseline and differential.
GenevisibleiP48448. HS.

Organism-specific databases

HPAiHPA045132.

Interactioni

Protein-protein interaction databases

BioGridi106724. 6 interactors.
STRINGi9606.ENSP00000255084.

Structurei

3D structure databases

ProteinModelPortaliP48448.
SMRiP48448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiP48448.
KOiK00129.
OMAiATCNDAF.
OrthoDBiEOG091G05HC.
PhylomeDBiP48448.
TreeFamiTF314264.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDEPRSTNL FMKLDSVFIW KEPFGLVLII APWNYPLNLT LVLLVGALAA
60 70 80 90 100
GSCVVLKPSE ISQGTEKVLA EVLPQYLDQS CFAVVLGGPQ ETGQLLEHKL
110 120 130 140 150
DYIFFTGSPR VGKIVMTAAT KHLTPVTLEL GGKNPCYVDD NCDPQTVANR
160 170 180 190 200
VAWFCYFNAG QTCVAPDYVL CSPEMQERLL PALQSTITRF YGDDPQSSPN
210 220 230 240 250
LGHIINQKQF QRLRALLGCS RVAIGGQSNE SDRYIAPTVL VDVQETEPVM
260 270 280 290 300
QEEIFGPILP IVNVQSVDEA IKFINRQEKP LALYAFSNSS QVVNQMLERT
310 320 330 340 350
SSGSFGGNEG FTYISLLSVP FGGVGHSGMG RYHGKFTFDT FSHHRTCLLA
360 370 380
PSGLEKLKEI HYPPYTDWNQ QLLRWGMGSQ SCTLL
Length:385
Mass (Da):42,635
Last modified:February 9, 2010 - v3
Checksum:i418879E834C3F9C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2K → E in BAC03897 (PubMed:14702039).Curated1
Sequence conflicti47 – 49ALA → TLP in AAA85441 (PubMed:7484374).Curated3
Sequence conflicti47 – 49ALA → TLP no nucleotide entry (PubMed:8890755).Curated3
Sequence conflicti132G → V in BAC03897 (PubMed:14702039).Curated1
Sequence conflicti290S → R in AAA85441 (PubMed:7484374).Curated1
Sequence conflicti290S → R no nucleotide entry (PubMed:8890755).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02205850A → T.Corresponds to variant rs3741178dbSNPEnsembl.1
Natural variantiVAR_05869652S → N.3 PublicationsCorresponds to variant rs1551888dbSNPEnsembl.1
Natural variantiVAR_058697203H → R.5 PublicationsCorresponds to variant rs6591270dbSNPEnsembl.1
Natural variantiVAR_058698220S → G.5 PublicationsCorresponds to variant rs2447571dbSNPEnsembl.1
Natural variantiVAR_058699276R → W.2 PublicationsCorresponds to variant rs17856219dbSNPEnsembl.1
Natural variantiVAR_055699302S → R.Corresponds to variant rs4646826dbSNPEnsembl.1
Natural variantiVAR_058700361H → R.3 PublicationsCorresponds to variant rs1551886dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37519 mRNA. Translation: AAA85441.1.
BT006810 mRNA. Translation: AAP35456.1.
AK092464 mRNA. Translation: BAC03897.1.
AP003385 mRNA. No translation available.
BC007685 mRNA. Translation: AAH07685.1.
CCDSiCCDS31622.1.
PIRiJC5019.
RefSeqiNP_000686.2. NM_000695.3.
NP_001026786.1. NM_001031615.1.
UniGeneiHs.87539.

Genome annotation databases

EnsembliENST00000349015; ENSP00000255084; ENSG00000132746.
ENST00000530069; ENSP00000431595; ENSG00000132746.
GeneIDi222.
KEGGihsa:222.
UCSCiuc001omr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37519 mRNA. Translation: AAA85441.1.
BT006810 mRNA. Translation: AAP35456.1.
AK092464 mRNA. Translation: BAC03897.1.
AP003385 mRNA. No translation available.
BC007685 mRNA. Translation: AAH07685.1.
CCDSiCCDS31622.1.
PIRiJC5019.
RefSeqiNP_000686.2. NM_000695.3.
NP_001026786.1. NM_001031615.1.
UniGeneiHs.87539.

3D structure databases

ProteinModelPortaliP48448.
SMRiP48448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106724. 6 interactors.
STRINGi9606.ENSP00000255084.

Chemistry databases

ChEMBLiCHEMBL3542434.

PTM databases

iPTMnetiP48448.
PhosphoSitePlusiP48448.

Polymorphism and mutation databases

BioMutaiALDH3B2.
DMDMi288558849.

Proteomic databases

MaxQBiP48448.
PaxDbiP48448.
PeptideAtlasiP48448.
PRIDEiP48448.

Protocols and materials databases

DNASUi222.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349015; ENSP00000255084; ENSG00000132746.
ENST00000530069; ENSP00000431595; ENSG00000132746.
GeneIDi222.
KEGGihsa:222.
UCSCiuc001omr.4. human.

Organism-specific databases

CTDi222.
DisGeNETi222.
GeneCardsiALDH3B2.
HGNCiHGNC:411. ALDH3B2.
HPAiHPA045132.
MIMi601917. gene.
neXtProtiNX_P48448.
OpenTargetsiENSG00000132746.
PharmGKBiPA24700.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiP48448.
KOiK00129.
OMAiATCNDAF.
OrthoDBiEOG091G05HC.
PhylomeDBiP48448.
TreeFamiTF314264.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
BioCyciZFISH:HS05686-MONOMER.
ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSiALDH3B2. human.
GeneWikiiALDH3B2.
GenomeRNAii222.
PROiP48448.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132746.
CleanExiHS_ALDH3B2.
ExpressionAtlasiP48448. baseline and differential.
GenevisibleiP48448. HS.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL3B2_HUMAN
AccessioniPrimary (citable) accession number: P48448
Secondary accession number(s): Q53Y98, Q8NAL5, Q96IB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 9, 2010
Last modified: November 2, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.