Reviewed, UniProtKB/Swiss-Prot P48444 (COPD_HUMAN)

Names and origin

Protein names

Recommended name:
    Coatomer subunit delta
Alternative name(s):
    Delta-coat protein
      Short name=Delta-COP
      Short name=Archain

Gene names

Name:	ARCN1
Synonyms:	COPD

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.
Subunit structure	Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
Subcellular location	Cytoplasm By similarity. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesicle › COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it By similarity.
Tissue specificity	Ubiquitously expressed.
Sequence similarities	Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily. Contains 1 MHD (mu homology) domain.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Cytoplasm Cytoplasmic vesicle Golgi apparatus Membrane
Coding sequence diversity	Polymorphism
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	COPI coating of Golgi vesicle Inferred from Experiment. Source: Reactome intracellular protein transport Ref.1 Traceable author statement. Source: ProtInc retrograde vesicle-mediated transport, Golgi to ER Inferred from Experiment. Source: Reactome
Cellular component	COPI vesicle coat Inferred from sequence or structural similarity. Source: UniProtKB clathrin adaptor complex Inferred from electronic annotation. Source: InterPro cytosol Inferred from Experiment. Source: Reactome
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Coatomer subunit delta		PRO_0000193841
Regions
	Domain	268 – 511	244	MHD
Amino acid modifications
	Modified residue	233	1	N6-acetyllysine Ref.4
	Modified residue	309	1	N6-acetyllysine Ref.4
Natural variations
	Natural variant	186	1	F → L: dbSNP rs682327.		VAR_011788
	Natural variant	309	1	K → N: dbSNP rs1063124.		VAR_011789

Sequences

	Sequence		Length	Mass (Da)
	P48444-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 4ED1F7D2D12A7F75	FASTA	511	57,210
	10 20 30 40 50 60 MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE TESVRYVYQP 70 80 90 100 110 120 MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN EISEHCFDLI FAFDEIVALG 130 140 150 160 170 180 YRENVNLAQI RTFTEMDSHE EKVFRAVRET QEREAKAEMR RKAKELQQAR RDAERQGKKA 190 200 210 220 230 240 PGFGGFGSSA VSGGSTAAMI TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD 250 260 270 280 290 300 KLKSEGETIM SSSMGKRTSE ATKMHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM 310 320 330 340 350 360 IMLRISDDKY GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE KSFPVNSDVG 370 380 390 400 410 420 VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED NLELNDVVIT IPLPSGVGAP 430 440 450 460 470 480 VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK SGSLEFSIAG QPNDFFPVQV SFVSKKNYCN 490 500 510 IQVTKVTQVD GNSPVRFSTE TTFLVDKYEI L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila." Radice P., Pensotti V., Jones C., Perry H., Pierotti M.A., Tunnacliffe A. Genomics 26:101-106(1995) [PubMed: 7782067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-233 AND LYS-309, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X81197 mRNA. Translation: CAA57071.1. X81198 mRNA. Translation: CAA57072.1. Different initiation. BC093636 mRNA. Translation: AAH93636.1. BC093638 mRNA. Translation: AAH93638.1.
IPI	IPI00514053.
PIR	A56750.
RefSeq	NP_001135753.1. NP_001646.2.
UniGene	Hs.33642
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P48444. 3 interactions.
STRING	P48444.
PTM databases
PhosphoSite	P48444.
2-D gel databases
OGP	P48444.
Proteomic databases
PRIDE	P48444.
Genome annotation databases
Ensembl	ENST00000264028; ENSP00000264028; ENSG00000095139; Homo sapiens. [Genome view]
GeneID	372.
KEGG	hsa:372.
UCSC	uc001ptq.1. human.
Organism-specific databases
CTD	372.
GeneCards	GC11P117948.
HGNC	HGNC:649. ARCN1.
MIM	600820. gene.
PharmGKB	PA24931.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P48444.
Enzyme and pathway databases
Reactome	REACT_11123. Membrane Trafficking.
Gene expression databases
ArrayExpress	P48444.
Bgee	P48444.
CleanEx	HS_ARCN1.
Genevestigator	P48444.
GermOnline	ENSG00000095139. Homo sapiens.
Family and domain databases
InterPro	IPR008968. Clathrin_mu_C. IPR011012. Longin-like. [Graphical view]
Pfam	PF00928. Adap_comp_sub. 1 hit. [Graphical view]
PROSITE	PS51072. MHD. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	1553.
SOURCE	Search...

Entry information

Entry name

COPD_HUMAN

Accession

Primary (citable) accession number: P48444
Secondary accession number(s): Q52M80

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 24, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.