Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P48444

- COPD_HUMAN

UniProt

P48444 - COPD_HUMAN

Protein

Coatomer subunit delta

Gene

ARCN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. cerebellar Purkinje cell layer maturation Source: Ensembl
    3. COPI coating of Golgi vesicle Source: Reactome
    4. intracellular protein transport Source: ProtInc
    5. membrane organization Source: Reactome
    6. pigmentation Source: Ensembl
    7. retrograde vesicle-mediated transport, Golgi to ER Source: Reactome

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_11096. COPI Mediated Transport.
    SignaLinkiP48444.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coatomer subunit delta
    Alternative name(s):
    Archain
    Delta-coat protein
    Short name:
    Delta-COP
    Gene namesi
    Name:ARCN1
    Synonyms:COPD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:649. ARCN1.

    Subcellular locationi

    Cytoplasm By similarity. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.By similarity

    GO - Cellular componenti

    1. clathrin adaptor complex Source: InterPro
    2. COPI vesicle coat Source: UniProtKB
    3. cytoplasm Source: HPA
    4. cytosol Source: Reactome
    5. endoplasmic reticulum Source: Ensembl
    6. Golgi apparatus Source: HPA
    7. intracellular membrane-bounded organelle Source: HPA
    8. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24931.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Coatomer subunit deltaPRO_0000193841Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei233 – 2331N6-acetyllysine1 Publication
    Modified residuei241 – 2411N6-acetyllysineBy similarity
    Modified residuei309 – 3091N6-acetyllysine1 Publication
    Modified residuei351 – 3511N6-acetyllysineBy similarity
    Modified residuei493 – 4931Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP48444.
    PaxDbiP48444.
    PRIDEiP48444.

    2D gel databases

    OGPiP48444.

    PTM databases

    PhosphoSiteiP48444.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.

    Gene expression databases

    ArrayExpressiP48444.
    BgeeiP48444.
    CleanExiHS_ARCN1.
    GenevestigatoriP48444.

    Organism-specific databases

    HPAiHPA037573.
    HPA044874.

    Interactioni

    Subunit structurei

    Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

    Protein-protein interaction databases

    BioGridi106867. 21 interactions.
    DIPiDIP-50375N.
    IntActiP48444. 13 interactions.
    MINTiMINT-3016718.
    STRINGi9606.ENSP00000264028.

    Structurei

    3D structure databases

    ProteinModelPortaliP48444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini271 – 511241MHDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG309668.
    HOGENOMiHOG000203984.
    HOVERGENiHBG005381.
    PhylomeDBiP48444.
    TreeFamiTF105760.

    Family and domain databases

    InterProiIPR022775. AP_mu_sigma_su.
    IPR008968. Clathrin_mu_C.
    IPR027059. Coatomer_dsu.
    IPR011012. Longin-like_dom.
    IPR028565. MHD.
    [Graphical view]
    PANTHERiPTHR10121. PTHR10121. 1 hit.
    PfamiPF00928. Adap_comp_sub. 1 hit.
    PF01217. Clat_adaptor_s. 1 hit.
    [Graphical view]
    SUPFAMiSSF49447. SSF49447. 1 hit.
    SSF64356. SSF64356. 1 hit.
    PROSITEiPS51072. MHD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P48444-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE    50
    TESVRYVYQP MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN 100
    EISEHCFDLI FAFDEIVALG YRENVNLAQI RTFTEMDSHE EKVFRAVRET 150
    QEREAKAEMR RKAKELQQAR RDAERQGKKA PGFGGFGSSA VSGGSTAAMI 200
    TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD KLKSEGETIM 250
    SSSMGKRTSE ATKMHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM 300
    IMLRISDDKY GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE 350
    KSFPVNSDVG VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED 400
    NLELNDVVIT IPLPSGVGAP VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK 450
    SGSLEFSIAG QPNDFFPVQV SFVSKKNYCN IQVTKVTQVD GNSPVRFSTE 500
    TTFLVDKYEI L 511
    Length:511
    Mass (Da):57,210
    Last modified:February 1, 1996 - v1
    Checksum:i4ED1F7D2D12A7F75
    GO
    Isoform 2 (identifier: P48444-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-89: MVLLAAAVCT...LETLRLFSRV → M

    Note: No experimental confirmation available.

    Show »
    Length:423
    Mass (Da):47,205
    Checksum:iD3688717D77E2AD2
    GO

    Sequence cautioni

    The sequence CAA57072.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti387 – 3871N → D in BAG64934. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti186 – 1861F → L.
    Corresponds to variant rs682327 [ dbSNP | Ensembl ].
    VAR_011788
    Natural varianti309 – 3091K → N.
    Corresponds to variant rs1063124 [ dbSNP | Ensembl ].
    VAR_011789

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8989MVLLA…LFSRV → M in isoform 2. 1 PublicationVSP_045636Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81197 mRNA. Translation: CAA57071.1.
    X81198 mRNA. Translation: CAA57072.1. Different initiation.
    AK304019 mRNA. Translation: BAG64934.1.
    AP000941 Genomic DNA. No translation available.
    BC093636 mRNA. Translation: AAH93636.1.
    BC093638 mRNA. Translation: AAH93638.1.
    CCDSiCCDS44749.1. [P48444-2]
    CCDS8400.1. [P48444-1]
    PIRiA56750.
    RefSeqiNP_001135753.1. NM_001142281.1. [P48444-2]
    NP_001646.2. NM_001655.4. [P48444-1]
    UniGeneiHs.33642.

    Genome annotation databases

    EnsembliENST00000264028; ENSP00000264028; ENSG00000095139. [P48444-1]
    ENST00000392859; ENSP00000376599; ENSG00000095139. [P48444-2]
    GeneIDi372.
    KEGGihsa:372.
    UCSCiuc001ptq.3. human. [P48444-1]

    Polymorphism databases

    DMDMi1351970.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81197 mRNA. Translation: CAA57071.1 .
    X81198 mRNA. Translation: CAA57072.1 . Different initiation.
    AK304019 mRNA. Translation: BAG64934.1 .
    AP000941 Genomic DNA. No translation available.
    BC093636 mRNA. Translation: AAH93636.1 .
    BC093638 mRNA. Translation: AAH93638.1 .
    CCDSi CCDS44749.1. [P48444-2 ]
    CCDS8400.1. [P48444-1 ]
    PIRi A56750.
    RefSeqi NP_001135753.1. NM_001142281.1. [P48444-2 ]
    NP_001646.2. NM_001655.4. [P48444-1 ]
    UniGenei Hs.33642.

    3D structure databases

    ProteinModelPortali P48444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106867. 21 interactions.
    DIPi DIP-50375N.
    IntActi P48444. 13 interactions.
    MINTi MINT-3016718.
    STRINGi 9606.ENSP00000264028.

    PTM databases

    PhosphoSitei P48444.

    Polymorphism databases

    DMDMi 1351970.

    2D gel databases

    OGPi P48444.

    Proteomic databases

    MaxQBi P48444.
    PaxDbi P48444.
    PRIDEi P48444.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264028 ; ENSP00000264028 ; ENSG00000095139 . [P48444-1 ]
    ENST00000392859 ; ENSP00000376599 ; ENSG00000095139 . [P48444-2 ]
    GeneIDi 372.
    KEGGi hsa:372.
    UCSCi uc001ptq.3. human. [P48444-1 ]

    Organism-specific databases

    CTDi 372.
    GeneCardsi GC11P118444.
    HGNCi HGNC:649. ARCN1.
    HPAi HPA037573.
    HPA044874.
    MIMi 600820. gene.
    neXtProti NX_P48444.
    PharmGKBi PA24931.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309668.
    HOGENOMi HOG000203984.
    HOVERGENi HBG005381.
    PhylomeDBi P48444.
    TreeFami TF105760.

    Enzyme and pathway databases

    Reactomei REACT_11096. COPI Mediated Transport.
    SignaLinki P48444.

    Miscellaneous databases

    ChiTaRSi ARCN1. human.
    GenomeRNAii 372.
    NextBioi 1553.
    PROi P48444.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48444.
    Bgeei P48444.
    CleanExi HS_ARCN1.
    Genevestigatori P48444.

    Family and domain databases

    InterProi IPR022775. AP_mu_sigma_su.
    IPR008968. Clathrin_mu_C.
    IPR027059. Coatomer_dsu.
    IPR011012. Longin-like_dom.
    IPR028565. MHD.
    [Graphical view ]
    PANTHERi PTHR10121. PTHR10121. 1 hit.
    Pfami PF00928. Adap_comp_sub. 1 hit.
    PF01217. Clat_adaptor_s. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49447. SSF49447. 1 hit.
    SSF64356. SSF64356. 1 hit.
    PROSITEi PS51072. MHD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila."
      Radice P., Pensotti V., Jones C., Perry H., Pierotti M.A., Tunnacliffe A.
      Genomics 26:101-106(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-233 AND LYS-309, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOPD_HUMAN
    AccessioniPrimary (citable) accession number: P48444
    Secondary accession number(s): B4E1X2, E9PEU4, Q52M80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3