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P48444

- COPD_HUMAN

UniProt

P48444 - COPD_HUMAN

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Protein

Coatomer subunit delta

Gene
ARCN1, COPD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. cerebellar Purkinje cell layer maturation Source: Ensembl
  3. COPI coating of Golgi vesicle Source: Reactome
  4. intracellular protein transport Source: ProtInc
  5. membrane organization Source: Reactome
  6. pigmentation Source: Ensembl
  7. retrograde vesicle-mediated transport, Golgi to ER Source: Reactome
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11096. COPI Mediated Transport.
SignaLinkiP48444.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit delta
Alternative name(s):
Archain
Delta-coat protein
Short name:
Delta-COP
Gene namesi
Name:ARCN1
Synonyms:COPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:649. ARCN1.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it By similarity.

GO - Cellular componenti

  1. clathrin adaptor complex Source: InterPro
  2. COPI vesicle coat Source: UniProtKB
  3. cytoplasm Source: HPA
  4. cytosol Source: Reactome
  5. endoplasmic reticulum Source: Ensembl
  6. Golgi apparatus Source: HPA
  7. intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Coatomer subunit deltaPRO_0000193841Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331N6-acetyllysine1 Publication
Modified residuei241 – 2411N6-acetyllysine By similarity
Modified residuei309 – 3091N6-acetyllysine1 Publication
Modified residuei351 – 3511N6-acetyllysine By similarity
Modified residuei493 – 4931Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP48444.
PaxDbiP48444.
PRIDEiP48444.

2D gel databases

OGPiP48444.

PTM databases

PhosphoSiteiP48444.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

ArrayExpressiP48444.
BgeeiP48444.
CleanExiHS_ARCN1.
GenevestigatoriP48444.

Organism-specific databases

HPAiHPA037573.
HPA044874.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Protein-protein interaction databases

BioGridi106867. 21 interactions.
DIPiDIP-50375N.
IntActiP48444. 12 interactions.
MINTiMINT-3016718.
STRINGi9606.ENSP00000264028.

Structurei

3D structure databases

ProteinModelPortaliP48444.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini271 – 511241MHDAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG309668.
HOGENOMiHOG000203984.
HOVERGENiHBG005381.
PhylomeDBiP48444.
TreeFamiTF105760.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR008968. Clathrin_mu_C.
IPR027059. Coatomer_dsu.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PANTHERiPTHR10121. PTHR10121. 1 hit.
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS51072. MHD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P48444-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE    50
TESVRYVYQP MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN 100
EISEHCFDLI FAFDEIVALG YRENVNLAQI RTFTEMDSHE EKVFRAVRET 150
QEREAKAEMR RKAKELQQAR RDAERQGKKA PGFGGFGSSA VSGGSTAAMI 200
TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD KLKSEGETIM 250
SSSMGKRTSE ATKMHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM 300
IMLRISDDKY GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE 350
KSFPVNSDVG VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED 400
NLELNDVVIT IPLPSGVGAP VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK 450
SGSLEFSIAG QPNDFFPVQV SFVSKKNYCN IQVTKVTQVD GNSPVRFSTE 500
TTFLVDKYEI L 511
Length:511
Mass (Da):57,210
Last modified:February 1, 1996 - v1
Checksum:i4ED1F7D2D12A7F75
GO
Isoform 2 (identifier: P48444-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MVLLAAAVCT...LETLRLFSRV → M

Note: No experimental confirmation available.

Show »
Length:423
Mass (Da):47,205
Checksum:iD3688717D77E2AD2
GO

Sequence cautioni

The sequence CAA57072.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861F → L.
Corresponds to variant rs682327 [ dbSNP | Ensembl ].
VAR_011788
Natural varianti309 – 3091K → N.
Corresponds to variant rs1063124 [ dbSNP | Ensembl ].
VAR_011789

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8989MVLLA…LFSRV → M in isoform 2. VSP_045636Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti387 – 3871N → D in BAG64934. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81197 mRNA. Translation: CAA57071.1.
X81198 mRNA. Translation: CAA57072.1. Different initiation.
AK304019 mRNA. Translation: BAG64934.1.
AP000941 Genomic DNA. No translation available.
BC093636 mRNA. Translation: AAH93636.1.
BC093638 mRNA. Translation: AAH93638.1.
CCDSiCCDS44749.1. [P48444-2]
CCDS8400.1. [P48444-1]
PIRiA56750.
RefSeqiNP_001135753.1. NM_001142281.1. [P48444-2]
NP_001646.2. NM_001655.4. [P48444-1]
UniGeneiHs.33642.

Genome annotation databases

EnsembliENST00000264028; ENSP00000264028; ENSG00000095139. [P48444-1]
ENST00000392859; ENSP00000376599; ENSG00000095139. [P48444-2]
ENST00000593602; ENSP00000468926; ENSG00000269382. [P48444-2]
ENST00000596715; ENSP00000471768; ENSG00000269382. [P48444-1]
GeneIDi372.
KEGGihsa:372.
UCSCiuc001ptq.3. human. [P48444-1]

Polymorphism databases

DMDMi1351970.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81197 mRNA. Translation: CAA57071.1 .
X81198 mRNA. Translation: CAA57072.1 . Different initiation.
AK304019 mRNA. Translation: BAG64934.1 .
AP000941 Genomic DNA. No translation available.
BC093636 mRNA. Translation: AAH93636.1 .
BC093638 mRNA. Translation: AAH93638.1 .
CCDSi CCDS44749.1. [P48444-2 ]
CCDS8400.1. [P48444-1 ]
PIRi A56750.
RefSeqi NP_001135753.1. NM_001142281.1. [P48444-2 ]
NP_001646.2. NM_001655.4. [P48444-1 ]
UniGenei Hs.33642.

3D structure databases

ProteinModelPortali P48444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106867. 21 interactions.
DIPi DIP-50375N.
IntActi P48444. 12 interactions.
MINTi MINT-3016718.
STRINGi 9606.ENSP00000264028.

PTM databases

PhosphoSitei P48444.

Polymorphism databases

DMDMi 1351970.

2D gel databases

OGPi P48444.

Proteomic databases

MaxQBi P48444.
PaxDbi P48444.
PRIDEi P48444.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264028 ; ENSP00000264028 ; ENSG00000095139 . [P48444-1 ]
ENST00000392859 ; ENSP00000376599 ; ENSG00000095139 . [P48444-2 ]
ENST00000593602 ; ENSP00000468926 ; ENSG00000269382 . [P48444-2 ]
ENST00000596715 ; ENSP00000471768 ; ENSG00000269382 . [P48444-1 ]
GeneIDi 372.
KEGGi hsa:372.
UCSCi uc001ptq.3. human. [P48444-1 ]

Organism-specific databases

CTDi 372.
GeneCardsi GC11P118444.
HGNCi HGNC:649. ARCN1.
HPAi HPA037573.
HPA044874.
MIMi 600820. gene.
neXtProti NX_P48444.
PharmGKBi PA24931.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309668.
HOGENOMi HOG000203984.
HOVERGENi HBG005381.
PhylomeDBi P48444.
TreeFami TF105760.

Enzyme and pathway databases

Reactomei REACT_11096. COPI Mediated Transport.
SignaLinki P48444.

Miscellaneous databases

ChiTaRSi ARCN1. human.
GenomeRNAii 372.
NextBioi 1553.
PROi P48444.
SOURCEi Search...

Gene expression databases

ArrayExpressi P48444.
Bgeei P48444.
CleanExi HS_ARCN1.
Genevestigatori P48444.

Family and domain databases

InterProi IPR022775. AP_mu_sigma_su.
IPR008968. Clathrin_mu_C.
IPR027059. Coatomer_dsu.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view ]
PANTHERi PTHR10121. PTHR10121. 1 hit.
Pfami PF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view ]
SUPFAMi SSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEi PS51072. MHD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila."
    Radice P., Pensotti V., Jones C., Perry H., Pierotti M.A., Tunnacliffe A.
    Genomics 26:101-106(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-233 AND LYS-309, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOPD_HUMAN
AccessioniPrimary (citable) accession number: P48444
Secondary accession number(s): B4E1X2, E9PEU4, Q52M80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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