Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P48443

- RXRG_HUMAN

UniProt

P48443 - RXRG_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Retinoic acid receptor RXR-gamma

Gene

RXRG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi136 – 21176Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 15921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19925NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. 9-cis retinoic acid receptor activity Source: ProtInc
  2. sequence-specific DNA binding Source: Ensembl
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. gene expression Source: Reactome
  2. heart development Source: Ensembl
  3. neuron differentiation Source: Ensembl
  4. peripheral nervous system development Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. regulation of myelination Source: Ensembl
  7. response to retinoic acid Source: Ensembl
  8. skeletal muscle tissue development Source: Ensembl
  9. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiP48443.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene namesi
Name:RXRG
Synonyms:NR2B3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10479. RXRG.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Retinoic acid receptor RXR-gammaPRO_0000053576Add
BLAST

Proteomic databases

MaxQBiP48443.
PaxDbiP48443.
PRIDEiP48443.

PTM databases

PhosphoSiteiP48443.

Expressioni

Gene expression databases

BgeeiP48443.
CleanExiHS_RXRG.
ExpressionAtlasiP48443. baseline and differential.
GenevestigatoriP48443.

Organism-specific databases

HPAiCAB002615.

Interactioni

Subunit structurei

Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RARAP102763EBI-712405,EBI-413374

Protein-protein interaction databases

BioGridi112170. 26 interactions.
DIPiDIP-56220N.
IntActiP48443. 9 interactions.
MINTiMINT-1378806.
STRINGi9606.ENSP00000352900.

Structurei

Secondary structure

1
463
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi236 – 24611Combined sources
Helixi279 – 2857Combined sources
Helixi290 – 2923Combined sources
Helixi295 – 31723Combined sources
Beta strandi320 – 3267Combined sources
Beta strandi332 – 3343Combined sources
Helixi335 – 3406Combined sources
Helixi344 – 35310Combined sources
Helixi355 – 3617Combined sources
Helixi365 – 37612Combined sources
Helixi387 – 40822Combined sources
Helixi415 – 4206Combined sources
Helixi423 – 43412Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GL8X-ray2.40A/B/C/D227-463[»]
ProteinModelPortaliP48443.
SMRiP48443. Positions 132-459.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48443.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 138138ModulatingBy similarityAdd
BLAST
Regioni205 – 26056HingeAdd
BLAST
Regioni261 – 463203Ligand-bindingBy similarityAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 15921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19925NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG327099.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP48443.
KOiK08526.
OMAiFIKFPAG.
OrthoDBiEOG72RMZ5.
PhylomeDBiP48443.
TreeFamiTF352097.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48443-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV
60 70 80 90 100
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL
110 120 130 140 150
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH
160 170 180 190 200
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL
210 220 230 240 250
VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL EAELAVEPKT
260 270 280 290 300
ESYGDMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
310 320 330 340 350
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV
360 370 380 390 400
LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT
410 420 430 440 450
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT
460
FLMEMLETPL QIT
Length:463
Mass (Da):50,871
Last modified:February 1, 1996 - v1
Checksum:iAED5C94BB62A3157
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38480 mRNA. Translation: AAA80681.1.
CR456705 mRNA. Translation: CAG32986.1.
AL160058 Genomic DNA. Translation: CAC00596.1.
CH471067 Genomic DNA. Translation: EAW90745.1.
BC012063 mRNA. Translation: AAH12063.1.
CCDSiCCDS1248.1.
RefSeqiNP_001243500.1. NM_001256571.1.
NP_008848.1. NM_006917.4.
UniGeneiHs.26550.

Genome annotation databases

EnsembliENST00000359842; ENSP00000352900; ENSG00000143171.
GeneIDi6258.
KEGGihsa:6258.
UCSCiuc001gda.3. human.

Polymorphism databases

DMDMi1350913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38480 mRNA. Translation: AAA80681.1 .
CR456705 mRNA. Translation: CAG32986.1 .
AL160058 Genomic DNA. Translation: CAC00596.1 .
CH471067 Genomic DNA. Translation: EAW90745.1 .
BC012063 mRNA. Translation: AAH12063.1 .
CCDSi CCDS1248.1.
RefSeqi NP_001243500.1. NM_001256571.1.
NP_008848.1. NM_006917.4.
UniGenei Hs.26550.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GL8 X-ray 2.40 A/B/C/D 227-463 [» ]
ProteinModelPortali P48443.
SMRi P48443. Positions 132-459.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112170. 26 interactions.
DIPi DIP-56220N.
IntActi P48443. 9 interactions.
MINTi MINT-1378806.
STRINGi 9606.ENSP00000352900.

Chemistry

BindingDBi P48443.
ChEMBLi CHEMBL2363070.
DrugBanki DB00459. Acitretin.
DB00210. Adapalene.
DB00523. Alitretinoin.
DB00307. Bexarotene.
DB00755. Tretinoin.
GuidetoPHARMACOLOGYi 612.

PTM databases

PhosphoSitei P48443.

Polymorphism databases

DMDMi 1350913.

Proteomic databases

MaxQBi P48443.
PaxDbi P48443.
PRIDEi P48443.

Protocols and materials databases

DNASUi 6258.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359842 ; ENSP00000352900 ; ENSG00000143171 .
GeneIDi 6258.
KEGGi hsa:6258.
UCSCi uc001gda.3. human.

Organism-specific databases

CTDi 6258.
GeneCardsi GC01M165370.
HGNCi HGNC:10479. RXRG.
HPAi CAB002615.
MIMi 180247. gene.
neXtProti NX_P48443.
PharmGKBi PA34892.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327099.
GeneTreei ENSGT00760000118948.
HOGENOMi HOG000260821.
HOVERGENi HBG005606.
InParanoidi P48443.
KOi K08526.
OMAi FIKFPAG.
OrthoDBi EOG72RMZ5.
PhylomeDBi P48443.
TreeFami TF352097.

Enzyme and pathway databases

Reactomei REACT_15525. Nuclear Receptor transcription pathway.
SignaLinki P48443.

Miscellaneous databases

EvolutionaryTracei P48443.
GeneWikii Retinoid_X_receptor_gamma.
GenomeRNAii 6258.
NextBioi 24303.
PROi P48443.
SOURCEi Search...

Gene expression databases

Bgeei P48443.
CleanExi HS_RXRG.
ExpressionAtlasi P48443. baseline and differential.
Genevestigatori P48443.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cooke T.A., Allegretto E.A., Heyman R.A., Lamph W.W.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. "Human retinoic acid receptor Rxr-gamma ligand-binding domain."
    Structural genomics consortium (SGC)
    Submitted (APR-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 227-463.

Entry informationi

Entry nameiRXRG_HUMAN
AccessioniPrimary (citable) accession number: P48443
Secondary accession number(s): A6NIP1, Q6IBU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3