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Protein

Retinoic acid receptor RXR-gamma

Gene

RXRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi136 – 211Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri175 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143171-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
R-HSA-5362517. Signaling by Retinoic Acid.
SignaLinkiP48443.
SIGNORiP48443.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene namesi
Name:RXRG
Synonyms:NR2B3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10479. RXRG.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6258.
OpenTargetsiENSG00000143171.
PharmGKBiPA34892.

Chemistry databases

ChEMBLiCHEMBL2004.
DrugBankiDB00459. Acitretin.
DB00210. Adapalene.
DB00523. Alitretinoin.
DB00307. Bexarotene.
DB00755. Tretinoin.
GuidetoPHARMACOLOGYi612.

Polymorphism and mutation databases

BioMutaiRXRG.
DMDMi1350913.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535761 – 463Retinoic acid receptor RXR-gammaAdd BLAST463

Proteomic databases

MaxQBiP48443.
PaxDbiP48443.
PeptideAtlasiP48443.
PRIDEiP48443.

PTM databases

iPTMnetiP48443.
PhosphoSitePlusiP48443.

Expressioni

Gene expression databases

BgeeiENSG00000143171.
CleanExiHS_RXRG.
ExpressionAtlasiP48443. baseline and differential.
GenevisibleiP48443. HS.

Organism-specific databases

HPAiCAB002615.

Interactioni

Subunit structurei

Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MPPED2Q157775EBI-712405,EBI-2350461
NR1H2F1D8P77EBI-712405,EBI-10177172
NR1H3Q131336EBI-712405,EBI-781356
NR1H3Q13133-34EBI-712405,EBI-11952806
RARAP1027614EBI-712405,EBI-413374
RARAP10276-23EBI-712405,EBI-10197061
RARBP10826-23EBI-712405,EBI-8583223
RARGP136314EBI-712405,EBI-2568901

Protein-protein interaction databases

BioGridi112170. 29 interactors.
DIPiDIP-56220N.
IntActiP48443. 13 interactors.
MINTiMINT-1378806.
STRINGi9606.ENSP00000352900.

Chemistry databases

BindingDBiP48443.

Structurei

Secondary structure

1463
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi236 – 246Combined sources11
Helixi279 – 285Combined sources7
Helixi290 – 292Combined sources3
Helixi295 – 317Combined sources23
Beta strandi320 – 326Combined sources7
Beta strandi332 – 334Combined sources3
Helixi335 – 340Combined sources6
Helixi344 – 353Combined sources10
Helixi355 – 361Combined sources7
Helixi365 – 376Combined sources12
Helixi387 – 408Combined sources22
Helixi415 – 420Combined sources6
Helixi423 – 434Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GL8X-ray2.40A/B/C/D227-463[»]
ProteinModelPortaliP48443.
SMRiP48443.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48443.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 138ModulatingBy similarityAdd BLAST138
Regioni205 – 260HingeAdd BLAST56
Regioni261 – 463Ligand-bindingBy similarityAdd BLAST203

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri175 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP48443.
KOiK08526.
OMAiCASGGHE.
OrthoDBiEOG091G0YX6.
PhylomeDBiP48443.
TreeFamiTF352097.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV
60 70 80 90 100
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL
110 120 130 140 150
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH
160 170 180 190 200
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL
210 220 230 240 250
VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL EAELAVEPKT
260 270 280 290 300
ESYGDMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
310 320 330 340 350
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV
360 370 380 390 400
LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT
410 420 430 440 450
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT
460
FLMEMLETPL QIT
Length:463
Mass (Da):50,871
Last modified:February 1, 1996 - v1
Checksum:iAED5C94BB62A3157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38480 mRNA. Translation: AAA80681.1.
CR456705 mRNA. Translation: CAG32986.1.
AL160058 Genomic DNA. Translation: CAC00596.1.
CH471067 Genomic DNA. Translation: EAW90745.1.
BC012063 mRNA. Translation: AAH12063.1.
CCDSiCCDS1248.1.
RefSeqiNP_001243500.1. NM_001256571.1.
NP_008848.1. NM_006917.4.
UniGeneiHs.26550.

Genome annotation databases

EnsembliENST00000359842; ENSP00000352900; ENSG00000143171.
GeneIDi6258.
KEGGihsa:6258.
UCSCiuc001gda.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38480 mRNA. Translation: AAA80681.1.
CR456705 mRNA. Translation: CAG32986.1.
AL160058 Genomic DNA. Translation: CAC00596.1.
CH471067 Genomic DNA. Translation: EAW90745.1.
BC012063 mRNA. Translation: AAH12063.1.
CCDSiCCDS1248.1.
RefSeqiNP_001243500.1. NM_001256571.1.
NP_008848.1. NM_006917.4.
UniGeneiHs.26550.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GL8X-ray2.40A/B/C/D227-463[»]
ProteinModelPortaliP48443.
SMRiP48443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112170. 29 interactors.
DIPiDIP-56220N.
IntActiP48443. 13 interactors.
MINTiMINT-1378806.
STRINGi9606.ENSP00000352900.

Chemistry databases

BindingDBiP48443.
ChEMBLiCHEMBL2004.
DrugBankiDB00459. Acitretin.
DB00210. Adapalene.
DB00523. Alitretinoin.
DB00307. Bexarotene.
DB00755. Tretinoin.
GuidetoPHARMACOLOGYi612.

PTM databases

iPTMnetiP48443.
PhosphoSitePlusiP48443.

Polymorphism and mutation databases

BioMutaiRXRG.
DMDMi1350913.

Proteomic databases

MaxQBiP48443.
PaxDbiP48443.
PeptideAtlasiP48443.
PRIDEiP48443.

Protocols and materials databases

DNASUi6258.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359842; ENSP00000352900; ENSG00000143171.
GeneIDi6258.
KEGGihsa:6258.
UCSCiuc001gda.4. human.

Organism-specific databases

CTDi6258.
DisGeNETi6258.
GeneCardsiRXRG.
HGNCiHGNC:10479. RXRG.
HPAiCAB002615.
MIMi180247. gene.
neXtProtiNX_P48443.
OpenTargetsiENSG00000143171.
PharmGKBiPA34892.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP48443.
KOiK08526.
OMAiCASGGHE.
OrthoDBiEOG091G0YX6.
PhylomeDBiP48443.
TreeFamiTF352097.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143171-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
R-HSA-5362517. Signaling by Retinoic Acid.
SignaLinkiP48443.
SIGNORiP48443.

Miscellaneous databases

ChiTaRSiRXRG. human.
EvolutionaryTraceiP48443.
GeneWikiiRetinoid_X_receptor_gamma.
GenomeRNAii6258.
PROiP48443.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143171.
CleanExiHS_RXRG.
ExpressionAtlasiP48443. baseline and differential.
GenevisibleiP48443. HS.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRXRG_HUMAN
AccessioniPrimary (citable) accession number: P48443
Secondary accession number(s): A6NIP1, Q6IBU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 172 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.