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Protein

Extracellular calcium-sensing receptor

Gene

Casr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • calcium ion binding Source: RGD
  • drug binding Source: RGD
  • G-protein coupled receptor activity Source: RGD
  • integrin binding Source: RGD
  • ion channel binding Source: RGD
  • magnesium ion binding Source: RGD
  • polyamine binding Source: RGD
  • protein kinase binding Source: RGD

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
  • apoptotic process Source: RGD
  • branching morphogenesis of an epithelial tube Source: RGD
  • calcium ion transport Source: RGD
  • cellular calcium ion homeostasis Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to hepatocyte growth factor stimulus Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to low-density lipoprotein particle stimulus Source: RGD
  • cellular response to peptide Source: RGD
  • cellular response to vitamin D Source: RGD
  • fat pad development Source: RGD
  • JNK cascade Source: RGD
  • ossification Source: RGD
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • positive regulation of ATPase activity Source: Ensembl
  • positive regulation of calcium ion import Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of gene expression Source: Ensembl
  • positive regulation of insulin secretion Source: RGD
  • positive regulation of positive chemotaxis Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • response to calcium ion Source: RGD
  • response to fibroblast growth factor Source: RGD
  • response to ischemia Source: RGD
  • response to metal ion Source: RGD
  • response to organic cyclic compound Source: RGD
  • vasodilation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.
R-RNO-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular calcium-sensing receptor
Short name:
CaSR
Alternative name(s):
Parathyroid cell calcium-sensing receptor
Short name:
PCaR1
Gene namesi
Name:Casr
Synonyms:Gprc2a, Pcar1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi2277. Casr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 612593ExtracellularSequence analysisAdd
BLAST
Transmembranei613 – 63523Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini636 – 64914CytoplasmicSequence analysisAdd
BLAST
Transmembranei650 – 67021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini671 – 68111ExtracellularSequence analysisAdd
BLAST
Transmembranei682 – 70019Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini701 – 72424CytoplasmicSequence analysisAdd
BLAST
Transmembranei725 – 74521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini746 – 76924ExtracellularSequence analysisAdd
BLAST
Transmembranei770 – 79223Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini793 – 80513CytoplasmicSequence analysisAdd
BLAST
Transmembranei806 – 82823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini829 – 8368ExtracellularSequence analysis
Transmembranei837 – 86226Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini863 – 1079217CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • axon Source: RGD
  • axon terminus Source: RGD
  • basolateral plasma membrane Source: RGD
  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: RGD
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • nucleus Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2516.
GuidetoPHARMACOLOGYi54.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 10791060Extracellular calcium-sensing receptorPRO_0000012948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence analysis
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence analysis
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence analysis
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence analysis
Glycosylationi541 – 5411N-linked (GlcNAc...)Sequence analysis
Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence analysis
Modified residuei920 – 9201PhosphoserineBy similarity
Modified residuei1062 – 10621PhosphoserineBy similarity

Post-translational modificationi

N-glycosylated.By similarity
Ubiquitinated by RNF19A; which induces proteasomal degradation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP48442.
PRIDEiP48442.

PTM databases

iPTMnetiP48442.
PhosphoSiteiP48442.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002265.
GenevisibleiP48442. RN.

Interactioni

Subunit structurei

Interacts with VCP and RNF19A (By similarity). Interacts with ARRB1.By similarity1 Publication

GO - Molecular functioni

  • integrin binding Source: RGD
  • ion channel binding Source: RGD
  • protein kinase binding Source: RGD

Protein-protein interaction databases

IntActiP48442. 1 interaction.
STRINGi10116.ENSRNOP00000003092.

Chemistry

BindingDBiP48442.

Structurei

3D structure databases

ProteinModelPortaliP48442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni880 – 90021Interaction with RNF19ABy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118974.
HOGENOMiHOG000232092.
HOVERGENiHBG052876.
InParanoidiP48442.
KOiK04612.
OMAiMGEQVTF.
PhylomeDBiP48442.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYSCCLAL LALAWHSSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD
60 70 80 90 100
LKSRPESVEC IRYNFRGFRW LQAMIFAIEE INSSPSLLPN MTLGYRIFDT
110 120 130 140 150
CNTVSKALEA TLSFVAQNKI DSLNLDEFCN CSEHIPSTIA VVGATGSGVS
160 170 180 190 200
TAVANLLGLF YIPQVSYASS SRLLSNKNQY KSFLRTIPND EHQATAMADI
210 220 230 240 250
IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS ELISQYSDEE
260 270 280 290 300
EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA
310 320 330 340 350
SSSLIAMPEY FHVVGGTIGF GLKAGQIPGF REFLQKVHPR KSVHNGFAKE
360 370 380 390 400
FWEETFNCHL QEGAKGPLPV DTFVRSHEEG GNRLLNSSTA FRPLCTGDEN
410 420 430 440 450
INSVETPYMD YEHLRISYNV YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA
460 470 480 490 500
DIKKVEAWQV LKHLRHLNFT NNMGEQVTFD ECGDLVGNYS IINWHLSPED
510 520 530 540 550
GSIVFKEVGY YNVYAKKGER LFINEEKILW SGFSREVPFS NCSRDCQAGT
560 570 580 590 600
RKGIIEGEPT CCFECVECPD GEYSGETDAS ACDKCPDDFW SNENHTSCIA
610 620 630 640 650
KEIEFLAWTE PFGIALTLFA VLGIFLTAFV LGVFIKFRNT PIVKATNREL
660 670 680 690 700
SYLLLFSLLC CFSSSLFFIG EPQDWTCRLR QPAFGISFVL CISCILVKTN
710 720 730 740 750
RVLLVFEAKI PTSFHRKWWG LNLQFLLVFL CTFMQILICI IWLYTAPPSS
760 770 780 790 800
YRNHELEDEI IFITCHEGSL MALGSLIGYT CLLAAICFFF AFKSRKLPEN
810 820 830 840 850
FNEAKFITFS MLIFFIVWIS FIPAYASTYG KFVSAVEVIA ILAASFGLLA
860 870 880 890 900
CIFFNKVYII LFKPSRNTIE EVRSSTAAHA FKVAARATLR RPNISRKRSS
910 920 930 940 950
SLGGSTGSIP SSSISSKSNS EDRFPQPERQ KQQQPLSLTQ QEQQQQPLTL
960 970 980 990 1000
HPQQQQQPQQ PRCKQKVIFG SGTVTFSLSF DEPQKNAMAH RNSMRQNSLE
1010 1020 1030 1040 1050
AQRSNDTLGR HQALLPLQCA DADSEMTIQE TGLQGPMVGD HQPEMESSDE
1060 1070
MSPALVMSTS RSFVISGGGS SVTENVLHS
Length:1,079
Mass (Da):120,868
Last modified:February 1, 1996 - v1
Checksum:iD7664550361F9736
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10354 mRNA. Translation: AAC52149.1.
U20289 mRNA. Translation: AAC52195.1.
PIRiI59362.
RefSeqiNP_001296567.1. NM_001309638.1.
NP_058692.1. NM_016996.2.
UniGeneiRn.10019.

Genome annotation databases

EnsembliENSRNOT00000003092; ENSRNOP00000003092; ENSRNOG00000002265.
ENSRNOT00000078341; ENSRNOP00000070633; ENSRNOG00000002265.
ENSRNOT00000086097; ENSRNOP00000069629; ENSRNOG00000002265.
GeneIDi24247.
KEGGirno:24247.
UCSCiRGD:2277. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10354 mRNA. Translation: AAC52149.1.
U20289 mRNA. Translation: AAC52195.1.
PIRiI59362.
RefSeqiNP_001296567.1. NM_001309638.1.
NP_058692.1. NM_016996.2.
UniGeneiRn.10019.

3D structure databases

ProteinModelPortaliP48442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP48442. 1 interaction.
STRINGi10116.ENSRNOP00000003092.

Chemistry

BindingDBiP48442.
ChEMBLiCHEMBL2516.
GuidetoPHARMACOLOGYi54.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP48442.
PhosphoSiteiP48442.

Proteomic databases

PaxDbiP48442.
PRIDEiP48442.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003092; ENSRNOP00000003092; ENSRNOG00000002265.
ENSRNOT00000078341; ENSRNOP00000070633; ENSRNOG00000002265.
ENSRNOT00000086097; ENSRNOP00000069629; ENSRNOG00000002265.
GeneIDi24247.
KEGGirno:24247.
UCSCiRGD:2277. rat.

Organism-specific databases

CTDi846.
RGDi2277. Casr.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118974.
HOGENOMiHOG000232092.
HOVERGENiHBG052876.
InParanoidiP48442.
KOiK04612.
OMAiMGEQVTF.
PhylomeDBiP48442.
TreeFamiTF331269.

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.
R-RNO-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

PROiP48442.

Gene expression databases

BgeeiENSRNOG00000002265.
GenevisibleiP48442. RN.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASR_RAT
AccessioniPrimary (citable) accession number: P48442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.