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P48441

- IDUA_MOUSE

UniProt

P48441 - IDUA_MOUSE

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Protein

Alpha-L-iduronidase

Gene

Idua

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811SubstrateBy similarity
Binding sitei171 – 1711SubstrateBy similarity
Active sitei172 – 1721Proton donorPROSITE-ProRule annotation
Binding sitei254 – 2541SubstrateBy similarity
Active sitei289 – 2891NucleophileBy similarity
Binding sitei339 – 3391SubstrateBy similarity
Binding sitei353 – 3531SubstrateBy similarity

GO - Molecular functioni

  1. L-iduronidase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell morphogenesis Source: MGI
  3. chemical homeostasis Source: MGI
  4. dermatan sulfate catabolic process Source: UniProtKB
  5. limb morphogenesis Source: MGI
  6. lysosome organization Source: MGI
  7. skeletal system morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_198967. HS-GAG degradation.
REACT_198981. CS/DS degradation.

Protein family/group databases

CAZyiGH39. Glycoside Hydrolase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-L-iduronidase (EC:3.2.1.76)
Gene namesi
Name:Idua
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96418. Idua.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. coated vesicle Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 634618Alpha-L-iduronidasePRO_0000012201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi531 ↔ 567By similarity

Post-translational modificationi

N-glycosylation contributes to substrate binding and is required for full enzymatic activity.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP48441.
PRIDEiP48441.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiP48441.
CleanExiMM_IDUA.
ExpressionAtlasiP48441. baseline and differential.
GenevestigatoriP48441.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP48441.
SMRiP48441. Positions 17-632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni295 – 2962Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the glycosyl hydrolase 39 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3664.
HOGENOMiHOG000007042.
HOVERGENiHBG006121.
InParanoidiP48441.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR000514. Glyco_hydro_39.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01229. Glyco_hydro_39. 1 hit.
[Graphical view]
PRINTSiPR00745. GLHYDRLASE39.
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01027. GLYCOSYL_HYDROL_F39. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48441-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTFFAAFLA APLALAESPY LVRVDAARPL RPLLPFWRST GFCPPLPHDQ
60 70 80 90 100
ADQYDLSWDQ QLNLAYIGAV PHSGIEQVRI HWLLDLITAR KSPGQGLMYN
110 120 130 140 150
FTHLDAFLDL LMENQLLPGF ELMGSPSGYF TDFDDKQQVF EWKDLVSLLA
160 170 180 190 200
RRYIGRYGLT HVSKWNFETW NEPDHHDFDN VSMTTQGFLN YYDACSEGLR
210 220 230 240 250
IASPTLKLGG PGDSFHPLPR SPMCWSLLGH CANGTNFFTG EVGVRLDYIS
260 270 280 290 300
LHKKGAGSSI AILEQEMAVV EQVQQLFPEF KDTPIYNDEA DPLVGWSLPQ
310 320 330 340 350
PWRADVTYAA LVVKVIAQHQ NLLFANSSSS MRYVLLSNDN AFLSYHPYPF
360 370 380 390 400
SQRTLTARFQ VNNTHPPHVQ LLRKPVLTVM GLMALLDGEQ LWAEVSKAGA
410 420 430 440 450
VLDSNHTVGV LASTHHPEGS AAAWSTTVLI YTSDDTHAHP NHSIPVTLRL
460 470 480 490 500
RGVPPGLDLV YIVLYLDNQL SSPYSAWQHM GQPVFPSAEQ FRRMRMVEDP
510 520 530 540 550
VAEAPRPFPA RGRLTLHRKL PVPSLLLVHV CTRPLKPPGQ VSRLRALPLT
560 570 580 590 600
HGQLILVWSD ERVGSKCLWT YEIQFSQKGE EYAPINRRPS TFNLFVFSPD
610 620 630
TAVVSGSYRV RALDYWARPG PFSDPVTYLD VPAS
Length:634
Mass (Da):71,254
Last modified:July 27, 2011 - v2
Checksum:i41A8F5B036B360DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti359 – 3591F → S in AAC42044. (PubMed:7698753)Curated
Sequence conflicti423 – 4231A → G in AAC42044. (PubMed:7698753)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34111 mRNA. Translation: AAC42044.1.
AC161813 Genomic DNA. No translation available.
PIRiA55683.
UniGeneiMm.358608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34111 mRNA. Translation: AAC42044.1 .
AC161813 Genomic DNA. No translation available.
PIRi A55683.
UniGenei Mm.358608.

3D structure databases

ProteinModelPortali P48441.
SMRi P48441. Positions 17-632.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH39. Glycoside Hydrolase Family 39.

Proteomic databases

MaxQBi P48441.
PRIDEi P48441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96418. Idua.

Phylogenomic databases

eggNOGi COG3664.
HOGENOMi HOG000007042.
HOVERGENi HBG006121.
InParanoidi P48441.

Enzyme and pathway databases

Reactomei REACT_198967. HS-GAG degradation.
REACT_198981. CS/DS degradation.

Miscellaneous databases

ChiTaRSi Idua. mouse.
PROi P48441.
SOURCEi Search...

Gene expression databases

Bgeei P48441.
CleanExi MM_IDUA.
ExpressionAtlasi P48441. baseline and differential.
Genevestigatori P48441.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR000514. Glyco_hydro_39.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF01229. Glyco_hydro_39. 1 hit.
[Graphical view ]
PRINTSi PR00745. GLHYDRLASE39.
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01027. GLYCOSYL_HYDROL_F39. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine alpha-L-iduronidase: cDNA isolation and expression."
    Clarke L.A.
    Genomics 24:311-316(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiIDUA_MOUSE
AccessioniPrimary (citable) accession number: P48441
Secondary accession number(s): E9QM17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3