Alpha-L-iduronidase precursor - Mus musculus (Mouse)

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P48441 (IDUA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Alpha-L-iduronidase
EC=3.2.1.76

Gene names

Name:

Idua

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	634 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate.
Subunit structure	Monomer Probable.
Subcellular location	Lysosome.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the glycosyl hydrolase 39 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro cell morphogenesis Inferred from mutant phenotype PubMed 9097952. Source: MGI chemical homeostasis Inferred from mutant phenotype PubMed 9097952. Source: MGI glycosaminoglycan catabolic process Inferred from electronic annotation. Source: Compara limb morphogenesis Inferred from mutant phenotype PubMed 9097952. Source: MGI lysosome organization Inferred from mutant phenotype PubMed 9097952. Source: MGI skeletal system morphogenesis Inferred from mutant phenotype PubMed 9097952. Source: MGI
Cellular_component	coated vesicle Inferred from electronic annotation. Source: Compara lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	L-iduronidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 16

Potential

Chain

17 – 634

618

Alpha-L-iduronidase

PRO_0000012201

Sites

Active site

172

Proton donor Potential

Active site

289

Nucleophile Potential

Experimental info

Sequence conflict

359

F → S in AAC42044. Ref.1

Sequence conflict

423

A → G in AAC42044. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P48441 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 41A8F5B036B360DB
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FASTA

634

71,254

        10         20         30         40         50         60 
MLTFFAAFLA APLALAESPY LVRVDAARPL RPLLPFWRST GFCPPLPHDQ ADQYDLSWDQ 

        70         80         90        100        110        120 
QLNLAYIGAV PHSGIEQVRI HWLLDLITAR KSPGQGLMYN FTHLDAFLDL LMENQLLPGF 

       130        140        150        160        170        180 
ELMGSPSGYF TDFDDKQQVF EWKDLVSLLA RRYIGRYGLT HVSKWNFETW NEPDHHDFDN 

       190        200        210        220        230        240 
VSMTTQGFLN YYDACSEGLR IASPTLKLGG PGDSFHPLPR SPMCWSLLGH CANGTNFFTG 

       250        260        270        280        290        300 
EVGVRLDYIS LHKKGAGSSI AILEQEMAVV EQVQQLFPEF KDTPIYNDEA DPLVGWSLPQ 

       310        320        330        340        350        360 
PWRADVTYAA LVVKVIAQHQ NLLFANSSSS MRYVLLSNDN AFLSYHPYPF SQRTLTARFQ 

       370        380        390        400        410        420 
VNNTHPPHVQ LLRKPVLTVM GLMALLDGEQ LWAEVSKAGA VLDSNHTVGV LASTHHPEGS 

       430        440        450        460        470        480 
AAAWSTTVLI YTSDDTHAHP NHSIPVTLRL RGVPPGLDLV YIVLYLDNQL SSPYSAWQHM 

       490        500        510        520        530        540 
GQPVFPSAEQ FRRMRMVEDP VAEAPRPFPA RGRLTLHRKL PVPSLLLVHV CTRPLKPPGQ 

       550        560        570        580        590        600 
VSRLRALPLT HGQLILVWSD ERVGSKCLWT YEIQFSQKGE EYAPINRRPS TFNLFVFSPD 

       610        620        630 
TAVVSGSYRV RALDYWARPG PFSDPVTYLD VPAS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Murine alpha-L-iduronidase: cDNA isolation and expression." Clarke L.A. Genomics 24:311-316(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Liver.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L34111 mRNA. Translation: AAC42044.1. AC161813 Genomic DNA. No translation available.
IPI	IPI01019180.
PIR	A55683.
UniGene	Mm.358608.
3D structure databases
ProteinModelPortal	P48441.
SMR	P48441. Positions 99-533.
ModBase	Search...
Protein family/group databases
CAZy	GH39. Glycoside Hydrolase Family 39.
Proteomic databases
PRIDE	P48441.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:96418. Idua.
Phylogenomic databases
eggNOG	COG3664.
HOGENOM	HOG000007042.
HOVERGEN	HBG006121.
InParanoid	P48441.
OrthoDB	EOG4THVSS.
Gene expression databases
ArrayExpress	P48441.
Bgee	P48441.
CleanEx	MM_IDUA.
Genevestigator	P48441.
GermOnline	ENSMUSG00000033540. Mus musculus.
Family and domain databases
Gene3D	3.20.20.80. 1 hit.
InterPro	IPR003961. Fibronectin_type3. IPR000514. Glyco_hydro_39. IPR013781. Glyco_hydro_catalytic_dom. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Pfam	PF01229. Glyco_hydro_39. 1 hit. [Graphical view]
PRINTS	PR00745. GLHYDRLASE39.
SUPFAM	SSF49265. FN_III-like. 1 hit. SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS01027. GLYCOSYL_HYDROL_F39. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IDUA. mouse.
SOURCE	Search...

Entry information

Entry name

IDUA_MOUSE

Accession

Primary (citable) accession number: P48441
Secondary accession number(s): E9QM17

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents