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P48441 (IDUA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-L-iduronidase

EC=3.2.1.76
Gene names
Name:Idua
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length634 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate. Ref.1

Subunit structure

Monomer By similarity.

Subcellular location

Lysosome By similarity.

Tissue specificity

Ubiquitous. Ref.1

Post-translational modification

N-glycosylation contributes to substrate binding and is required for full enzymatic activity By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 39 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 634618Alpha-L-iduronidase
PRO_0000012201

Regions

Region295 – 2962Substrate binding By similarity

Sites

Active site1721Proton donor By similarity
Active site2891Nucleophile By similarity
Binding site811Substrate By similarity
Binding site1711Substrate By similarity
Binding site2541Substrate By similarity
Binding site3391Substrate By similarity
Binding site3531Substrate By similarity

Amino acid modifications

Disulfide bond531 ↔ 567 By similarity

Experimental info

Sequence conflict3591F → S in AAC42044. Ref.1
Sequence conflict4231A → G in AAC42044. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P48441 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 41A8F5B036B360DB

FASTA63471,254
        10         20         30         40         50         60 
MLTFFAAFLA APLALAESPY LVRVDAARPL RPLLPFWRST GFCPPLPHDQ ADQYDLSWDQ 

        70         80         90        100        110        120 
QLNLAYIGAV PHSGIEQVRI HWLLDLITAR KSPGQGLMYN FTHLDAFLDL LMENQLLPGF 

       130        140        150        160        170        180 
ELMGSPSGYF TDFDDKQQVF EWKDLVSLLA RRYIGRYGLT HVSKWNFETW NEPDHHDFDN 

       190        200        210        220        230        240 
VSMTTQGFLN YYDACSEGLR IASPTLKLGG PGDSFHPLPR SPMCWSLLGH CANGTNFFTG 

       250        260        270        280        290        300 
EVGVRLDYIS LHKKGAGSSI AILEQEMAVV EQVQQLFPEF KDTPIYNDEA DPLVGWSLPQ 

       310        320        330        340        350        360 
PWRADVTYAA LVVKVIAQHQ NLLFANSSSS MRYVLLSNDN AFLSYHPYPF SQRTLTARFQ 

       370        380        390        400        410        420 
VNNTHPPHVQ LLRKPVLTVM GLMALLDGEQ LWAEVSKAGA VLDSNHTVGV LASTHHPEGS 

       430        440        450        460        470        480 
AAAWSTTVLI YTSDDTHAHP NHSIPVTLRL RGVPPGLDLV YIVLYLDNQL SSPYSAWQHM 

       490        500        510        520        530        540 
GQPVFPSAEQ FRRMRMVEDP VAEAPRPFPA RGRLTLHRKL PVPSLLLVHV CTRPLKPPGQ 

       550        560        570        580        590        600 
VSRLRALPLT HGQLILVWSD ERVGSKCLWT YEIQFSQKGE EYAPINRRPS TFNLFVFSPD 

       610        620        630 
TAVVSGSYRV RALDYWARPG PFSDPVTYLD VPAS 

« Hide

References

« Hide 'large scale' references
[1]"Murine alpha-L-iduronidase: cDNA isolation and expression."
Clarke L.A.
Genomics 24:311-316(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
Strain: C57BL/6 X CBA.
Tissue: Liver.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34111 mRNA. Translation: AAC42044.1.
AC161813 Genomic DNA. No translation available.
PIRA55683.
UniGeneMm.358608.

3D structure databases

ProteinModelPortalP48441.
SMRP48441. Positions 17-632.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH39. Glycoside Hydrolase Family 39.

Proteomic databases

PRIDEP48441.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:96418. Idua.

Phylogenomic databases

eggNOGCOG3664.
HOGENOMHOG000007042.
HOVERGENHBG006121.
InParanoidP48441.

Gene expression databases

ArrayExpressP48441.
BgeeP48441.
CleanExMM_IDUA.
GenevestigatorP48441.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR000514. Glyco_hydro_39.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF01229. Glyco_hydro_39. 1 hit.
[Graphical view]
PRINTSPR00745. GLHYDRLASE39.
SUPFAMSSF49265. SSF49265. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEPS01027. GLYCOSYL_HYDROL_F39. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIDUA. mouse.
PROP48441.
SOURCESearch...

Entry information

Entry nameIDUA_MOUSE
AccessionPrimary (citable) accession number: P48441
Secondary accession number(s): E9QM17
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries