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Protein

Alpha-L-iduronidase

Gene

Idua

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81SubstrateBy similarity1
Binding sitei171SubstrateBy similarity1
Active sitei172Proton donorPROSITE-ProRule annotation1
Binding sitei254SubstrateBy similarity1
Active sitei289NucleophileBy similarity1
Binding sitei339SubstrateBy similarity1
Binding sitei353SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: GO_Central
  • cell morphogenesis Source: MGI
  • chemical homeostasis Source: MGI
  • dermatan sulfate catabolic process Source: UniProtKB
  • limb morphogenesis Source: MGI
  • lysosome organization Source: MGI
  • skeletal system morphogenesis Source: MGI

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH39. Glycoside Hydrolase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-L-iduronidase (EC:3.2.1.76)
Gene namesi
Name:Idua
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96418. Idua.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001220117 – 634Alpha-L-iduronidaseAdd BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi531 ↔ 567By similarity

Post-translational modificationi

N-glycosylation contributes to substrate binding and is required for full enzymatic activity.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP48441.
PaxDbiP48441.
PeptideAtlasiP48441.
PRIDEiP48441.

PTM databases

PhosphoSitePlusiP48441.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

CleanExiMM_IDUA.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071577.

Structurei

3D structure databases

ProteinModelPortaliP48441.
SMRiP48441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni295 – 296Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 39 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEET. Eukaryota.
ENOG410XWW3. LUCA.
HOGENOMiHOG000007042.
HOVERGENiHBG006121.
InParanoidiP48441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR000514. Glyco_hydro_39.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
PfamiView protein in Pfam
PF01229. Glyco_hydro_39. 1 hit.
PRINTSiPR00745. GLHYDRLASE39.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS01027. GLYCOSYL_HYDROL_F39. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTFFAAFLA APLALAESPY LVRVDAARPL RPLLPFWRST GFCPPLPHDQ
60 70 80 90 100
ADQYDLSWDQ QLNLAYIGAV PHSGIEQVRI HWLLDLITAR KSPGQGLMYN
110 120 130 140 150
FTHLDAFLDL LMENQLLPGF ELMGSPSGYF TDFDDKQQVF EWKDLVSLLA
160 170 180 190 200
RRYIGRYGLT HVSKWNFETW NEPDHHDFDN VSMTTQGFLN YYDACSEGLR
210 220 230 240 250
IASPTLKLGG PGDSFHPLPR SPMCWSLLGH CANGTNFFTG EVGVRLDYIS
260 270 280 290 300
LHKKGAGSSI AILEQEMAVV EQVQQLFPEF KDTPIYNDEA DPLVGWSLPQ
310 320 330 340 350
PWRADVTYAA LVVKVIAQHQ NLLFANSSSS MRYVLLSNDN AFLSYHPYPF
360 370 380 390 400
SQRTLTARFQ VNNTHPPHVQ LLRKPVLTVM GLMALLDGEQ LWAEVSKAGA
410 420 430 440 450
VLDSNHTVGV LASTHHPEGS AAAWSTTVLI YTSDDTHAHP NHSIPVTLRL
460 470 480 490 500
RGVPPGLDLV YIVLYLDNQL SSPYSAWQHM GQPVFPSAEQ FRRMRMVEDP
510 520 530 540 550
VAEAPRPFPA RGRLTLHRKL PVPSLLLVHV CTRPLKPPGQ VSRLRALPLT
560 570 580 590 600
HGQLILVWSD ERVGSKCLWT YEIQFSQKGE EYAPINRRPS TFNLFVFSPD
610 620 630
TAVVSGSYRV RALDYWARPG PFSDPVTYLD VPAS
Length:634
Mass (Da):71,254
Last modified:July 27, 2011 - v2
Checksum:i41A8F5B036B360DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti359F → S in AAC42044 (PubMed:7698753).Curated1
Sequence conflicti423A → G in AAC42044 (PubMed:7698753).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34111 mRNA. Translation: AAC42044.1.
AC161813 Genomic DNA. No translation available.
PIRiA55683.
UniGeneiMm.358608.

Similar proteinsi

Entry informationi

Entry nameiIDUA_MOUSE
AccessioniPrimary (citable) accession number: P48441
Secondary accession number(s): E9QM17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families