Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor SOX-2

Gene

SOX2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'.By similarity2 Publications

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi39 – 107HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-GGA-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-2
Short name:
cSox2
Alternative name(s):
delta EF2a
Gene namesi
Name:SOX2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487181 – 315Transcription factor SOX-2Add BLAST315

Proteomic databases

PaxDbiP48430
PRIDEiP48430

Expressioni

Tissue specificityi

First expressed in the embryonic neural plate shortly before closure and expression continues in the neural tube. From stage 16 onwards, expressed throughout the CNS including the brain, with expression predominant in the undifferentiated cells of the neural epithelium. Also expressed at a low level in the retina and the gut epithelium. Highly expressed in the lens placode at stage 13 and in the lens at stage 17.2 Publications

Developmental stagei

Expression is maximal at stages 24-31, then begins to decline. Expression is low by stage 37 and is absent by stage 39. Does not appear to be expressed in adults.1 Publication

Gene expression databases

BgeeiENSGALG00000008848

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014363

Structurei

3D structure databases

ProteinModelPortaliP48430
SMRiP48430
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi246 – 249Poly-Ser4

Phylogenomic databases

eggNOGiENOG410IPZI Eukaryota
ENOG411009V LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231647
HOVERGENiHBG105663
InParanoidiP48430
KOiK16796
OMAiQSYMNGS
OrthoDBiEOG091G0F15
PhylomeDBiP48430
TreeFamiTF351735

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR032643 SOX-2
IPR022097 SOX_fam
PANTHERiPTHR10270:SF231 PTHR10270:SF231, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNMMETELK PPAPQQTSGG GTGNSNSAAN NQKNSPDRVK RPMNAFMVWS
60 70 80 90 100
RGQRRKMAQE NPKMHNSEIS KRLGAEWKLL SEAEKRPFID EAKRLRALHM
110 120 130 140 150
KEHPDYKYRP RRKTKTLMKK DKYTLPGGLL APGTNTMTTG VGVGATLGAG
160 170 180 190 200
VNQRMDSYAH MNGWTNGGYG MMQEQLGYPQ HPGLNAHNAA QMQPMHRYDV
210 220 230 240 250
SALQYNSMTS SQTYMNGSPT YSMSYSQQGT PGMALGSMGS VVKTESSSSP
260 270 280 290 300
PVVTSSSHSR APCQAGDLRD MISMYLPGAE VPEPAAPSRL HMSQHYQSAP
310
VPGTAINGTL PLSHM
Length:315
Mass (Da):34,511
Last modified:February 1, 1996 - v1
Checksum:i6EDC91E00F5E9335
GO

Sequence cautioni

The sequence BAA09168 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12532 mRNA Translation: AAB09662.1
D50603 mRNA Translation: BAA09168.1 Different initiation.
AB092842 Genomic DNA Translation: BAC67545.1
PIRiI50706
RefSeqiNP_990519.2, NM_205188.2
UniGeneiGga.601

Genome annotation databases

EnsembliENSGALT00000068561; ENSGALP00000045318; ENSGALG00000043460
GeneIDi396105
KEGGigga:396105

Similar proteinsi

Entry informationi

Entry nameiSOX2_CHICK
AccessioniPrimary (citable) accession number: P48430
Secondary accession number(s): Q54A48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health