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Protein

Transcription factor SOX-2

Gene

SOX2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi39 – 10769HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-2
Short name:
cSox2
Alternative name(s):
delta EF2a
Gene namesi
Name:SOX2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • cell Source: AgBase
  • cytosol Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Transcription factor SOX-2PRO_0000048718Add
BLAST

Proteomic databases

PaxDbiP48430.

Expressioni

Tissue specificityi

First expressed in the embryonic neural plate shortly before closure and expression continues in the neural tube. From stage 16 onwards, expressed throughout the CNS including the brain, with expression predominant in the undifferentiated cells of the neural epithelium. Also expressed at a low level in the retina and the gut epithelium. Highly expressed in the lens placode at stage 13 and in the lens at stage 17.2 Publications

Developmental stagei

Expression is maximal at stages 24-31, then begins to decline. Expression is low by stage 37 and is absent by stage 39. Does not appear to be expressed in adults.1 Publication

Gene expression databases

BgeeiENSGALG00000008848.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014363.

Structurei

3D structure databases

ProteinModelPortaliP48430.
SMRiP48430. Positions 37-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 2494Poly-Ser

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPZI. Eukaryota.
ENOG411009V. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105663.
InParanoidiP48430.
KOiK16796.
OMAiMSALQYN.
OrthoDBiEOG091G0F15.
PhylomeDBiP48430.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR032643. SOX-2.
IPR022097. SOX_fam.
[Graphical view]
PANTHERiPTHR10270:SF231. PTHR10270:SF231. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNMMETELK PPAPQQTSGG GTGNSNSAAN NQKNSPDRVK RPMNAFMVWS
60 70 80 90 100
RGQRRKMAQE NPKMHNSEIS KRLGAEWKLL SEAEKRPFID EAKRLRALHM
110 120 130 140 150
KEHPDYKYRP RRKTKTLMKK DKYTLPGGLL APGTNTMTTG VGVGATLGAG
160 170 180 190 200
VNQRMDSYAH MNGWTNGGYG MMQEQLGYPQ HPGLNAHNAA QMQPMHRYDV
210 220 230 240 250
SALQYNSMTS SQTYMNGSPT YSMSYSQQGT PGMALGSMGS VVKTESSSSP
260 270 280 290 300
PVVTSSSHSR APCQAGDLRD MISMYLPGAE VPEPAAPSRL HMSQHYQSAP
310
VPGTAINGTL PLSHM
Length:315
Mass (Da):34,511
Last modified:February 1, 1996 - v1
Checksum:i6EDC91E00F5E9335
GO

Sequence cautioni

The sequence BAA09168 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12532 mRNA. Translation: AAB09662.1.
D50603 mRNA. Translation: BAA09168.1. Different initiation.
AB092842 Genomic DNA. Translation: BAC67545.1.
PIRiI50706.
RefSeqiNP_990519.2. NM_205188.2.
UniGeneiGga.601.

Genome annotation databases

EnsembliENSGALT00000014379; ENSGALP00000014363; ENSGALG00000008848.
GeneIDi396105.
KEGGigga:396105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12532 mRNA. Translation: AAB09662.1.
D50603 mRNA. Translation: BAA09168.1. Different initiation.
AB092842 Genomic DNA. Translation: BAC67545.1.
PIRiI50706.
RefSeqiNP_990519.2. NM_205188.2.
UniGeneiGga.601.

3D structure databases

ProteinModelPortaliP48430.
SMRiP48430. Positions 37-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014363.

Proteomic databases

PaxDbiP48430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000014379; ENSGALP00000014363; ENSGALG00000008848.
GeneIDi396105.
KEGGigga:396105.

Organism-specific databases

CTDi6657.

Phylogenomic databases

eggNOGiENOG410IPZI. Eukaryota.
ENOG411009V. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105663.
InParanoidiP48430.
KOiK16796.
OMAiMSALQYN.
OrthoDBiEOG091G0F15.
PhylomeDBiP48430.
TreeFamiTF351735.

Enzyme and pathway databases

ReactomeiR-GGA-3769402. Deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

PROiP48430.

Gene expression databases

BgeeiENSGALG00000008848.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR032643. SOX-2.
IPR022097. SOX_fam.
[Graphical view]
PANTHERiPTHR10270:SF231. PTHR10270:SF231. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOX2_CHICK
AccessioniPrimary (citable) accession number: P48430
Secondary accession number(s): Q54A48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.