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Protein

Thermosome subunit beta

Gene

thsB

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.9. 6324.

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosome subunit beta
Alternative name(s):
Chaperonin subunit beta
Thermosome subunit 2
Gene namesi
Name:thsB
Ordered Locus Names:Ta1276
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001284101 – 543Thermosome subunit betaAdd BLAST543

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PRIDEiP48425.

Interactioni

Subunit structurei

Forms a Heterooligomeric complex of two stacked eight-membered rings.

Protein-protein interaction databases

MINTiMINT-1534042.
STRINGi273075.Ta1276.

Structurei

Secondary structure

1543
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 38Combined sources18
Beta strandi48 – 51Combined sources4
Beta strandi57 – 60Combined sources4
Helixi63 – 69Combined sources7
Helixi75 – 84Combined sources10
Helixi94 – 114Combined sources21
Helixi119 – 140Combined sources22
Helixi148 – 160Combined sources13
Helixi164 – 168Combined sources5
Helixi169 – 183Combined sources15
Beta strandi184 – 186Combined sources3
Beta strandi188 – 193Combined sources6
Helixi195 – 197Combined sources3
Beta strandi198 – 206Combined sources9
Helixi208 – 210Combined sources3
Beta strandi212 – 220Combined sources9
Beta strandi230 – 242Combined sources13
Beta strandi250 – 255Combined sources6
Helixi262 – 283Combined sources22
Beta strandi288 – 293Combined sources6
Helixi297 – 305Combined sources9
Beta strandi309 – 311Combined sources3
Helixi316 – 326Combined sources11
Beta strandi330 – 332Combined sources3
Helixi334 – 336Combined sources3
Helixi339 – 341Combined sources3
Beta strandi343 – 353Combined sources11
Beta strandi356 – 368Combined sources13
Beta strandi370 – 378Combined sources9
Helixi379 – 402Combined sources24
Beta strandi404 – 407Combined sources4
Turni408 – 410Combined sources3
Helixi411 – 426Combined sources16
Helixi431 – 442Combined sources12
Helixi444 – 453Combined sources10
Helixi457 – 469Combined sources13
Beta strandi475 – 478Combined sources4
Turni479 – 482Combined sources4
Beta strandi483 – 486Combined sources4
Turni487 – 491Combined sources5
Beta strandi493 – 495Combined sources3
Helixi496 – 515Combined sources20
Beta strandi516 – 520Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6DX-ray2.60B1-543[»]
1A6EX-ray3.20B1-543[»]
1E0RX-ray2.80B214-367[»]
ProteinModelPortaliP48425.
SMRiP48425.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48425.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiarCOG01257. Archaea.
COG0459. LUCA.
HOGENOMiHOG000226729.
OMAiVMNTAPE.

Family and domain databases

CDDicd03343. cpn60. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAGQPIFIL KEGTKRESGK DAMKENIEAA IAISNSVRSS LGPRGMDKML
60 70 80 90 100
VDSLGDIVIT NDGVTILKEM DVEHPAAKMM VEVSKTQDSF VGDGTTTAVI
110 120 130 140 150
IAGGLLQQAQ GLINQNVHPT VISEGYRMAS EEAKRVIDEI STKIGADEKA
160 170 180 190 200
LLLKMAQTSL NSKSASVAKD KLAEISYEAV KSVAELRDGK YYVDFDNIQV
210 220 230 240 250
VKKQGGAIDD TQLINGIIVD KEKVHPGMPD VVKDAKIALL DAPLEIKKPE
260 270 280 290 300
FDTNLRIEDP SMIQKFLAQE ENMLREMVDK IKSVGANVVI TQKGIDDMAQ
310 320 330 340 350
HYLSRAGIYA VRRVKKSDMD KLAKATGASI VSTIDEISSS DLGTAERVEQ
360 370 380 390 400
VKVGEDYMTF VTGCKNPKAV SILVRGETEH VVDEMERSIT DSLHVVASAL
410 420 430 440 450
EDGAYAAGGG ATAAEIAFRL RSYAQKIGGR QQLAIEKFAD AIEEIPRALA
460 470 480 490 500
ENAGLDPIDI LLKLRAEHAK GNKTYGINVF TGEIEDMVKN GVIEPIRVGK
510 520 530 540
QAIESATEAA IMILRIDDVI ATKSSSSSSN PPKSGSSSES SED
Length:543
Mass (Da):58,480
Last modified:February 1, 1996 - v1
Checksum:iF9CDAEE63E8B84E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46650 Genomic DNA. Translation: CAA86611.1.
AL445067 Genomic DNA. Translation: CAC12400.1.
PIRiS53817.
RefSeqiWP_010901684.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12400; CAC12400; CAC12400.
GeneIDi1456762.
KEGGitac:Ta1276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46650 Genomic DNA. Translation: CAA86611.1.
AL445067 Genomic DNA. Translation: CAC12400.1.
PIRiS53817.
RefSeqiWP_010901684.1. NC_002578.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6DX-ray2.60B1-543[»]
1A6EX-ray3.20B1-543[»]
1E0RX-ray2.80B214-367[»]
ProteinModelPortaliP48425.
SMRiP48425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1534042.
STRINGi273075.Ta1276.

Proteomic databases

PRIDEiP48425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC12400; CAC12400; CAC12400.
GeneIDi1456762.
KEGGitac:Ta1276.

Phylogenomic databases

eggNOGiarCOG01257. Archaea.
COG0459. LUCA.
HOGENOMiHOG000226729.
OMAiVMNTAPE.

Enzyme and pathway databases

BRENDAi3.6.4.9. 6324.

Miscellaneous databases

EvolutionaryTraceiP48425.

Family and domain databases

CDDicd03343. cpn60. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHSB_THEAC
AccessioniPrimary (citable) accession number: P48425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.