Thermosome subunit beta - Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

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P48425 (THSB_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 93. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Thermosome subunit beta

Alternative name(s):
Chaperonin subunit beta
Thermosome subunit 2

Gene names

Name:	thsB
Ordered Locus Names:	Ta1276

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma ›

Protein attributes

Sequence length	543 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
Subunit structure	Forms a Heterooligomeric complex of two stacked eight-membered rings.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the TCP-1 chaperonin family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 543

543

Thermosome subunit beta

PRO_0000128410

Secondary structure

543

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P48425 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: F9CDAEE63E8B84E6
Show »

FASTA

543

58,480

        10         20         30         40         50         60 
MIAGQPIFIL KEGTKRESGK DAMKENIEAA IAISNSVRSS LGPRGMDKML VDSLGDIVIT 

        70         80         90        100        110        120 
NDGVTILKEM DVEHPAAKMM VEVSKTQDSF VGDGTTTAVI IAGGLLQQAQ GLINQNVHPT 

       130        140        150        160        170        180 
VISEGYRMAS EEAKRVIDEI STKIGADEKA LLLKMAQTSL NSKSASVAKD KLAEISYEAV 

       190        200        210        220        230        240 
KSVAELRDGK YYVDFDNIQV VKKQGGAIDD TQLINGIIVD KEKVHPGMPD VVKDAKIALL 

       250        260        270        280        290        300 
DAPLEIKKPE FDTNLRIEDP SMIQKFLAQE ENMLREMVDK IKSVGANVVI TQKGIDDMAQ 

       310        320        330        340        350        360 
HYLSRAGIYA VRRVKKSDMD KLAKATGASI VSTIDEISSS DLGTAERVEQ VKVGEDYMTF 

       370        380        390        400        410        420 
VTGCKNPKAV SILVRGETEH VVDEMERSIT DSLHVVASAL EDGAYAAGGG ATAAEIAFRL 

       430        440        450        460        470        480 
RSYAQKIGGR QQLAIEKFAD AIEEIPRALA ENAGLDPIDI LLKLRAEHAK GNKTYGINVF 

       490        500        510        520        530        540 
TGEIEDMVKN GVIEPIRVGK QAIESATEAA IMILRIDDVI ATKSSSSSSN PPKSGSSSES 


SED

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure of the thermosome from Thermoplasma acidophilum." Waldmann T., Lupas A.N., Kellermann J., Peters J., Baumeister W. Biol. Chem. Hoppe-Seyler 376:119-126(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 188-195. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[2]	"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[3]	"The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC." Waldmann T., Nimmesgern E., Nitsch M., Peters J., Pfeifer G., Mueller S., Kellermann J., Engel A., Hartl F.-U., Baumeister W. Eur. J. Biochem. 227:848-856(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 80-113 AND 421-445. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[4]	"Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT." Ditzel L., Loewe J., Stock D., Stetter K.-O., Huber H., Huber R., Steinbacher S. Cell 93:125-138(1998) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z46650 Genomic DNA. Translation: CAA86611.1.
AL445067 Genomic DNA. Translation: CAC12400.1.

PIR

S53817.

RefSeq

NP_394733.1. NC_002578.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A6D	X-ray	2.60	B	1-543	[»]
1A6E	X-ray	3.20	B	1-543	[»]
1E0R	X-ray	2.80	B	215-366	[»]

ProteinModelPortal

P48425.

SMR

P48425. Positions 20-521.

ModBase

Search...

Protein-protein interaction databases

STRING

273075.Ta1276.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

CAC12400; CAC12400; CAC12400.

GeneID

1456762.

KEGG

tac:Ta1276.

Phylogenomic databases

eggNOG

COG0459.

HOGENOM

HOG000226729.

OMA

CPNNKAV.

ProtClustDB

CLSK227872.

Family and domain databases

InterPro

IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR012714. Thermosome_arc.
[Graphical view]

PANTHER

PTHR11353. PTHR11353. 1 hit.
PTHR11353:SF27. PTHR11353:SF27. 1 hit.

Pfam

PF00118. Cpn60_TCP1. 1 hit.
[Graphical view]

PRINTS

PR00304. TCOMPLEXTCP1.

SUPFAM

SSF48592. GroEL-ATPase. 1 hit.

TIGRFAMs

TIGR02339. thermosome_arch. 1 hit.

PROSITE

PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P48425.

Entry information

Entry name

THSB_THEAC

Accession

Primary (citable) accession number: P48425

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents