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P48425 (THSB_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thermosome subunit beta
Alternative name(s):
Chaperonin subunit beta
Thermosome subunit 2
Gene names
Name:thsB
Ordered Locus Names:Ta1276
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

Subunit structure

Forms a Heterooligomeric complex of two stacked eight-membered rings.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the TCP-1 chaperonin family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Thermosome subunit beta
PRO_0000128410

Secondary structure

............................................................................ 543
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P48425 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: F9CDAEE63E8B84E6

FASTA54358,480
        10         20         30         40         50         60 
MIAGQPIFIL KEGTKRESGK DAMKENIEAA IAISNSVRSS LGPRGMDKML VDSLGDIVIT 

        70         80         90        100        110        120 
NDGVTILKEM DVEHPAAKMM VEVSKTQDSF VGDGTTTAVI IAGGLLQQAQ GLINQNVHPT 

       130        140        150        160        170        180 
VISEGYRMAS EEAKRVIDEI STKIGADEKA LLLKMAQTSL NSKSASVAKD KLAEISYEAV 

       190        200        210        220        230        240 
KSVAELRDGK YYVDFDNIQV VKKQGGAIDD TQLINGIIVD KEKVHPGMPD VVKDAKIALL 

       250        260        270        280        290        300 
DAPLEIKKPE FDTNLRIEDP SMIQKFLAQE ENMLREMVDK IKSVGANVVI TQKGIDDMAQ 

       310        320        330        340        350        360 
HYLSRAGIYA VRRVKKSDMD KLAKATGASI VSTIDEISSS DLGTAERVEQ VKVGEDYMTF 

       370        380        390        400        410        420 
VTGCKNPKAV SILVRGETEH VVDEMERSIT DSLHVVASAL EDGAYAAGGG ATAAEIAFRL 

       430        440        450        460        470        480 
RSYAQKIGGR QQLAIEKFAD AIEEIPRALA ENAGLDPIDI LLKLRAEHAK GNKTYGINVF 

       490        500        510        520        530        540 
TGEIEDMVKN GVIEPIRVGK QAIESATEAA IMILRIDDVI ATKSSSSSSN PPKSGSSSES 


SED 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure of the thermosome from Thermoplasma acidophilum."
Waldmann T., Lupas A.N., Kellermann J., Peters J., Baumeister W.
Biol. Chem. Hoppe-Seyler 376:119-126(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 188-195.
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[2]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[3]"The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC."
Waldmann T., Nimmesgern E., Nitsch M., Peters J., Pfeifer G., Mueller S., Kellermann J., Engel A., Hartl F.-U., Baumeister W.
Eur. J. Biochem. 227:848-856(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 80-113 AND 421-445.
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[4]"Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT."
Ditzel L., Loewe J., Stock D., Stetter K.-O., Huber H., Huber R., Steinbacher S.
Cell 93:125-138(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46650 Genomic DNA. Translation: CAA86611.1.
AL445067 Genomic DNA. Translation: CAC12400.1.
PIRS53817.
RefSeqNP_394733.1. NC_002578.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6DX-ray2.60B1-543[»]
1A6EX-ray3.20B1-543[»]
1E0RX-ray2.80B214-367[»]
ProteinModelPortalP48425.
SMRP48425. Positions 20-521.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1534042.
STRING273075.Ta1276.

Proteomic databases

PRIDEP48425.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC12400; CAC12400; CAC12400.
GeneID1456762.
KEGGtac:Ta1276.

Phylogenomic databases

eggNOGCOG0459.
HOGENOMHOG000226729.
OMAAERSMRD.

Family and domain databases

Gene3D1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PANTHERPTHR11353. PTHR11353. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00304. TCOMPLEXTCP1.
SUPFAMSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsTIGR02339. thermosome_arch. 1 hit.
PROSITEPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP48425.

Entry information

Entry nameTHSB_THEAC
AccessionPrimary (citable) accession number: P48425
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references