Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P48425

- THSB_THEAC

UniProt

P48425 - THSB_THEAC

Protein

Thermosome subunit beta

Gene

thsB

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thermosome subunit beta
    Alternative name(s):
    Chaperonin subunit beta
    Thermosome subunit 2
    Gene namesi
    Name:thsB
    Ordered Locus Names:Ta1276
    OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
    Taxonomic identifieri273075 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001024: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Thermosome subunit betaPRO_0000128410Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Proteomic databases

    PRIDEiP48425.

    Interactioni

    Subunit structurei

    Forms a Heterooligomeric complex of two stacked eight-membered rings.

    Protein-protein interaction databases

    MINTiMINT-1534042.
    STRINGi273075.Ta1276.

    Structurei

    Secondary structure

    1
    543
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi21 – 3818
    Beta strandi48 – 514
    Beta strandi57 – 604
    Helixi63 – 697
    Helixi75 – 8410
    Helixi94 – 11421
    Helixi119 – 14022
    Helixi148 – 16013
    Helixi164 – 1685
    Helixi169 – 18315
    Beta strandi184 – 1863
    Beta strandi188 – 1936
    Helixi195 – 1973
    Beta strandi198 – 2069
    Helixi208 – 2103
    Beta strandi212 – 2209
    Beta strandi230 – 24213
    Beta strandi250 – 2556
    Helixi262 – 28322
    Beta strandi288 – 2936
    Helixi297 – 3059
    Beta strandi309 – 3113
    Helixi316 – 32611
    Beta strandi330 – 3323
    Helixi334 – 3363
    Helixi339 – 3413
    Beta strandi343 – 35311
    Beta strandi356 – 36813
    Beta strandi370 – 3789
    Helixi379 – 40224
    Beta strandi404 – 4074
    Turni408 – 4103
    Helixi411 – 42616
    Helixi431 – 44212
    Helixi444 – 45310
    Helixi457 – 46913
    Beta strandi475 – 4784
    Turni479 – 4824
    Beta strandi483 – 4864
    Turni487 – 4915
    Beta strandi493 – 4953
    Helixi496 – 51520
    Beta strandi516 – 5205

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A6DX-ray2.60B1-543[»]
    1A6EX-ray3.20B1-543[»]
    1E0RX-ray2.80B214-367[»]
    ProteinModelPortaliP48425.
    SMRiP48425. Positions 20-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP48425.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCP-1 chaperonin family.Curated

    Phylogenomic databases

    eggNOGiCOG0459.
    HOGENOMiHOG000226729.
    OMAiAERSMRD.

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProiIPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    IPR012714. Thermosome_arc.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00304. TCOMPLEXTCP1.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
    PROSITEiPS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48425-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIAGQPIFIL KEGTKRESGK DAMKENIEAA IAISNSVRSS LGPRGMDKML    50
    VDSLGDIVIT NDGVTILKEM DVEHPAAKMM VEVSKTQDSF VGDGTTTAVI 100
    IAGGLLQQAQ GLINQNVHPT VISEGYRMAS EEAKRVIDEI STKIGADEKA 150
    LLLKMAQTSL NSKSASVAKD KLAEISYEAV KSVAELRDGK YYVDFDNIQV 200
    VKKQGGAIDD TQLINGIIVD KEKVHPGMPD VVKDAKIALL DAPLEIKKPE 250
    FDTNLRIEDP SMIQKFLAQE ENMLREMVDK IKSVGANVVI TQKGIDDMAQ 300
    HYLSRAGIYA VRRVKKSDMD KLAKATGASI VSTIDEISSS DLGTAERVEQ 350
    VKVGEDYMTF VTGCKNPKAV SILVRGETEH VVDEMERSIT DSLHVVASAL 400
    EDGAYAAGGG ATAAEIAFRL RSYAQKIGGR QQLAIEKFAD AIEEIPRALA 450
    ENAGLDPIDI LLKLRAEHAK GNKTYGINVF TGEIEDMVKN GVIEPIRVGK 500
    QAIESATEAA IMILRIDDVI ATKSSSSSSN PPKSGSSSES SED 543
    Length:543
    Mass (Da):58,480
    Last modified:February 1, 1996 - v1
    Checksum:iF9CDAEE63E8B84E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46650 Genomic DNA. Translation: CAA86611.1.
    AL445067 Genomic DNA. Translation: CAC12400.1.
    PIRiS53817.
    RefSeqiNP_394733.1. NC_002578.1.
    WP_010901684.1. NC_002578.1.

    Genome annotation databases

    EnsemblBacteriaiCAC12400; CAC12400; CAC12400.
    GeneIDi1456762.
    KEGGitac:Ta1276.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46650 Genomic DNA. Translation: CAA86611.1 .
    AL445067 Genomic DNA. Translation: CAC12400.1 .
    PIRi S53817.
    RefSeqi NP_394733.1. NC_002578.1.
    WP_010901684.1. NC_002578.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A6D X-ray 2.60 B 1-543 [» ]
    1A6E X-ray 3.20 B 1-543 [» ]
    1E0R X-ray 2.80 B 214-367 [» ]
    ProteinModelPortali P48425.
    SMRi P48425. Positions 20-521.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1534042.
    STRINGi 273075.Ta1276.

    Proteomic databases

    PRIDEi P48425.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC12400 ; CAC12400 ; CAC12400 .
    GeneIDi 1456762.
    KEGGi tac:Ta1276.

    Phylogenomic databases

    eggNOGi COG0459.
    HOGENOMi HOG000226729.
    OMAi AERSMRD.

    Miscellaneous databases

    EvolutionaryTracei P48425.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProi IPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    IPR012714. Thermosome_arc.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00304. TCOMPLEXTCP1.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsi TIGR02339. thermosome_arch. 1 hit.
    PROSITEi PS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the thermosome from Thermoplasma acidophilum."
      Waldmann T., Lupas A.N., Kellermann J., Peters J., Baumeister W.
      Biol. Chem. Hoppe-Seyler 376:119-126(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 188-195.
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
    2. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
      Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
      Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
    3. "The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC."
      Waldmann T., Nimmesgern E., Nitsch M., Peters J., Pfeifer G., Mueller S., Kellermann J., Engel A., Hartl F.-U., Baumeister W.
      Eur. J. Biochem. 227:848-856(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 80-113 AND 421-445.
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
    4. "Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT."
      Ditzel L., Loewe J., Stock D., Stetter K.-O., Huber H., Huber R., Steinbacher S.
      Cell 93:125-138(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS).

    Entry informationi

    Entry nameiTHSB_THEAC
    AccessioniPrimary (citable) accession number: P48425
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3