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P48425

- THSB_THEAC

UniProt

P48425 - THSB_THEAC

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Protein

Thermosome subunit beta

Gene
thsB, Ta1276
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosome subunit beta
Alternative name(s):
Chaperonin subunit beta
Thermosome subunit 2
Gene namesi
Name:thsB
Ordered Locus Names:Ta1276
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Thermosome subunit betaPRO_0000128410Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PRIDEiP48425.

Interactioni

Subunit structurei

Forms a Heterooligomeric complex of two stacked eight-membered rings.

Protein-protein interaction databases

MINTiMINT-1534042.
STRINGi273075.Ta1276.

Structurei

Secondary structure

1
543
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 3818
Beta strandi48 – 514
Beta strandi57 – 604
Helixi63 – 697
Helixi75 – 8410
Helixi94 – 11421
Helixi119 – 14022
Helixi148 – 16013
Helixi164 – 1685
Helixi169 – 18315
Beta strandi184 – 1863
Beta strandi188 – 1936
Helixi195 – 1973
Beta strandi198 – 2069
Helixi208 – 2103
Beta strandi212 – 2209
Beta strandi230 – 24213
Beta strandi250 – 2556
Helixi262 – 28322
Beta strandi288 – 2936
Helixi297 – 3059
Beta strandi309 – 3113
Helixi316 – 32611
Beta strandi330 – 3323
Helixi334 – 3363
Helixi339 – 3413
Beta strandi343 – 35311
Beta strandi356 – 36813
Beta strandi370 – 3789
Helixi379 – 40224
Beta strandi404 – 4074
Turni408 – 4103
Helixi411 – 42616
Helixi431 – 44212
Helixi444 – 45310
Helixi457 – 46913
Beta strandi475 – 4784
Turni479 – 4824
Beta strandi483 – 4864
Turni487 – 4915
Beta strandi493 – 4953
Helixi496 – 51520
Beta strandi516 – 5205

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6DX-ray2.60B1-543[»]
1A6EX-ray3.20B1-543[»]
1E0RX-ray2.80B214-367[»]
ProteinModelPortaliP48425.
SMRiP48425. Positions 20-521.

Miscellaneous databases

EvolutionaryTraceiP48425.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.

Phylogenomic databases

eggNOGiCOG0459.
HOGENOMiHOG000226729.
OMAiAERSMRD.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48425-1 [UniParc]FASTAAdd to Basket

« Hide

MIAGQPIFIL KEGTKRESGK DAMKENIEAA IAISNSVRSS LGPRGMDKML    50
VDSLGDIVIT NDGVTILKEM DVEHPAAKMM VEVSKTQDSF VGDGTTTAVI 100
IAGGLLQQAQ GLINQNVHPT VISEGYRMAS EEAKRVIDEI STKIGADEKA 150
LLLKMAQTSL NSKSASVAKD KLAEISYEAV KSVAELRDGK YYVDFDNIQV 200
VKKQGGAIDD TQLINGIIVD KEKVHPGMPD VVKDAKIALL DAPLEIKKPE 250
FDTNLRIEDP SMIQKFLAQE ENMLREMVDK IKSVGANVVI TQKGIDDMAQ 300
HYLSRAGIYA VRRVKKSDMD KLAKATGASI VSTIDEISSS DLGTAERVEQ 350
VKVGEDYMTF VTGCKNPKAV SILVRGETEH VVDEMERSIT DSLHVVASAL 400
EDGAYAAGGG ATAAEIAFRL RSYAQKIGGR QQLAIEKFAD AIEEIPRALA 450
ENAGLDPIDI LLKLRAEHAK GNKTYGINVF TGEIEDMVKN GVIEPIRVGK 500
QAIESATEAA IMILRIDDVI ATKSSSSSSN PPKSGSSSES SED 543
Length:543
Mass (Da):58,480
Last modified:February 1, 1996 - v1
Checksum:iF9CDAEE63E8B84E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46650 Genomic DNA. Translation: CAA86611.1.
AL445067 Genomic DNA. Translation: CAC12400.1.
PIRiS53817.
RefSeqiNP_394733.1. NC_002578.1.
WP_010901684.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12400; CAC12400; CAC12400.
GeneIDi1456762.
KEGGitac:Ta1276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46650 Genomic DNA. Translation: CAA86611.1 .
AL445067 Genomic DNA. Translation: CAC12400.1 .
PIRi S53817.
RefSeqi NP_394733.1. NC_002578.1.
WP_010901684.1. NC_002578.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A6D X-ray 2.60 B 1-543 [» ]
1A6E X-ray 3.20 B 1-543 [» ]
1E0R X-ray 2.80 B 214-367 [» ]
ProteinModelPortali P48425.
SMRi P48425. Positions 20-521.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1534042.
STRINGi 273075.Ta1276.

Proteomic databases

PRIDEi P48425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC12400 ; CAC12400 ; CAC12400 .
GeneIDi 1456762.
KEGGi tac:Ta1276.

Phylogenomic databases

eggNOGi COG0459.
HOGENOMi HOG000226729.
OMAi AERSMRD.

Miscellaneous databases

EvolutionaryTracei P48425.

Family and domain databases

Gene3Di 1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProi IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view ]
PANTHERi PTHR11353. PTHR11353. 1 hit.
Pfami PF00118. Cpn60_TCP1. 1 hit.
[Graphical view ]
PRINTSi PR00304. TCOMPLEXTCP1.
SUPFAMi SSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsi TIGR02339. thermosome_arch. 1 hit.
PROSITEi PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the thermosome from Thermoplasma acidophilum."
    Waldmann T., Lupas A.N., Kellermann J., Peters J., Baumeister W.
    Biol. Chem. Hoppe-Seyler 376:119-126(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 188-195.
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
  2. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
  3. "The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC."
    Waldmann T., Nimmesgern E., Nitsch M., Peters J., Pfeifer G., Mueller S., Kellermann J., Engel A., Hartl F.-U., Baumeister W.
    Eur. J. Biochem. 227:848-856(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 80-113 AND 421-445.
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
  4. "Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT."
    Ditzel L., Loewe J., Stock D., Stetter K.-O., Huber H., Huber R., Steinbacher S.
    Cell 93:125-138(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS).

Entry informationi

Entry nameiTHSB_THEAC
AccessioniPrimary (citable) accession number: P48425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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