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Reviewed, UniProtKB/Swiss-Prot P48424 (THSA_THEAC)

Last modified February 9, 2010. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Thermosome subunit alpha
Alternative name(s):
    Thermosome subunit 1
    Chaperonin subunit alpha
Gene names
Name: thsA
Ordered Locus Names: Ta0980
OrganismThermoplasma acidophilum [Complete proteome] [HAMAP]
Taxonomic identifier2303 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

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Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

Subunit structure

Forms a Heterooligomeric complex of two stacked eight-membered rings.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the TCP-1 chaperonin family.

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Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processprotein folding

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

unfolded protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 545545Thermosome subunit alpha
PRO_0000128409

Secondary structure

1 ............................................................................... 545
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P48424-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 0E0B3241DF62C63C

FASTA54558,281
        10         20         30         40         50         60 
MMTGQVPILV LKEGTQREQG KNAQRNNIEA AKAIADAVRT TLGPKGMDKM LVDSIGDIII 

        70         80         90        100        110        120 
SNDGATILKE MDVEHPTAKM IVEVSKAQDT AVGDGTTTAV VLSGELLKQA ETLLDQGVHP 

       130        140        150        160        170        180 
TVISNGYRLA VNEARKIIDE IAEKSTDDAT LRKIALTALS GKNTGLSNDF LADLVVKAVN 

       190        200        210        220        230        240 
AVAEVRDGKT IVDTANIKVD KKNGGSVNDT QFISGIVIDK EKVHSKMPDV VKNAKIALID 

       250        260        270        280        290        300 
SALEIKKTEI EAKVQISDPS KIQDFLNQET NTFKQMVEKI KKSGANVVLC QKGIDDVAQH 

       310        320        330        340        350        360 
YLAKEGIYAV RRVKKSDMEK LAKATGAKIV TDLDDLTPSV LGEAETVEER KIGDDRMTFV 

       370        380        390        400        410        420 
MGCKNPKAVS ILIRGGTDHV VSEVERALND AIRVVAITKE DGKFLWGGGA VEAELAMRLA 

       430        440        450        460        470        480 
KYANSVGGRE QLAIEAFAKA LEIIPRTLAE NAGIDPINTL IKLKAEHEKG RISVGVDLDN 

       490        500        510        520        530        540 
NGVGDMKAKG VVDPLRVKTH ALESAVEVAT MILRIDDVIA SKKSTPPSGQ GGQGQGMPGG 


GMPEY

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References

« Hide 'large scale' references
[1]"Primary structure of the thermosome from Thermoplasma acidophilum."
Waldmann T., Lupas A.N., Kellermann J., Peters J., Baumeister W.
Biol. Chem. Hoppe-Seyler 376:119-126(1995) [PubMed: 7794526] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 88-97 AND 427-436.
Strain: ATCC 25905 / AMRC-C165 / DSM 1728 / IFO 15155 / JCM 9062.
[2]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed: 11029001] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / AMRC-C165 / DSM 1728 / IFO 15155 / JCM 9062.
[3]"The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC."
Waldmann T., Nimmesgern E., Nitsch M., Peters J., Pfeifer G., Mueller S., Kellermann J., Engel A., Hartl F.-U., Baumeister W.
Eur. J. Biochem. 227:848-856(1995) [PubMed: 7867646] [Abstract]
Cited for: PROTEIN SEQUENCE OF 80-114 AND 420-444.
Strain: ATCC 25905 / AMRC-C165 / DSM 1728 / IFO 15155 / JCM 9062.
[4]"Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin."
Klumpp M., Baumeister W., Essen L.-O.
Cell 91:263-270(1997) [PubMed: 9346243] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 213-364.
[5]"Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT."
Ditzel L., Loewe J., Stock D., Stetter K.-O., Huber H., Huber R., Steinbacher S.
Cell 93:125-138(1998) [PubMed: 9546398] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46649 Genomic DNA. Translation: CAA86610.1.
AL445066 Genomic DNA. Translation: CAC12109.1. Different initiation.
PIRS53816.
RefSeqNP_394440.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6DX-ray2.60A1-545[»]
1A6EX-ray3.20A1-545[»]
1ASSX-ray2.30A214-365[»]
1ASXX-ray2.80A214-365[»]
ModBaseSearch...

Genome annotation databases

GeneID1456505.
KEGGtac:Ta0980.
NMPDRfig|273075.1.peg.962.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG497503.
OMAATILDEM.

Enzyme and pathway databases

BioCycTACI273075:TA0980-MONOMER.

Family and domain databases

InterProIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR012714. Thermosome_arc.
[Graphical view]
PANTHERPTHR11353. Cpn60/TCP-1. 1 hit.
PTHR11353:SF27. Thermosome_arc. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00304. TCOMPLEXTCP1.
TIGRFAMsTIGR02339. thermosome_arch. 1 hit.
PROSITEPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameTHSA_THEAC
AccessionPrimary (citable) accession number: P48424
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 9, 2010
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents