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Protein

Thermosome subunit alpha

Gene

thsA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.9. 6324.

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosome subunit alpha
Alternative name(s):
Chaperonin subunit alpha
Thermosome subunit 1
Gene namesi
Name:thsA
Ordered Locus Names:Ta0980
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001284091 – 545Thermosome subunit alphaAdd BLAST545

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PRIDEiP48424.

Interactioni

Subunit structurei

Forms a Heterooligomeric complex of two stacked eight-membered rings.

Protein-protein interaction databases

MINTiMINT-1534030.
STRINGi273075.Ta0980.

Structurei

Secondary structure

1545
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 39Combined sources20
Beta strandi48 – 52Combined sources5
Beta strandi54 – 56Combined sources3
Beta strandi58 – 61Combined sources4
Helixi64 – 70Combined sources7
Helixi76 – 82Combined sources7
Helixi83 – 86Combined sources4
Turni88 – 90Combined sources3
Helixi95 – 116Combined sources22
Helixi120 – 141Combined sources22
Helixi148 – 158Combined sources11
Turni159 – 161Combined sources3
Helixi168 – 182Combined sources15
Beta strandi184 – 191Combined sources8
Helixi194 – 196Combined sources3
Beta strandi197 – 201Combined sources5
Beta strandi216 – 219Combined sources4
Beta strandi229 – 241Combined sources13
Helixi247 – 255Combined sources9
Helixi259 – 261Combined sources3
Helixi262 – 282Combined sources21
Beta strandi286 – 292Combined sources7
Helixi296 – 304Combined sources9
Beta strandi308 – 310Combined sources3
Helixi315 – 325Combined sources11
Beta strandi330 – 332Combined sources3
Helixi333 – 335Combined sources3
Helixi338 – 340Combined sources3
Beta strandi342 – 352Combined sources11
Beta strandi355 – 362Combined sources8
Beta strandi369 – 373Combined sources5
Beta strandi376 – 378Combined sources3
Helixi381 – 401Combined sources21
Beta strandi403 – 406Combined sources4
Turni407 – 409Combined sources3
Helixi410 – 424Combined sources15
Helixi428 – 441Combined sources14
Helixi443 – 452Combined sources10
Helixi456 – 468Combined sources13
Beta strandi474 – 477Combined sources4
Turni478 – 481Combined sources4
Beta strandi482 – 485Combined sources4
Helixi486 – 489Combined sources4
Beta strandi492 – 494Combined sources3
Helixi495 – 513Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6DX-ray2.60A1-545[»]
1A6EX-ray3.20A1-545[»]
1ASSX-ray2.30A214-365[»]
1ASXX-ray2.80A214-365[»]
ProteinModelPortaliP48424.
SMRiP48424.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48424.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiarCOG01257. Archaea.
COG0459. LUCA.
HOGENOMiHOG000226730.
OMAiHYLAQEG.

Family and domain databases

CDDicd03343. cpn60. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTGQVPILV LKEGTQREQG KNAQRNNIEA AKAIADAVRT TLGPKGMDKM
60 70 80 90 100
LVDSIGDIII SNDGATILKE MDVEHPTAKM IVEVSKAQDT AVGDGTTTAV
110 120 130 140 150
VLSGELLKQA ETLLDQGVHP TVISNGYRLA VNEARKIIDE IAEKSTDDAT
160 170 180 190 200
LRKIALTALS GKNTGLSNDF LADLVVKAVN AVAEVRDGKT IVDTANIKVD
210 220 230 240 250
KKNGGSVNDT QFISGIVIDK EKVHSKMPDV VKNAKIALID SALEIKKTEI
260 270 280 290 300
EAKVQISDPS KIQDFLNQET NTFKQMVEKI KKSGANVVLC QKGIDDVAQH
310 320 330 340 350
YLAKEGIYAV RRVKKSDMEK LAKATGAKIV TDLDDLTPSV LGEAETVEER
360 370 380 390 400
KIGDDRMTFV MGCKNPKAVS ILIRGGTDHV VSEVERALND AIRVVAITKE
410 420 430 440 450
DGKFLWGGGA VEAELAMRLA KYANSVGGRE QLAIEAFAKA LEIIPRTLAE
460 470 480 490 500
NAGIDPINTL IKLKAEHEKG RISVGVDLDN NGVGDMKAKG VVDPLRVKTH
510 520 530 540
ALESAVEVAT MILRIDDVIA SKKSTPPSGQ GGQGQGMPGG GMPEY
Length:545
Mass (Da):58,281
Last modified:February 1, 1996 - v1
Checksum:i0E0B3241DF62C63C
GO

Sequence cautioni

The sequence CAC12109 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46649 Genomic DNA. Translation: CAA86610.1.
AL445066 Genomic DNA. Translation: CAC12109.1. Different initiation.
PIRiS53816.
RefSeqiWP_048161900.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12109; CAC12109; CAC12109.
GeneIDi1456505.
KEGGitac:Ta0980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46649 Genomic DNA. Translation: CAA86610.1.
AL445066 Genomic DNA. Translation: CAC12109.1. Different initiation.
PIRiS53816.
RefSeqiWP_048161900.1. NC_002578.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6DX-ray2.60A1-545[»]
1A6EX-ray3.20A1-545[»]
1ASSX-ray2.30A214-365[»]
1ASXX-ray2.80A214-365[»]
ProteinModelPortaliP48424.
SMRiP48424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1534030.
STRINGi273075.Ta0980.

Proteomic databases

PRIDEiP48424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC12109; CAC12109; CAC12109.
GeneIDi1456505.
KEGGitac:Ta0980.

Phylogenomic databases

eggNOGiarCOG01257. Archaea.
COG0459. LUCA.
HOGENOMiHOG000226730.
OMAiHYLAQEG.

Enzyme and pathway databases

BRENDAi3.6.4.9. 6324.

Miscellaneous databases

EvolutionaryTraceiP48424.

Family and domain databases

CDDicd03343. cpn60. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHSA_THEAC
AccessioniPrimary (citable) accession number: P48424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.