Thermosome subunit alpha - Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Contribute

Send feedback

Read comments (?) or add your own

P48424 (THSA_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Thermosome subunit alpha

Alternative name(s):
Chaperonin subunit alpha
Thermosome subunit 1

Gene names

Name:	thsA
Ordered Locus Names:	Ta0980

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
Subunit structure	Forms a Heterooligomeric complex of two stacked eight-membered rings.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the TCP-1 chaperonin family.
Sequence caution	The sequence CAC12109.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 545

545

Thermosome subunit alpha

PRO_0000128409

Secondary structure

545

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P48424 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 0E0B3241DF62C63C
Show »

FASTA

545

58,281

        10         20         30         40         50         60 
MMTGQVPILV LKEGTQREQG KNAQRNNIEA AKAIADAVRT TLGPKGMDKM LVDSIGDIII 

        70         80         90        100        110        120 
SNDGATILKE MDVEHPTAKM IVEVSKAQDT AVGDGTTTAV VLSGELLKQA ETLLDQGVHP 

       130        140        150        160        170        180 
TVISNGYRLA VNEARKIIDE IAEKSTDDAT LRKIALTALS GKNTGLSNDF LADLVVKAVN 

       190        200        210        220        230        240 
AVAEVRDGKT IVDTANIKVD KKNGGSVNDT QFISGIVIDK EKVHSKMPDV VKNAKIALID 

       250        260        270        280        290        300 
SALEIKKTEI EAKVQISDPS KIQDFLNQET NTFKQMVEKI KKSGANVVLC QKGIDDVAQH 

       310        320        330        340        350        360 
YLAKEGIYAV RRVKKSDMEK LAKATGAKIV TDLDDLTPSV LGEAETVEER KIGDDRMTFV 

       370        380        390        400        410        420 
MGCKNPKAVS ILIRGGTDHV VSEVERALND AIRVVAITKE DGKFLWGGGA VEAELAMRLA 

       430        440        450        460        470        480 
KYANSVGGRE QLAIEAFAKA LEIIPRTLAE NAGIDPINTL IKLKAEHEKG RISVGVDLDN 

       490        500        510        520        530        540 
NGVGDMKAKG VVDPLRVKTH ALESAVEVAT MILRIDDVIA SKKSTPPSGQ GGQGQGMPGG 


GMPEY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure of the thermosome from Thermoplasma acidophilum." Waldmann T., Lupas A.N., Kellermann J., Peters J., Baumeister W. Biol. Chem. Hoppe-Seyler 376:119-126(1995) [PubMed: 7794526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 88-97 AND 427-436. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[2]	"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[3]	"The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC." Waldmann T., Nimmesgern E., Nitsch M., Peters J., Pfeifer G., Mueller S., Kellermann J., Engel A., Hartl F.-U., Baumeister W. Eur. J. Biochem. 227:848-856(1995) [PubMed: 7867646] [Abstract] Cited for: PROTEIN SEQUENCE OF 80-114 AND 420-444. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
[4]	"Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin." Klumpp M., Baumeister W., Essen L.-O. Cell 91:263-270(1997) [PubMed: 9346243] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 213-364.
[5]	"Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT." Ditzel L., Loewe J., Stock D., Stetter K.-O., Huber H., Huber R., Steinbacher S. Cell 93:125-138(1998) [PubMed: 9546398] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z46649 Genomic DNA. Translation: CAA86610.1.
AL445066 Genomic DNA. Translation: CAC12109.1. Different initiation.

PIR

S53816.

RefSeq

NP_394440.1. NC_002578.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A6D	X-ray	2.60	A	1-545	[»]
1A6E	X-ray	3.20	A	1-545	[»]
1ASS	X-ray	2.30	A	214-365	[»]
1ASX	X-ray	2.80	A	214-365	[»]

ProteinModelPortal

P48424.

SMR

P48424. Positions 17-519.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1456505.

GenomeReviews

Gene locus Ta0980 in contig AL139299_GR.

KEGG

tac:Ta0980.

NMPDR

fig|273075.1.peg.962.

Phylogenomic databases

HOGENOM

HBG497503.

OMA

QRMNILA.

PhylomeDB

P48424.

ProtClustDB

CLSK227871.

Enzyme and pathway databases

BioCyc

TACI273075:TA0980-MONOMER.

Family and domain databases

InterPro

IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR012714. Thermosome_arc.
[Graphical view]

PANTHER

PTHR11353. Cpn60/TCP-1. 1 hit.

Pfam

PF00118. Cpn60_TCP1. 1 hit.
[Graphical view]

PRINTS

PR00304. TCOMPLEXTCP1.

SUPFAM

SSF48592. GroEL-ATPase. 1 hit.

TIGRFAMs

TIGR02339. Thermosome_arch. 1 hit.

PROSITE

PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

THSA_THEAC

Accession

Primary (citable) accession number: P48424

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	December 14, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents