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Protein

ATP-binding cassette sub-family D member 1

Gene

Abcd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter. Could be involved in the import of VLCFA-CoA synthetase into the peroxisomal membrane.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi507 – 5148ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.
R-MMU-2046105. Linoleic acid (LA) metabolism.
R-MMU-2046106. alpha-linolenic acid (ALA) metabolism.
R-MMU-390247. Beta-oxidation of very long chain fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family D member 1
Alternative name(s):
Adrenoleukodystrophy protein
Short name:
ALDP
Gene namesi
Name:Abcd1
Synonyms:Ald, Aldgh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1349215. Abcd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei92 – 11221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei131 – 15121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei238 – 25821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei338 – 35821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei473 – 49321HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of peroxisomal membrane Source: MGI
  • membrane Source: MGI
  • mitochondrion Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • peroxisomal membrane Source: HGNC
  • peroxisome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736ATP-binding cassette sub-family D member 1PRO_0000093305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP48410.
MaxQBiP48410.
PaxDbiP48410.
PRIDEiP48410.

PTM databases

iPTMnetiP48410.
PhosphoSiteiP48410.

Expressioni

Tissue specificityi

Widely expressed at low levels with higher levels in heart, lung, intestine and spleen than in skeletal muscle, brain, liver and kidney.1 Publication

Developmental stagei

Most abundant in embryo. Gradually decreases during maturation.1 Publication

Inductioni

By dietary fenofibrate.1 Publication

Gene expression databases

BgeeiP48410.
ExpressionAtlasiP48410. baseline and differential.
GenevisibleiP48410. MM.

Interactioni

Subunit structurei

Interacts with PEX19 (By similarity). Could form a heterodimer with ABCD2/ALDR.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ABCD1P338972EBI-81118,EBI-81045From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198062. 2 interactions.
IntActiP48410. 2 interactions.
MINTiMINT-4086454.
STRINGi10090.ENSMUSP00000002084.

Structurei

3D structure databases

ProteinModelPortaliP48410.
SMRiP48410. Positions 459-678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 386293ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini474 – 729256ABC transporterPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 186120Interaction with PEX19By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0064. Eukaryota.
COG4178. LUCA.
GeneTreeiENSGT00390000003950.
HOGENOMiHOG000206081.
HOVERGENiHBG050438.
InParanoidiP48410.
KOiK05675.
OMAiPRVLCRE.
OrthoDBiEOG70ZZMP.
PhylomeDBiP48410.
TreeFamiTF105205.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR031237. ALDP.
IPR005283. FA_transporter.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11384:SF21. PTHR11384:SF21. 1 hit.
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00954. 3a01203. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVLSTPRPS RVTTLKRTAV VLALTAYGVH KIYPLVRQCL TPARGPQVPA
60 70 80 90 100
GEPTQEASGA TATKAGMNRV FLQRLLALLR LLFPRVLCRE TGLLALHSAA
110 120 130 140 150
LVSRTFLSVY VARLDGRLAR CIVRKDPRAF SWQLLQWLLI ALPATFINSA
160 170 180 190 200
IRYLEGQLAL SFRSRLVAHA YGLYFSQQTY YRVSNMDGRL RNPDQSLTED
210 220 230 240 250
VVAFAASVAH LYSNLTKPLL DVAVTSYTLL RAARSRGAGT AWPSAIAGLV
260 270 280 290 300
VFLTANVLRA FSPKFGELVA EEARRKGELR YMHSRVVANS EEIAFYGGHE
310 320 330 340 350
VELALLQHSY QDLASQINLI LLERLWYVML EQFLMKYVWS ASGLLMVAVP
360 370 380 390 400
IITATGYAES DSEAMKKAAL EMKEEELVSE RTEAFTIARN LLTAAADATE
410 420 430 440 450
RIMSSYKEVT ELAGYTARVY EMFQVFEDVK HCRFKRTGDL EEAQAGPGVM
460 470 480 490 500
VQSGVHVEGP LKIQGQVVDV EQGIICENIP IITPTGEVVV ASLNIRVEEG
510 520 530 540 550
MHLLITGPNG CGKSSLFRIL GGLWPTYSGV LYKPPPQRMF YIPQRPYMSV
560 570 580 590 600
GSLRDQVIYP DSAEDMRRKG CSEQQLEAIL GIVHLRHILQ REGGWEAVCD
610 620 630 640 650
WKDVLSGGEK QRIGMARMFY HRPKYALLDE CTSAVSIDVE GKIFQAAKDA
660 670 680 690 700
GIALLSITHR PSLWKYHTHL LQFDGEGGWK FEKLDSAARL SLTEEKQRLE
710 720 730
QQLAGIPKMQ GRLQELRQIL GEAAAPVQPL VPGVPT
Length:736
Mass (Da):81,859
Last modified:February 1, 1996 - v1
Checksum:i20B1B191DFC599E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33637 mRNA. Translation: CAA83917.1.
AK088792 mRNA. Translation: BAC40574.1.
BC011273 mRNA. Translation: AAH11273.1.
BC079840 mRNA. Translation: AAH79840.1.
AJ009991 Genomic DNA. Translation: CAA08935.1.
AF133093 Genomic DNA. No translation available.
CCDSiCCDS30210.1.
PIRiS47044.
RefSeqiNP_031461.1. NM_007435.2.
UniGeneiMm.365.

Genome annotation databases

EnsembliENSMUST00000002084; ENSMUSP00000002084; ENSMUSG00000031378.
GeneIDi11666.
KEGGimmu:11666.
UCSCiuc009tml.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33637 mRNA. Translation: CAA83917.1.
AK088792 mRNA. Translation: BAC40574.1.
BC011273 mRNA. Translation: AAH11273.1.
BC079840 mRNA. Translation: AAH79840.1.
AJ009991 Genomic DNA. Translation: CAA08935.1.
AF133093 Genomic DNA. No translation available.
CCDSiCCDS30210.1.
PIRiS47044.
RefSeqiNP_031461.1. NM_007435.2.
UniGeneiMm.365.

3D structure databases

ProteinModelPortaliP48410.
SMRiP48410. Positions 459-678.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198062. 2 interactions.
IntActiP48410. 2 interactions.
MINTiMINT-4086454.
STRINGi10090.ENSMUSP00000002084.

PTM databases

iPTMnetiP48410.
PhosphoSiteiP48410.

Proteomic databases

EPDiP48410.
MaxQBiP48410.
PaxDbiP48410.
PRIDEiP48410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002084; ENSMUSP00000002084; ENSMUSG00000031378.
GeneIDi11666.
KEGGimmu:11666.
UCSCiuc009tml.1. mouse.

Organism-specific databases

CTDi215.
MGIiMGI:1349215. Abcd1.

Phylogenomic databases

eggNOGiKOG0064. Eukaryota.
COG4178. LUCA.
GeneTreeiENSGT00390000003950.
HOGENOMiHOG000206081.
HOVERGENiHBG050438.
InParanoidiP48410.
KOiK05675.
OMAiPRVLCRE.
OrthoDBiEOG70ZZMP.
PhylomeDBiP48410.
TreeFamiTF105205.

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.
R-MMU-2046105. Linoleic acid (LA) metabolism.
R-MMU-2046106. alpha-linolenic acid (ALA) metabolism.
R-MMU-390247. Beta-oxidation of very long chain fatty acids.

Miscellaneous databases

NextBioi279283.
PROiP48410.
SOURCEiSearch...

Gene expression databases

BgeeiP48410.
ExpressionAtlasiP48410. baseline and differential.
GenevisibleiP48410. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR031237. ALDP.
IPR005283. FA_transporter.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11384:SF21. PTHR11384:SF21. 1 hit.
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00954. 3a01203. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequence of Aldgh, the mouse homolog of the X-linked adrenoleukodystrophy gene."
    Sarde C.-O., Thomas J., Sadoulet H., Garnier J.-M., Mandel J.-L.
    Mamm. Genome 5:810-813(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibrotic liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Mammary gland.
  4. "The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression."
    Berger J., Albet S., Bentejac M., Netik A., Holzinger A., Roscher A., Bugaut M., Forss-Petter S.
    Eur. J. Biochem. 265:719-727(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: 129/SvJ.
  5. "Comparative sequence analysis of the mouse L1cam locus and the corresponding region of human Xq28."
    Platzer M., Brenner V., Reichwald K., Wiehe T., Oksche A., Rosenthal A.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 362-736.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Lung and Spleen.

Entry informationi

Entry nameiABCD1_MOUSE
AccessioniPrimary (citable) accession number: P48410
Secondary accession number(s): Q9QY41, Q9QZ32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.