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P48404

- CHSB_IPOTR

UniProt

P48404 - CHSB_IPOTR

Protein

Chalcone synthase B

Gene

CHSB

Organism
Ipomoea triloba (Trilobed morning glory)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    • Comment

    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei172 – 1721PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase B (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase B
    Short name:
    CHS-B
    Gene namesi
    Name:CHSB
    OrganismiIpomoea triloba (Trilobed morning glory)
    Taxonomic identifieri35885 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›366›366Chalcone synthase BPRO_0000216000Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP48404.
    SMRiP48404. Positions 14-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P48404-1 [UniParc]FASTAAdd to Basket

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    MSTTVTVLTD TWGRRAKRFE IEGYAKILAI GTATPANWVD QTTYPDFYFR    50
    ITNSQHLLEH KEKFRRICNK SKIRKRHLVL TEELLQKNPS LCTYNETSLN 100
    TRQDILVSEV PKLGKEAAMK AIKEWGRPIS EITHLVFCTT SGVDMPGADF 150
    RLTKLLGLNS SVKRLMMYQQ GCNAGAAMLR LAKDLAESNK GGRILVVCSE 200
    ITINIFRGPS LEQDDNLLAQ CLFGDGSAAM IVGTDPRPDL ETPLFELVSS 250
    AQTIVPNTDS HLKLTLREMG LTFHCSRAVP SVLAENVEDC LVKAFEPYGI 300
    SDWNSIFWVF HPGGNAIVDR VEERLGLGAQ RFRASRDVLS EYGNLTSACV 350
    LFILDEVRNK SKKNEQ 366
    Length:366
    Mass (Da):40,976
    Last modified:February 1, 1996 - v1
    Checksum:iE80E424EF56A9B4D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei366 – 3661

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15953 Genomic DNA. Translation: AAC49035.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15953 Genomic DNA. Translation: AAC49035.1 .

    3D structure databases

    ProteinModelPortali P48404.
    SMRi P48404. Positions 14-364.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the chalcone synthase gene family in the genus Ipomoea."
      Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
      Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCHSB_IPOTR
    AccessioniPrimary (citable) accession number: P48404
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3