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P48404 (CHSB_IPOTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase B

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase B
Short name=CHS-B
Gene names
Name:CHSB
OrganismIpomoea triloba (Trilobed morning glory)
Taxonomic identifier35885 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

Protein attributes

Sequence length366 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›366›366Chalcone synthase B
PRO_0000216000

Sites

Active site1721 By similarity

Experimental info

Non-terminal residue3661

Sequences

Sequence LengthMass (Da)Tools
P48404 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: E80E424EF56A9B4D

FASTA36640,976
        10         20         30         40         50         60 
MSTTVTVLTD TWGRRAKRFE IEGYAKILAI GTATPANWVD QTTYPDFYFR ITNSQHLLEH 

        70         80         90        100        110        120 
KEKFRRICNK SKIRKRHLVL TEELLQKNPS LCTYNETSLN TRQDILVSEV PKLGKEAAMK 

       130        140        150        160        170        180 
AIKEWGRPIS EITHLVFCTT SGVDMPGADF RLTKLLGLNS SVKRLMMYQQ GCNAGAAMLR 

       190        200        210        220        230        240 
LAKDLAESNK GGRILVVCSE ITINIFRGPS LEQDDNLLAQ CLFGDGSAAM IVGTDPRPDL 

       250        260        270        280        290        300 
ETPLFELVSS AQTIVPNTDS HLKLTLREMG LTFHCSRAVP SVLAENVEDC LVKAFEPYGI 

       310        320        330        340        350        360 
SDWNSIFWVF HPGGNAIVDR VEERLGLGAQ RFRASRDVLS EYGNLTSACV LFILDEVRNK 


SKKNEQ 

« Hide

References

[1]"Evolution of the chalcone synthase gene family in the genus Ipomoea."
Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15953 Genomic DNA. Translation: AAC49035.1.

3D structure databases

ProteinModelPortalP48404.
SMRP48404. Positions 14-364.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSB_IPOTR
AccessionPrimary (citable) accession number: P48404
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways