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P48403 (CHSA_IPOTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase A

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase A
Short name=CHS-A
Gene names
Name:CHSA
OrganismIpomoea triloba (Trilobed morning glory)
Taxonomic identifier35885 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

Protein attributes

Sequence length362 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›362›362Chalcone synthase A
PRO_0000215999

Sites

Active site1681 By similarity

Experimental info

Non-terminal residue3621

Sequences

Sequence LengthMass (Da)Tools
P48403 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: FC275F289E8707EC

FASTA36240,472
        10         20         30         40         50         60 
MSPTVTVQLT DDTAKRFEGH AKLLAIGTAT PTNWVDQATY PDFYFRITNS ERLLEHKEKF 

        70         80         90        100        110        120 
RRICNKSKIR FRHLVLTEEL LKKSPNLCTY NDASLNTRQD ILVSEVPKLG KEAAMKAIKE 

       130        140        150        160        170        180 
WGRPISEITH LVFCTTSGVD MPGADFQLTK LLGLNSSVKR LMMYQQGCNA GAAMLRLVKD 

       190        200        210        220        230        240 
LAENNKGARV LVVCSEITIN IFRGPSLEQD DNLLAQCLFG DGSAAMIVGK DPRPGLETPL 

       250        260        270        280        290        300 
FELVSSAQTI VPNTDSHLKL TLREMGLTFH CSRAVPSVLA ENVEDCLVKA FEPYGISDWN 

       310        320        330        340        350        360 
SIFWVFHPGG YAIVDRVEER LGLGPERLRA SRDVLSEYGN LTSACVLFIL DEMRKKSKKD 


EQ 

« Hide

References

[1]"Evolution of the chalcone synthase gene family in the genus Ipomoea."
Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15952 Genomic DNA. Translation: AAC49034.1.

3D structure databases

ProteinModelPortalP48403.
SMRP48403. Positions 14-360.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSA_IPOTR
AccessionPrimary (citable) accession number: P48403
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways