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P48401

- CHSA_IPOTF

UniProt

P48401 - CHSA_IPOTF

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Protein

Chalcone synthase A

Gene
CHSA
Organism
Ipomoea trifida (Morning glory)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681 By similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase A (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase A
Short name:
CHS-A
Gene namesi
Name:CHSA
OrganismiIpomoea trifida (Morning glory)
Taxonomic identifieri35884 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›362›362Chalcone synthase APRO_0000215997Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48401.
SMRiP48401. Positions 14-360.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P48401-1 [UniParc]FASTAAdd to Basket

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MSPTATVQLT DDTAKRFEGH AKLLAIGTAT PTNWVDQATY PDFYFRITNS    50
EHLLEHKEKF RRICNKSKIR KRHLVLTKEL LKKNPNLCTY NDASLNTRQD 100
ILVSEVPKLG KEAAMKAIKE WGRPISEITH LVFCTTSGVD MPGADFQLTK 150
LLGLNSSVKR LMMYQQGCNA GAAMLRLVKD LAENNKGARV LVVCSEITIN 200
IFRGPSLEQD DNLLAQCLFG DGSAAMIVGK DPRPGLETPL FELVSSAQTI 250
VPNTDSHLKL HLREMGLTFH CSRAVPSVLA ENVEDCLVKA FEPYGISDWN 300
SIFWVFHPGG NAIVDRVEER LGLGPERLRA SRDVLSEYGN LTSACVLFIL 350
DEMRKKSKKD EQ 362
Length:362
Mass (Da):40,419
Last modified:February 1, 1996 - v1
Checksum:i10E9C8136FB640B8
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei362 – 3621

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15950 Genomic DNA. Translation: AAC49032.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15950 Genomic DNA. Translation: AAC49032.1 .

3D structure databases

ProteinModelPortali P48401.
SMRi P48401. Positions 14-360.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the chalcone synthase gene family in the genus Ipomoea."
    Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
    Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHSA_IPOTF
AccessioniPrimary (citable) accession number: P48401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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