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P48400

- CHSA_IPOPL

UniProt

P48400 - CHSA_IPOPL

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Protein

Chalcone synthase A

Gene

CHSA

Organism
Ipomoea platensis (Morning glory)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase A (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase A
Short name:
CHS-A
Gene namesi
Name:CHSA
OrganismiIpomoea platensis (Morning glory)
Taxonomic identifieri35881 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›362›362Chalcone synthase APRO_0000215996Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48400.
SMRiP48400. Positions 12-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P48400-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTTVLPDTW SRRAKRFEGH AKILAVGTAT PANWVDQTTY PDFYFRITNS
60 70 80 90 100
EHLLEHKEKF RRICNKSKIR KRHLVLTEEL LKKNPNLCTY NETSLNTRQD
110 120 130 140 150
TLVSEVPKLG KEAAMKAIKE WGRPISEITH LVFCTTSGVD MPGADFQLTK
160 170 180 190 200
LLGLNISVKR LMMYQQGCNA GAAMLRLAKD LAENNKGARV LVVCSEVTLS
210 220 230 240 250
VFRGPSLQQE DNLLAQCLFG DGSAAVIVGT DPRPGLETPL FELVSSAQTI
260 270 280 290 300
IPDTDSHLKL HLLEMGLTFH CSKAVPSLIT QNVEDCLVKA FEPFGISDWN
310 320 330 340 350
SIFWILHPGG NAILDRVEER LGLGPEKLRA SRDVLSEYGN LTSACVLFIL
360
DLVRRKSKKQ QQ
Length:362
Mass (Da):40,434
Last modified:February 1, 1996 - v1
Checksum:i9589BB9E159081EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei362 – 3621

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15945 mRNA. Translation: AAA62497.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15945 mRNA. Translation: AAA62497.1 .

3D structure databases

ProteinModelPortali P48400.
SMRi P48400. Positions 12-359.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the chalcone synthase gene family in the genus Ipomoea."
    Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
    Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCHSA_IPOPL
AccessioniPrimary (citable) accession number: P48400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3