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P48400

- CHSA_IPOPL

UniProt

P48400 - CHSA_IPOPL

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Protein
Chalcone synthase A
Gene
CHSA
Organism
Ipomoea platensis (Morning glory)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681 By similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase A (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase A
Short name:
CHS-A
Gene namesi
Name:CHSA
OrganismiIpomoea platensis (Morning glory)
Taxonomic identifieri35881 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›362›362Chalcone synthase A
PRO_0000215996Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48400.
SMRiP48400. Positions 12-359.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P48400-1 [UniParc]FASTAAdd to Basket

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MSTTVLPDTW SRRAKRFEGH AKILAVGTAT PANWVDQTTY PDFYFRITNS    50
EHLLEHKEKF RRICNKSKIR KRHLVLTEEL LKKNPNLCTY NETSLNTRQD 100
TLVSEVPKLG KEAAMKAIKE WGRPISEITH LVFCTTSGVD MPGADFQLTK 150
LLGLNISVKR LMMYQQGCNA GAAMLRLAKD LAENNKGARV LVVCSEVTLS 200
VFRGPSLQQE DNLLAQCLFG DGSAAVIVGT DPRPGLETPL FELVSSAQTI 250
IPDTDSHLKL HLLEMGLTFH CSKAVPSLIT QNVEDCLVKA FEPFGISDWN 300
SIFWILHPGG NAILDRVEER LGLGPEKLRA SRDVLSEYGN LTSACVLFIL 350
DLVRRKSKKQ QQ 362
Length:362
Mass (Da):40,434
Last modified:February 1, 1996 - v1
Checksum:i9589BB9E159081EA
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei362 – 3621

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15945 mRNA. Translation: AAA62497.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15945 mRNA. Translation: AAA62497.1 .

3D structure databases

ProteinModelPortali P48400.
SMRi P48400. Positions 12-359.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the chalcone synthase gene family in the genus Ipomoea."
    Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
    Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCHSA_IPOPL
AccessioniPrimary (citable) accession number: P48400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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