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P48398 (CHSB_IPOPU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase B

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase B
Short name=CHS-B
Gene names
Name:CHSB
OrganismIpomoea purpurea (Common morning glory) (Pharbitis purpurea)
Taxonomic identifier4121 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Chalcone synthase B
PRO_0000215993

Sites

Active site1701 By similarity

Sequences

Sequence LengthMass (Da)Tools
P48398 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 352C478C1AF892B6

FASTA39643,927
        10         20         30         40         50         60 
MSTTVTVLTD TWSRRAKRLE GDAKILAIGT ATPASWVDQT TYPDFYFRIT NSQHLLEHKE 

        70         80         90        100        110        120 
KFRRICNKSK IRKRHLVLTE ELLKKNPNLC TYNETSLNTR QDILVSEVPK LGKEAAMKAI 

       130        140        150        160        170        180 
KEWGRPISEI THLVFCTTSG VDMPGADFQL TKLLGLNSSV KRLMMYQQGC NAGAAMLRLA 

       190        200        210        220        230        240 
KDLAESNKGG RVLVVCAEIT INIFRGPSLE QDDNLLAQCL FGDGAAAMIV AADPRPGLET 

       250        260        270        280        290        300 
PLFELVSSAQ TIVPNTDSHL KLHLREMGLT FHCSKAVPSV LAENVEDCLV KAFEPYGISD 

       310        320        330        340        350        360 
WNSIFWVFHP GGNAIVDRVE ERLGLGPEKL RASRDVLSEY GNLTSACVLF ILDEMRKKSK 

       370        380        390 
KDEQMTTGEG LEWGVVFGFG PGLTIDTIII RSVPIN 

« Hide

References

[1]"Evolution of the chalcone synthase gene family in the genus Ipomoea."
Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15947 Genomic DNA. Translation: AAC49030.1.
PIRT10951.

3D structure databases

ProteinModelPortalP48398.
SMRP48398. Positions 14-395.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSB_IPOPU
AccessionPrimary (citable) accession number: P48398
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways