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P48398

- CHSB_IPOPU

UniProt

P48398 - CHSB_IPOPU

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Protein

Chalcone synthase B

Gene

CHSB

Organism
Ipomoea purpurea (Common morning glory) (Pharbitis purpurea)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase B (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase B
Short name:
CHS-B
Gene namesi
Name:CHSB
OrganismiIpomoea purpurea (Common morning glory) (Pharbitis purpurea)
Taxonomic identifieri4121 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Chalcone synthase BPRO_0000215993Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48398.
SMRiP48398. Positions 14-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48398-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTTVTVLTD TWSRRAKRLE GDAKILAIGT ATPASWVDQT TYPDFYFRIT
60 70 80 90 100
NSQHLLEHKE KFRRICNKSK IRKRHLVLTE ELLKKNPNLC TYNETSLNTR
110 120 130 140 150
QDILVSEVPK LGKEAAMKAI KEWGRPISEI THLVFCTTSG VDMPGADFQL
160 170 180 190 200
TKLLGLNSSV KRLMMYQQGC NAGAAMLRLA KDLAESNKGG RVLVVCAEIT
210 220 230 240 250
INIFRGPSLE QDDNLLAQCL FGDGAAAMIV AADPRPGLET PLFELVSSAQ
260 270 280 290 300
TIVPNTDSHL KLHLREMGLT FHCSKAVPSV LAENVEDCLV KAFEPYGISD
310 320 330 340 350
WNSIFWVFHP GGNAIVDRVE ERLGLGPEKL RASRDVLSEY GNLTSACVLF
360 370 380 390
ILDEMRKKSK KDEQMTTGEG LEWGVVFGFG PGLTIDTIII RSVPIN
Length:396
Mass (Da):43,927
Last modified:February 1, 1996 - v1
Checksum:i352C478C1AF892B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15947 Genomic DNA. Translation: AAC49030.1.
PIRiT10951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15947 Genomic DNA. Translation: AAC49030.1 .
PIRi T10951.

3D structure databases

ProteinModelPortali P48398.
SMRi P48398. Positions 14-395.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the chalcone synthase gene family in the genus Ipomoea."
    Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
    Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHSB_IPOPU
AccessioniPrimary (citable) accession number: P48398
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3