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P48397

- CHSA_IPOPU

UniProt

P48397 - CHSA_IPOPU

Protein

Chalcone synthase A

Gene

CHSA

Organism
Ipomoea purpurea (Common morning glory) (Pharbitis purpurea)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei170 – 1701PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase A (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase A
    Short name:
    CHS-A
    Gene namesi
    Name:CHSA
    OrganismiIpomoea purpurea (Common morning glory) (Pharbitis purpurea)
    Taxonomic identifieri4121 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Chalcone synthase APRO_0000215992Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP48397.
    SMRiP48397. Positions 15-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48397-1 [UniParc]FASTAAdd to Basket

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    MSTTVTVLTD TWSHRAKRLE GDAKILAIGT ATPANWVDQT TYPDFYFRIT    50
    NSEHLLEHKE KFRRICNKSK IMKRHLVITE ELLKKNPNLC TYNEASLNTR 100
    QDILVSEVPK LGKDAAMKAI KEWGRPISEI THLVFCTTSG VDMPGADFQL 150
    TKLLGLNSSV KRLMMYQQGC NAGAAMLRLA KDLAENNKGG RVLVVCSEVM 200
    LSVFRGPSLQ QEDNLLAQCL FGDGAAAVIV GTEPRPGLET PLFELVSAAQ 250
    TTIPDTDSYL KLQLREMGLT FHCSKAVPSL ITQNVEDCLV KAFEPFGISD 300
    WNSIFWILHP GGNAILDGVE EKLGLEPEKL RASRDVLSQY GNLTSACVLF 350
    ILDEVRKKSK KDEQMTTGEG LEWGVVFGFG PGLTIDTVVI RSVPIN 396
    Length:396
    Mass (Da):43,805
    Last modified:July 15, 1999 - v2
    Checksum:i2C06EA046DFCAC7C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 196HRAKRL → RREKRN(PubMed:7724563)Curated
    Sequence conflicti114 – 1141D → E in AAB02620. (PubMed:7724563)Curated
    Sequence conflicti190 – 1901G → A in AAB02620. (PubMed:7724563)Curated
    Sequence conflicti225 – 2251A → S in AAB02620. (PubMed:7724563)Curated
    Sequence conflicti285 – 2851V → I in AAB02620. (PubMed:7724563)Curated
    Sequence conflicti362 – 3632DE → QQ in AAB02620. (PubMed:7724563)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15946 Genomic DNA. Translation: AAB02620.1.
    U84905 Genomic DNA. Translation: AAB62582.1.
    U84907 Genomic DNA. Translation: AAB62584.1.
    U84908 Genomic DNA. Translation: AAB62585.1.
    U84909 Genomic DNA. Translation: AAB62586.1.
    PIRiT10958.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15946 Genomic DNA. Translation: AAB02620.1 .
    U84905 Genomic DNA. Translation: AAB62582.1 .
    U84907 Genomic DNA. Translation: AAB62584.1 .
    U84908 Genomic DNA. Translation: AAB62585.1 .
    U84909 Genomic DNA. Translation: AAB62586.1 .
    PIRi T10958.

    3D structure databases

    ProteinModelPortali P48397.
    SMRi P48397. Positions 15-395.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the chalcone synthase gene family in the genus Ipomoea."
      Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
      Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide polymorphism in the chalcone synthase-A locus and evolution of the chalcone synthase multigene family of common morning glory (Ipomoea purpurea)."
      Huttley G.A., Durbin M.L., Glover D.E., Clegg M.T.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: IMEX16, IMEX19, IMEX22 and IMEX8.

    Entry informationi

    Entry nameiCHSA_IPOPU
    AccessioniPrimary (citable) accession number: P48397
    Secondary accession number(s): O04984
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3