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P48395 (CHSA_IPONI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase A

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase A
Short name=CHS-A
Gene names
Name:CHSA
OrganismIpomoea nil (Japanese morning glory) (Pharbitis nil)
Taxonomic identifier35883 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

Protein attributes

Sequence length344 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›344›344Chalcone synthase A
PRO_0000216035

Sites

Active site1671 By similarity

Experimental info

Non-terminal residue3441

Sequences

Sequence LengthMass (Da)Tools
P48395 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 16EDC8D76F940404

FASTA34438,352
        10         20         30         40         50         60 
MSTILTNTWT RREKRIEGHA KILAIGTAIP ANWVDQTTYP DFYFRITNSE HLLEHKEKFR 

        70         80         90        100        110        120 
RICNKSKIRK RHLVITEELL KKNPNLCTYN EASLNTRQDI LVSEVPKLGK EAAMKAIKEW 

       130        140        150        160        170        180 
GRPISEITHL VFCTSSGVDM PGADFQLAKL LGLSSSVNRL MMYQQGCNAG AAMLRLAKDL 

       190        200        210        220        230        240 
AENNKGGRVL VVCSEVMLNV FRGPSLEQED YLLAQCLFGD GSAAVIVGTE PRPGLETPLF 

       250        260        270        280        290        300 
ELVSAAQTTI PDTDSHLKLH LREMGLTFHC SKAVPSLITQ NVEDYLVKAF EPFGISDWNS 

       310        320        330        340 
IFWILHPGGI AILDRVEEKL GLEPEKLRAS RDVLSESGNL TSAC 

« Hide

References

[1]"Evolution of the chalcone synthase gene family in the genus Ipomoea."
Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15943 Genomic DNA. Translation: AAC49028.1.

3D structure databases

ProteinModelPortalP48395.
SMRP48395. Positions 11-344.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSA_IPONI
AccessionPrimary (citable) accession number: P48395
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways