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P48395

- CHSA_IPONI

UniProt

P48395 - CHSA_IPONI

Protein

Chalcone synthase A

Gene

CHSA

Organism
Ipomoea nil (Japanese morning glory) (Pharbitis nil)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    • Comment

    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei167 – 1671PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase A (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase A
    Short name:
    CHS-A
    Gene namesi
    Name:CHSA
    OrganismiIpomoea nil (Japanese morning glory) (Pharbitis nil)
    Taxonomic identifieri35883 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›344›344Chalcone synthase APRO_0000216035Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP48395.
    SMRiP48395. Positions 11-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P48395-1 [UniParc]FASTAAdd to Basket

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    MSTILTNTWT RREKRIEGHA KILAIGTAIP ANWVDQTTYP DFYFRITNSE    50
    HLLEHKEKFR RICNKSKIRK RHLVITEELL KKNPNLCTYN EASLNTRQDI 100
    LVSEVPKLGK EAAMKAIKEW GRPISEITHL VFCTSSGVDM PGADFQLAKL 150
    LGLSSSVNRL MMYQQGCNAG AAMLRLAKDL AENNKGGRVL VVCSEVMLNV 200
    FRGPSLEQED YLLAQCLFGD GSAAVIVGTE PRPGLETPLF ELVSAAQTTI 250
    PDTDSHLKLH LREMGLTFHC SKAVPSLITQ NVEDYLVKAF EPFGISDWNS 300
    IFWILHPGGI AILDRVEEKL GLEPEKLRAS RDVLSESGNL TSAC 344
    Length:344
    Mass (Da):38,352
    Last modified:February 1, 1996 - v1
    Checksum:i16EDC8D76F940404
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei344 – 3441

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15943 Genomic DNA. Translation: AAC49028.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15943 Genomic DNA. Translation: AAC49028.1 .

    3D structure databases

    ProteinModelPortali P48395.
    SMRi P48395. Positions 11-344.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the chalcone synthase gene family in the genus Ipomoea."
      Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
      Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCHSA_IPONI
    AccessioniPrimary (citable) accession number: P48395
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3