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P48394 (CHSB_IPOCO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase B

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase B
Short name=CHS-B
Gene names
Name:CHSB
OrganismIpomoea cordatotriloba (Cotton morning glory)
Taxonomic identifier35882 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

Protein attributes

Sequence length363 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›363›363Chalcone synthase B
PRO_0000215991

Sites

Active site1701 By similarity

Experimental info

Non-terminal residue3631

Sequences

Sequence LengthMass (Da)Tools
P48394 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: C7E4838342E575BB

FASTA36340,413
        10         20         30         40         50         60 
MCTTVTVLTD TWSRREKRFE GHAKILAIGT ATPANWVDQT TYPDFYFRIT NSQHLLDHKE 

        70         80         90        100        110        120 
KFRRICNKSK IRKRHMILTE ELLKKNPNLC TYNDASLNTR QDILVSEVPK LGKEAAMKAI 

       130        140        150        160        170        180 
KEWGRPISEI THLVFCTTSG VDMPGADFQL TKLLGLNSSV KRLMMYQQGC NAGAAMLRLA 

       190        200        210        220        230        240 
KDVAENNKGA RVLVVCSEVM LSVFRGPSLQ QEDNLLAQCL FGDGSAALIV GTDPRPGLET 

       250        260        270        280        290        300 
PLFELISAAQ TIIPNTDSHL KLHVREMGLT FHCSKAVPTF ITQNVEDCLV KAFEPYGISD 

       310        320        330        340        350        360 
WNSIFWVLHP GGNAIVDGVE ETLGLAPEKL RASRDVLSGY GNLTSACVLF ILDEVRKKSK 


KDE 

« Hide

References

[1]"Evolution of the chalcone synthase gene family in the genus Ipomoea."
Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.
Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15942 Genomic DNA. Translation: AAC49027.1.

3D structure databases

ProteinModelPortalP48394.
SMRP48394. Positions 14-362.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSB_IPOCO
AccessionPrimary (citable) accession number: P48394
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways