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Protein

Chalcone synthase A

Gene

CHSA

Organism
Ipomoea cordatotriloba (Tievine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase A (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase A
Short name:
CHS-A
Gene namesi
Name:CHSA
OrganismiIpomoea cordatotriloba (Tievine)
Taxonomic identifieri35882 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159901 – ›361Chalcone synthase AAdd BLAST›361

Structurei

3D structure databases

ProteinModelPortaliP48393.
SMRiP48393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
PANTHERiPTHR11877. PTHR11877. 1 hit.
PfamiView protein in Pfam
PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiView protein in PROSITE
PS00441. CHALCONE_SYNTH. 1 hit.

Sequencei

Sequence statusi: Fragment.

P48393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPTVTVQLT DDTAKRFEGH AKLLAIGTAT PTNWVDQATY PDFYFRITNS
60 70 80 90 100
EHLLEHKEKF RRICNKSKIR KRHLVLTEEL LKENPNLCTY NDASLNTRQD
110 120 130 140 150
ILVSEVPKLG KEAAMKAIKE WGRPISEITH LVFCTTSGVD MPGADFQLTK
160 170 180 190 200
LLGLNSSVKR LMMYQQGCNA GAAMLRLVKG LAENNKGARV LVVCSGITIN
210 220 230 240 250
IFRGPSLEQD DNLLAQCLFG DGSAAMIDGK DPRPGLETPL FELVSSAQTI
260 270 280 290 300
VPNTDSHLKL HLREMGLTFH CSRAVPSVLA ENVEDCLVKA FEPYGISDWN
310 320 330 340 350
SIFWVFHPGG NAIVDRVEER SGLGPERLRA SRDVLSEYGN LTSACVLFIL
360
DEMRKKSKKD E
Length:361
Mass (Da):40,194
Last modified:February 1, 1996 - v1
Checksum:i68645ED2801FDED8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei3611

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15941 Genomic DNA. Translation: AAC49026.1.

Similar proteinsi

Entry informationi

Entry nameiCHSA_IPOCO
AccessioniPrimary (citable) accession number: P48393
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 22, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families