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P48392 (CHS3_GERHY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 3

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 3
Gene names
Name:CHS3
OrganismGerbera hybrida (Daisy)
Taxonomic identifier18101 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeMutisioideaeMutisieaeGerbera

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Chalcone synthase 3
PRO_0000215978

Sites

Active site1701 By similarity

Sequences

Sequence LengthMass (Da)Tools
P48392 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 819E10C6E4255140

FASTA40344,129
        10         20         30         40         50         60 
MATSPAVIDV ETIRKAQRAE GPATILAIGT ATPANCVYQA DYPDYYFRVT ESEHMVDLKE 

        70         80         90        100        110        120 
KFQRMCDKSM IRKRYMHITE EFLKENPSMC KFMAPSLDAR QDLVVVEVPK LGKEAATKAI 

       130        140        150        160        170        180 
KEWGFPKSKI THLVFCTTSG VDMPGADYQL TKLLGLRPSV KRLMMYQQGC FAGGTVLRLA 

       190        200        210        220        230        240 
KDLAENNKGA RVLVVCSEIT AVTFRGPNEG HLDSLVGQAL FGDGAAAVII GSDPDLSVER 

       250        260        270        280        290        300 
PLFEMVSAAQ TILPDSEGAI DGHLKEVGLT FHLLKDVPAL IAKNIEKALI QAFSPLNIND 

       310        320        330        340        350        360 
WNSIFWIAHP GGPAILDQVE FKLGLREEKL RASRHVLSEY GNMSSACVLF ILDEMRKKSI 

       370        380        390        400 
KDGKTTTGEG LEWGVLFGFG PGLTVETVVL HSLPATISVA TQN 

« Hide

References

[1]"Chalcone synthase-like genes active during corolla development are differentially expressed and encode enzymes with different catalytic properties in Gerbera hybrida (Asteraceae)."
Helariutta Y., Elomaa P., Kotilainen M., Griesbach R.J., Schroeder J., Teeri T.H.
Plant Mol. Biol. 28:47-60(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Corolla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38098 mRNA. Translation: CAA86220.1.
PIRS55464. S56701.

3D structure databases

ProteinModelPortalP48392.
SMRP48392. Positions 10-393.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS3_GERHY
AccessionPrimary (citable) accession number: P48392
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways