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Protein

2-pyrone synthase

Gene

2PS

Organism
Gerbera hybrida (Daisy)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Polyketide synthase, which uses acetyl-CoA and two condensation reactions with malonyl-CoA to form triacetic acid lactone (also called methylpyrone), a precursor of phytoalexin. May participate in insect and pathogen resistance.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
2-pyrone synthase (EC:2.3.1.-)
Short name:
2-PS
Alternative name(s):
G2ps1
Gene namesi
Name:2PS
Synonyms:CHS2
OrganismiGerbera hybrida (Daisy)
Taxonomic identifieri18101 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeMutisioideaeMutisieaeGerbera

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002160921 – 4022-pyrone synthaseAdd BLAST402

Structurei

Secondary structure

1402
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 30Combined sources8
Beta strandi35 – 37Combined sources3
Helixi38 – 48Combined sources11
Helixi55 – 67Combined sources13
Beta strandi72 – 74Combined sources3
Helixi79 – 84Combined sources6
Helixi86 – 89Combined sources4
Beta strandi90 – 94Combined sources5
Helixi96 – 122Combined sources27
Helixi126 – 128Combined sources3
Beta strandi131 – 135Combined sources5
Beta strandi141 – 143Combined sources3
Helixi145 – 153Combined sources9
Beta strandi160 – 164Combined sources5
Helixi171 – 185Combined sources15
Beta strandi191 – 197Combined sources7
Helixi199 – 202Combined sources4
Helixi211 – 216Combined sources6
Turni217 – 219Combined sources3
Beta strandi223 – 232Combined sources10
Turni235 – 237Combined sources3
Beta strandi242 – 251Combined sources10
Helixi256 – 258Combined sources3
Beta strandi259 – 264Combined sources6
Helixi276 – 292Combined sources17
Helixi293 – 295Combined sources3
Helixi300 – 302Combined sources3
Beta strandi303 – 307Combined sources5
Helixi312 – 321Combined sources10
Turni326 – 329Combined sources4
Helixi330 – 339Combined sources10
Helixi343 – 345Combined sources3
Helixi346 – 360Combined sources15
Beta strandi370 – 379Combined sources10
Turni380 – 382Combined sources3
Beta strandi383 – 391Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EE0X-ray2.05A/B1-402[»]
1QLVX-ray2.10A/B1-402[»]
ProteinModelPortaliP48391.
SMRiP48391.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48391.

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSYSSDDVE VIREAGRAQG LATILAIGTA TPPNCVAQAD YADYYFRVTK
60 70 80 90 100
SEHMVDLKEK FKRICEKTAI KKRYLALTED YLQENPTMCE FMAPSLNARQ
110 120 130 140 150
DLVVTGVPML GKEAAVKAID EWGLPKSKIT HLIFCTTAGV DMPGADYQLV
160 170 180 190 200
KLLGLSPSVK RYMLYQQGCA AGGTVLRLAK DLAENNKGSR VLIVCSEITA
210 220 230 240 250
ILFHGPNENH LDSLVAQALF GDGAAALIVG SGPHLAVERP IFEIVSTDQT
260 270 280 290 300
ILPDTEKAMK LHLREGGLTF QLHRDVPLMV AKNIENAAEK ALSPLGITDW
310 320 330 340 350
NSVFWMVHPG GRAILDQVER KLNLKEDKLR ASRHVLSEYG NLISACVLFI
360 370 380 390 400
IDEVRKRSMA EGKSTTGEGL DCGVLFGFGP GMTVETVVLR SVRVTAAVAN

GN
Length:402
Mass (Da):43,749
Last modified:August 14, 2001 - v2
Checksum:i593257F979EE45A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38097 mRNA. Translation: CAA86219.2.
PIRiS56700. S55465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38097 mRNA. Translation: CAA86219.2.
PIRiS56700. S55465.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EE0X-ray2.05A/B1-402[»]
1QLVX-ray2.10A/B1-402[»]
ProteinModelPortaliP48391.
SMRiP48391.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP48391.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei2PS_GERHY
AccessioniPrimary (citable) accession number: P48391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 14, 2001
Last modified: November 2, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Ref. 3 has shown that this is not a chalcone synthase, but a pyrone synthase.Curated

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.