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Protein

2-pyrone synthase

Gene

2PS

Organism
Gerbera hybrida (Daisy)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Polyketide synthase, which uses acetyl-CoA and two condensation reactions with malonyl-CoA to form triacetic acid lactone (also called methylpyrone), a precursor of phytoalexin. May participate in insect and pathogen resistance.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
2-pyrone synthase (EC:2.3.1.-)
Short name:
2-PS
Alternative name(s):
G2ps1
Gene namesi
Name:2PS
Synonyms:CHS2
OrganismiGerbera hybrida (Daisy)
Taxonomic identifieri18101 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeMutisioideaeMutisieaeGerbera

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4024022-pyrone synthasePRO_0000216092Add
BLAST

Structurei

Secondary structure

1
402
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 308Combined sources
Beta strandi35 – 373Combined sources
Helixi38 – 4811Combined sources
Helixi55 – 6713Combined sources
Beta strandi72 – 743Combined sources
Helixi79 – 846Combined sources
Helixi86 – 894Combined sources
Beta strandi90 – 945Combined sources
Helixi96 – 12227Combined sources
Helixi126 – 1283Combined sources
Beta strandi131 – 1355Combined sources
Beta strandi141 – 1433Combined sources
Helixi145 – 1539Combined sources
Beta strandi160 – 1645Combined sources
Helixi171 – 18515Combined sources
Beta strandi191 – 1977Combined sources
Helixi199 – 2024Combined sources
Helixi211 – 2166Combined sources
Turni217 – 2193Combined sources
Beta strandi223 – 23210Combined sources
Turni235 – 2373Combined sources
Beta strandi242 – 25110Combined sources
Helixi256 – 2583Combined sources
Beta strandi259 – 2646Combined sources
Helixi276 – 29217Combined sources
Helixi293 – 2953Combined sources
Helixi300 – 3023Combined sources
Beta strandi303 – 3075Combined sources
Helixi312 – 32110Combined sources
Turni326 – 3294Combined sources
Helixi330 – 33910Combined sources
Helixi343 – 3453Combined sources
Helixi346 – 36015Combined sources
Beta strandi370 – 37910Combined sources
Turni380 – 3823Combined sources
Beta strandi383 – 3919Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EE0X-ray2.05A/B1-402[»]
1QLVX-ray2.10A/B1-402[»]
ProteinModelPortaliP48391.
SMRiP48391. Positions 18-395.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48391.

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSYSSDDVE VIREAGRAQG LATILAIGTA TPPNCVAQAD YADYYFRVTK
60 70 80 90 100
SEHMVDLKEK FKRICEKTAI KKRYLALTED YLQENPTMCE FMAPSLNARQ
110 120 130 140 150
DLVVTGVPML GKEAAVKAID EWGLPKSKIT HLIFCTTAGV DMPGADYQLV
160 170 180 190 200
KLLGLSPSVK RYMLYQQGCA AGGTVLRLAK DLAENNKGSR VLIVCSEITA
210 220 230 240 250
ILFHGPNENH LDSLVAQALF GDGAAALIVG SGPHLAVERP IFEIVSTDQT
260 270 280 290 300
ILPDTEKAMK LHLREGGLTF QLHRDVPLMV AKNIENAAEK ALSPLGITDW
310 320 330 340 350
NSVFWMVHPG GRAILDQVER KLNLKEDKLR ASRHVLSEYG NLISACVLFI
360 370 380 390 400
IDEVRKRSMA EGKSTTGEGL DCGVLFGFGP GMTVETVVLR SVRVTAAVAN

GN
Length:402
Mass (Da):43,749
Last modified:August 14, 2001 - v2
Checksum:i593257F979EE45A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38097 mRNA. Translation: CAA86219.2.
PIRiS56700. S55465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38097 mRNA. Translation: CAA86219.2.
PIRiS56700. S55465.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EE0X-ray2.05A/B1-402[»]
1QLVX-ray2.10A/B1-402[»]
ProteinModelPortaliP48391.
SMRiP48391. Positions 18-395.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP48391.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Chalcone synthase-like genes active during corolla development are differentially expressed and encode enzymes with different catalytic properties in Gerbera hybrida (Asteraceae)."
    Helariutta Y., Elomaa P., Kotilainen M., Griesbach R.J., Schroeder J., Teeri T.H.
    Plant Mol. Biol. 28:47-60(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Corolla.
  2. Teeri T.H.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 259.
  3. Cited for: FUNCTION.
  4. "Structural control of polyketide formation in plant-specific polyketide synthases."
    Jez J.M., Austin M.B., Ferrer J.-L., Bowman M.E., Schroeder J., Noel J.P.
    Chem. Biol. 7:919-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) IN COMPLEX WITH ACETOACETYL-COA.

Entry informationi

Entry namei2PS_GERHY
AccessioniPrimary (citable) accession number: P48391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 14, 2001
Last modified: October 14, 2015
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Ref. 3 has shown that this is not a chalcone synthase, but a pyrone synthase.Curated

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.