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P48390 (CHS1_GERHY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 1

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 1
Gene names
Name:CHS1
OrganismGerbera hybrida (Daisy)
Taxonomic identifier18101 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeMutisioideaeMutisieaeGerbera

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Chalcone synthase 1
PRO_0000215977

Sites

Active site1671 By similarity

Sequences

Sequence LengthMass (Da)Tools
P48390 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: A5D095314D6F9A1D

FASTA39843,494
        10         20         30         40         50         60 
MASSVDMKAI RDAQRAEGPA TILAIGTATP ANCVYQADYP DYYFRITKSE HMVDLKEKFK 

        70         80         90        100        110        120 
RMCDKSMIRK RYMHITEEYL KQNPNMCAYM APSLDVRQDL VVVEVPKLGK EAAMKAIKEW 

       130        140        150        160        170        180 
GHPKSKITHL IFCTTSGVDM PGADYQLTKL LGLRPSVKRF MMYQQGCFAG GTVLRLAKDL 

       190        200        210        220        230        240 
AENNKGARVL VVCSEITAVT FRGPNDTHLD SLVGQALFGD GAAAVIVGSD PDLTTERPLF 

       250        260        270        280        290        300 
EMVSAAQTIL PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIEKALTTAF SPLGINDWNS 

       310        320        330        340        350        360 
IFWIAHPGGP AILDQVELKL GLKEEKLRAT RHVLSEYGNM SSACVLFIID EMRKKSSENG 

       370        380        390 
AGTTGEGLEW GVLFGFGPGL TVETVVLHSV PTTVTVAV 

« Hide

References

[1]"Chalcone synthase-like genes active during corolla development are differentially expressed and encode enzymes with different catalytic properties in Gerbera hybrida (Asteraceae)."
Helariutta Y., Elomaa P., Kotilainen M., Griesbach R.J., Schroeder J., Teeri T.H.
Plant Mol. Biol. 28:47-60(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Corolla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38096 mRNA. Translation: CAA86218.1.
PIRS56699.

3D structure databases

ProteinModelPortalP48390.
SMRP48390. Positions 10-390.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS1_GERHY
AccessionPrimary (citable) accession number: P48390
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways