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P48387

- CHS2_CAMSI

UniProt

P48387 - CHS2_CAMSI

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Protein
Chalcone synthase 2
Gene
CHS2
Organism
Camellia sinensis (Tea)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641 By similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 2 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 2
Gene namesi
Name:CHS2
OrganismiCamellia sinensis (Tea)
Taxonomic identifieri4442 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridsEricalesTheaceaeCamellia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Chalcone synthase 2
PRO_0000215961Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48387.
SMRiP48387. Positions 3-388.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48387-1 [UniParc]FASTAAdd to Basket

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MVTVEEVRRA QRAEGPATVM AIGTATPPNC VDQSTYPDYY FRITNSEHKT    50
ELKEKFQRMC DKSMIKKRYM YLTEEILKEN PNVCAYMAPS LDARQDMVVV 100
EVPKLGKEAA TKAIKEWGQP KSKITHLVFC TTSGVDMPGA DYQLTKLLGL 150
RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG 200
PSDAHLDSLV GQALFGDGAA AIIVGSDPIP EVEKPLFELV SAAQTILPDS 250
DGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLNEAFQPL NITDWNSLFW 300
IAHPGGPAIL DQVELKLALK PEKLRATRHV LSEYGNMSSA CVLFILDEMR 350
KSSAKKGLKT TGEGLDWGVL FGFGPGLTVE TVVLHSVST 389
Length:389
Mass (Da):42,595
Last modified:February 1, 1996 - v1
Checksum:i74ACC577956F9DBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26594 mRNA. Translation: BAA05641.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26594 mRNA. Translation: BAA05641.1 .

3D structure databases

ProteinModelPortali P48387.
SMRi P48387. Positions 3-388.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chalcone synthase from Camellia sinensis: isolation of the cDNAs and the organ-specific and sugar-responsive expression of the genes."
    Takeuchi A., Matsumoto S., Hayatsu M.
    Plant Cell Physiol. 35:1011-1018(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Yabukita.
    Tissue: Leaf.

Entry informationi

Entry nameiCHS2_CAMSI
AccessioniPrimary (citable) accession number: P48387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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