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P48385

- CHSY_CALCH

UniProt

P48385 - CHSY_CALCH

Protein

Chalcone synthase

Gene

CHS

Organism
Callistephus chinensis (China aster) (Callistemma chinense)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    • Comment

    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei167 – 1671PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase
    Gene namesi
    Name:CHS
    OrganismiCallistephus chinensis (China aster) (Callistemma chinense)
    Taxonomic identifieri13379 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeAstereaeAustralasian lineagesCallistephus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Chalcone synthasePRO_0000215959Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP48385.
    SMRiP48385. Positions 7-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48385-1 [UniParc]FASTAAdd to Basket

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    MASTIDIAAI REAQRRQGPA TILAIGTATP SNCVYQADYP DYYFRITKSE    50
    HMVDLKEKFK RMCDKSMIRK RYMHLTEEYL KENPSLCEYM APSLDARQDV 100
    VVVEVPKLGK EAATKAIKEW GQPKSKITHL IFCTTSGVDM PGADYQLTKL 150
    LGLRPSVKRF MMYQQGCFAG GTVLRLAKDL AENNKGARVL VVCSEITAVT 200
    FRGPNDTHLD SLVGQALFGD GAAAVIVGAD PDLTTERPLF EMISAAQTIL 250
    PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIEKALTQAF SPLGITDWNS 300
    IFWIAHPGGP AILDQVELKL GLKEEKMRAT RHVLSEYGNM SSACVLFIID 350
    EMRKKSAEDG AATTGEGLDW GVLFGFGPGL TVETVVLHSL PTTMAIAT 398
    Length:398
    Mass (Da):43,541
    Last modified:December 15, 1998 - v2
    Checksum:i8B7D4E11B4FAFFC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z67988 mRNA. Translation: CAA91930.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z67988 mRNA. Translation: CAA91930.1 .

    3D structure databases

    ProteinModelPortali P48385.
    SMRi P48385. Positions 7-390.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Henkel J., Wassenegger M., Sommer H., Forkmann G.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: L 01.
      Tissue: Petal.

    Entry informationi

    Entry nameiCHSY_CALCH
    AccessioniPrimary (citable) accession number: P48385
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3