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Protein

Transcription factor RFX3

Gene

RFX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Acts as a transcription factor. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi183 – 25876RFX-type winged-helixPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: GO_Central
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: ProtInc
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. cell maturation Source: BHF-UCL
  2. cilium assembly Source: BHF-UCL
  3. cilium-dependent cell motility Source: UniProtKB
  4. endocrine pancreas development Source: UniProtKB
  5. epithelial cilium movement involved in determination of left/right asymmetry Source: UniProtKB
  6. negative regulation of transcription, DNA-templated Source: UniProtKB
  7. positive regulation of transcription, DNA-templated Source: UniProtKB
  8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  9. positive regulation of type B pancreatic cell development Source: BHF-UCL
  10. regulation of insulin secretion Source: UniProtKB
  11. regulation of transcription, DNA-templated Source: UniProtKB
  12. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  13. transcription from RNA polymerase II promoter Source: GOC
  14. type B pancreatic cell differentiation Source: GO_Central
  15. type B pancreatic cell maturation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor RFX3
Alternative name(s):
Regulatory factor X 3
Gene namesi
Name:RFX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:9984. RFX3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nuclear chromatin Source: BHF-UCL
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Transcription factor RFX3PRO_0000215290Add
BLAST

Proteomic databases

MaxQBiP48380.
PaxDbiP48380.
PRIDEiP48380.

PTM databases

PhosphoSiteiP48380.

Expressioni

Gene expression databases

BgeeiP48380.
CleanExiHS_RFX3.
ExpressionAtlasiP48380. baseline and differential.
GenevestigatoriP48380.

Organism-specific databases

HPAiHPA035689.

Interactioni

Protein-protein interaction databases

BioGridi111923. 14 interactions.
IntActiP48380. 3 interactions.
STRINGi9606.ENSP00000371434.

Structurei

3D structure databases

ProteinModelPortaliP48380.
SMRiP48380. Positions 184-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RFX family.PROSITE-ProRule annotation
Contains 1 RFX-type winged-helix DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG264634.
GeneTreeiENSGT00550000074532.
HOVERGENiHBG002753.
InParanoidiP48380.
KOiK09173.
OMAiDMQYMAL.
OrthoDBiEOG7TF793.
PhylomeDBiP48380.
TreeFamiTF321340.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003150. DNA-bd_RFX.
IPR007668. RFX1_trans_act.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04589. RFX1_trans_act. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
PROSITEiPS51526. RFX_DBD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P48380-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQTSETGSDT GSTVTLQTSV ASQAAVPTQV VQQVPVQQQV QQVQTVQQVQ
60 70 80 90 100
HVYPAQVQYV EGSDTVYTNG AIRTTTYPYT ETQMYSQNTG GNYFDTQGSS
110 120 130 140 150
AQVTTVVSSH SMVGTGGIQM GVTGGQLISS SGGTYLIGNS MENSGHSVTH
160 170 180 190 200
TTRASPATIE MAIETLQKSD GLSTHRSSLL NSHLQWLLDN YETAEGVSLP
210 220 230 240 250
RSTLYNHYLR HCQEHKLDPV NAASFGKLIR SIFMGLRTRR LGTRGNSKYH
260 270 280 290 300
YYGIRVKPDS PLNRLQEDMQ YMAMRQQPMQ QKQRYKPMQK VDGVADGFTG
310 320 330 340 350
SGQQTGTSVE QTVIAQSQHH QQFLDASRAL PEFGEVEISS LPDGTTFEDI
360 370 380 390 400
KSLQSLYREH CEAILDVVVN LQFSLIEKLW QTFWRYSPST PTDGTTITES
410 420 430 440 450
SNLSEIESRL PKAKLITLCK HESILKWMCN CDHGMYQALV EILIPDVLRP
460 470 480 490 500
IPSALTQAIR NFAKSLEGWL SNAMNNIPQR MIQTKVAAVS AFAQTLRRYT
510 520 530 540 550
SLNHLAQAAR AVLQNTSQIN QMLSDLNRVD FANVQEQASW VCQCDDNMVQ
560 570 580 590 600
RLETDFKMTL QQQSTLEQWA AWLDNVMMQA LKPYEGRPSF PKAARQFLLK
610 620 630 640 650
WSFYSSMVIR DLTLRSAASF GSFHLIRLLY DEYMFYLVEH RVAQATGETP
660 670 680 690 700
IAVMGEFGDL NAVSPGNLDK DEGSEVESEM DEELDDSSEP QAKREKTELS
710 720 730 740
QAFPVGCMQP VLETGVQPSL LNPIHSEHIV TSTQTIRQCS ATGNTYTAV

Note: No experimental confirmation available.

Length:749
Mass (Da):83,530
Last modified:June 20, 2003 - v2
Checksum:i531F5CFCA7A707C7
GO
Isoform 2 (identifier: P48380-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     657-707: FGDLNAVSPG...ELSQAFPVGC → VREAERAVTH...RDCGVIARVP
     708-749: Missing.

Show »
Length:707
Mass (Da):79,357
Checksum:iA1959E3F23E0D8F0
GO
Isoform 3 (identifier: P48380-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-413: SNLSEIESRLPKA → RSESTSFPIHFHG
     414-749: Missing.

Note: No experimental confirmation available.

Show »
Length:413
Mass (Da):45,715
Checksum:i8C355CDF0E4837D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501H → P in BAF82229 (PubMed:14702039).Curated
Sequence conflicti310 – 3101E → G in AAH67778 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei401 – 41313SNLSE…RLPKA → RSESTSFPIHFHG in isoform 3. 1 PublicationVSP_015162Add
BLAST
Alternative sequencei414 – 749336Missing in isoform 3. 1 PublicationVSP_015163Add
BLAST
Alternative sequencei657 – 70751FGDLN…FPVGC → VREAERAVTHWVIKNKPELH FSLNTLLIKTMVPNQVSLRA RRDCGVIARVP in isoform 2. 1 PublicationVSP_007626Add
BLAST
Alternative sequencei708 – 74942Missing in isoform 2. 1 PublicationVSP_007627Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76092 mRNA. Translation: CAA53706.1.
AK289540 mRNA. Translation: BAF82229.1.
AL365202, AL133549, AL354941 Genomic DNA. Translation: CAI13403.1.
AL365202, AL133549, AL354941 Genomic DNA. Translation: CAI13404.1.
AL133549, AL354941, AL365202 Genomic DNA. Translation: CAI40199.1.
AL133549, AL354941, AL365202 Genomic DNA. Translation: CAI40200.1.
AL354941, AL133549, AL365202 Genomic DNA. Translation: CAI41215.1.
AL354941, AL133549, AL365202 Genomic DNA. Translation: CAI41216.1.
CH471071 Genomic DNA. Translation: EAW58795.1.
CH471071 Genomic DNA. Translation: EAW58796.1.
CH471071 Genomic DNA. Translation: EAW58798.1.
CH471071 Genomic DNA. Translation: EAW58799.1.
BC022191 mRNA. Translation: AAH22191.1.
BC067778 mRNA. Translation: AAH67778.1.
CCDSiCCDS6449.1. [P48380-1]
CCDS6450.1. [P48380-2]
CCDS75809.1. [P48380-3]
PIRiD55926.
RefSeqiNP_001269045.1. NM_001282116.1. [P48380-1]
NP_001269046.1. NM_001282117.1. [P48380-3]
NP_002910.1. NM_002919.3. [P48380-2]
NP_602304.1. NM_134428.2. [P48380-1]
UniGeneiHs.136829.
Hs.438858.
Hs.734648.

Genome annotation databases

EnsembliENST00000302303; ENSP00000303847; ENSG00000080298. [P48380-3]
ENST00000358730; ENSP00000351574; ENSG00000080298. [P48380-2]
ENST00000382004; ENSP00000371434; ENSG00000080298. [P48380-1]
ENST00000617270; ENSP00000482598; ENSG00000080298. [P48380-1]
GeneIDi5991.
KEGGihsa:5991.
UCSCiuc003zhr.3. human. [P48380-1]
uc003zhs.1. human. [P48380-2]
uc003zht.1. human. [P48380-3]

Polymorphism databases

DMDMi32172437.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76092 mRNA. Translation: CAA53706.1.
AK289540 mRNA. Translation: BAF82229.1.
AL365202, AL133549, AL354941 Genomic DNA. Translation: CAI13403.1.
AL365202, AL133549, AL354941 Genomic DNA. Translation: CAI13404.1.
AL133549, AL354941, AL365202 Genomic DNA. Translation: CAI40199.1.
AL133549, AL354941, AL365202 Genomic DNA. Translation: CAI40200.1.
AL354941, AL133549, AL365202 Genomic DNA. Translation: CAI41215.1.
AL354941, AL133549, AL365202 Genomic DNA. Translation: CAI41216.1.
CH471071 Genomic DNA. Translation: EAW58795.1.
CH471071 Genomic DNA. Translation: EAW58796.1.
CH471071 Genomic DNA. Translation: EAW58798.1.
CH471071 Genomic DNA. Translation: EAW58799.1.
BC022191 mRNA. Translation: AAH22191.1.
BC067778 mRNA. Translation: AAH67778.1.
CCDSiCCDS6449.1. [P48380-1]
CCDS6450.1. [P48380-2]
CCDS75809.1. [P48380-3]
PIRiD55926.
RefSeqiNP_001269045.1. NM_001282116.1. [P48380-1]
NP_001269046.1. NM_001282117.1. [P48380-3]
NP_002910.1. NM_002919.3. [P48380-2]
NP_602304.1. NM_134428.2. [P48380-1]
UniGeneiHs.136829.
Hs.438858.
Hs.734648.

3D structure databases

ProteinModelPortaliP48380.
SMRiP48380. Positions 184-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111923. 14 interactions.
IntActiP48380. 3 interactions.
STRINGi9606.ENSP00000371434.

PTM databases

PhosphoSiteiP48380.

Polymorphism databases

DMDMi32172437.

Proteomic databases

MaxQBiP48380.
PaxDbiP48380.
PRIDEiP48380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302303; ENSP00000303847; ENSG00000080298. [P48380-3]
ENST00000358730; ENSP00000351574; ENSG00000080298. [P48380-2]
ENST00000382004; ENSP00000371434; ENSG00000080298. [P48380-1]
ENST00000617270; ENSP00000482598; ENSG00000080298. [P48380-1]
GeneIDi5991.
KEGGihsa:5991.
UCSCiuc003zhr.3. human. [P48380-1]
uc003zhs.1. human. [P48380-2]
uc003zht.1. human. [P48380-3]

Organism-specific databases

CTDi5991.
GeneCardsiGC09M003214.
HGNCiHGNC:9984. RFX3.
HPAiHPA035689.
MIMi601337. gene.
neXtProtiNX_P48380.
PharmGKBiPA34354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG264634.
GeneTreeiENSGT00550000074532.
HOVERGENiHBG002753.
InParanoidiP48380.
KOiK09173.
OMAiDMQYMAL.
OrthoDBiEOG7TF793.
PhylomeDBiP48380.
TreeFamiTF321340.

Miscellaneous databases

ChiTaRSiRFX3. human.
GeneWikiiRFX3.
GenomeRNAii5991.
NextBioi23335.
PROiP48380.
SOURCEiSearch...

Gene expression databases

BgeeiP48380.
CleanExiHS_RFX3.
ExpressionAtlasiP48380. baseline and differential.
GenevestigatoriP48380.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003150. DNA-bd_RFX.
IPR007668. RFX1_trans_act.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04589. RFX1_trans_act. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
PROSITEiPS51526. RFX_DBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins."
    Reith W., Ucla C., Barras E., Gaud A., Durand B., Herrero-Sanchez C., Kobr M., Mach B.
    Mol. Cell. Biol. 14:1230-1244(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Muscle and Testis.
  6. "Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter."
    Nakayama A., Murakami H., Maeyama N., Yamashiro N., Sakakibara A., Mori N., Takahashi M.
    J. Biol. Chem. 278:233-240(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH RFX6.

Entry informationi

Entry nameiRFX3_HUMAN
AccessioniPrimary (citable) accession number: P48380
Secondary accession number(s): A8K0H5
, D3DRH8, D3DRH9, Q5JTL7, Q5JTL8, Q6NW13, Q8WTU4, Q95HL5, Q95HL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 20, 2003
Last modified: February 4, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.