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P48379

- RFX2_MOUSE

UniProt

P48379 - RFX2_MOUSE

Protein

DNA-binding protein RFX2

Gene

Rfx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi194 – 26976RFX-type winged-helixPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-binding protein RFX2
    Alternative name(s):
    Regulatory factor X 2
    Gene namesi
    Name:Rfx2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:106583. Rfx2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 717717DNA-binding protein RFX2PRO_0000215289Add
    BLAST

    Proteomic databases

    PaxDbiP48379.
    PRIDEiP48379.

    PTM databases

    PhosphoSiteiP48379.

    Expressioni

    Gene expression databases

    BgeeiP48379.
    GenevestigatoriP48379.

    Interactioni

    Protein-protein interaction databases

    BioGridi202873. 4 interactions.
    IntActiP48379. 1 interaction.
    STRINGi10090.ENSMUSP00000002444.

    Structurei

    3D structure databases

    ProteinModelPortaliP48379.
    SMRiP48379. Positions 195-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RFX family.PROSITE-ProRule annotation
    Contains 1 RFX-type winged-helix DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG264634.
    GeneTreeiENSGT00550000074532.
    HOGENOMiHOG000294091.
    HOVERGENiHBG002753.
    InParanoidiQ8BXR3.
    KOiK09173.
    OMAiEAQIYAP.
    OrthoDBiEOG7TF793.
    PhylomeDBiP48379.
    TreeFamiTF321340.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR003150. DNA-bd_RFX.
    IPR007668. RFX1_trans_act.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF04589. RFX1_trans_act. 1 hit.
    PF02257. RFX_DNA_binding. 1 hit.
    [Graphical view]
    PROSITEiPS51526. RFX_DBD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P48379-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MQNSEGGADS PASVALRPAA QPMPASPQRV LVQAAGSTPK GTPMQTLTLP    50
    RVQPVPPQVQ HVYPAQVQYV EGGDAVYANG AIRAAYAYNP DPQLYAPSSA 100
    ASYFETPGGT QVTVAASSPP AVPSHGMVGI TMDVSGTPIV SGAGAYLIHG 150
    GMDGTRHSLA HTARSSPATL EMAIETLQKS EGLAPHKGGL LNSHLQWLLD 200
    NYETAEGVSL PRSSLYNHYL RHCQEHKLEP VNAASFGKLI RSVFMGLRTR 250
    RLGTRGNSKY HYYGIRLKPD SPLNRLQEDT QYMAMRQQPT HQKPRYRPAQ 300
    KSDSLGDGSA HSNMHGMPDQ AMATQGQHHQ QYIDVSHVFP EFPAPDLGST 350
    LLQESVTLHD VKALQLVYRR HCEATLDVVM NLQFQYIEKL WLSFWNCKAT 400
    SSDSCASLPA SDEDPEVTLL PKEKLISLCK CEPILQWMRS CDHILYQTLV 450
    ETLIPDVLRP VPSSLTQAIR NFAKSLEGWL INAMSGFPQQ VIQTKVGVVS 500
    AFAQTLRRYT SLNHLAQAAR AVLQNTSQIN QMLSDLNRVD FANVQEQASW 550
    VCQCEESLVQ RLEHDFKVTL QQQSSLDQWA SWLDNVVTQV LKQHSGSPSF 600
    PKAARQFLLK WSFYSSMVIR DLTLRSAASF GSFHLIRLLY DEYMFYLVEH 650
    RVAQATGETP IAVMGEFNDL ASLSLTLLDK EDIGDGHSSE ADVDGRSLGE 700
    PLVKRERSDP SHPLQGI 717
    Length:717
    Mass (Da):79,190
    Last modified:July 28, 2009 - v2
    Checksum:i3A0EBF008ECD8B61
    GO
    Isoform 2 (identifier: P48379-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         170-194: Missing.

    Show »
    Length:692
    Mass (Da):76,534
    Checksum:iE4A187A90CD88F81
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei170 – 19425Missing in isoform 2. 2 PublicationsVSP_037812Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76089 mRNA. Translation: CAA53703.1.
    AK044439 mRNA. Translation: BAC31919.1.
    BC004654 mRNA. Translation: AAH04654.1.
    CCDSiCCDS28915.1. [P48379-2]
    CCDS50156.1. [P48379-1]
    PIRiC55926.
    RefSeqiNP_033082.1. NM_009056.2. [P48379-2]
    NP_082063.1. NM_027787.1. [P48379-1]
    UniGeneiMm.102.

    Genome annotation databases

    EnsembliENSMUST00000002444; ENSMUSP00000002444; ENSMUSG00000024206. [P48379-1]
    ENSMUST00000086801; ENSMUSP00000084010; ENSMUSG00000024206. [P48379-2]
    GeneIDi19725.
    KEGGimmu:19725.
    UCSCiuc008ddf.2. mouse. [P48379-2]
    uc008ddg.2. mouse. [P48379-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76089 mRNA. Translation: CAA53703.1 .
    AK044439 mRNA. Translation: BAC31919.1 .
    BC004654 mRNA. Translation: AAH04654.1 .
    CCDSi CCDS28915.1. [P48379-2 ]
    CCDS50156.1. [P48379-1 ]
    PIRi C55926.
    RefSeqi NP_033082.1. NM_009056.2. [P48379-2 ]
    NP_082063.1. NM_027787.1. [P48379-1 ]
    UniGenei Mm.102.

    3D structure databases

    ProteinModelPortali P48379.
    SMRi P48379. Positions 195-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202873. 4 interactions.
    IntActi P48379. 1 interaction.
    STRINGi 10090.ENSMUSP00000002444.

    PTM databases

    PhosphoSitei P48379.

    Proteomic databases

    PaxDbi P48379.
    PRIDEi P48379.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002444 ; ENSMUSP00000002444 ; ENSMUSG00000024206 . [P48379-1 ]
    ENSMUST00000086801 ; ENSMUSP00000084010 ; ENSMUSG00000024206 . [P48379-2 ]
    GeneIDi 19725.
    KEGGi mmu:19725.
    UCSCi uc008ddf.2. mouse. [P48379-2 ]
    uc008ddg.2. mouse. [P48379-1 ]

    Organism-specific databases

    CTDi 5990.
    MGIi MGI:106583. Rfx2.

    Phylogenomic databases

    eggNOGi NOG264634.
    GeneTreei ENSGT00550000074532.
    HOGENOMi HOG000294091.
    HOVERGENi HBG002753.
    InParanoidi Q8BXR3.
    KOi K09173.
    OMAi EAQIYAP.
    OrthoDBi EOG7TF793.
    PhylomeDBi P48379.
    TreeFami TF321340.

    Miscellaneous databases

    NextBioi 297132.
    PROi P48379.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48379.
    Genevestigatori P48379.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR003150. DNA-bd_RFX.
    IPR007668. RFX1_trans_act.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF04589. RFX1_trans_act. 1 hit.
    PF02257. RFX_DNA_binding. 1 hit.
    [Graphical view ]
    PROSITEi PS51526. RFX_DBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins."
      Reith W., Ucla C., Barras E., Gaud A., Durand B., Herrero-Sanchez C., Kobr M., Mach B.
      Mol. Cell. Biol. 14:1230-1244(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: BALB/c.
      Tissue: Spleen.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Retina.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiRFX2_MOUSE
    AccessioniPrimary (citable) accession number: P48379
    Secondary accession number(s): Q8BXR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3