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P48377

- RFX1_MOUSE

UniProt

P48377 - RFX1_MOUSE

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Protein
MHC class II regulatory factor RFX1
Gene
Rfx1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi423 – 49876RFX-type winged-helix
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MHC class II regulatory factor RFX1
Alternative name(s):
Regulatory factor X 1
Transcription factor RFX1
Gene namesi
Name:Rfx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:105982. Rfx1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963MHC class II regulatory factor RFX1
PRO_0000215287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei962 – 9621Phosphoserine By similarity
Modified residuei963 – 9631Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48377.
PRIDEiP48377.

PTM databases

PhosphoSiteiP48377.

Expressioni

Gene expression databases

BgeeiP48377.
GenevestigatoriP48377.

Interactioni

Protein-protein interaction databases

BioGridi202872. 1 interaction.
STRINGi10090.ENSMUSP00000005600.

Structurei

3D structure databases

ProteinModelPortaliP48377.
SMRiP48377. Positions 423-498.

Family & Domainsi

Sequence similaritiesi

Belongs to the RFX family.

Phylogenomic databases

eggNOGiNOG264634.
GeneTreeiENSGT00550000074532.
HOGENOMiHOG000294091.
HOVERGENiHBG002753.
InParanoidiQ6PGH8.
KOiK09173.
OMAiSTYSYPE.
OrthoDBiEOG7TF793.
TreeFamiTF321340.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003150. DNA-bd_RFX.
IPR007668. RFX1_trans_act.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04589. RFX1_trans_act. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
PROSITEiPS51526. RFX_DBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48377-1 [UniParc]FASTAAdd to Basket

« Hide

MATQSYVTEL QAAPQASQPP QAPPQALPQP PPPAAPQPPA AATPQPQYVT    50
ELQSPQPQTQ PPGSQKQYVA ELPAAPAPSQ PATPAPSPVA QQYIVVTVSE 100
GAMRASETVS EASPSSTASQ TGVPTQVVQQ VQGTQQRLLV QASVQAKPGH 150
VSPLQLTNIQ VPQQAIPTQH LVVQSPAPGT KSGQVSLTVH SAQQVHSAPE 200
RSPVQANNST SKTAGTPAAT VQQLQVHSVQ QSVPVTQERS VVQATPQTKA 250
GPVQQLTVQG LQPVHVAQEV QQLPQVPVPH VYSSQVQYVE GGDASYTASA 300
IRSSTYQYPE TPIYTQTAGT SYYEASGTAA QVSTPATSQT VASSGSVPMY 350
VSGSPIVASS SSSEAGASNS SVGAGGNGGG GSSGGGSGGS SGSGAGTYVI 400
QGGYMLGNAS QSYSHTTRAS PATVQWLLDN YETAEGVSLP RSTLYCHYLL 450
HCQEQKLEPV NAASFGKLIR SVFMGLRTRR LGTRGNSKYH YYGLRIKASS 500
PLLRLMEDQQ HMAMRGQPFS QKQRLKPIQK MEGVANGVAV GQQSTGLSDI 550
SAQVQQYQQF LDASRSLPDF AELDLQGKVL PEGVGPGDIK AFQVLYREHC 600
EAIVDVMVNL QFTLVETLWK TFWRYNLSQP SEAPPLAVHD EAEKRLPRAS 650
LVLLSKFQPV LQWTKHCDNV LYQGLVEILI PDVLRPIPSA LTQAIRNFAK 700
SLESWLTHAM VNIPEEMLRV KVAAAGAFAQ TLRRYTSLNH LAQAARAVLQ 750
NTAQINQMLS DLNRVDFANV QEQASWVCRC EDRVVQRLEQ DFKVTLQQQN 800
SLEQWAAWLD GVVSQVLKPY QGSSGFPKAA KLFLLKWSFY SSMVIRDLTL 850
RSAASFGSFH LIRLLYDEYM YYLIEHRVAQ AKGETPIAVM GEFANLATSL 900
NPLDPDKDEE EEEEEESEDE LPQDISLAAG SESPALGPEA LEPPAKLART 950
DTRGLFVQAL PSS 963
Length:963
Mass (Da):103,707
Last modified:July 27, 2011 - v2
Checksum:iC868182B206BA9F0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti169 – 1702QH → HD in CAA53702. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76088 mRNA. Translation: CAA53702.1.
CH466525 Genomic DNA. Translation: EDL10930.1.
BC057018 mRNA. Translation: AAH57018.1.
CCDSiCCDS22468.1.
PIRiA55926.
RefSeqiNP_033081.3. NM_009055.4.
UniGeneiMm.7892.

Genome annotation databases

EnsembliENSMUST00000005600; ENSMUSP00000005600; ENSMUSG00000031706.
GeneIDi19724.
KEGGimmu:19724.
UCSCiuc009mlv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76088 mRNA. Translation: CAA53702.1 .
CH466525 Genomic DNA. Translation: EDL10930.1 .
BC057018 mRNA. Translation: AAH57018.1 .
CCDSi CCDS22468.1.
PIRi A55926.
RefSeqi NP_033081.3. NM_009055.4.
UniGenei Mm.7892.

3D structure databases

ProteinModelPortali P48377.
SMRi P48377. Positions 423-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202872. 1 interaction.
STRINGi 10090.ENSMUSP00000005600.

PTM databases

PhosphoSitei P48377.

Proteomic databases

PaxDbi P48377.
PRIDEi P48377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005600 ; ENSMUSP00000005600 ; ENSMUSG00000031706 .
GeneIDi 19724.
KEGGi mmu:19724.
UCSCi uc009mlv.2. mouse.

Organism-specific databases

CTDi 5989.
MGIi MGI:105982. Rfx1.

Phylogenomic databases

eggNOGi NOG264634.
GeneTreei ENSGT00550000074532.
HOGENOMi HOG000294091.
HOVERGENi HBG002753.
InParanoidi Q6PGH8.
KOi K09173.
OMAi STYSYPE.
OrthoDBi EOG7TF793.
TreeFami TF321340.

Miscellaneous databases

ChiTaRSi RFX1. mouse.
NextBioi 297128.
PROi P48377.
SOURCEi Search...

Gene expression databases

Bgeei P48377.
Genevestigatori P48377.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR003150. DNA-bd_RFX.
IPR007668. RFX1_trans_act.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF04589. RFX1_trans_act. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view ]
PROSITEi PS51526. RFX_DBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins."
    Reith W., Ucla C., Barras E., Gaud A., Durand B., Herrero-Sanchez C., Kobr M., Mach B.
    Mol. Cell. Biol. 14:1230-1244(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiRFX1_MOUSE
AccessioniPrimary (citable) accession number: P48377
Secondary accession number(s): Q6PGH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi