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P48377

- RFX1_MOUSE

UniProt

P48377 - RFX1_MOUSE

Protein

MHC class II regulatory factor RFX1

Gene

Rfx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi423 – 49876RFX-type winged-helixPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MHC class II regulatory factor RFX1
    Alternative name(s):
    Regulatory factor X 1
    Transcription factor RFX1
    Gene namesi
    Name:Rfx1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:105982. Rfx1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 963963MHC class II regulatory factor RFX1PRO_0000215287Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei962 – 9621PhosphoserineBy similarity
    Modified residuei963 – 9631PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP48377.
    PRIDEiP48377.

    PTM databases

    PhosphoSiteiP48377.

    Expressioni

    Gene expression databases

    BgeeiP48377.
    GenevestigatoriP48377.

    Interactioni

    Protein-protein interaction databases

    BioGridi202872. 1 interaction.
    STRINGi10090.ENSMUSP00000005600.

    Structurei

    3D structure databases

    ProteinModelPortaliP48377.
    SMRiP48377. Positions 423-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RFX family.PROSITE-ProRule annotation
    Contains 1 RFX-type winged-helix DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG264634.
    GeneTreeiENSGT00550000074532.
    HOGENOMiHOG000294091.
    HOVERGENiHBG002753.
    InParanoidiQ6PGH8.
    KOiK09173.
    OMAiSTYSYPE.
    OrthoDBiEOG7TF793.
    TreeFamiTF321340.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR003150. DNA-bd_RFX.
    IPR007668. RFX1_trans_act.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF04589. RFX1_trans_act. 1 hit.
    PF02257. RFX_DNA_binding. 1 hit.
    [Graphical view]
    PROSITEiPS51526. RFX_DBD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48377-1 [UniParc]FASTAAdd to Basket

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    MATQSYVTEL QAAPQASQPP QAPPQALPQP PPPAAPQPPA AATPQPQYVT    50
    ELQSPQPQTQ PPGSQKQYVA ELPAAPAPSQ PATPAPSPVA QQYIVVTVSE 100
    GAMRASETVS EASPSSTASQ TGVPTQVVQQ VQGTQQRLLV QASVQAKPGH 150
    VSPLQLTNIQ VPQQAIPTQH LVVQSPAPGT KSGQVSLTVH SAQQVHSAPE 200
    RSPVQANNST SKTAGTPAAT VQQLQVHSVQ QSVPVTQERS VVQATPQTKA 250
    GPVQQLTVQG LQPVHVAQEV QQLPQVPVPH VYSSQVQYVE GGDASYTASA 300
    IRSSTYQYPE TPIYTQTAGT SYYEASGTAA QVSTPATSQT VASSGSVPMY 350
    VSGSPIVASS SSSEAGASNS SVGAGGNGGG GSSGGGSGGS SGSGAGTYVI 400
    QGGYMLGNAS QSYSHTTRAS PATVQWLLDN YETAEGVSLP RSTLYCHYLL 450
    HCQEQKLEPV NAASFGKLIR SVFMGLRTRR LGTRGNSKYH YYGLRIKASS 500
    PLLRLMEDQQ HMAMRGQPFS QKQRLKPIQK MEGVANGVAV GQQSTGLSDI 550
    SAQVQQYQQF LDASRSLPDF AELDLQGKVL PEGVGPGDIK AFQVLYREHC 600
    EAIVDVMVNL QFTLVETLWK TFWRYNLSQP SEAPPLAVHD EAEKRLPRAS 650
    LVLLSKFQPV LQWTKHCDNV LYQGLVEILI PDVLRPIPSA LTQAIRNFAK 700
    SLESWLTHAM VNIPEEMLRV KVAAAGAFAQ TLRRYTSLNH LAQAARAVLQ 750
    NTAQINQMLS DLNRVDFANV QEQASWVCRC EDRVVQRLEQ DFKVTLQQQN 800
    SLEQWAAWLD GVVSQVLKPY QGSSGFPKAA KLFLLKWSFY SSMVIRDLTL 850
    RSAASFGSFH LIRLLYDEYM YYLIEHRVAQ AKGETPIAVM GEFANLATSL 900
    NPLDPDKDEE EEEEEESEDE LPQDISLAAG SESPALGPEA LEPPAKLART 950
    DTRGLFVQAL PSS 963
    Length:963
    Mass (Da):103,707
    Last modified:July 27, 2011 - v2
    Checksum:iC868182B206BA9F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti169 – 1702QH → HD in CAA53702. (PubMed:8289803)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76088 mRNA. Translation: CAA53702.1.
    CH466525 Genomic DNA. Translation: EDL10930.1.
    BC057018 mRNA. Translation: AAH57018.1.
    CCDSiCCDS22468.1.
    PIRiA55926.
    RefSeqiNP_033081.3. NM_009055.4.
    UniGeneiMm.7892.

    Genome annotation databases

    EnsembliENSMUST00000005600; ENSMUSP00000005600; ENSMUSG00000031706.
    GeneIDi19724.
    KEGGimmu:19724.
    UCSCiuc009mlv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76088 mRNA. Translation: CAA53702.1 .
    CH466525 Genomic DNA. Translation: EDL10930.1 .
    BC057018 mRNA. Translation: AAH57018.1 .
    CCDSi CCDS22468.1.
    PIRi A55926.
    RefSeqi NP_033081.3. NM_009055.4.
    UniGenei Mm.7892.

    3D structure databases

    ProteinModelPortali P48377.
    SMRi P48377. Positions 423-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202872. 1 interaction.
    STRINGi 10090.ENSMUSP00000005600.

    PTM databases

    PhosphoSitei P48377.

    Proteomic databases

    PaxDbi P48377.
    PRIDEi P48377.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005600 ; ENSMUSP00000005600 ; ENSMUSG00000031706 .
    GeneIDi 19724.
    KEGGi mmu:19724.
    UCSCi uc009mlv.2. mouse.

    Organism-specific databases

    CTDi 5989.
    MGIi MGI:105982. Rfx1.

    Phylogenomic databases

    eggNOGi NOG264634.
    GeneTreei ENSGT00550000074532.
    HOGENOMi HOG000294091.
    HOVERGENi HBG002753.
    InParanoidi Q6PGH8.
    KOi K09173.
    OMAi STYSYPE.
    OrthoDBi EOG7TF793.
    TreeFami TF321340.

    Miscellaneous databases

    ChiTaRSi RFX1. mouse.
    NextBioi 297128.
    PROi P48377.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48377.
    Genevestigatori P48377.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR003150. DNA-bd_RFX.
    IPR007668. RFX1_trans_act.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF04589. RFX1_trans_act. 1 hit.
    PF02257. RFX_DNA_binding. 1 hit.
    [Graphical view ]
    PROSITEi PS51526. RFX_DBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins."
      Reith W., Ucla C., Barras E., Gaud A., Durand B., Herrero-Sanchez C., Kobr M., Mach B.
      Mol. Cell. Biol. 14:1230-1244(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Spleen.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiRFX1_MOUSE
    AccessioniPrimary (citable) accession number: P48377
    Secondary accession number(s): Q6PGH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3