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Protein

MHC class II regulatory factor RFX1

Gene

Rfx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi423 – 49876RFX-type winged-helixPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MHC class II regulatory factor RFX1
Alternative name(s):
Regulatory factor X 1
Transcription factor RFX1
Gene namesi
Name:Rfx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:105982. Rfx1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963MHC class II regulatory factor RFX1PRO_0000215287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei962 – 9621PhosphoserineBy similarity
Modified residuei963 – 9631PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP48377.
PaxDbiP48377.
PRIDEiP48377.

PTM databases

PhosphoSiteiP48377.

Expressioni

Gene expression databases

BgeeiP48377.
ExpressionAtlasiP48377. baseline and differential.
GenevisibleiP48377. MM.

Interactioni

Protein-protein interaction databases

BioGridi202872. 1 interaction.
STRINGi10090.ENSMUSP00000005600.

Structurei

3D structure databases

ProteinModelPortaliP48377.
SMRiP48377. Positions 423-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RFX family.PROSITE-ProRule annotation
Contains 1 RFX-type winged-helix DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG264634.
GeneTreeiENSGT00550000074532.
HOGENOMiHOG000294091.
HOVERGENiHBG002753.
InParanoidiP48377.
KOiK09173.
OMAiLKPYQHS.
OrthoDBiEOG7TF793.
TreeFamiTF321340.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003150. DNA-bd_RFX.
IPR007668. RFX1_trans_act.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04589. RFX1_trans_act. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
PROSITEiPS51526. RFX_DBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQSYVTEL QAAPQASQPP QAPPQALPQP PPPAAPQPPA AATPQPQYVT
60 70 80 90 100
ELQSPQPQTQ PPGSQKQYVA ELPAAPAPSQ PATPAPSPVA QQYIVVTVSE
110 120 130 140 150
GAMRASETVS EASPSSTASQ TGVPTQVVQQ VQGTQQRLLV QASVQAKPGH
160 170 180 190 200
VSPLQLTNIQ VPQQAIPTQH LVVQSPAPGT KSGQVSLTVH SAQQVHSAPE
210 220 230 240 250
RSPVQANNST SKTAGTPAAT VQQLQVHSVQ QSVPVTQERS VVQATPQTKA
260 270 280 290 300
GPVQQLTVQG LQPVHVAQEV QQLPQVPVPH VYSSQVQYVE GGDASYTASA
310 320 330 340 350
IRSSTYQYPE TPIYTQTAGT SYYEASGTAA QVSTPATSQT VASSGSVPMY
360 370 380 390 400
VSGSPIVASS SSSEAGASNS SVGAGGNGGG GSSGGGSGGS SGSGAGTYVI
410 420 430 440 450
QGGYMLGNAS QSYSHTTRAS PATVQWLLDN YETAEGVSLP RSTLYCHYLL
460 470 480 490 500
HCQEQKLEPV NAASFGKLIR SVFMGLRTRR LGTRGNSKYH YYGLRIKASS
510 520 530 540 550
PLLRLMEDQQ HMAMRGQPFS QKQRLKPIQK MEGVANGVAV GQQSTGLSDI
560 570 580 590 600
SAQVQQYQQF LDASRSLPDF AELDLQGKVL PEGVGPGDIK AFQVLYREHC
610 620 630 640 650
EAIVDVMVNL QFTLVETLWK TFWRYNLSQP SEAPPLAVHD EAEKRLPRAS
660 670 680 690 700
LVLLSKFQPV LQWTKHCDNV LYQGLVEILI PDVLRPIPSA LTQAIRNFAK
710 720 730 740 750
SLESWLTHAM VNIPEEMLRV KVAAAGAFAQ TLRRYTSLNH LAQAARAVLQ
760 770 780 790 800
NTAQINQMLS DLNRVDFANV QEQASWVCRC EDRVVQRLEQ DFKVTLQQQN
810 820 830 840 850
SLEQWAAWLD GVVSQVLKPY QGSSGFPKAA KLFLLKWSFY SSMVIRDLTL
860 870 880 890 900
RSAASFGSFH LIRLLYDEYM YYLIEHRVAQ AKGETPIAVM GEFANLATSL
910 920 930 940 950
NPLDPDKDEE EEEEEESEDE LPQDISLAAG SESPALGPEA LEPPAKLART
960
DTRGLFVQAL PSS
Length:963
Mass (Da):103,707
Last modified:July 27, 2011 - v2
Checksum:iC868182B206BA9F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti169 – 1702QH → HD in CAA53702 (PubMed:8289803).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76088 mRNA. Translation: CAA53702.1.
CH466525 Genomic DNA. Translation: EDL10930.1.
BC057018 mRNA. Translation: AAH57018.1.
CCDSiCCDS22468.1.
PIRiA55926.
RefSeqiNP_033081.3. NM_009055.4.
UniGeneiMm.7892.

Genome annotation databases

EnsembliENSMUST00000005600; ENSMUSP00000005600; ENSMUSG00000031706.
GeneIDi19724.
KEGGimmu:19724.
UCSCiuc009mlv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76088 mRNA. Translation: CAA53702.1.
CH466525 Genomic DNA. Translation: EDL10930.1.
BC057018 mRNA. Translation: AAH57018.1.
CCDSiCCDS22468.1.
PIRiA55926.
RefSeqiNP_033081.3. NM_009055.4.
UniGeneiMm.7892.

3D structure databases

ProteinModelPortaliP48377.
SMRiP48377. Positions 423-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202872. 1 interaction.
STRINGi10090.ENSMUSP00000005600.

PTM databases

PhosphoSiteiP48377.

Proteomic databases

MaxQBiP48377.
PaxDbiP48377.
PRIDEiP48377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005600; ENSMUSP00000005600; ENSMUSG00000031706.
GeneIDi19724.
KEGGimmu:19724.
UCSCiuc009mlv.2. mouse.

Organism-specific databases

CTDi5989.
MGIiMGI:105982. Rfx1.

Phylogenomic databases

eggNOGiNOG264634.
GeneTreeiENSGT00550000074532.
HOGENOMiHOG000294091.
HOVERGENiHBG002753.
InParanoidiP48377.
KOiK09173.
OMAiLKPYQHS.
OrthoDBiEOG7TF793.
TreeFamiTF321340.

Miscellaneous databases

ChiTaRSiRfx1. mouse.
NextBioi297128.
PROiP48377.
SOURCEiSearch...

Gene expression databases

BgeeiP48377.
ExpressionAtlasiP48377. baseline and differential.
GenevisibleiP48377. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003150. DNA-bd_RFX.
IPR007668. RFX1_trans_act.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04589. RFX1_trans_act. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
PROSITEiPS51526. RFX_DBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins."
    Reith W., Ucla C., Barras E., Gaud A., Durand B., Herrero-Sanchez C., Kobr M., Mach B.
    Mol. Cell. Biol. 14:1230-1244(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiRFX1_MOUSE
AccessioniPrimary (citable) accession number: P48377
Secondary accession number(s): Q6PGH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.