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P48377 (RFX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MHC class II regulatory factor RFX1
Alternative name(s):
Regulatory factor X 1
Transcription factor RFX1
Gene names
Name:Rfx1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length963 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the RFX family.

Contains 1 RFX-type winged-helix DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from direct assay PubMed 8224874. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 963963MHC class II regulatory factor RFX1
PRO_0000215287

Regions

DNA binding423 – 49876RFX-type winged-helix

Amino acid modifications

Modified residue9621Phosphoserine By similarity
Modified residue9631Phosphoserine By similarity

Experimental info

Sequence conflict169 – 1702QH → HD in CAA53702. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P48377 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: C868182B206BA9F0

FASTA963103,707
        10         20         30         40         50         60 
MATQSYVTEL QAAPQASQPP QAPPQALPQP PPPAAPQPPA AATPQPQYVT ELQSPQPQTQ 

        70         80         90        100        110        120 
PPGSQKQYVA ELPAAPAPSQ PATPAPSPVA QQYIVVTVSE GAMRASETVS EASPSSTASQ 

       130        140        150        160        170        180 
TGVPTQVVQQ VQGTQQRLLV QASVQAKPGH VSPLQLTNIQ VPQQAIPTQH LVVQSPAPGT 

       190        200        210        220        230        240 
KSGQVSLTVH SAQQVHSAPE RSPVQANNST SKTAGTPAAT VQQLQVHSVQ QSVPVTQERS 

       250        260        270        280        290        300 
VVQATPQTKA GPVQQLTVQG LQPVHVAQEV QQLPQVPVPH VYSSQVQYVE GGDASYTASA 

       310        320        330        340        350        360 
IRSSTYQYPE TPIYTQTAGT SYYEASGTAA QVSTPATSQT VASSGSVPMY VSGSPIVASS 

       370        380        390        400        410        420 
SSSEAGASNS SVGAGGNGGG GSSGGGSGGS SGSGAGTYVI QGGYMLGNAS QSYSHTTRAS 

       430        440        450        460        470        480 
PATVQWLLDN YETAEGVSLP RSTLYCHYLL HCQEQKLEPV NAASFGKLIR SVFMGLRTRR 

       490        500        510        520        530        540 
LGTRGNSKYH YYGLRIKASS PLLRLMEDQQ HMAMRGQPFS QKQRLKPIQK MEGVANGVAV 

       550        560        570        580        590        600 
GQQSTGLSDI SAQVQQYQQF LDASRSLPDF AELDLQGKVL PEGVGPGDIK AFQVLYREHC 

       610        620        630        640        650        660 
EAIVDVMVNL QFTLVETLWK TFWRYNLSQP SEAPPLAVHD EAEKRLPRAS LVLLSKFQPV 

       670        680        690        700        710        720 
LQWTKHCDNV LYQGLVEILI PDVLRPIPSA LTQAIRNFAK SLESWLTHAM VNIPEEMLRV 

       730        740        750        760        770        780 
KVAAAGAFAQ TLRRYTSLNH LAQAARAVLQ NTAQINQMLS DLNRVDFANV QEQASWVCRC 

       790        800        810        820        830        840 
EDRVVQRLEQ DFKVTLQQQN SLEQWAAWLD GVVSQVLKPY QGSSGFPKAA KLFLLKWSFY 

       850        860        870        880        890        900 
SSMVIRDLTL RSAASFGSFH LIRLLYDEYM YYLIEHRVAQ AKGETPIAVM GEFANLATSL 

       910        920        930        940        950        960 
NPLDPDKDEE EEEEEESEDE LPQDISLAAG SESPALGPEA LEPPAKLART DTRGLFVQAL 


PSS 

« Hide

References

« Hide 'large scale' references
[1]"RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins."
Reith W., Ucla C., Barras E., Gaud A., Durand B., Herrero-Sanchez C., Kobr M., Mach B.
Mol. Cell. Biol. 14:1230-1244(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Spleen.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76088 mRNA. Translation: CAA53702.1.
CH466525 Genomic DNA. Translation: EDL10930.1.
BC057018 mRNA. Translation: AAH57018.1.
CCDSCCDS22468.1.
PIRA55926.
RefSeqNP_033081.3. NM_009055.4.
UniGeneMm.7892.

3D structure databases

ProteinModelPortalP48377.
SMRP48377. Positions 423-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202872. 1 interaction.
STRING10090.ENSMUSP00000005600.

PTM databases

PhosphoSiteP48377.

Proteomic databases

PaxDbP48377.
PRIDEP48377.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000005600; ENSMUSP00000005600; ENSMUSG00000031706.
GeneID19724.
KEGGmmu:19724.
UCSCuc009mlv.2. mouse.

Organism-specific databases

CTD5989.
MGIMGI:105982. Rfx1.

Phylogenomic databases

eggNOGNOG264634.
GeneTreeENSGT00550000074532.
HOGENOMHOG000294091.
HOVERGENHBG002753.
InParanoidQ6PGH8.
KOK09173.
OMASTYSYPE.
OrthoDBEOG7TF793.
TreeFamTF321340.

Gene expression databases

BgeeP48377.
GenevestigatorP48377.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR003150. DNA-bd_RFX.
IPR007668. RFX1_trans_act.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF04589. RFX1_trans_act. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
PROSITEPS51526. RFX_DBD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRFX1. mouse.
NextBio297128.
PROP48377.
SOURCESearch...

Entry information

Entry nameRFX1_MOUSE
AccessionPrimary (citable) accession number: P48377
Secondary accession number(s): Q6PGH8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot